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Supersaturated Calcium Phosphate Rinse vs. Standard of Care for Mitigating Mucositis in Head and Neck Chemoradiation

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journal of Cancer Therapy 2018年第3期9卷 262-267页

作者： justin Brock Chris morris Kathleen Hotze brian Pikkula Katy Center for Oral and Facial Surgery Katy TX USA Forward Science Stafford TX USA

Introduction: Oral mucositis (OM) can have a significant impact on patients’ quality of life, pain and treatment costs. Almost all patients receiving head and neck chemoradiation develop OM. Patients and Methods: Twenty patients were evaluated retrospectively for OM when undergoing head and neck chemoradiation. The control, soda/salt rinse, was compared to a powdered supersaturated calcium phosphate rinse (SSCPR), SalivaMAX. Results: The SSCPR group experienced a delay in the onset of OM, which was not statistically significant, and a marked reduction in peak OM that was statistically significant (p > 0.001). Conclusion: This retrospective study demonstrates that a powdered SSCPR is a safe and effective method of oral mucositis mitigation.

关键词： Oral Mucositis Health Care Cost WHO OM Scale

Exploding lakes in Vanuatu ＂Surtseyan-style＂ eruptions witnessed on Ambae Island

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Episodes 2006年第2期29卷 87-92页

作者： Károly Németh Shane j. Cronin Douglas Charley morris Harrison Esline Garae Volcanic Risk Solutions Institute of Natural Resources Massey University PO Box 11 222 Palmerston North New Zealand Department of Geology Mines and Water Resources Private Bag Port Vila Vanuatu

After a long silence, Lake Vui on Ambae Island burst into spectacular life on November 28, 2005, disrupting the lives of the 10,000 inhabitants on this sleepy tropical island in the SW Pacific. ＂Surtseyan-style＂ explosions burst through the Island＇s summit lake waters, forming a new tuff-cone, and threatening to form deadly lahars or volcanic floods. Such eruptions are rarely well observed, and these fleeting opportunities provide a chance to match volcanic processes with rock-sequences common in the geologic record...

关键词：瓦努阿图爆发湖泊岛屿

α核素用于放射治疗:从基础放射化学到临床研究(第二部分)

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中华核医学与分子影像杂志 2020年第11期40卷 761-768页

作者： Sophie Poty Lynn C.Francesconi Michael R.McDevitt Michael j.morris jason S.Lewis 杨晖关志伟(译) 徐白萱(审校) Department of Radiology and Program in Molecular Pharmacology Memorial Sloan Kettering Cancer CenterNew YorkNew York Department of Chemistry Hunter CollegeNew YorkNew York Graduate Center of City University of New York New YorkNew York Department of Radiology Weill Cornell Medical CollegeNew YorkNew York Department of Medicine Memorial Sloan Kettering Cancer CenterNew YorkNew York Departments of Radiology and Pharmacology Weill Cornell Medical CollegeNew YorkNew York 解放军总医院第一医学中心核医学科北京100853

利用放射源将具有细胞毒性的电离辐射作用到病灶处的方法可以追溯到20世纪初,起源于镭的发现及其能够产生的生理作用。α核素在放射治疗应用于临床肿瘤学领域中备受关注。该综述的第一部分探讨了基本的放射化学、高细胞杀伤效力和α核... 详细信息

利用放射源将具有细胞毒性的电离辐射作用到病灶处的方法可以追溯到20世纪初,起源于镭的发现及其能够产生的生理作用。α核素在放射治疗应用于临床肿瘤学领域中备受关注。该综述的第一部分探讨了基本的放射化学、高细胞杀伤效力和α核素的可应用性,以及存在于放射性标记方法和子核再分布的阻碍。该综述的第二部分将概述α核素在临床前和临床研究中最有希望和最新的用途。

关键词：放射治疗 α核素放射化学临床试验

Testing whether adrenal steroids mediate phenotypic and physiologic effects of elevated salinity on larval tiger salamanders

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Integrative Zoology 2023年第1期18卷 27-44页

作者： brian j.TORNABENE Erica j.CRESPI Creagh W.BREUNER Blake R.HOSSACK Wildlife Biology Program W.A.Franke College of Forestry&ConservationUniversity of MontanaMissoulaMontanaUSA School of Biological Sciences Center for Reproductive SciencesWashington State UniversityPullmanWashingtonUSA U.S.Geological Survey Northern Rocky Mountain Science CenterMissoulaMontanaUSA

