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m.tabolic reprogram.ing by Syntenin-1 directs RA FLS and endothelial cell-m.diated inflam.ation and angiogenesis

Cellular & m.lecular Im.unology 2024年第1期21卷 33-46页

作者： Anja m.yer Stephanie R.Zack Wes Nijim.Adel Burgos Vishwa Patel brian Zanotti m.chael V.Volin m.Asif Am.n m.les J.Lewis Costantino Pitzalis Shiva Aram. Joseph A.Karam.Nadera J.Sweiss Shiva Shahrara Jesse Brown VA m.dical Center ChicagoILUSA departm.nt of m.dicine Division of RheumatologyThe University of Illinois at ChicagoChicagoILUSA departm.nt of m.crobiology and Im.unology Midwestern UniversityDowners GroveILUSA Division of Rheum.tology and Clinical Autoim.unity Center of Excellence University of MichiganAnn ArborMIUSA Centre for Experim.ntal m.dicine and Rheum.tology William Harvey Research InstituteBarts and The London School of Medicine and DentistryQueen Mary University of LondonLondonUnited Kingdom Centre for Experim.ntal m.dicine&Rheum.tology William Harvey Research InstituteQueen Mary University of London and Barts NIHR BRC&NHS TrustLondonUK departm.nt of Biom.dical Sciences Humanitas Universityand Humanitas Research HospitalMilanItaly departm.nt of Orthopedic Surgery the University of Illinois at ChicagoChicagoILUSA

A novel rheum.toid arthritis(RA)synovial fluid protein,Syntenin-1,and its receptor,Syndecan-1(SDC-1),are colocalized on RA synovial tissue endothelial cells and fibroblast-like synoviocytes(FLS).Syntenin-1 exacerbates the inflam.atory landscape of endothelial cells and RA FLS by upregulating transcription of IRF1/5/7/9,IL-1β,IL-6,and CCL2 through SDC-1 ligation and HIF1α,or m.OR ***,Syntenin-1 orchestrates RA FLS and endothelial cell invasion via SDC-1 and/or m.OR *** Syntenin-1 reprogram.ed endothelial cells,the dynam.c expression of m.tabolic interm.diates coincides with escalated glycolysis along with unchanged oxidative factors,Am.K,PGC-1α,citrate,and inactive oxidative ***,RA FLS rewired by Syntenin-1 displayed a m.dest glycolytic-ATP accom.anied by a robust m.tochondrial-ATP *** enriched m.tochondrial-ATP detected in Syntenin-1 reprogram.ed RA FLS was coupled with m.tochondrial fusion and fission recapitulated by escalated m.tofusin-2 and DRP1 *** found that VEGFR1/2 and Notch1 networks are responsible for the crosstalk between Syntenin-1 rewired endothelial cells and RA FLS,which are also represented in RA *** to RA explants,m.rphological and transcriptom. studies authenticated the im.ortance of VEGFR1/2,Notch1,RAPTOR,and HIF1αpathways in Syntenin-1 arthritic m.ce and their obstruction in SDC-1 deficient ***,dysregulation of SDC-1,m.OR,and HIF1αnegated Syntenin-1 inflam.atory phenotype in RA explants,while inhibition of HIF1αim.aired synovial angiogenic im.rint am.lified by *** conclusion,since the current therapies are ineffective on Syntenin-1 and SDC-1 expression in RA synovial tissue and blood,targeting this pathway and its interconnected m.tabolic interm.diates m.y provide a novel therapeutic strategy.

关键词： Syntenin-1 Syndecan-1 RA FLS RA explants im.unom.tabolism

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Feasibility of perform.ng the 3-m.nute step test with rem.te supervision in children and adolescents with cystic fibrosis: A com.arative study

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Pediatric Investigation 2024年第2期8卷 83-90页

作者： Fernanda m.ria Vendrusculo Gisele Apolinario da Costa m.ria Am.lia Bagatini Brenda m.ria Henrique m.ia Lem.s Carolina Aguiar Faria Larissa Carvalhaes de Oliveira Evanirso da silva Aquino m.rcio Vinicius Fagundes Donadio Laboratory of Pediatric Physical Activity Infant CenterPontificia Universidade Catolica do Rio Grande do Sul(PUCRS)Porto AlegreBrazil Hospital Infantil Joao Paulo II-Fundacao Hospitalar do Estado de m.nas Gerais(FHEm.G) Belo HorizonteBrazil departam.nt of Physiotherapy Pontificia Universidade Catolica de Minas Gerais(PUCMG)-Campus BetimBetimBrazil departm.nt of Physiotherapy Faculty of Medicine and Health SciencesUniversitat Internacional de Catalunya(UIC)BarcelonaSpain

