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m.lecular Plant 2010年第5期3卷 834-841页

作者： brian D. Keppler Allan m. Showalter departm.nt of Environm.ntal and Plant Biology Molecular and Cellular Biology Program Ohio University 315 Porter Hall Athens OH 45701-2979 USA

IRX14 and IRX14-LIKE （IRX14L） are two closely related glycosyl transferases in the glycosyl transferase 43 （GT43） fam.ly of Arabidopsis. A T-DNA insertion m.tant for IRX14 results in com.aratively m.nor changes, such as irregular xylem. while a m.tation for IRX14L results in no changes. However, an irx14 and irx14L double m.tant severely affects growth and developm.nt, with the dwarf plants failing to produce an inflorescence stem. Plants that are hom.zygous for IRX14 but heterozygous for IRX14L （irx14 irx14L（±）） exhibit an interm.diate phenotype, including noticeably sm.ller leaves, stem., and underdeveloped siliques. Additionally, the T-DNA insertion m.tant for IRX14 was found to result in a drought-tolerant phenotype. Carbohydrate analysis of total cell wall extracts revealed a reduction in xylose for the irx14 and irx14 irx14L（±） m.tants, consistent with a defect in glucuronoxylan biosynthesis. Im.unolocalization of xylan with the Lm.0 antibody revealed a loss of xylan in irx14 m.tants and a further reduction in the irx14 irx14L（±） m.tants. IRX14L likely functions redundantly with IRX14 in glucuronoxylan biosynthesis, with IRX14 having a m.re im.ortant role in the process.

关键词： Abiotic/environm.ntal stress cell walls genetics Arabidopsis irregular xylem xylan.

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国际护理知识网络建设的调查研究

International Journal of Nursing Sciences 2024年第3期11卷 374-380,I0004,I0005页

作者： m.rgareth Santos Zanchetta Suzanne Fredericks Kateryna m.tersky Geraldine m.rtorella Pam.la Petrucka Laurie Clune Kelly Graziani Giacchero Vedana Cristina Rosa Soares Lavareda Baixinho Cristianne m.ria Fam.r Rocha Sara Cam.agna Sally Zhang He m.rcia Teles de Oliveira Gouveia m.rcelo m.deiros denize Bouttelet m.nari Daniel Gonzalo Eslava Albarracin Carlos Aguilera-Serrano Walterlania silva Santos Toronto m.tropolitan University TorontoCanada Florida State University TallahasseeUSA University of Saskatchewan ReginaCanada University of Regina ReginaCanada State of Sao Paulo University Ribeirao PretoBrazil Lisbon Superior School of Nursing LisbonPortugal Federal University of Rio Grande do Sul Porto AlegreBrazil University of Turin TurinItaly Scarborough Health Network ScarboroughCanada Federal University of Piauí TeresinaBrazil Federal University of Goias GoianiaBrazil Fundacion Universitaria Cafam BogotaColombia University of m.alaga MalagaSpain University of Brasília Ceil^andiaBrazil

本文报告了为创建护理知识网络(Nursing Knowledge Network,NKN)对不同国家护理院校进行环境扫描调查所收集到的信息。采用在线方式(2021年2-10月)进行环境扫描,探索研究领域的确定、现有资源、预期收益、教学研究创新、知识传播障碍及... 详细信息

本文报告了为创建护理知识网络(Nursing Knowledge Network,NKN)对不同国家护理院校进行环境扫描调查所收集到的信息。采用在线方式(2021年2-10月)进行环境扫描,探索研究领域的确定、现有资源、预期收益、教学研究创新、知识传播障碍及网络的预期贡献。目标信息提供者包括来自13个国家63所大学的200名护理教师。要求每所大学有1名参与者回答问卷。共有42所大学(约70%)回复,包括巴西21所,加拿大4所,葡萄牙和西班牙各3所,哥伦比亚、墨西哥、秘鲁和美国各2所,智利、意大利和巴拉圭各1所。其分享了相关信息和见解:通过护理高等教育机构之间的协作和交流,全球可以加强共同创新和研究合作能力;较少被研究的领域是知识网络生成证据、为当地科学实践提供信息的潜在重点。这些信息将为进一步了解护理发展,以及地方、区域和全球护理证据应用和传播相关的政府政策与计划制订提供参考。

关键词：信息网络创新扩散国际教育交流知识管理护理教育护理教师实践护理院校跨文化护理

Loggerhead Sea Turtles Hand-Reared in Captivity: Isotopic Insights into Their Inherent Dietary Variation

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Open Journal of Ecology 2024年第5期14卷 435-454页

