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Severe acute respiratory syndrome coronavirus-2-related and imputable deaths in children:results from the French pediatric national registry

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World Journal of Pediatrics 2024年第6期20卷 611-620页

作者： Marguerite Lockhart-Bouron Noemie Vanel Michael Levy Anais R.briant Etienne Javouhey Sophie Breinig Julia Dina Marion Caseris Francois Angoulvant Stephane Leteurtre Morgan Recher David W.Brossier Univ.Lille CHU LilleULR 2694-METRICS:Evaluation Des Technologies de Sante Et Des Pratiques Medicales59000LilleFrance Pediatric Intensive Care Unit CHU de MarseilleMarseilleFrance Pediatric Intensive Care Unit CHU Robert-DebreAssistance Publique Hopitaux de ParisParisFrance UniversitéParis-Cite ParisFrance Biostatistics and Clinical Research Unit CHU de Caen Normandie14000CaenFrance Pediatric Intensive Care Hospices Civils de LyonLyonFrance Neonatal andPediatric IntensiveCare Unit Children's HospitalToulouseFrance Virology Department INSERM U1311 DynamicureUniv CAEN NormandieCHU de Caen14000 CaenFrance Medical School Universite Caen Normandie14000 CaenFrance Department of Pediatrics CHU Robert-DebréAssistance Publique Hopitaux de ParisParisFrance Department Women-Mother-Child Service of PediatricsLausanne University Hospital(CHUV)LausanneSwitzerland Pediatric Intensive Care Unit Réanimation Et Soins Intensifs PéediatriquesCHU de CAENAvenue de La Cote de Nacre14000 CaenFrance CHU Sainte Justine Research Center MontréalCanada

Background Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)is responsible for an important mortality rate *** aimed to evaluate the actual imputability of SARS-CoV-2 on the mortality rate associated with SARS-CoV-2-related illnesses in the pediatric intensive care unit(PICU).Secondary objectives were to identify risk factors for *** This national multicenter comparative study comprised all patients under 18 years old with positive SARS-CoV-2 polymerase chain reactions(PCRs)[acute corona virus disease 2019(COVID-19)or incidental SARS-CoV-2 infection]and/or pediatric inflammatory multisystem syndrome(PIMS)recorded in the French PICU registry(PICURe)between September 1,2021,and August 31,*** patients were classified and compared according to their living status at the end of their PICU *** patients were evaluated by four experts in the field of pediatric infectiology and/or pediatric intensive *** imputability of SARS-CoV-2 as the cause of death was classified into four categories:certain,very probable,possible,or unlikely,and was defined by any of the first three *** There were 948 patients included of which 43 died(4.5%).From this,26 deaths(67%)could be attributed to SARS-CoV-2 infection,with an overall mortality rate of 2.8%.The imputability of death to SARS-CoV-2 was considered certain in only one case(O.1%).Deceased patients suffered more often from comorbidities,especially heart disease,neurological disorders,hematological disease,cancer,and *** of the deceased patients were admitted for pediatric inflam-matory multisystem syndrome(PIMS).Mortality risk factors were male gender,cardiac comorbidities,cancer,and acute respiratorydistress *** SARS-CoV-2 mortality in the French pediatric population was *** though the imputability of SARS-Cov-2 on mortality was considered in almost two-thirds of cases,this imputability was considered certain in only one case.

关键词： Death Pediatric intensive care unit SARS-CoV-2

Review: laser ignition for aerospace propulsion

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Propulsion and Power Research 2016年第1期5卷 1-21页

作者： Steven A.O’briant Sreenath B.Gupta Subith S.Vasu Department of Mechanicaland Aerospace Engineering Center for Advanced Turbomachinery and Energy ResearchUniversity of Central FloridaOrlandoFL32816USA Argonne National Laboratory ArgonneIL60439USA

Renewed interest in the use of high-speed ramjets and scramjets and more efficient lean burning engines has led to many subsequent developments in the field of laser ignition for aerospace use and *** for newer,more advanced forms of ignition,are increasing as individuals strive to meet regulations that seek to reduce the level of pollutants in the atmosphere,such as CH_(x),NO_(x),and SO_(2).Many aviation gas turbine manufacturers are interested in increasing combustion efficiency in engines,all the while reducing the aforementioned *** is also a desire for a new generation of aircraft and spacecraft,utilizing technologies such as scramjet propulsion,which will never realize their fullest potential without the use of advanced ignition *** scenarios are all limited by the use of conventional spark ignition methods,thus leading to the desire to find new,alternative methods of *** paper aims to provide the reader an overview of advanced ignition methods,with an emphasis on laser ignition and its applications to aerospace propulsion.A comprehensive review of advanced ignition systems in aerospace applications is *** includes studies on gas turbine applications,ramjet and scramjet systems,and space and rocket applications.A brief overview of ignition and laser ignition phenomena is also provided in earlier sections of the *** the reading,research papers,which were presented at the 2nd Laser Ignition Conference in April 2014,are mentioned to indicate the vast array of projects that are currenty being pursued.