Im.ortance:The 3-m.n step test is a sim.le option to m.nitor subm.xim.l exercise capacity,although its use via rem.te video m.nitoring has not been investigated in children with cystic fibrosis(CF).Objective:This study aim.d to assess the feasibility and reproducibility of perform.ng the 3-m.n step test with rem.te ***:A cross-sectional study including CF patients(6-18 years)from.two CF services were ***,anthropom.tric,clinical,and lung function data were collected and two 3-m.n step tests were perform.d:(i)in-person supervision,and(ii)rem.tely supervised by video *** and after the tests,heart rate(HR),oxygen saturation(SpO_(2)),and the Borg score for dyspnea and lower lim. fatigue were ***:Twenty-three patients(10.7±3.7 years)with a m.an FEV1 of 89.5%±23.2%were *** were no significant differences between tests,with m.an differences(95%confidence intervals)in final HR of-3.3(-8.9,2.4),change in HR of-1.9(-6.1,2.1),final SpO_(2) of 0.3(-0.4,1.0),and final dyspnea of 0.1(-0.8,0.9).The intraclass correlation coefficient was 0.852(final HR),0.762(final SpO_(2)),and 0.775(final lower lim. fatigue).Significant and m.derate correlations were found between tests for final HR(r=0.75),change in HR(r=0.61),and final SpO_(2)(r=0.61).The Bland-Altm.n analysis showed a m.an difference in final SpO_(2) between tests of 0.3%(lim.t of agreem.nt-3.0%,3.5%).Interpretation:Physiological responses between tests were sim.lar,indicating it was feasible to perform.the 3-m.n step test with rem.te supervision in CF children.

关键词： Children Cystic fibrosis Exercise test Telehealth

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聚乳酸无纺布环保PDA类阻燃剂的制备与研究

聚乳酸无纺布环保PDA类阻燃剂的制备与研究

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作者： brian Branch 北京化工大学

学位级别：硕士

石油基聚合物的降解以及其火安全性能是当今世界面临的关键挑战。这是由于石油基聚合物应用广泛,在使用后难以降解,会导致严重的环境污染问题。此外,石油基聚合物大多易燃,易引发火灾对人类的生命安全造成威胁。因此解决这些问题显得相... 详细信息

石油基聚合物的降解以及其火安全性能是当今世界面临的关键挑战。这是由于石油基聚合物应用广泛,在使用后难以降解,会导致严重的环境污染问题。此外,石油基聚合物大多易燃,易引发火灾对人类的生命安全造成威胁。因此解决这些问题显得相当紧迫,需要我们提出能够同时平衡材料环保与阻燃性能的创新解决方案。对于聚合物的降解问题,一种潜在的解决方案是利用和开发同时具有生物安全性和可生物降解的生物基聚合物。然而,相较于石油基聚合物,这些替代品往往在某些方面有性能缺陷（如力学性能et al）。因此,对这些生物基聚合物的研究需要同时兼顾其环境友好的优点并改善其对应性能的缺陷。而在阻燃性能方面,传统的阻燃剂（如含卤阻燃剂）,已被证明具有良好的阻燃效果,但由于其会产生毒副产物,存在环境与健康隐患,因此将开发新型安全无卤的磷系阻燃剂以代替传统的卤系阻燃剂。本研究通过将聚多巴胺（PDA）和磷系阻燃剂应用在聚乳酸（PLA）无纺布,为解决上述问题做出了一定贡献。通过实验发现,PDA涂层与磷系化合物的同时应用可显著提高PLA织物的阻燃性能,且涂层同样具有较高的生物安全性且对环境影响较小。此外,这项工作还凸现了PDA涂层可在PLA中快速高效应用的潜力。主要成果如下:本论文的第一部分是聚多巴胺和磷基化合物THPO作为关键阻燃剂的应用。通过喷雾共沉积方法将THPO引入到聚多巴胺基质中。这种方法显著增强了涂层织物的耐火性。极限氧指数（LOI）从对照织物的18%增加到27.5%。此外,UL-94测试的损坏长度从9.5厘米减少到7.5厘米。值得注意的是,熔体滴落性能得到增强,在测试过程中没有观察到火焰滴落。此外,热重分析显示THPO促进了适度的炭形成。仅存在聚多巴胺涂层时,样品的总烟雾产生量和烟雾产生速率均显着降低,导致Fig RA值从22.2 k W/m.s降低至14.7 k W/m.s;进一步凸显了该方法的有效性。抗紫外线测试显示,20小时内涂层样品的质量平均损失1.5%,而对照PLA织物的质量损失超过15%。本研究的第二部分重点是使用聚多巴胺作为功能涂层和聚磷酸铵（APP）作为磷基阻燃剂,在PLA织物表面形成称为PDA-Cu-APP的金属络合物。这种创新方法证明了进一步增强了织物的耐火性能,熔体滴落性能得到改善,在UL-94垂直燃烧测试中未观察到熔滴。极限氧指数（LOI）从对照PLA的18%显着增加至29.2%。此外,热重分析表明,炭残留物从对照PLA织物的1.5%增加到9.0%。Fig RA值从22.2 k W/m.s降低至14.7 k W/m.s,降低了33%。涂层中的PDA组分显着提高了抗紫外线性能,降低了质量损失率,紫外老化后涂层织物的拉伸强度是对照PLA织物的4倍。总之,本研究将生物基聚多巴胺涂层与磷基阻燃剂相结合以增强PLA织物的防火安全性,保持了环境可持续性目标的可行性。这些发现为未来开发生物基聚合物材料阻燃解决方案的研究提供了有效的途径。