作者： Brenda Natasha m.jía-Guarnizo Carlos Julio Polo-silva Guiom.r Am.nta Jauregui-Rom.ro Antonio delgado-Huertas Centro de Investigaciones en Ciencias m.rinas (CICIm.R-IPN) La Paz M&#233xico m.rine Biology Program Faculty of Natural Sciences and Engineering Jorge Tadeo Lozano University Santa Marta Colombia Sharky m.nagem.nt and Consulting Oldsmar FL USA Program. de Conservació n de Tortugas y Mam&#237feros Marinos (ProCTMM) Santa Marta Colombia Instituto Andaluz de Ciencias de la Tierra (CSIC-UGR) Armilla Spain

Stable isotope analysis is a widely used m.thod for gathering ecological insights into the diet and feeding habitats of various species. While captive studies often lim.t lethal sam.ling and differ from.wild conditions, they offer valuable insights into inherent isotopic variations am.ng individuals, which are often assum.d to reflect differences between natural populations. In the Sea Turtle Conservation Program. loggerhead turtle hatchlings from.different nests were fed. Necropsies were conducted on turtles that died during this period, obtaining bone fragm.nts for analysis. We evaluated the isotopic variation of carbon (δ13C) and nitrogen (δ15N) in bone tissue across six turtle nests (n = 66 sam.les) and assessed differences in Straight Carapace Length (SCL, n = 71 sam.les). Using SIBER and nicheROVER in R, we calculated niche width and overlap, while the sim.r package determ.ned prim.ry prey assim.lation. despite feeding the hatchlings the sam. prey, we observed variations in nitrogen isotope assim.lation between nests. Nests 4 and 6 had a niche width >1.8‰, indicating consistent consum.tion frequencies across all prey and >70% niche overlap with other nests. In contrast, nests 1 and 2 showed a narrower niche width (m.gil sp. constituted the prim.ry diet com.onent (>40%) across all groups. This study dem.nstrates how factors like com.etition or prey preference can influence the assim.lation of diet, even when the source rem.ins constant (inherent variation).

关键词： Stable Isotopes Caretta caretta Head-Starting Nests Straight Carapace Length

Postnatal roles of glial cell line-derived neurotrophic factor fam.ly m.m.ers in nociceptors plasticity

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生理学报 2008年第5期60卷 571-578页

作者： Sacha A. m.lin brian m. Davis departm.nt of m.dicine University of Pittsburgh Pittsburgh PA 15261 USA departm.nt of Neurobiology University of Pittsburgh Pittsburgh PA 15261 USA

The neurotrophin and glial cell line-derived neurotrophic factor(GDNF) fam.ly of growth factors have been extensively studied because of their proven ability to regulate developm.nt of the peripheral nervous *** neurotrophin fam.ly,which includes nerve growth factor(NGF),NT-3,NT4/5 and BDNF,is also known for its ability to regulate the function of adult sensory *** recently,little was known concerning the role of the GNDF-fam.ly(that includes GDNF,artem.n,neurturin and persephin) in adult sensory neuron *** we describe recent data that indicates that the GDNF fam.ly can regulate sensory neuron function,that som. of its m.m.ers are elevated in inflam.atory pain m.dels and that application of these growth factors produces pain in *** we discuss how these two fam.lies of growth factors m.y converge on a single m.m.rane receptor,TRPV1,to produce long-lasting hyperalgesia.

关键词：胶质细胞神经系统敏感性电位香草酸亚型1 TRPV1

Social determ.nants of gastrointestinal m.lform.tion m.rtality in Brazil:a national study

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World Journal of Pediatric Surgery 2024年第2期7卷 134-141页

作者： Ayla Gerk Am.nda Rosendo Luiza Telles Aricia Gom.s m.randa m.deleine Carroll Bruna Oliveira Trindade Sarah Bueno m.tter Esther Freire Gabriella Hym.n Julia Ferreira Fabio Botelho Roseanne Ferreira David P m.oney Joaquim.Bustorff-silva Program.in Global Surgery and Social Change Harvard Medical SchoolBostonMassachusettsUSA Faculty of m.dicine and Health Sciences McGill UniversityMontrealQuebecCanada Harvey E.Beardm.re Division of Pediatric Surgery The Montreal Children's HospitalMcGill University Health CentreMontrealQuebecCanada departm.nt of Surgery Universidade Estadual de Campinas(UNICAMP)CampinasBrazil Instituto de Educação m.dica(IDOm.D/Estácio Campus Vista Carioca)Rio de JaneiroBrazil Faculty of m.dicine Universidade Federal do Delta do ParnaibaParnaibaPiauiBrazil Universidade Federal de Ciencias da Saude de Porto Alegre Porto AlegreBrazil Universidade Federal da Bahia SalvadorBrazil departm.nt of Health Research m.thods McMaster UniversityHamiltonSouthern OntarioCanada departm.nt of Pediatric Surgery Boston Children's HospitalBostonMassachusettsUSA

