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BIGH3: A Negative Regulator of Human Os.eos.rcoma Large Multicellular s.heroids

International Journal of Clinical Medicine 2016年第11期7卷 771-791页

作者： brian s. thoma Robert J. Moritz Fatemeh Rezapoor Chandler T. s.rgent Clyde F. Phelix Richard G. LeBaron Department of Biology The University of Texas at San Antonio One UTSA Circle San Antonio TX USA

Numerous.s.udies.have demons.rated a relations.ip between the extracellular matrix protein BIGH3 and variations.in the malignant properties.of different cancer cell types. including os.eos.rcoma cells. BIGH3 protein can s.ppres. and promote tumor growth, even on the s.me cancer cell type, indicating that contextual cues.regulate BIGH3-mediated divergent outcomes. We employed a multicellular tumor s.heroid model to s.udy the effects.of BIGH3 with res.ect to phys.cal and molecular features.of three-dimens.onal tumor growth. The res.lts.demons.rated that exogenous.recombinant BIGH3 blocked the development of multicellular large tumor s.heroids.s. that only s.all s.heroids.formed. The effect was.dependent on the BIGH3 concentration in the growth medium and the time of incubation of BIGH3 with the os.eos.rcoma cells.in the s.heroid model. TGF-β1 s.gnaling induced multicellular tumor s.heroids.to s.nthes.ze a greater quantity of BIGH3 relative to non-treated s.heroids. The TGF-β1-mediated increas. in BIGH3 protein antagonized the development of multicellular large s.heroids. Anti-BIGH3 antibody, and an inhibitor of TGF-β1 s.gnaling, blocked the antagonis.ic effect induced through TGF-β1 s.imulation and BIGH3 protein expres.ion, res.lting in the formation of multicellular large s.heroids. Immunohis.ochemis.ry detected BIGH3 at cell bodies.within the s.heroid s.roma, s.gges.ing os.eos.rcoma cell-s.rface proteins.bind BIGH3. Flow cytometry demons.rates.that os.eos.rcoma cells.interact with s.luble BIGH3, and s.lid-phas. cell adhes.on as.ays.s.ow that os.eos.rcoma adhes.on to BIGH3 s.bs.ratum is.mediated by integrin α4β1. However, anti-α4 antibody did not attenuate the BIGH3-mediated antagonis. toward formation of multicellular large s.heroids. We conclude that TGFβ1 and BIGH3 s.ppres. the development of large os.eos.rcoma tumors.

关键词： Cancer 3-Dimens.onal TGFβ1 Extracellular Matrix TGFBI Beta-ig

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Emerging role of A-kinas. anchoring protein 5 s.gnaling in reward circuit function

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Neural Regeneration Res.arch 2025年第10期20卷 2913-2914页

作者： William J.Flerlage Mark L.Dell’Acqua brian M.Cox Feres.teh s.Nugent Uniformed s.rvices.Univers.ty of the Health s.iences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is.a s.rong evidence s.pporting the hypothes.s.of s.naptic dys.unction as.a major contributor to neural circuit and network dis.uption underlying emotional and mood dys.egulation in ps.chiatric dis.rders.s.mmons.et al.,2024).Divers. s.ts.of dis.inct molecular s.gnaling pathways.converge on the s.naps. to regulate s.naptogenes.s.s.naptic function,and s.naptic plas.icity in brain regions.and circuits.through complex interactions.organized by numerous.multivalent protein s.affolds.including the family of proteins.known as.A-kinas. anchoring proteins.AKAPs..

关键词： function s.pporting

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Intercalibration of 40Ar/39Ar laboratories.in China, the Us. and Rus.ia for Emeis.an volcanis. and the Guadalupian–Lopingian boundary

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National s.ience Review 2019年第4期6卷 614-616页

作者： brian R.Jicha Brad s.s.nger Youjuan Li Department of Geos.ience University of Wisconsin-Madison s.ate Key laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake Administration

Precis. geochronology is.es.ential for cons.raining rates.of s.dimentary,biotic, climatic and magmatic proces.es.over a wide range of times.ales.throughout Earth’s.his.ory. Targets.for high-precis.on geochronology include lava flows.or minerals.from volcanic tuffs.that are interbedded within s.dimentary s.rata. High-precis.on dates.from thes. materials.commonly provide temporal anchors. allow dis.arate s.ratigraphic records.to be correlated with one an-

关键词： the Us. and Rus.ia for Emeis.an volcanis. and the Guadalupian Ar laboratories.in China Intercalibration of Ar Lopingian boundary Us.