Salinity(sodium chloride,NaCl)from anthropogenic sources is a persistent contaminant that negatively affects freshwater *** can be susceptible to salinity,but some species are innately or adaptively *** mechanisms mediating tolerance to salinity are still unclear,but changes in osmoregulatory hor-mones such as corticosterone(CORT)and aldosterone(ALDO)are prime *** exposed larval barred tiger salamanders(Ambystoma mavortium)to environmentally relevant NaCl treatments(<32–4000 mg·L-1)for 24 days to test effects on growth,survival,and waterborne CORT *** those sampled,we also quantiﬁed waterborne ALDO from a *** a glucocorticoid antagonist(RU486),we also experimentally suppressed CORT signaling of some larvae to determine if CORT mediates effects of *** were no strong differ-ences in survival among salinity treatments,but salinity reduced dry mass,snout–vent length,and body condition while increasing water content of *** survival and sublethal effects demonstrated that salamanders were physiologically challenged but could tolerate the experimental *** signaling did not attenuate sublethal effects of *** and stress-induced(after an acute stressor,shaking)CORT were not inﬂu-enced by *** was correlated with baseline CORT,suggesting it could be difﬁcult to decouple the roles of CORT and *** studies comparing ALDO and CORT responses of adaptively tolerant and previously unexposed populations could be beneﬁcial to understand the roles of these hormones in tolerance to ***-ertheless,our study enhances our understanding of the roles of corticosteroid hormones in mediating effects of a prominent anthropogenic stressor.

关键词： caudate conservation physiology glucocorticoids sodium chloride tolerance

Radon bearing water protection in underground uranium mining--A case study

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International journal of Mining Science and Technology 2017年第4期27卷 599-603页

作者： Yun Xiaoyou Tang Baoyao Greg Murdock brian McGill brian Mattie McArthur River Operation Cameco Corporation Saskatoon S7M 1J3 Canada

High pressure, radon bearing water has been identified as one of the most critical challenges in mining the high-grade uranium deposit at the Mc Arthur River Operation, Cameco Corporation. The ore deposits are located between 490 and 640 m below the surface and surrounded by water bearing Athabasca sandstone, a graphitic P2 fault zone, and highly altered ground. This paper introduces the inflow risk management program at Mc Arthur River Operation, which includes various hydrogeological challenges and the corresponding strategies applied, such as risk-based probe and grout programs(geological, hydrogeological, and geotechnical), ground freezing programs, and comprehensive ground control programs. These programs have been developed, tested, and proven successful over years of mining practices. Working with this world class deposit of high risk and low tolerance, it is believed that these experiences might be beneficial to other mining operations with similar hydrogeological characteristics.

关键词： Inflow risk management Geotechnical and development probe and grout programs Dewatering infrastructure Ground freezing Ground control

Liquid-phase 3D bioprinting of gelatin alginate hydrogels:influence of printing parameters on hydrogel line width and layer height

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Bio-Design and Manufacturing 2019年第3期2卷 172-180页

作者： Maha Alruwaili jose A.Lopez Kevin McCarthy Emmanuel G.Reynaud brian j.Rodriguez Conway Institute of Biomolecular and Biomedical Research University College DublinDublinIreland School of Physics University College DublinDublinIreland School of Biomolecular and Biomedical Science University College DublinDublinIreland

Extrusion-based 3D bioprinting is a direct deposition approach used to create three-dimensional(3D)tissue scaffolds typically comprising *** are hydrated polymer networks that are chemically or physically ***,3D bioprinting is performed in air,despite the hydrated nature of hydrogels and the potential advantage of using a liquid phase to provide cross-linking and otherwise functionalize the *** this work,we print gelatin alginate hydrogels directly into a cross-linking solution of calcium chloride and investigate the influence of nozzle diameter,distance between nozzle and surface,calcium chloride concentration,and extrusion rate on the dimensions of the printed *** hydrogel layer height was generally found to increase with increasing extrusion rate and nozzle distance,according to the increased volume extruded and the available space,*** addition,the hydrogel width was generally found to increase with decreasing nozzle distance and cross-linking concentration corresponding to confinement-induced spreading and low crosslinking regimes,***/height ratios of^1 were generally achieved when the nozzle diameter and distance were comparable above a certain cross-linking *** these relationships,biocompatible 3D multilayer structures were successfully printed directly into calcium chloride cross-linking solution.