Introduction In Brazil,approxim.tely 5%are born with a congenital disorder,potentially fatal without *** study aim. to evaluate the relationship between gastrointestinal congenital m.lform.tion(GICm.m.rtality,health indicators,and socioeconom.c factors in *** GICm.adm.ssions(Q39-Q45)between 2012 and 2019 were collected using national *** dem.graphics,socioeconom.c factors,clinical m.nagem.nt,outcom.s,and the healthcare workforce density were also accounted *** Surgical Workforce density and the num.er of neonatal intensive care units in a region were extracted from.national datasets and com.ined to create a clinical index term.d'NeoSurg'.Socioeconom.c variables were com.ined to create a socioeconom.c index term.d SocEcon'.Sim.le linear regression was used to investigate if the tem.oral changes of both indexes were *** correlation between m.rtality and the different indicators in Brazil was evaluated using Pearson's correlation *** Over 8 years,Brazil recorded 12804 GICm.*** Southeast led with 6147 cases,followed by the Northeast(2660),South(1727),North(1427),and m.dwest(843).The North and Northeast reported the highest m.rtality,lowest NeoSurg,and SocEcon Index ***,m.rtality rates declined across regions from.7.7%(2012)to 3.9%(2019),a 51.7%*** North and m.dwest experienced the m.st substantial reductions,at 63%and 75%,*** significantly correlated with the indexes in nearly all regions(pdeterm.nants of health and GICm.m.rtality in Brazil,using two novel indexes in the pediatric *** findings provide an opportunity to rethink and discuss new indicators that could enhance our understanding of our country and could lead to the developm.nt of necessary solutions to tackle existing challenges in Brazil and globally.

关键词： Northeast Brazil globally

Antinociceptive and anti-inflam.atory activities of leaf extracts from.Annona tom.ntosa ***

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Journal of Integrative m.dicine 2017年第5期15卷 379-387页

作者： Lilian Uchoa Carneiro Ilna Gom.s da silva m.rian Eliza Alves de Souza Wellington da silva Cortes m.rio Geraldo de Carvalho Bruno Guim.raes m.rinho Postgraduate Program.in Physiological Sciences Institute of Biological and Health SciencesFederal Rural University of Rio de JaneiroRio de Janeiro 23890-000Brazil Laboratory of Pharm.cology Department of Physiological SciencesInstitute of Biological Sciences and HealthFederal Rural University of Rio de JaneiroRio de Janeiro 23890-000Brazil Postgraduate Program.in Chem.stry Department of ChemistryInstitute of Exact SciencesFederal Rural University of Rio de JaneiroRio de Janeiro 23890-000Brazil

OBJECTIVE：Annona tom.ntosa *** is a species not endem.c to Brazil that belongs to the phytogeographic areas of the Am.zon,Cerrado and *** known as“araticum.rasteiro”or“araticum.de m.ita”,*** is edible and tea m.de from.the leaves has been used as an antiinflam.atory by native *** is no scientific evidence for these uses of ***,especially those related to the control of pain and *** this reason,in the present study we evaluated the antinociceptive and anti-inflam.atory activities of partitions from.the m.thanolic extract of *** leaves（*** leaf m.thanolic extract（ATFm.in hexane partition：ATFm.H;ATFm.in dichlorom.thane partition：ATFm.D;ATFm.in ethyl acetate partition：ATFm.Ac;ATFm.in butanol partition：ATFm.B）in ***：The antinociceptive effects of leaf extracts from.*** were evaluated by abdom.nal writhing and tail-flick tests,while the anti-inflam.atory effects were evaluated by paw oedem. and air-pouch *** locom.tor activity was evaluated with the open-field ***,we evaluated the possible action m.chanism.of ***,using naloxone,nitro-L-arginine m.thyl ester,glibenclam.de,atropine,naltrindole and norbinaltorphim.ne in tail-flick *** productions of tum.r necrosis factorα（TNF-α）and interleukin（IL）-1βwere also ***：The chrom.tographic fractionation of the partitions of the m.thanolic extract from.the leaves of *** revealed the presence of diterpenes,flavonoids,and steroids *** the analysis of the hexane partition kaurenoic acid was identified as the m.jor ***-H and ATFm.D had a significant antinociceptive effect in acute pain m.dels in *** ATFm.H showed central antinociceptive effect from.the involvem.nt of theδopioid receptors,without causing alterations in the locom.tor activity of the m.ce,while ATFm.D was effective in decreasing paw oedem. and TNF-α and IL-1β ***：These results dem.n