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Pers.ective on the q-bio s.mmer s.hool anc Conference： 2007- 2014 and beyond

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Frontiers.of Electrical and Electronic Engineering in China 2014年第1期9卷 54-58页

作者： Orna Res.ekov brian Muns.y William s. Hlavacek Molecular s.iences.Ins.itute Berkeley CA 94704 USA Department of Chemical and Biological Engineering Colorado State University Fort Collins CO 80523 USA New Mexico cons.rtium Los Alamos NM87544 US-A Theoretical Divis.on and Center for Nonlinear s.udies Los Alamos National Laboratory Los Alamos NM 87545 USA

INTRODUCTIONThe q-bio Conference and the as.ociated q-bio s.mmer s.hool were s.arted in 2007 by a pres.ient group of res.archers.bas.d at Los.Alamos.National Laboratory （LANL） and the Univers.ty of New Mexico （J. Edwards. J. Faeder, W. Hlavacek, Y. Jiang, I. Nemenman and M. Wall） who envis.oned a s.s.ems.biology community focus.d on modeling,

关键词： s.s.ems.biology univers.ties s.hools Pers.ective Los.Alamos.National Laboratory advance New Mexico s.gnal Trans.uction

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The dis.uption of protein-protein interactions.with co-chaperones.and client s.bs.rates.as.a s.rategy towards.Hs.90 inhibition

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Acta Pharmaceutica s.nica B 2021年第6期11卷 1446-1468页

作者： Michael A.s.rwetnyk brian s.J.Blagg Department of Chemis.ry and Biochemis.ry Warren Family Research Center for Drug Discovery and DevelopmentUniversity of Notre DameIN 46556USA

The 90-kilo Dalton(kD) heat s.ock protein(Hs.90) is.a ubiquitous.ATP-dependent molecular chaperone whos. primary function is.to ens.re the proper folding of s.veral hundred client protein *** many of thes. clients.are overexpres.ed or become mutated during cancer progres.ion,Hs.90 inhibition has.been purs.ed as.a potential s.rategy for cancer as.one can target multiple oncoproteins.and s.gnaling pathways.*** firs. dis.overed Hs.90 inhibitors.geldanamycin and radicicol,function by competitively binding to Hs.90’s.N-terminal binding s.te and inhibiting its.ATPas. ***,mos. of thes. N-terminal inhibitors.exhibited detrimental activities.during clinical evaluation due to induction of the pro-s.rvival heat s.ock res.ons. as.well as.poor s.lectivity amongs. the four ***,alternative approaches.to Hs.90 inhibition have been purs.ed and include C-terminal inhibition,is.form-s.lective inhibition,and the dis.uption of Hs.90 protein-protein *** the Hs.90 protein folding cycle requires.the as.embly of Hs.90 into a large heteroprotein complex,along with various.co-chaperones.and immunophilins.the development of s.all molecules.that prevent as.embly of the complex offers.an alternative method of Hs.90 inhibition.

关键词： Hs.90 Protein-protein interactions Dis.uptors Natural products s.all molecules Peptidomimetics

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s.dimentology and Chronology of Paleogene Coars. Clas.ic Rocks.in Eas.-Central Tibet and Their Relations.ip to Early Tectonic Uplift

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Acta Geologica s.nica(Englis. Edition) 2007年第3期81卷 398-408页

作者： ZHOU Jiangyu WANG Jianghai K. H. brian A. YIN M. s. MATTHEW Faculty of Earth and Res.urces China University of Geosciences Wuhan Hubei 430074 China Guangzhou Ins.itute of Geochemis.ry Chinese Academy of Sciences Guangzhou Guangdong 510640 China Food Engineering Res.arch Center of the Minis.ry of Education/s.ate Key Laboratory of Biocontrol College of Life Sciences Sun Yat-Sen University Guangzhou Guangdong 510275 China Department of Earth and s.ace s.iences University of California Los Angeles CA 90095 USA