关键词： Laser ignition Ignition limit Scramjet Gas turbines Rocket Plasma ignition Propulsion

Role of Aedes aegypti and Aedes albopictus during the 2011 dengue fever epidemics in Hanoi, Vietnam

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Asian Pacific Journal of Tropical Medicine 2015年第7期8卷 541-546页

作者： Pham Thi Kim Lien Vu Trong Duoc Laurent Gavotte Emmanuel Cornillot Phan Thi Nga Laurence briant Roger Frutos Tran Nhu Duong National Institute of Hygiene and Epidemiology CPBS UMR 5236 CNRS-UM1-UM2 1919 route de Mende 34293 Montpellier Cedex 5France ISEM UMR 5554 CNRS-UM2-IRD Université Montpellier 2 CC065 Place E. Bataillon34095 Montpellier Cedex 5 France CPBS UMR 5236 CNRS-UM1-UM2 1919 route de Mende 34293 Montpellier Cedex 5France Intertryp UMR 17 Cirad-IRD Campus International de Baillarguet34398 Montpellier Cedex 5 France

Objective: To record the human cases of dengue fever(DF) and investigate the Aedes mosquito species circulating during the Hanoi 2011 DF epidemics. Methods: 24 different outbreak points were recorded in 8 districts between August and December 2011. Results: 140 patients were hospitalized following dengue diagnostic with a predominance of males(59.3%) and the 15-34 age class. Only DENV-1(11.27%) and DENV-2(88.73%) serotypes were detected in human samples. Mosquito sampling performed in and around patients households revealed the predominance of Aedes aegypti(95.15%) versus Aedes albopictus(4.85%). There is a positive correlation between the population density of Aedes aegypti and the number of human cases and duration of outbreaks. Conclusions: This was not observed for Aedes albopictus. 3 pools of Aedes aegypti were positive with dengue virus, two with DENV-1 and one with DENV-2.

关键词： Aedes aegypti Aedes albopictus Dengue Vector density

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When in China...

当代外语研究 2000年第12期 4-7页

作者： Erin O' briant 林益寿

闲聊半小时,半盛的宴会,卡拉OK……最后谈判签署合同,这就是西方人眼里的“中国式”谈判方式。本文较详细和生动地说明了在经贸谈判过程中,中国(以及日本和韩国)与西方国家在文化背景和习俗等方面的区别,如:颜色、礼物、衣着、饮食和话... 详细信息

闲聊半小时,半盛的宴会,卡拉OK……最后谈判签署合同,这就是西方人眼里的“中国式”谈判方式。本文较详细和生动地说明了在经贸谈判过程中,中国(以及日本和韩国)与西方国家在文化背景和习俗等方面的区别,如:颜色、礼物、衣着、饮食和话题等方面。作者告诉西方商人:入乡随俗也是经营之道,是生意成功的诀窍之一。本文的后面附两篇短文,分别略述了西方人眼中的日本人和亚洲人的某些特殊生活习惯和文化风俗,简短而耐读,琐细而典型,值得一读。】

关键词： In When in China

HIV-1 Assembly, Release and Maturation

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World Journal of AIDS 2011年第4期1卷 111-130页

作者： Laurence briant Bernard Gay Christian Devaux Nathalie Chazal 不详

Late steps of HIV-1 life cycle are determinant for optimal dissemination of the virus to new target cells. These steps include assembly of structural precursors, budding of the new particle and maturation into fully infectious virions. Each step is finely tuned and timely regulated to allow the appropriate assembly of structural components, the efficient recruitment of viral and cell partners and the timely regulated proteolytic processing of the protein precursors. Despite the huge number of studies devoted to the definition of molecular mechanisms regulating these steps, a number of question remains to be answered before they are clearly apprehended. The elucidation of the role played by each viral proteins, nucleic acids as well as host-encoded factors will provide new clues in the understanding of the retroviral assembly/maturation process and will allow further development of new antiviral compounds. This review reports the most recent progress as well as the questions that remain to be answered in the field of HIV-1 assembly, release and maturation. Finally, we also describe the data available on the design and use of new antiretroviral drugs targeting these specific steps of the retroviral replication.