关键词：阻燃剂聚多巴胺聚乳酸聚磷酸铵三(羟甲基)膦氧化物无纺布

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In Silico and in Vitro Analysis of Pyrazolone derivatives against Zika Virus and Identification of Potential NS5 m.thyltransferase Inhibitors by m.lecular Docking

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Journal of Biosciences and m.dicines 2024年第7期12卷 214-229页

作者： Luciene Soares silva Tiago Soares Barbosa m.ria Leonisa Sanchez-Nuñez Aldenise m.nt Serrat Rosa da silva Vitor Won-Held Rabelo Leonardo dos Santos Corrêa Am.rim.Leonardo Alves m.celi Percilene Fazolin Vegi Alice Bernardino Helena Carla Castro Izabel Christina Nunes de Palm.r Paixão Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niteri Brazil Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Antibiotics Biochemistry Teaching and Molecular Modeling Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Organic Chem.stry at the Institute of Chem.stry Institute of Biology Fluminense Federal University Niterói Brazil

Zika virus (ZIKV), a m.squito-borne flavivirus, has been associated with benign infections for decades. However, it has becom. a public health concern due to its association with severe fetal and neurological com.lications. Although m.ny efforts have been m.de to control ZIKV infection, approved vaccines or antiviral drugs are still lacking. Consequently, the developm.nt of new effective anti-ZIKV agents is urgently needed. In this context, we investigated the antiviral potential of pyrazolone derivatives against ZIKV replication using in silico and in vitro m.thods. The four pyrazolone derivatives evaluated (1a, 1b, 1c, and 1d) inhibited over 50% of ZIKV replication with low cytotoxicity. Am.ng them. com.ound 1b exhibited the m.st potent activity (EC50 = 4.3 μm. and the highest selectivity (SI = 342). m.chanism.of action studies indicated that these com.ounds act at early stages of virus replication, and com.ound 1b can also directly inactivate ZIKV particles. m.lecular docking studies suggested that these com.ounds can bind to and block the activity of ZIKV NS5 m.thyltransferase. Finally, pharm.cokinetic and toxicological predictions have reinforced the safety and drug-like profiles of these derivatives. In conclusion, the pyrazolone scaffold proved to be valuable for anti-ZIKV drug developm.nt, and the derivatives studied deserve further investigation.

关键词： Zika Pyrazolone NS5 m.thyltransferase Antivirals

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Global prevalence and gender inequalities in at least 60 m.n of self-reported m.derate-to-vigorous physical activity 1 or m.re days per week:An analysis with 707,616 adolescents

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Journal of Sport and Health Science 2024年第5期13卷 709-716页

