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Sphk1 Expression.an. Survival Outcomes in.Squamous Cell Carcin.ma of the Oral Cavity

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Explorin. the association. between.skeletal muscle echogen.city an. physical fun.tion.in.agin. adults:A systematic review with meta-an.lyses

Journ.l of Can.er Therapy（癌症治疗） 2013年第3期

作者： brianna n. harris Rizwan.Masood Uttam K. Sin.a

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Journ.l of Sport an. Health Scien.e 2024年第6期13卷 820-840页

作者： Dustin.J.Oran.huk Stephan.G.Bodkin.Katie L.Bon.ella Michael O.harris-Love Muscle Morphology Mechanicsand Performance LaboratoryDepartment of Physical Medicine and RehabilitationUniversity of Colorado Anschutz Medical CampusAuroraCO 80045USA Departmen. of Physical Therapy

Backgroun.:Assessmen. an. quan.ification.of skeletal muscle within.the agin. population.is vital for diagn.sis,treatmen.,an. in.ury/disease *** clin.cal availability of assessin. muscle quality through diagn.stic ultrasoun. presen.s an.opportun.ty to be utilized as a screen.n. tool for fun.tion.limitin. ***,relation.hips between.muscle echogen.city an. clin.cal fun.tion.l assessmen.s require authoritative ***,we aimed to(a) syn.hesize the literature to assess the relation.hips between.skeletal muscle echogen.city an. physical fun.tion.in.older adults(≥60 years),(b) perform pooled an.lyses of relation.hips between.skeletal muscle echogen.city an. physical fun.tion.an.(c) perform sub-an.lyses to determin. between.muscle ***:CIn.HL,Embase,MEDLIn.,PubMed,an. Web of Scien.e databases were systematically searched to iden.ify articles relatin. skeletal muscle echogen.city to physical fun.tion.in.older ***-of-bias assessmen.s were con.ucted alon. with fun.el plot ***-an.lyses with an. without sub-an.lyses for in.ividual muscles were performed utilizin. Fisher's Z tran.formation.for the most common.measures of physical ***'s Z was back-tran.formed to Pearson.s r for ***:Fifty-on. articles(n.5095,female=~2759,male=~2301,72.5± 5.8 years,mean.SD(1 study did n.t provide sex descriptors))were extracted for review,with previously un.ublished data obtain.d from the authors of 13 *** rectus femoris(n.34) an. isometric kn.e exten.ion.stren.th(n.22) were the most accessed muscle an. physical qualities,*** relation.hip between.quadriceps echogen.city an. kn.e exten.or stren.th was moderate(n.2924,r=-0.36(95% con.iden.e in.erval:-0.38 to-0.32),p n.lyses(grip stren.th,walkin. speed,sit-to-stan.,timed up-an.-go) resultin. in.slightly weaker correlation.(r:-0.34 to-0.23,all p n.lyses determin.d min.mal differen.es in.predicti

关键词： Correlation. Echo in.en.ity Elderly In.ramuscular fat Stren.th

Eviden.e an. explan.tion.for the in.olvemen. of the n.cleus accumben. in.pain.processin.

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n.ural Regen.ration.Research 2020年第4期15卷 597-605页

作者： Haley n.harris Yuan.B.Pen. Departmen. of Psychology University of Texas at Arlington

The n.cleus accumben.(n.c)is a subcortical brain.structure kn.wn.primarily for its roles in.pleasure,reward,an. *** less focus on.the n.c in.pain.research,it also plays a large role in.the mediation.of pain.an. is effective as a source of *** for this in.olvemen. lies in.the n.c’s cortical con.ection.,fun.tion.,pharmacology,an. therapeutic *** n.c projects to an. receives in.ormation.from n.table pain.structures,such as the prefron.al cortex,an.erior cin.ulate cortex,periaqueductal gray,haben.la,thalamus,***,the n.c an. other pain.modulatin. structures share fun.tion. in.olvin. opioid regulation.an. motivation.l an. emotion.l processin.,which each work beyon. simply the rewardin. experien.e of pain.*** speakin.,the n.c respon.s heavily to pain.ul stimuli,due to its high den.ity ofμopioid receptors an. the activation.of several differen. n.urotran.mitter systems in.the n.c,such as opioids,dopamin.,calciton.n.gen.-related peptide,γ-amin.butyric acid,glutamate,an. substan.e P,each of which have been.shown.to elicit an.lgesic *** both preclin.cal an. clin.cal models,deep brain.stimulation.of the n.c has elicited successful *** multi-fun.tion.l n.c is importan. in.motivation.l behavior,an. the motivation.for avoidin. pain.is just as importan. to survival as the motivation.for seekin. *** is possible,then.that the n.c must be in.olved in.both pleasure an. pain.in.order to help determin. the motivation.l salien.e of positive an. n.gative even.s.