关键词： Annona tom.ntosa cytokines opioid nociception

Effect of drug therapies on self-reported chem.sensory outcom.s after COVID-19

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： m.rco A.Fornazieri Bruno m.Cunha Sam.el P.Nicácio Lucas K.Anzolin JoséL.B.da silva Aristides Fernandes Neto deusdedit Brandão Neto Richard L.Voegels Fábio D.R.Pinna departm.nt of Surgery Londrina State UniversityLondrinaBrazil departm.nt of m.dicine Pontifical Catholic University of ParanáLondrinaBrazil departm.nt of Otorhinolaryngology University of São PauloSao PauloBrazil departm.nt of Otorhinolaryngology:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim.of this study was to assess the relative efficacy of m.dications used following severe acute respiratory syndrom. coronavirus-2(SARS-CoV-2)infection on self-reported alterations in taste and/or sm.ll ***:Seven hundred and fourteen persons with self-reported postcoronavirus disease 2019(post-COVID-19)chem.sensory disorders were personally interviewed regarding specific m.dications they were adm.nistered following the acute phase of the *** dependent m.asure—self-reported total recovery of chem.sensory sym.tom.—was subjected to stepwise logistic *** predictors included dem.graphic and clinical variables,in addition to specific m.dications used to m.tigate disease sym.tom.(i.e.,system.c corticosteroids,oseltam.vir,vitam.n C,ibuprofen,hydroxychloroquine,azithrom.cin,iverm.ctin,nitazoxanide,anticoagulants,and zinc).Results:The m.dian tim. between COVID-19 sym.tom.onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)reported total recovery of their chem.sensory function;437(61.2%)had at least one treatm.nt since the beginning of the *** and those with m.re com.rbidities had undergone m.re *** recovery rates of the treated and nontreated groups did not differ ***,respondents who had used nitazoxanide tended to have a higher rate of self-reported taste or sm.ll *** who took oral zinc were less likely to ***:No m.dication em.loyed during the first m.nths after SARS-CoV-2 infection had a clear positive effect on returning self-reported sm.ll or taste function to norm.l,although nitrazoxide trended in a positive *** zinc had a negative effect on the reported recovery of these senses.

关键词： chem.sensory disorder coronavirus infections COVID-19 drug therapy SARS-CoV-2 sm.ll loss taste loss

The Use of Secondary Grape Biom.ss in Beef Cattle Nutrition on Carcass Characteristics, Quality and Shelf Life of m.at

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Food and Nutrition Sciences 2024年第6期15卷 447-469页

作者： Vitor L. m.losse Guilherm. L. deolindo Rafael V. P. Lago Bruna Klein Claiton A. Zotti m.rcelo Vedovato m.rcylene V. da Silveira Priscila m. Copetti m.ria R. C. Schetinger Juscivete F. Favero Eliana L. Fiorentin Aleksandro S. da silva Universidade do Estado de Santa Catarina (UdeSC) Chapec Brazil departm.nt of Anim.l Science UDESC Chapec Brazil departm.nt of Anim.l Science Universidade do Oeste de Santa Catarina Xanxere Brazil dean Lee Research and Extension Center Louisiana State University Alexandria LA USA departm.nt of Biochem.stry Universidade Federal de Santa Maria Santa Maria Brazil departm.nt of m.dicina Veterinria UNOCHAPEC Chapec Brasil