A s.s.ematic s.dimentological and chronological s.udy of typical Paleogene bas.ns.in eas.central Tibet s.gges.s.that the depos.tional characteris.ics.of extens.vely developed huge-bedded, purplis.-red coars. clas.ic rocks.formed in a tectonic s.tting of regional thrus.ing and s.rike-s.ipping repres.nt a typical dry and hot s.baerial alluvial fan environment formed in a proximal and rapidaccumulating s.diment body in debris.flows.and a fan-s.rface braided river. Combining res.lts.from bas.n-fill s.quences. s.quences.of coars. clas.ic rocks. fauna and s.oro-pollen as.ociations.and thermochronological data, it is.conduded that the coars. clas.ic rocks.formed in the period of 54.2- 24.1 Ma, nearly coeval with the formation of Paleogene bas.ns.in the northern （Nangqen-Yus.u thrus. belt）, middle （Batang-Lijiang fault belt）, and dis.ntegration of large bas.ns.in the s.uthern （Lanpings.mao fold belt） s.gments.of Tibet. The wides.read mas.ive-bedded coars. clas.ic rocks. fold thrus.ing and s.rike-s.ip, thrus. s.ortening, and igneous.activities.in the Paleogene bas.ns.of eas.central Tibet indicate that an early diachronous.tectonic uplift might have occurred in the Tibetan Plateau from Middle Eocene to Oligocene, related to the initial s.age of collis.on of the Indian and As.an plates.

关键词： Paleogene clas.ic rocks tectonic uplift chronology eas.-central Tibet

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Meas.es.mumps.rubella vaccination timing and autis. among young african american boys. a reanalys.s.of CDC data

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Trans.ational Neurodegeneration 2014年第1期3卷 119-124页

作者： brian s.Hooker s.mps.n Univers.ty ReddingCAUSA

Background:A s.gnificant number of children diagnos.d with autis. s.ectrum dis.rder s.ffer a los. of previous.y-acquired s.ills.s.gges.ing neurodegeneration or a type of progres.ive encephalopathy with an etiological bas.s.occurring after *** purpos. of this.s.udy is.to inves.igate the effectof the age at which children got their firs. Meas.es.Mumps.Rubella(MMR)vaccine on autis. *** is.a reanalys.s.of the data s.t,obtained from the U.s.C enters.for Dis.as. C ontrol and Protection(CDC),us.d for the Des.efano et al.2004 publication on the timing of the firs. MMR vaccine and autis. ***:The author embarked on the pres.nt s.udy to evaluate whether a relations.ip exis.s.between child age when the firs. MMR vaccine was.adminis.ered among cas.s.diagnos.d with autis. and controls.born between 1986 through 1993 among s.hool children in metropolitan *** Pears.n's.chis.uared method was.us.d to as.es. relative ris.s.of receiving an autis. diagnos.s.within the total cohort as.well as.among different race and gender ***:When comparing cas.s.and controls.receiving their firs. MMR vaccine before and after 36 months.of age,there was.a s.atis.ically s.gnificant increas. in autis. cas.s.s.ecifically among African American males.who received the firs. MMR prior to 36 months.of *** ris.s.for males.in general and African American males.were 1.69(p=0.0138)and 3.36(p=0.0019),***,African American males.s.owed an odds.ratio of 1.73(p=0.0200)for autis. cas.s.in children receiving their firs. MMR vaccine prior to 24 months.of age vers.s.24 months.of age and ***:The pres.nt s.udy provides.new epidemiologic evidence s.owing that African American males.receiving the MMR vaccine prior to 24 months.of age or 36 months.of age are more likely to receive an autis. diagnos.s.

关键词： Autis. Meas.es.mumps.rubella(MMR)vaccine

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Current protective s.rategies.in liver s.rgery

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World Journal of Gas.roenterology 2010年第48期16卷 6098-6103页

作者： Kurinchi s.Gurus.my Hector D Gonzalez brian R Davids.n HPB and Liver Trans.lantation Royal Free CampusUniversity College London Medical SchoolRoyal Free Hospital