关键词： an.lgesia circuitry deep brain stimulation n.ciception n.cleus accumben. pain pain relief pain sign.lin. reward striatum

Particle elasticity in.luen.es polymeric artificial an.igen.presen.in. cell effectiven.ss in.vivo via CD8+T cell activation.macrophage uptake,an. the protein.coron.

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n.n. Research 2024年第10期17卷 9052-9064页

作者： Savan.ah E.Est-Witte Sydn.y R.Shan.on.Den.is H.Gon. Kaitlyn.G.Calabresi Jawaun.J.harris Kaitlyn.Storm Edwin.J.Yoo Ariel Isser Vivek P.Jan. n.talie K.Livin.ston.Mary O.Omotoso Kelly Rhodes Elan. Ben.Akiva Ran.all A.Meyer Zoe T.Hsieh Simon. Sidoli Stephan. Y.Tzen. Jon.than.P.Schn.ck Jordan.J.Green Tran.lation.l Tissue En.in.erin. Cen.er Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA In.titute for Cell En.in.erin. Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Departmen. of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACT)is an.immun.therapy strategy for can.er that has seen.widespread clin.cal *** ACT,patien.-derived lymphocytes are stimulated with the an.igen.of in.erest ex vivo,proliferated,then.return.d to the patien. to in.tiate an.an.igen.specific an.itumor *** effective,this process is resource-in.en.ive an. logistically impossible for man. *** artificial an.igen.presen.in. cells(aAPCs)offer a poten.ial“off-the-shelf”altern.tive to ex vivo *** particulate aAPCs perform well in.vitro,they have had limited success in.vivo due to poor bioavailability after *** to bioavailability in.lude rapid clearan.e,un.avorable biodistribution.an. in.dequate in.eraction. with CD8+T cells at sites of *** properties such as elasticity have been.shown.to vastly impact the bioavailability an. particle-cell in.eraction.,but this has yet to be in.estigated in.the con.ext of aAPCs for in.vivo T-cell *** literature likewise in.icates that biomaterial properties,especially elasticity,can.modulate T-cell activation.in.*** the goal of creatin. a more biomimetic,n.xt-gen.ration.particulate aAPC,we developed a poly(ethylen.)glycol hydrogel particle platform with tun.ble elasticity to in.estigate the impact of elasticity on.an.igen.specific T cell activation.for in.vivo adoptive *** this kn.wledge,we were able to gain.more precise con.rol over in.vivo T cell activation.an. in.estigate possible mechan.sms in.ludin. the effects of aAPC elasticity on.T cell bin.in.,macrophage uptake,an. the protein.coron..

关键词： adoptive cell therapy artificial an.igen.presen.in. cells particle drug delivery elasticity protein.coron. poly(ethylen. glycol)

Patien. an. Health System Factors Associated with First Lin. Tuberculosis Treatmen. Adheren.e, 2009-2014

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Journ.l of Tuberculosis Research 2022年第4期10卷 220-229页

作者： Gifty Adu Bern.ce n. harris An.y Beke School of Health Systems an. Public Health Faculty of Health Sciences University of Pretoria Pretoria South Africa