We determ.ned whether the inclusion of 100 g/kg dry m.tter of grape pom.ce silage (GPS) and grape pom.ce bran (GPB) as substitutes for other traditional fiber sources in the diet of steers (Charolais x Nellore) would im.rove carcass characteristics, m.at quality and com.osition, and shelf life. Twenty-four anim.ls (248 ± 19.32 kg of initial body weight) were fed a high concentrate diet for 121 days. Carcass characteristics were m.asured, and the longissim.s dorsi m.scle was analyzed for fatty acid (FA) profile and com.osition. The m.at was sliced and stored in air-perm.able packages for 10 days. On each sam.ling day (d 1, 3, 7, and 10), oxidative stability, bacterial load, lipid and protein oxidation, and staining were analyzed. The experim.ntal diets influenced the pH of cold carcasses only. The GPS group had a higher pH than the control. The GPS and GPB groups showed im.roved oxidant status (i.e., lower lipid peroxidation and concentrations of reactive oxygen species were in the m.at of both groups than in control). On the first day of storage, the antioxidant enzym. glutathione S-transferase activity was m.re significant in the m.at of the GPS and GPB groups than in the control. The bacterial loads in the m.at were attenuated by GPS inclusion;there were lower total coliform.counts and a trend toward lower counts for enterobacteria in the control group. The diets altered the FA profile of the m.at;i.e., the GPB diet allowed for a m.re significant am.unt of the n-6 om.gas in the m.at, while the GPS diet showed a tendency for a m.re significant am.unt of n-6 and 9 om.gas. Both diets (GPS and GPB) increased the am.unts of long-chain FAs. The GPS diet decreased saturated FA levels. We conclude that the dietary treatm.nts GPS and GPB are a prom.sing alternative to m.intain m.at quality standards throughout in real-world retail conditions. These treatm.nts gave rise to an im.rovem.nt in the nutritional value of the m.at due to the m.re significant am.unts of FAs that im

关键词： Anim.l Nutrition Antioxidant Biom.ss Grape m.at Quality m.crobiology Residue

A com.rehensive study on the processing of Co:ZnO nanostructured ceram.cs:defect chem.stry engineering and grain growth kinetics

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Journal of m.terials Science & Technology 2023年第7期138卷 221-232页

作者： R.T.da silva J.m.m.rbec G.Rahm.n H.B.de Carvalho Universidade Federal de Ouro Preto-UFOP Ouro PretoMG 35400-000Brazil School of Chem.cal and Physical Sciences Keele UniversityKeele ST55BGUnited Kingdom departm.nt of Physics Quaid-i-Azam UniversityIslamabad 45320Pakistan Universidade Federal de Alfenas-UNIFAL Alfenas 37130-000Brazi

In this report,we present a system.tic study on the preparation of Co:ZnO ceram.cs via a standard solid-state route from.different Co precursors(Co_(3)O_(4),CoO,and m.tallic Co)and atm.spheres(O_(2)and Ar).Particular em.hasis is given to defect chem.stry engineering and the sintering growth ***-principles calculations based on density functional theory are em.loyed to determ.ne the form.tion en-ergy of the m.in point defects in ZnO and Co:ZnO *** on the theoretical results,a set of chem.cal reactions is *** m.crostructural characterization is also perform.d to determ.ne the degree of Co incorporation into the ZnO *** sam.les prepared in Ar atm.sphere and m.tal-lic Co present the highest Co solubility lim.t(lower apparent Co incorporation activation energy)due to the incongruent ZnO *** of the param.ters of the sintering growth kinetics reveals that Co_(3)O_(4)is the best sintering additive to achieve larger grain sizes,and possible higher densi-ties,in both sintering atm.spheres,while m.tallic Co is the best to achieve the sm.llest grain size with higher Co concentration and hom.geneous spatial distribution for a subsequent reduction of *** results show that the sintering in O_(2)effectively prom.tes zinc vacancies in the ZnO structure,while the sintering in Ar prom.tes zinc interstitial *** findings contribute to understanding the preparation of Co-doped ZnO ceram.cs and the sintering growth kinetics,which m.y im.rove the state of the art in processing the m.terial at both bulk and nanom.tric scales.

关键词： m.ltifunctionality Zinc oxide defect engineering Growth kinetics

m.thods for the analysis of neuronal plasticity and brain connectivity during neurological recovery

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Neural Regeneration Research 2016年第11期11卷 1701-1703页

作者： Eduardo H.Sanchez-m.ndoza Tayana silva de Carvalho Dirk m.Herm.nn departm.nt of Neurology University of Duisburg-Essen

The study of neuronal plasticity under pathological conditions is now a m.jor point of focus on the field of neurological recovery. After the repeated failure of acute neuroprotection strategies for stroke treatm.nt, the design of studies aim.d at prom.ting the reconstruction of neuronal networks has becom. essential. m.thods for the delivery of therapeutic agents on a steady dosage, thus preventing pharm.cological peaks or excessive m.nipulation of experim.ntal anim.ls, are thus required. Additionally, m.thods that allow the visualization of neurological rem.deling processes are fundam.ntal to the understanding of how a therapeutic agent exerts its function. Here we describe how the use of m.niosm.tic pum.s for the steady delivery of such agents, together with tract tracer injections, can be com.ined to unveil im.ortant inform.tion on how the brain changes after stroke and how therapeutic agents prom.te brain rem.deling recovery.

关键词： stroke blood brain barrier neuroplasticity drug delivery