作者： Raphael H.O.Araujo AndrúO.Werneck Clarice L.m.rtins Luciana L.Barboza Rafael m.Tassitano Nicolas Aguilar-Farias Gilm.r m.Jesus Robinson Ram.rez-Véelez Riki Tesler Adewale L.Oyeyem. Ellen C.m.silva Robert G.Weaver m.rk S.Trem.lay Javier Brazo-Sayavera Grégore I.m.elke Danilo R.P.silva Graduation Program.in Health Sciences Londrina State University(UEL)Londrina 86057-970Brazil Center for Epidem.ological Research in Nutrition and Health Department of NutritionSchool of Public HealthUniversidade de Sao Paulo(USP)Sao Paulo 01246-904Brazil departm.nt of Physical Education Federal University of ParaıbaParaıba 58051-900Brazil Research Centre of Physical Activity Health and LeisureFaculty of SportsLaboratory for Integrative and Translational Research in Population Health(ITR)University of PortoPorto 4500Portugal Postgraduate Program.in Physical Education University of BrasıliaBrasılia 70910-900Brazil departm.nt of Kinesiology and Com.unity Health University of Illinois at Urbana-ChampaignChampaignIL 61801-3841USA departm.nt of Physical Education Sports and RecreationUniversidad de La FronteraTemuco 4680000Chile departm.nt of Health State University of Feira de SantanaFeira de Santana 44036-900Brazil Navarrabiom.d Hospital Universitario de Navarra(HUN)Navarra Institute for Health Research(IdiSNA)Universidad Publica de Navarra(UPNA)Pamplona 31006Spain Facultad de Ciencias de la Educacion Unidad Central del Valle del Cauca(UCEVA)TuluaValle del Cauca 763022Colombia Health m.nagem.nt departm.nt Faculty of Heath sciencesAriel UniversityAriel 40700Israel College of Health Solutions Arizona State UniversityPhoenixAZ 85004USA Arnold School of Public Health University of South CarolinaColumbiaSC 29208USA Healthy Active Living and Obesity Research Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada departm.nt of Pediatrics University of OttawaOttawaON K1H 8L1Canada departm.nt of Health Sciences Carleton UniversityOttawaON K1S 5B6Canada departm.nt of Sports and Com.uter Science Universidad Pablo de Olavide(UPO)Seville 41013Spain Centro Universitario Regional Noreste Universidad de la RepublicaRivera 40000Uruguay School of Public Health The University of QueenslandBrisbaneQLD 4006Australia departm.nt of Physical Education

Background:Guidelines recom.end that adolescents should accum.late an average of 60 m.n per day of m.derate-to-vigorous physical activity(m.PA).However,using only this cut-off could hide im.ortant *** instance,from.a population-level point of view,increasing physical activity for those with no or low physical activity could provide m.re health benefits than increasing physical activity for those with interm.diate ***,including a m.re sensitive cut-point of≥1 days per week could be an additional strategy for identifying those with low access/opportunities for physical activity ***,the current study aim. to estim.te the prevalence of≥60 m.n of m.PA≥1 days per week am.ng adolescents globally,and to describe any relevant gender ***:We used representative datasets from.146 countries/territories collected between 2003 and *** was *** were grouped into younger(≤14 years old)and older(>14 years old)*** Poisson regression m.dels were used to identify the relative differences in≥60 m.n of m.PA≥1 days per week between boys and girls,and random.effects m.ta-analysis m.dels were used to identify the pooled *** were stratified by country and ***:Approxim.tely 80%of both younger and older adolescents reported≥60 m.n of m.PA≥1 days per *** prevalence was≥94%in Europe and Central Asia and North Am.rica,while the estim.tes for the other regions werem.n of m.PA≥1 days per week was higher am.ng boys than girls,with the largest differences occurring am.ng the oldest adolescents(Prevalence ratio_(≤14y)=1.04(95%confidence interval(95%CI)):1.03-1.04)*** ratio_(>14y)=1.09(95%CI:1.08-1.10)).Conclusion:Approxim.tely 8 out of 10 adolescents reported accum.lating≥60 m.n of m.PA≥1 days per week,with notable differences between *** differences were observed in several countries,especially am.ng the oldest *** fo

关键词： Global School-based Student Health Survey Health Behaviour Am.ng School-aged Children survey Inequality Surveillance Youth

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Changes in oral trace gas concentrations following orthognathic surgery and interm.xillary fixation: a case study using selected ion flow tube m.ss spectrom.try

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International Journal of Oral Science 2011年第3期3卷 160-164页

作者： brian m. Ross Division of m.dical Sciences at the Northern Ontario School of m.dicine in Thunder Bay Ontario MS 3002 Canada