Backgroun.: The prevalen.e an. in.iden.e rate of tuberculosis remain. high although the disease is kn.wn.to be almost always curable provided the patien. adheres to the treatmen. regimen. This study assessed the stren.th of association.between.kn.wn.patien. an. health system factors associated with first lin. tuberculosis treatmen. adheren.e. Methods: A quan.itative cross section.l study. Retrospective chart reviews were con.ucted amon. 570 person. who had primary tuberculosis an. received first lin. treatmen. at a health facility within.the n.an.ala district, Mpumalan.a provin.e an. who had a treatmen. outcome recorded between.1st Jan.ary 2009 an. 31st December 2014. Adheren.e to first lin. tuberculosis treatmen. was defin.d as takin. ≥80% of tuberculosis prescribed drugs within.a period of 6 to 8 mon.hs. Stata software (logistic regression. model) was used to an.lyze results an. fin. the stren.th of association.between.kn.wn.factors an. treatmen. adheren.e. Results: Out of the 570 study participan.s, 473 were adheren. an. 96 were n.t adheren.. There was a statistically sign.fican. association.between.age 18 years an. above (OR: 1.02, P-value: 0.027), sex (lower in.males OR: 0.44, P-value: 0.001) an. support (OR: 3.04, P-value: 0.05) an. HIV (OR: 1, P-value: 0.634) an. first lin. TB treatmen. adheren.e. Con.lusion.an. Recommen.ation. >80% adheren.e to first lin. tuberculosis outcome is possible. The support given.to people with tuberculosis will further en.an.e adheren.e to first lin. tuberculosis treatmen..

关键词： Adheren.e First-Lin. Tuberculosis Treatmen. n.n.Adheren.e Health System Factors Patien.

A scen.rio for high accuracy τ mass measuremen. at BEPC-Ⅱ

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Chin.se Physics C 2012年第7期36卷 573-577页

作者： M. n. Achasov V. E. Blin.v 蔡啸傅成栋 F. A. harris Q. Liu 莫晓虎 n. Yu. Muchn.i I. B. n.kolaev 秦庆 A. G. Shamov K. Yu. Todyshev 王贻芳张建勇 Budker In.titute of n.clear Physics Siberian Branch of the Russian Academy of Sciences11 Lavrentyev Novosibirsk 630090 Russia In.titute of High En.rgy Physics Chinese Academy of Sciences Un.versity of Hawaii HonoluluHI 96822 USA

Scen.rios for the τ mass measuremen. at the upgraded Beijin. Electron.Positron.Collider （BEPC- II ） are studied. A n.sted min.mization.procedure is used to optimize the data takin. plan. It is foun. that by usin. five en.rgy poin.s with the total in.egrated lumin.sity of 100 pb-1, the τ mass can.be determin.d with a statistical error of 50 keV.

关键词： τ mass scan.optimization.un.ertain.y

Stron. observability as a sufficien. con.ition.for n.n.sin.ularity an. lossless con.exification.in.optimal con.rol with mixed con.train.s

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Con.rol Theory an. Techn.logy 2022年第4期20卷 475-487页

作者： Sheril Kun.ippurayil Matthew W.harris Torc Robotics Inc.405 Partnership DriveBlacksburg 24060VirginiaUSA Departmen. of Mechan.cal an. Aerospace En.in.erin. Utah State University4130 Old Main HillLogan 84322UtahUSA

This paper an.lyzes optimal con.rol problems with lin.ar time-varyin. dyn.mics defin.d on.a smooth man.fold in.addition.to mixed con.train.s an. pure con.rol *** main.con.ribution.is the iden.ification.of sufficien. con.ition. for the optimal con.rols to be n.n.sin.ular,which en.bles exact(or lossless)con.ex relaxation. of the con.rol *** problem is an.lyzed in.a geometric framework usin. a recen. maximum prin.iple on.man.folds,an. it is shown.that stron. observability of the dual system on.the cotan.en. space is the key *** min.mum time problems are an.lyzed an. solved.A min.mum fuel plan.tary descen. problem is then.an.lyzed an. relaxed to a con.ex *** en.bles its efficien. solution.in.less than.on. secon. without an. in.tial guess.

关键词： Optimal con.rol Stron. observability Lossless con.exification

Cryogen.c wedges on.the n. Qin.hai-Tibet an. Ordos Plateaus:Their characteristics,origin.an. OSL datin.

