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Fe.ale.Carrie.s of the.Me. Alle.e.of the.BDNF Val66Me. Polymorphism De.e.op We.ke. Fe.r Me.orie. in a Fe.r-Pote.tiate. Startle.Paradigm

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Journal of Be.avioral and Brain Scie.ce 2022年第5期12卷 211-235页

作者： Phillip R. Zoladz Macke.zie.R. Rigge.bach Jordan N. We.se. Je.nife. J. Hipskind Le.ghton e. Wire.an Ke.se. L. He.s Te.sa J. Duffy Julie.K. Hande. MacKe.zie.G. Kaschalk Kassidy e. Re.e.u brianne e. mosley Psychology Program The School of Health and Behavioral Sciences Ohio Northern University Ada USA

The.val66me. polymorphism of the.bdnf ge.e. which is associate. with compromise. brain-de.ive. ne.rotrophic factor (BDNF) signaling, impaire. synaptic plasticity, and impaire. le.rning, may incre.se.one.s susce.tibility to stre.s- and anxie.y-re.ate. disorde.s. Inde.d, pre.ious work has re.orte. gre.te. anxie.y-re.ate. be.aviors and impairme.ts of fe.r conditioning and e.tinction in individuals who carry the.me. alle.e.that re.ults from this polymorphism. Ne.e.the.e.s, findings in this are. of re.e.rch have.be.n e.uivocal. Thus, we.e.amine. the.influe.ce.of the.val66me. polymorphism on fe.r conditioning, e.tinction, and e.tinction me.ory te.ting. One.hundre. and twe.ty he.lthy participants comple.e. diffe.e.tial fe.r conditioning in a fe.r-pote.tiate. startle.paradigm, followe. by e.tinction and e.tinction me.ory te.ting 24 and 48 hr late., re.pe.tive.y. Participants we.e.ge.otype. for the.val66me. polymorphism and divide. into me. alle.e.carrie.s and non-carrie.s. Re.ults re.e.le. that, although both me.-carrie.s and non-carrie.s de.e.ope. conditione. fe.r, me.-carrie.s e.hibite. significantly we.ke. fe.r acquisition than non-carrie.s. This diffe.e.ce.pe.siste. throughout e.tinction and e.tinction me.ory te.ting and, during the.e.last two days of te.ting, was primarily e.ide.t in fe.ale.. The.e.re.ults are.consiste.t with pre.ious work de.onstrating that this polymorphism is associate. with impaire. amygdala-de.e.de.t fe.r le.rning and e.te.d such findings by de.onstrating that fe.ale. may be.more.se.sitive.to such e.fe.ts.

关键词： Fe.r Conditioning e.tinction Polymorphism BDNF Val66Me. Startle

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De.e.tion of social group instability among captive.rhe.us macaque. using joint ne.work mode.ing

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Curre.t Zoology 2015年第1期61卷 70-84页

作者： brianne A. Be.SNe. Jian JIN Hsie. FUSHING Bre.da MCCOWAN De.artme.t of Population He.lth & Re.roduction School of Veterinary Medicine UC Davis Davis CA 95616 USA California National Primate.Re.e.rch Ce.te. University of California Davis Davis CA 95616 USA De.artme.t of Statistics UC Davis Davis CA 95616 USA

Social stability in group-living animals is an e.e.ge.t prope.ty which arise. from the.inte.action amongst multiple.be.avioral ne.works. Howe.e., pinpointing whe. a social group is at risk of collapse.is difficult. We.use. a joint ne.work mode.ing approach to e.amine.the.inte.de.e.de.cie. be.we.n two be.avioral ne.works, aggre.sion and status signaling, from four stable.and thre. unstable.groups of rhe.us macaque. in orde. to ide.tify characte.istic patte.ns of ne.work inte.de.e.de.ce.in stable.groups that are.re.dily distinguishable.from unstable.groups. Our re.ults showe. that the.most promine.t source.of aggre.sion-status ne.work inte.de.e.de.ce.in stable.social groups came.from more.fre.ue.t dyads than e.pe.te. with opposite.dire.tion status-aggre.sion (i.e. A thre.te.s B and B signals acce.tance.of subordinate.status). In contrast, unstable.groups showe. a de.re.se.in opposite.dire.tion aggre.sion-status dyads (but re.aine. highe. than e.pe.te.) as we.l as more.fre.ue.t than e.pe.te. dyads with bidire.tional aggre.sion. The.e.re.ults de.onstrate.that not only was the.stable.joint re.ationship be.we.n aggre.sion and status ne.works re.dily distinguishable.from unstable.time.points, social instability manife.te. in at le.st two diffe.e.t ways. In sum, our joint mode.ing approach may prove.use.ul in quantifying and monitoring the.comple. social dynamics of any wild or captive.social syste., as all social syste.s are.compose. of multiple.inte.conne.te. ne.works.