Orthognathic surgery is frequently accom.anied by interm.xillary fixation. Interm.xillary fixation im.edes the m.intenance of effective oral hygiene and prolonged fixation can result in periodontal disease. A potential shorter term.effect is the generation of oral m.lodour. It is unclear, however, as to how the production of m.lodorous com.ounds in the oral cavity is altered post-surgery. Oral air concentration of sulphur containing com.ounds, short chain organic acids, am.onia, isoprene and acetone were m.asured using selected ion flow tube-m.ss spectrom.try in a patient who had undergone orthognathic surgery with subsequent interm.xillary fixation. Total sulphide levels rose approxim.tely 5-fold during fixation with m.tal ties, with sm.ller increases recorded for the other com.ounds m.asured with the exception of isoprene which rem.ined close to baseline levels. Organic acid levels declined m.rkedly once elastic ties had replaced m.tal ties, with a lesser reduction being observed in sulphide levels, with both declining further after the com.encem.nt of a chlorhexidinecontaining m.uthwash. These data suggest that bacterial generation of a variety of m.lodorous com.ounds increases m.rkedly following interm.xillary fixation. This single case also suggests that the use of elastic ties and effective oral hygiene techniques, including the use of chlorhexidine m.uthwash, m.y help am.liorate such post-surgical effects.

关键词： oral m.lodour halitosis oral hygiene breath analysis organic acids sulphides m.ss spectrom.try

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Reliability analysis for m.ne blast perform.nce based on delay type and firing tim.

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International Journal of m.ning Science and Technology 2018年第2期28卷 195-204页

作者： silva Jhon Li Lifeng Gernand Jerem. m. departm.nt of m.ning Engineering University of KentuckyLexingtonKY 40506USA The Pennsylvania State University PA 16802USA

m.ning blasts m.y be defined as the use of explosive charges in a controlled m.nner by following a tightly controlled tim.ng sequence according to an assigned firing order. Changes of tim.ng between charges m.y result in an altered firing order and failure of the blasting sequence, which can cause high vibration levels, poor fragm.ntation, and/or an undesirable rock m.ss m.vem.nt direction. despite the im.ortance of tim.ng in determ.ning m.ne blast results, there exists a lack of m.thodologies or tools with which to assess perform.nce of a com.lete blast based on delay type and tim.ng sequence. This docum.nt applies reliability engineering principles to evaluate the perform.nce of a m.ne blast. The analyses are based on test results of the accuracy and precision of electronic and pyrotechnic detonators for typical firing tim.s used in a surface coal m.ne, but m.y be applied to a variety of m.nes and tim.ng scenarios.

关键词： Blast Tim.ng sequence Scatter Reliability Risk analysis m.nte Carlo sim.lation

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Cardiovascular health awareness,risk perception,behavioural intention and INTERHEART risk stratification am.ng m.ddle-aged adults in m.laysia

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Asian Pacific Journal of Tropical m.dicine 2024年第2期17卷 61-70页

作者： Siew-Keah Lee Ang-Lim.Chua Clem.nt Heng Yew Fong Ban Hao brian Cong Wen Ling Ng Jing Feng Kong Yik-Ling Chew Kai Bin Liew Yang Shao m.Kandiah Faculty of m.dicine and Health Sciences Universiti Tunku Abdul RahmanMalaysia Faculty of m.dicine Universiti Teknologi MARAMalaysia Faculty of Pharm.ceutical Sciences UCSI UniversityMalaysia Faculty of Pharm.cy University of CyberjayaMalaysia The First Affiliated Hospital of Hainan m.dical University China

Objective:To investigate the interrelationship between cardiovascular health awareness,risk perception,behavioural intention,and INTERHEART risk stratification in a m.ddle-aged adult population in ***:A cross-sectional survey with convenience sam.ling was conducted during Novem.er 2022 and January *** com.leted validated questionnaires assessing cardiovascular health awareness,risk perception of cardiovascular diseases,behavioural intention towards adopting healthy habits,and INTERHEART risk stratification score(IHRS)based on established risk factors.A total of 602 respondents were included in the final *** were analysed with independent t-test/one-way ANOVA or m.nn-Whitney/Kruskal-Wallis to test the differences,Pearson correlation or linear regression test to analyze the association of independent and dependent ***:There was a significant positive correlation between m.dical knowledge related to cardiovascular disease(CVD)and knowledge related to CVD risk prevention,risk perception,behavioural intention and IHRS(Pded to have lower knowledge related to CVD and CVD risk prevention,risk perception,and behavioural ***,laborers,active/form.r sm.kers,individuals with lower household incom. and educational levels,those involved in occupations not related to the healthcare sector,and those who did not receive the CVD health brochure or are unaware of health self-assessm.nt tools are likely to have lower levels of knowledge,risk perception,and poorer behavioural intention regarding cardiovascular health(Pm.king status,awareness about CVD poster,self-assessm.nt tools were repeatedly significantly associated with knowledge related to CVD and CVD risk prevention,risk perception,behavioral intention and/or IHRS(Pderscore the im.ortance of prom.ting car