关键词： HIV-1 Assembly Maturation Release Gag Antiviral Molecule

Surveillance of dengue and chikungunya infection in Dong Thap,Vietnam:A 13-month study

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Asian Pacific Journal of Tropical Medicine 2016年第1期9卷 36-40页

作者： Pham Thi Kim Lien Laurence briant Truong Ba Tang Bui Minh Trang Laurent Gavotte Emmanuel Comillot Vu Trong Duoc Tran Nhu Duong Roger Frutos Phan Thi Nga National Institute of Hygiene and Epidemiology University of Montpellier Department of Biology Dong Thap General Hospital Cirad TA-A17/GCampus International de Raillarguet

Objective:To establish a surveillance in Dong Thap,at the border with Cambodia by assessing the presence of DHNV serotypes and CHIKV among patients hospitalized at Dong Thap general ***:Cross-sectional descriptive analysis was conducted on a cohort of 131 patients hospitalized with acute fever and symptoms compatible with dengue or *** study was conducted from January 2012 to February *** full clinical picture was established as well as serological and molecular *** analysis was sequentially performed on blood samples collected on admission and an average of seven days after *** detection of IgM antibody to DENV was performed by IgM capture ELTSA and the detection of DENV and CHIKV RNA was done by reverse-transcription multiplex ***:101 patients out of 131(77%) were confirmed with *** four dengue serotypes were detected with a predominance of DENV2 and *** chikungunya infection was detected although reported in neighboring Cambodia.A differential efficiency of serological dengue detection was *** was 29%upon admission and 53%after seven days on the same patients.30 patients out of 131(23%) were negative with both DENV and ***:Dengue is at risk of being underestimated and chikungunya is not systematically *** in detection and surveillance procedures are therefore discussed to increase efficiency of dengue detection and continue the monitoring the emergence of CHIKV in Dong Thap province and in Vietnam.

关键词： Dengue Chikungunya Arbovirus Dong ThapVietnam

Water Resource Monitoring Exploiting Sentinel-2 Satellite and Sentinel-2 Satellite Like Time Series;Application in Yangtze River Water Bodies

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Journal of Geodesy and Geoinformation Science 2020年第4期3卷 41-49页

作者： Julien briant Huber CLAIRE Studer MATHIAS Lei CAO Kunpeng YI Yésou HERV ICube-SERTIT Universitéde StrasbourgIllkirch-Graffenstaden BP10413France State Key Lab of Urban and Regional Ecology Chinese Academy of SciencesBeijing 100864China

As part of the Dragon 4 project,the water extents of Wuchang and Shengjin lakes have been extracted from Sentinel-2 time series,using all exploitable images since the beginning of the acquisitions in *** aim of the study is to assess the capability of the Sentinel-2 constellation and Landsat 8 over the Anhui region,especially the high temporal resolution.A total of 32 dates have been used and 10 Landsat 8 images(Libra)have been added to try to reduce the temporal gaps in the Sentinel-2 acquisitions caused by cloudy *** were done using a SERTIT-ICube automatized routine based on a supervised Maximum Likelihood *** extractions allow to recreate the dynamic of the two lakes and show the drought and wet *** the 3 years interval,the surface peaks in July 2016 for both *** lowest level appears at two different dates for each lake;in January 2018 for Wuchang,in February 2017 for *** Lake surface area appears to be more variable than Shengjin Lake,with many local maximum and minimum between the end of 2017 and April *** the case of Wuchang Lake,floating vegetation is a problem for automatic water surface area *** lake is covered by vegetation during long periods of time and the water below can’t be detected by automatic radiometric ***,Sentinel-2 stays a pertinent and powerful tool for hydrological monitoring of lakes confirming the expectation from the remote sensing wetland community before *** presence of NIR and SWIR bands induces a strong discrimination between water and other classes,and the systematic acquisitions create dense time series,making analysis more *** makes possible to sensor events occurring over short periods of *** to this a link can be done between endangered bird species,such as the Siberian Crane and the Lesser White-Fronted Goose and periodically flooded *** midterm results illustrated the pertinence and powerful of

关键词： Wuchang Lake Sentinel-2 Landsat 8 endangered bird species