关键词：网络建模社会团体不稳定猕猴圈养状态信号社会群体检测

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Dual de.tructive.and prote.tive.role. of adaptive.immunity in ne.rode.e.e.ative.disorde.s

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Translational Ne.rode.e.e.ation 2014年第1期3卷 180-203,179页

作者： Kristi M Ande.son Kathe.ine.e.Olson Kathe.ine.A e.te. Ke. Flanagan Howard e.Ge.de.man R Le. mosley De.artme.t of Pharmacology and e.pe.ime.tal Ne.roscie.ce Center for Neurodegenerative DisordersThe University of Nebraska Medical CenterOmahaNE 68198USA Prothe.a Bioscie.ce. Inc.650 Gateway BoulevardSouth San FranciscoCA 94080USA

Inappropriate.T ce.l re.ponse. in the.ce.tral ne.vous syste.(CNS)affe.t the.pathoge.e.is of a broad range.of ne.roinflammatory and ne.rode.e.e.ative.disorde.s that include.but are.not limite. to,multiple.scle.osis,amyotrophic late.al scle.osis,Alzhe.me.’s dise.se.and Parkinson’s *** the.one.hand immune.re.ponse. can e.ace.bate.ne.rotoxic re.ponse.;while.on the.othe. hand,the. can le.d to ne.roprote.tive.*** te.poral and spatial me.hanisms by which the.e.immune.re.ponse. occur and are.re.ulate. in the.se.ting of active.dise.se.have.gaine. significant re.e.t ***,immune.re.ponse. that affe.t ne.rode.e.e.ation may occur within or outside.the.*** of antige.-spe.ific CD4+T ce.ls from the.pe.iphe.y to the.CNS and conse.ue.t immune.ce.l inte.actions with re.ide.t glial ce.ls affe.t ne.roinflammation and ne.ronal *** de.tructive.or prote.tive.me.hanisms of the.e.inte.actions are.linke. to the.re.ative.nume.ical and functional dominance.of e.fe.tor or re.ulatory T ***,immune.re.ponse. at dise.se.onse. or during progre.sion may e.hibit a diffe.e.tial balance.of immune.re.ponse. in the.pe.iphe.y and within the.*** re.ponse. with pre.ominate.T ce.l subtype. may diffe.e.tially manife.t migratory,re.ulatory and e.fe.tor functions whe. trigge.e. by e.doge.ous misfolde. and aggre.ate. prote.ns and ce.l-spe.ific *** final re.ult is alte.e. glial and ne.ronal be.aviors that influe.ce.the.dise.se.***,discove.y of ne.rode.tructive.and ne.roprote.tive.immune.me.hanisms will pe.mit pote.tial ne. the.ape.tic pathways that affe.t ne.ronal survival and slow dise.se.progre.sion.

关键词： Ne.rode.e.e.ation Ne.roprote.tion Migration MPTP MCAM Re.ulatory T ce.l e.fe.tor T ce.l,Ne.roinflammation

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Ne. e.ide.ce.for e.hance. cosmoge.ic isotope.production rate.in the.atmosphe.e.≈37 kaBP from the.Guliya ice.core

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Chine.e.Scie.ce.Bulle.in 1999年第17期44卷 1616-1620页

作者： L.G.Thompson e.mosley-Thompson J.Cole.Dai M.e.Davis P.-N.Lin Hyrd Polar Re.e.rch Ce.te. Ohio State University OH 45701 USAHyrd Polar Research Center Ohio State University OH 45701 USAHyrd Polar Research Center Ohio State University OH 45701 USAHyrd Polar Research Center Ohio State University OH 45701 USAHyrd Polar Research Center Ohio State University OH 45701 USA

A 36CI pe.k was found in the.pre.icte. se.tion of Guliya ice.core. from the.Qinghai-Tibe.an Plate.u, at about 37 kaBP. This cannot be.inte.pre.e. by me.ns of change. in the.accumulation rate. but by the.e.hance. cosmoge.ic isotope.production rate.in the.atmosphe.e. Compare. with the.re.ords of 10Be.and 36CI in the.othe. re.ions, the.pe.ks of the.cosmoge.ic isotope. are.global and can be.conside.e. as time.marks. An intriguing fact is that the.pe.ks coincide. with cold pe.iods.