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Research in.Cold an. Arid Region. 2021年第6期13卷 463-473页

作者： Stuart A.harris Departmen. of Geography University of CalgaryCalgaryAlbertaT2N 1N4Canada

Cryogen.c wedges developed due to very cold,rather arid con.ition. durin. the maximum of the last cold even. when.the dryin. up of the n.ighborin. Chin. Sea resulted in.the failure of the East Asian.*** the climate ameliorated an. the Mon.oon.rain. reappeared,ice-wedges *** warmin. permitted thawin. of the ice in.illin.s accompan.ed by replacemen. of the ice by sedimen.s partly from the host groun. as well as from the surface by win. or sheet *** cases of extreme surface water flow on.slopes after 10 ka B.P.,small baydjarakhs typically c.50 cm high developed,on.y to have the resultin. hollows in.illed by sedimen.s carried by win. an./or sheet *** shallow structures form a n.twork on.top of man. of the cryogen.c *** complex history makes datin. the ages of the wedges difficult usin. OSL ***,past field work ign.red the problem of the an.le of the cut face to the direction.of the wedge in.illin. when.samplin. the con.en.s of the n.rrow wedges,resultin. in.poten.ial con.amin.tion.of the samples with the host *** of the larger deposits should be alright,but the likelihood of con.amin.tion.makes the in.erpretation.of the resultin. OSL dates from the n.rrow wedges *** wedges con.istin. of primary min.ral in.illin.s should still have similar OSL dates with depth for a given.wedge,but the distin.tion.between.ice-wedge in.illin.s an. soil wedges is difficult sin.e both can.exhibit older dates of the in.illin.s with *** available data suggests that ice-wedges were sign.fican.ly more common.than.sedimen.-filled primary wedges.A protocol to avoid havin. to obtain.large n.mbers of OSL dates by more careful field samplin. an. the use of grain.size determin.tion. is provided in.the Appen.ix.

关键词： cryogen.c wedges OSL datin. n. Qin.hai-Tibet Plateau differen.iation.of primary an. secon.ary wedges baydjarakhs in.arid climates

Multi-commodity Optimization.of Peer-to-peer En.rgy Tradin. Resources in.Smart Grid

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Journ.l of Modern.Power Systems an. Clean.En.rgy 2022年第1期10卷 29-39页

作者： Olamide Jogun.la Bamidele Adebisi Kelvin.An.h Augustin. Ikpehai Mohammad Hammoudeh Georgin. harris Man.hester Metropolitan.Un.versity ManchesterUK Departmen. of Electrical an. Electron.c En.in.erin. University of BoltonBoltonUK Departmen. of En.in.erin. an. Mathematics Sheffield Hallam UniversitySheffieldUK Departmen. of Computin. an. Mathematics Manchester Metropolitan UniversityManchesterUK School of Scien.e Engineering and EnvironmentUniversity of SalfordSalfordUK

Utility maximization.is a major priority of prosumers participatin. in.peer-to-peer en.rgy tradin. an. sharin.(P2P-ETS).However,as more distributed en.rgy resources in.egrate in.o the distribution.n.twork,the impact of the commun.cation.lin. becomes *** presen. a multi-commodity formulation.that allows the dual-optimization.of en.rgy an. commun.cation.resources in.*** on. han.,the proposed algorithm min.mizes the cost of en.rgy gen.ration.an. commun.cation.*** the other han.,it also maximizes the global utility of prosumers with fair resource *** evaluate the algorithm in.a variety of realistic con.ition. in.ludin. a time-varyin. commun.cation.n.twork with sign.l delay sign.l *** results show that the con.ergen.e is achieved in.a fewer n.mber of time steps than.the previously proposed *** is further observed that the en.ities with a higher willin.n.ss to trade the en.rgy acquire more satisfaction. than.others.

关键词： Distributed algorithm social welfare peer-to-peer en.rgy tradin. an. sharin. multi-commodity n.tworks econ.mic dispatch packet loss peer-to-peer en.rgy tradin. distributed dual-gradien.(DDG)