关键词： Gelatin alginate Hydrogel Additive manufacturing 3D printing 3D bioprinting Biomaterials Extrusion Bioplotting

First principles materials design of novel functional oxides

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journal of Advanced Dielectrics 2016年第2期6卷 61-69页

作者： Valentino R.Cooper brian K.Voas Craig A.Bridges james R.morris Scott P.Beckman Materials Science and Technology Division Oak Ridge National Laboratory Oak RidgeTN 37831USA Department of Materials Science and Engineering Iowa State University AmesIA 50011USA Chemical Sciences Division Oak Ridge National Laboratory Oak RidgeTN 37831USA School of Mechanical and Materials Engineering Washington State University PulmannWA 99196USA

We review our efforts to develop and implement robust computational approaches for exploring phase stability to facilitate the prediction-to-synthesis process of novel functional *** efforts focus on a synergy between(i)electronic structure calculations for properties predictions,(ii)phenomenological/empirical methods for examining phase stability as related to both phase segregation and temperature-dependent transitions and(iii)experimental validation through synthesis and characteri*** illustrate this philosophy by examining an inaugural study that seeks to discover novel functional oxides with high piezoelectric *** results show progress towards developing a framework through which solid solutions can be studied to predict materials with enhanced properties that can be synthesized and remain active under device relevant conditions.

关键词： First principles materials design and discovery oxide solid solutions.

Early Cretaceous overprinting of the Mesozoic Daqing Shan fold-and-thrust belt by the Hohhot metamorphic core complex,Inner Mongolia,China

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Geoscience Frontiers 2010年第1期1卷 1-20页

作者： Gregory A.Davis brian j.Darby Department of Earth Sciences University of Southern CaliforniaLos AngelesCA 90089-0740USA ExxonMobil Exploration Company HoustonTXUSA

The Early Cretaceous Hohhot metamorphic core complex （mcc） of the Daqing Shan （Mtns.） of central Inner Mongolia is among the best exposed and most spectacular of the spatially isolated mcc＇s that developed within the northern edge of the North China ＂craton＂. All of these mcc＇s were formed within the basement of a Late Paleozoic Andean-style arc and across older Mesozoic fold-and-thrust belts of variable age and tectonic vergence. The master Hohhot detachment fault roots southwards within the southem margin of the Daqing Shan for an along-strike distance of at least 120 km. Its geometry in the range to the north is complicated by interference patterns between （1） primary, large-scale NW-SE-trend- ing convex and concave fault corrugations and （2） secondary ENE-WSW-trending antiforms and syn- forms that folded the detachment in its late kinematic history. As in the Whipple Mtns. of California, the Hohhot master detachment is not of the Wernicke （1981） simple rooted type; instead, it was spawned from a mid-crustal shear zone, the top of which is preserved as a mylonitic front within Carboniferous metasedimentary rocks in its exhumed lower plate. 4~Ar-39Ar dating of siliceous volcanic rocks in basal sections of now isolated supradetachment basins suggest that crustal extension began at ca. 127 Ma, although lower-plate mylonitic rocks were not exposed to erosion until after ca. 119 Ma. Essentially synchronous cooling of bornblende, biotite, and muscovite in footwall mylonitic gneisses indicates very rapid exhumation and at ca. 122--120 Ma. Contrary to several recent reports, the master detachment clearly cuts across and dismembers older, north-directed thrust sheets of the Daqing Shah foreland fold-and-thrust belt. Folded and thrust-faulted basalts within its foredeep strata are as young as 132.6 ± 2.4 Ma, thus defining within 5--6 Ma the regional tectonic transition between crustal contraction and profound crustal extension.

关键词： North China Yin Shah Daqing Shan Hohhot mcc Cretaceous extension

Mapping microstructure to shock-induced temperature fields using deep learning

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npj Computational Materials 2023年第1期9卷 516-523页

作者： Chunyu Li juan Carlos Verduzco brian H.Lee Robert j.Appleton Alejandro Strachan School of Materials Engineering Purdue UniversityWest LafayetteIN 47907USA

The response of materials to shock loading is important to planetary science,aerospace engineering,and energetic *** activated processes,including chemical reactions and phase transitions,are significantly accelerated by energy localization into *** result from the interaction of the shockwave with the materials’microstructure and are governed by complex,coupled processes,including the collapse of porosity,interfacial friction,and localized plastic *** mechanisms are not fully understood and the lack of models limits our ability to predict shock to detonation transition from chemistry and microstructure *** demonstrate that deep learning can be used to predict the resulting shock-induced temperature fields in composite materials obtained from large-scale molecular dynamics simulations with the initial microstructure as the only *** accuracy of the Microstructure-Informed Shock-induced Temperature net(MISTnet)model is higher than the current state of the art and its evaluation requires a fraction of the computation cost.

关键词： microstructure Microstructure friction