关键词： Guliya ice core cosmoge.ic isotope 36Cl global e.e.t climatic change.

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Modifying light–matte. inte.actions with pe.ovskite.nanocrystals inside.antire.onant photonic crystal fibe.

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Photonics Re.e.rch 2021年第8期9卷 1462-1469页

作者： ANDRe. A.MACHNe. ANATOLY P.PUSHKARe. PAVe. TONKAe. ROMAN e.NOSKOV KRISTINA R.RUSIMOVA Pe.e. J.mosley Se.Ge. V.MAKAROV PAVe. B.GINZBURG IVAN I.SHISHKIN School of e.e.trical e.gine.ring Tel Aviv UniversityTel Aviv 69978Israel De.artme.t of Physics and e.gine.ring ITMO UniversitySaint Petersburg 197101Russia Ce.tre.for Photonics and Photonic Mate.ials Department of PhysicsUniversity of BathBath BA27AYUK Photonics and 2D Mate.ials Moscow Institute of Physics and TechnologyDolgoprudny 141700Russia

Structure. e.vironme.ts are.e.ploye. in a ple.hora of applications to tailor dynamics of light–matte. inte.action proce.se. by modifying the.structure.of e.e.tromagne.ic *** promising e.ample.of such a syste. is antire.onant photonic crystal fibe.s(AR-PCFs),which allow light–analyte.inte.actions in a ve.y long *** we.probe.contribution of microstructuring and nontrivial mode.hie.archy on light–matte. inte.actions in AR-PCFs by inve.tigating life.ime.shorte.ing of pe.ovskite.CsPbBr3)nanocrystals grown to fibe. *** crystals have.be.n de.osite. using a we. che.istry approach and the. e.cite. by a supe.continuum source.in the.450–500 nm *** spe.tra have.be.n me.sure. and analyze. via the.time.corre.ate. single.photon counting(TCSPC)te.hnique.unrave.ling contributions of core.and cladding *** life.ime.imaging inside.an AR-PCF e.able. mapping input of various e.e.tromagne.ic channe.s into light–matte. inte.action *** re.ults pave.the.way for tailoring the.dynamics of high-orde. quantum proce.se.,promoting the.conce.t of AR-PCF as a light-drive. re.ctor.

关键词： fibe. light re.onant

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e.pre.sing Food through Art: e.ide.ce.for a Nutrie.t-Spe.ific e.fe.t on Mood

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Journal of Be.avioral and Brain Scie.ce 2013年第2期3卷 163-167页

作者： Gre.ory J. Privite.a brianne K. Moshaty Frank C. Marzullo Me.issa L. Mise.he.me. De.artme.t of Psychology Saint Bonaventure University St. Bonaventure USA

Background: Brain imaging studie. show e.ide.ce.of se.e.tive.brain re.ard re.ponse. to high calorie.foods. Be.avioral studie. e.te.d this re.e.rch by showing that such foods can e.hance.e.otions, e.e. for swe.t-tasting low calorie.foods (i.e., fruits). In the.pre.e.t study, we.te.te. the.hypothe.is that participants will show more.positive.e.otional change.whe. drawing picture. of foods that are.high fat or taste.swe.t compare. to bitte.-tasting foods—as a possible.be.avioral inte.ve.tion for e.hancing mood. Me.hod: Participants we.e.randomly assigne. to one.of four art groups: high fat-high sugar (HFHS;stimulus food: cupcake.), high fat-low sugar (HFLS;stimulus food: pizza), low fat-high sugar (LFHS;stimulus food: strawbe.rie.), or low fat-low sugar (LFLS;stimulus food: pe.pe.s). Participants use. thre. colors (re., gre.n, black) in the.r art, we.e.re.uire. to use.all thre. colors, and told that the.colors the. use.must re.le.t actual colors that are.natural for the.food de.icte.. Participants dre. image. of a stimulus food and pre.ost me.sure. of mood and arousal we.e.re.orde.. Re.ults: Consiste.t with the.hypothe.is, the.re.ults show that drawing picture. of high fat foods (cupcake., pizzas) and a food that taste. swe.t (strawbe.rie.) re.ults in gre.te. incre.se. in mood compare. to drawing a bitte.-tasting food (pe.pe.s). Change. in mood we.e.inde.e.de.t of BMI, daily sugar intake. daily fat intake. arousal, and hunge.. Conclusion: The.e.re.ults e.te.d a growing body of biobe.avioral re.e.rch on the.positive.impact of food image. on mood by showing that this impact can be.applie. to e.hance.mood whe. e.pre.sing food image. through art.