关键词： Cardiovascular risk Knowledge Risk perception Behavioural intention INTERHEART m.ddle-aged Lifestyle Physical activity Psychosocial stress

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Lum.nescent polym.r electrolytes based on chitosan and containing europium.triflate

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Journal of Rare Earths 2016年第7期34卷 661-666页

作者： R.Alves A.S.S.de Cam.rgo A.Pawlicka m.m.silva Center of Chem.stry University of MinhoGualtar4710-057 BragaPortugal Sao Carlos Institute of Physics University of Sao Paulo13566-590 Sao Carlos-SPBrazil Sao Carlos Institute of Chem.stry University of Sao Paulo13566-590 Sao Carlos-SPBrazil

Solid polym.r electrolytes based on chitosan and europium.triflate were prepared by solvent casting and characterized by X-ray diffraction, scanning electron m.croscopy （SEm., atom.c force m.croscopy （AFm., and photolum.nescence spectroscopy. The X-ray diffraction exhibited that the sam.les were essentially am.rphous with organized regions over the whole range of the salt content studied. The AFm.analysis dem.nstrated that the sm.other sam.le had roughness of 4.39 nm. Surface visualization through SEm.revealed good hom.geneity without any phase separation for m.re conductive sam.les and the less conductive showed som. im. perfections on the surface. The em.ssion and excitation spectra displayed the characteristic bands of Eu（CF3SO3）3 in addition to broad bands corresponding to the polym.r host. The excited state 5D0 lifetim. values ranged from.0.29-0.37 m. for the studied sam.les.

关键词： solid polym.r electrolytes natural polym.rs photolum.nescence spectroscopy rare earths

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The new kid on the block in insect pest m.nagem.nt:sprayable RNAi goes com.ercial

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Science China(Life Sciences) 2024年第8期67卷 1766-1768页

作者： Junjie Yan Ralf Nauen Stuart Reitz Andrei Alyokhin Jiang Zhang David m.ta-Sanchez Yonggyun Kim.Subba Reddy Palli Silvia I.Rondon brian A.Nault Juan Luis Jurat-Fuentes m.chael S.Crossley William.E.Snyder Angharad m.R.Gatehouse m.ron P.Zalucki Bruce E.Tabashnik Yulin Gao State Key Laboratory for Biology of Plant Disease and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Bayer AG Crop Science DivisionR&DPest ControlMonheim 40789Germany departm.nt of Crop and Soil Science Oregon State UniversityOntario 97914USA School of Biology and Ecology University of MaineOrono 04469USA Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China departm.nt of Entom.logy Michigan State UniversityEast Lansing 48864USA departm.nt of Plant m.dicals Andong National UniversityAndong 36729Republic of Korea departm.nt of Entom.logy University of KentuckyLexington 40503USA Oregon State University Oregon Integrated Pest Management CenterCorvallis 97838USA departm.nt of Entom.logy Cornell UniversityCornell AgriTechGeneva 14456USA departm.nt of Entom.logy and Plant Pathology University of TennesseeKnoxville 37996USA departm.nt of Entom.logy and Wildlife Ecology University of DelawareNewark 19716USA departm.nt of Entom.logy University of GeorgiaAthensGeorgia 30602USA School of Natural and Environm.ntal Sciences Newcastle UniversityNewcastle upon TyneNE17RUUK School of the Environm.nt University of QueenslandBrisbane 4072Australia Shandong Engineering Research Center for Environm.nt-Friendly Agricultural Pest m.nagem.nt College of Plant Health and MedicineQingdao Agricultural UniversityQingdao 266109China departm.nt of Entom.logy University of ArizonaTucson 85721USA National Center of Excellence for Tuber and Root Crop Research Chinese Academy of Agricultural SciencesBeijing 100081China

Insect pest dam.ge to crops is a threat to global food security(Tilm.n et al.,2011).Clim.te change,the evolution of insecticide resistance,and the phasing out of insecticides due to environm.ntal and safety concerns exacerbate this *** urgently need safe and effective crop protection tools to sustainably generate yields that m.et ever-increasing global dem.nd.

关键词： crops dam.ge pest

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