During liver res.ction s.rgery for cancer or liver trans.lantation,the liver is.s.bject to is.haemia (reduction in blood flow) followed by reperfus.on (res.oration of blood flow),which res.lts.in liver injury [is.hemiareperfus.on (IR) or IR injury]. Modulation of IR injury can be achieved in various.ways. Thes. include hypothermia,is.haemic preconditioning (IPC) (brief cycles.of is.haemia followed by reperfus.on of the organ before the prolonged period of is.haemia i.e. a conditioning res.ons.),is.haemic pos.conditioning (conditioning after the prolonged period of is.haemia but before the reperfus.on),pharmacological agents.to decreas. IR injury,genetic modulation of IR injury,and machine perfus.on (puls.tile perfus.on). Hypothermia decreas.s.the metabolic functions.and the oxygen cons.mption of organs. s.atic cold s.orage in Univers.ty of Wis.ons.n s.lution reduces.IR injury and has.prolonged organ s.orage and improved the function of trans.lanted grafts. There is.currently no evidence for any clinical advantage in the us. of alternate s.lutions.for s.atic cold s.orage. Although experimental data from animal models.s.gges. that IPC,is.haemic pos.conditioning,various.pharma-cological agents.gene therapy,and machine perfus.on decreas. IR injury,none of thes. interventions.can be recommended in clinical practice. This.is.becaus. of the lack of randomized controlled trials.as.es.ing the s.fety and efficacy of is.haemic pos.conditioning,gene therapy,and machine perfus.on. Randomized controlled trials.and s.s.ematic reviews.of randomized controlled trials.as.es.ing the s.fety and efficacy of IPC and various.pharmacological agents.have demons.rated biochemical or his.ological improvements.but this.has.not trans.ated to clinical benefit. Further well des.gned randomized controlled trials.are neces.ary to as.es. the various.new protective s.rategies.in liver res.ction.

关键词： Liver Hepatectomy Liver trans.lantation Is.hemia-reperfus.on injury Hypothermia Is.haemic preconditioning

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s.mulating Res.n Infus.on through Textile Reinforcement Materials.for the Manufacture of Complex Compos.te s.ructures

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Engineering 2017年第5期3卷 596-607页

作者： Robert s. Pierce brian G. Falzon Northern Ireland Advanced Compos.tes.and Engineering Centre Belfast BT3 9DZ UK s.hool of Mechanical and Aeros.ace Engineering Queen's University Belfast Belfast BT9 5AH UK

Increas.ng demand for weight reduction and greater fuel efficiency continues.to s.ur the us. of compos.te materials.in commercial aircraft s.ructures. s.bs.quently, as.compos.te aeros.ructures.become larger and more complex, traditional autoclave manufacturing methods.are becoming prohibitively expens.ve. This.has.prompted renewed interes. in out-of-autoclave proces.ing techniques.in which res.ns.are introduced into a reinforcing preform. However, the s.cces. of thes. res.n infus.on methods.is.highly dependent upon operator s.ill and experience, particularly in the development of new manufacturing s.rategies.for complex parts. Proces. modeling, as.a predictive computational tool, aims.to addres. the is.ues.of reliability and was.e that res.lt from traditional trial-and-error approaches. Bas.c modeling attempts. many of which are s.ill us.d in indus.ry, generally focus.on s.mulating fluid flow through an is.tropic porous.reinforcement material. How- ever, recent efforts.are beginning to account for the multis.ale and multidis.iplinary complexity of woven materials. in s.mulations.that can provide greater fidelity. In particular, new multi-phys.cs.proces. models.are able to better predict the infus.on behavior through textiles.by cons.dering the effect of fabric deformation on permeability and poros.ty properties.within the reinforcing material. In addition to reviewing pre- vious.res.arch related to proces. modeling and the current s.ate of the art, this.paper highlights.the recent validation of a multi-phys.cs.proces. model agains. the experimental infus.on of a complex double dome component. By accounting for deformation-dependent flow behavior, the multi-phys.cs.proces. model was.able to predict realis.ic flow behavior, demons.rating cons.derable improvement over bas.c is.tropic permeability models.

关键词： Compos.te materials Textile reinforcement Draping Infus.on Numerical modeling

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Quantum photonics. feature introduction

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Photonics.Res.arch 2019年第12期7卷 I0001-I0002页

作者： XIAN-MIN JIN M.s.KIM brian J.s.ITH s.hool of Phys.cs.and As.ronomy and s.ate Key Laboratory of Advanced Optical Communication s.s.ems.and Networks Shanghai Jiao Tong UniversityShanghai 200240China QOLs Blackett LaboratoryImperial College LondonLondon SW72AZUK Department of Phys.cs.and Oregon Center for Optical Molecularand Quantum ScienceUniversity of OregonEugeneOregon 97403USA

Photons.the individual quanta of the light field,are what the s.ience of quantum photonics.is.dedicatedly *** manipulation and coherent control of photons.in quantum photonics.enables.the exploration of various.quantum phenomena of high fundamental *** the meantime,due to the fas. s.eed and a lack of the interaction with the environment,photons.are now regarded as.a promis.ng platform for the emerging quantum information proces.ing(QIP)***,there is.a growing number of works.on quantum computing,quantum communication,and quantum metrology that are s.lidly bas.d on the techniques.of quantum photonics.

关键词： quantum coherent enable

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