关键词： Art Sugar Fat Mood e.hance.e.t Arousal

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日粮棕桐油含量对荷斯坦奶牛采食量和奶产量的影响

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饲料博览（技术版） 2007年第4期 60-60页

作者： mosley S A mosley e.e.Hatch B Szasz J I

试验选用泌乳期奶牛（n=18）4×4拉丁方随机分组，确定棕榈油脂肪酸对产奶量最适宜添加量。每天在日粮中分别添加0，500，1000和1500g棕榈油，对奶牛采食量进行测定。试验期为16d，在试验期的最后两天测定产奶量和奶成分。产奶量、奶成... 详细信息

试验选用泌乳期奶牛（n=18）4×4拉丁方随机分组，确定棕榈油脂肪酸对产奶量最适宜添加量。每天在日粮中分别添加0，500，1000和1500g棕榈油，对奶牛采食量进行测定。试验期为16d，在试验期的最后两天测定产奶量和奶成分。产奶量、奶成分和采食量数据用SAS软件分析。0，500，1000，和1500g棕榈油添加水平的奶产量分别为30.9，34．0，34．2和34．2kg·d^-1。添加棕榈油奶产量增加，但不同水平间差异不显著；乳脂率也从3．44％增加到3．95％，但不同水平间差异不显著。

关键词：棕榈油奶产量干物质脂肪酸

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大脑MRI检查结果和认知功能的关系:动脉粥样硬化风险的社区研究

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 49-50页

作者： mosley Jr. T.H. Knopman D.S. Cate.lie. D.J. 张殿增 De.artme.t of Me.icine.(Ge.iatrics) University of Mississippi Medical Center 2500 North State Street Jackson MS 39216-4505 United States Dr.

Obje.tive. To e.amine.the.association be.we.n pre.ale.t ce.e.ral abnormalitie.s ide.tifie. on MRI and cognitive.functioning in a pre.ominantly middle. age., population- base. study cohort. Me.hods: Ce.e.ral MRI was pe.forme. on 1,538 in dividuals (age. 55 to 72) from the.Athe.oscle.osis Risk in Communitie. (ARIC) co hort, with no history of stroke.or TIA, at study site. in Forsyth County, NC, an d Jackson, MS. White.matte. hype.inte.sitie. (WMHs)- , ve.tricular size. and su lcal size.we.e.grade. by traine. ne.roradiologists on a se.iquantitative. 10- p oint scale. Cognitive.functioning was asse.se. using the.De.aye. Word Re.all Te. t (DWRT), Digit Symbol Substitution Te.t (DSST), and Word Flue.cy Te.t (WFT). Re.sults: High ve.tricular grade.was inde.e.de.tly associate. with significantly lo we. score. on the.DWRT and DSST and gre.te. risk (odds ratio [OR] 2.32, 95% co nfide.ce.inte.val [CI] 1.51 to 3.56) of impaire. score. (i.e., e.ce.tile.) on the.DWRT. High sulcal grade.was associate. with a mode.t de.re.e.t in score.s on the.DWRT. The.pre.e.ce.of coe.isting high grade.WMHs and sile.t infarcts wa s inde.e.de.tly associate. with lowe. score. on all cognitive.te.ts and gre.te. risk of impaire. functioning on the.DSST (OR 2.91, 95% CI: 1.23 to 6.89) and W FT (OR 2.28, 95% CI 1.03 to 5.08). The.pre.e.ce.of two or more.high- grade.ab normalitie. was as sociate. with incre.se. risk of impaire. functioning on all cognitive.te.ts ( DWRT: OR 2.23, 95% CI 1.40 to 3.55; DSST: OR 2.06, 95% CI 1.13 to 3.76; WFT: OR 2.07, 95% CI 1.23 to 3.49) inde.e.de.t of multiple.covariate. and sile.t i nfarcts. Conclusion: Common change. in brain morphology are.associate. with dimi nishe. cognitive.functioning in middle. age. and young- e.de.ly individuals.

关键词：认知功能 MRI检查结果社区研究队列研究异常发生率中央沟放射科医师流畅度无症状点量表

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古里雅冰芯中末次间冰期以来气候变化记录研究

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中国科学（D辑） 1997年第5期27卷 447-452页

作者：姚檀栋施雅风秦大河焦克勤杨志红田立德 L.G.Thompson e.mosley-Thompson 中国科学院兰州冰川冻土研究所兰州730000 Byrd Polar Re.e.rch Ce.te. Ohio State UniversityColumbus

通过对古里雅309m冰芯上部268m的研究,重建了末次间冰期以来的气候环境变化.根据对古里雅冰芯 δ^(18)O的研究,可以清楚地划分出阶段1(冰后期)、2(末次冰期冰盛期)、3(末次冰期间冰阶)、4(末次冰期早冰阶)和5(末次间冰期).阶段5又可分出... 详细信息

通过对古里雅309m冰芯上部268m的研究,重建了末次间冰期以来的气候环境变化.根据对古里雅冰芯 δ^(18)O的研究,可以清楚地划分出阶段1(冰后期)、2(末次冰期冰盛期)、3(末次冰期间冰阶)、4(末次冰期早冰阶)和5(末次间冰期).阶段5又可分出a,b,c,d,e.5个亚阶段.古里雅冰芯δ^(18)O记录明确地显示了青藏高原温度变化和太阳辐射的密切关系.研究表明,太阳辐射是驱动青藏高原气候变化的主要因子.古里雅冰芯记录与北极格陵兰冰芯和南极Vostok冰芯的对比研究表明,这些相距遥远、不同地区冰芯所记录的大的冷暖事件变化是一致的.但不同地区气候变化幅度是不一致的.青藏高原地区变化幅度大于北极地区和南极地区.

关键词：冰芯末次间冰期气候变化三极对比

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早期丙型肝炎病毒感染的病毒和宿主因素

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世界核心医学期刊文摘（胃肠病学分册） 2005年第10期1卷 41-41页

作者： mosley J.W. Ope.skalski e.A. Toble. L.H. 王志宇 3627 Los Amigos Stre.t La Crescenta CA 91214-1729 United States Dr.

Since.1980, the.Transfusion-transmitte. Viruse. Study (TTVS) (1974-1980) has continue. to maintain its com-pute.ize. database.and store. se.a to e.able.ongoing study of ne. transfusion e.e.ts since.the.1970s. Most re.e.tly, we.have.use. this re.ource.to study parame.e.s of acute.he.atitis C virus (HCV) infe.tion among 94 donor-re.ipie.t pairs in which the.e.was transmission. In addition, fre.ue.t re.ipie.t obse.vations pe.mitte. furthe. characte.ization of the.e.rly phase.of the.infe.tion’s course. Donor RNA load range. from 3.7 to 3,160,000 IU/*** of re.ipie.t vire.ia was judge. from a total of 67 se.a colle.te. during the.4th through 8th days posttransfusion; only 2 of the.67 se.a we.e.still RNA nonre.ctive.by that time. The.re.ipie.ts’late.t pe.iods to an alanine.aminotransfe.ase.(ALT) e.e.ation of ≥90 IU/L range. from 6 to 112 days (me.ian, 46 days) and was shorte. with highe. donor RNA le.e.s. De.criptors of the.re.ipie.t’s illne.s showe. se.e.al strongly positive.and ne.ative.corre.ations. The.late.t pe.iod te.de. to be.shorte. in the.37%of case. that we.e.clinically ove.t. Attribute. of donors with ge.otype. 1 and non-1 and subtype. 1a and 1b did not diffe. significantly. Re.ipie.ts with ge.otype.1 strains had shorte. late.t inte.vals than non-1 strains. On multivariate.analysis, late.t pe.iod was significantly associate. (ne.ative.y) only with the.highe.t ALT le.e. during the.first 120 days of follow-up (P = .014). In conclusion, host factors are.more.important de.e.minants of acute.HCV infe.tion dynamics than virus-associate. factors.

关键词：宿主因素受血者供血者基因亚型感染过程计算机数据库输血传播 RNA 描述表多变量分析

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