检索结果-南通市图书馆

Reply to Letter by Dr. Christoph Kupferschmid： Commentary on ＂Countries with high circumcision prevalence have lower prostate cancer mortality＂

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian journal of Andrology 2016年第6期18卷 950-951页

作者： Mitchell S Wachtel Shengping Yang brian j morris Texas Tech University Health Sciences Center Lubbock Texas USA School of Medical Sciences University of Sydney Sydney New South Wales Australia

Dear Editor, We thank Dr. Kupferschmid for his interest in our study, which examined male circumcision （MC） and prostate cancer mortality〉2 Considerable strong evidence has been accumulated since 1951.3 Most of his references4-10 do not address MC and the risk of death from prostate cancer. That is a different question than MC and the risk of developing prostate cancer, which none of his references validly assess. One reference addressed bacterial colonization,6 not prostate cancer. Another7 concerned sexually transmitted infections and prostate cancer.

关键词： @@

Comments by opponents on the British Medical Association’s guidance on non-therapeutic male circumcision of children seem one-sided and may undermine public health

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Clinical Pediatrics 2023年第5期12卷 244-262页

作者： Stephen Moreton Guy Cox Mark Sheldon Stefan A Bailis jeffrey D Klausner brian j morris CircFacts Warrington WA51HYCheshireUnited Kingdom Australian Centre for Microscopy&Microanalysis and School of Aeronautical Mechanical and Mechatronic EngineeringUniversity of SydneySydney 2006New South WalesAustralia Medical Humanities and Bioethics Program Feinberg School of MedicineNorthwestern UniversityChicagoIL 60661United States Cornerstone Therapy&Recovery Center St.PaulMN 55101United States Department of Medicine Population and Public Health SciencesKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90089United States School of Medical Sciences University of SydneySydney 2006New South WalesAustralia

The British Medical Association(BMA)guidance on non-therapeutic circumcision(NTMC)of male children is limited to ethical,legal and religious *** we evaluate criticisms of the BMA’s guidance by Lempert et *** their arguments promoting autonomy and consent might be superficially appealing,their claim of high procedural risks and negligible benefits seem one-sided and contrast with high quality evidence of low risk and lifelong *** literature reviews by the American Academy of Pediatrics and the United States Centers for Disease Control and Prevention in developing evidence-based policies,as well as risk-benefit analyses,have found that the medical benefits of infant NTMC greatly exceed the risks,and there is no reduction in sexual function and *** BMA’s failure to consider the medical benefits of early childhood NTMC may partly explain why this prophylactic intervention is discouraged in the United *** consequence is higher prevalence of preventable infections,adverse medical conditions,suffering and net costs to the UK’s National Health Service for treatment of *** of the issues and contradictions in the BMA guidance identified by Lempert et al stem from the BMA’s guidance not being sufficiently ***,that document called for a review by others of the medical issues surrounding *** societal factors apply,ultimately,NTMC can only be justified rationally on scientific,evidence-based *** are entitled to an accurate presentation of the medical evidence so that they can make an informed *** decision either for or against NTMC should then be respected.

关键词： Circumcision,Male Child Infections Risk Policy Public health

Male Circumcision Does Not Reduce Sexual Function, Sensitivity or Satisfaction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Sexual Medicine 2015年第3期5卷 53-60页

作者： brian j. morris john N. Krieger School of Medical Sciences University of Sydney Sydney Australia Section of Urology VA Puget Sound Health Care System School of Medicine University of Washington Seattle USA

We disagree with Boyle’s recent article questioning our systematic review in journal of Sexual Medicine in 2013 (Volume 10, pages 2644-2657). In particular, he disputed the quality ranking we assigned to 7 of the 36 articles that met our inclusion criteria. These had been ranked for quality by the Scottish Intercollegiate Guidelines Network (SIGN) grading system. We found that, “the highest-quality studies suggest that medical male circumcision has no adverse effect on sexual function, sensitivity, sexual sensation or satisfaction.” This conclusion was supported by two randomized controlled trials, regarded as high-quality (1++) evidence and the majority of surveys and studies involving physiological measurements comparing uncircumcised and circumcised men. Here we explain why the 2 randomized controlled trials merit a 1++ ranking and why 4 reports that Boyle believes merit a higher ranking only meet the criteria set down for low quality (2?) evidence according to the SIGN system. We therefore stand by our conclusions. These are supported by a meta-analysis of sexual dysfunctions and by a recent detailed systematic review of the histological correlates of male sexual sensation.

关键词： Circumcision Erectile Function Sexual Satisfaction Premature Ejaculation Penile Sensitivity

Critical Evaluation of a Survey Claiming “Long-Term Adverse Outcomes from Neonatal Circumcision”

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Sexual Medicine 2019年第4期9卷 67-109页

作者： Stefan A. Bailis Stephen Moreton brian j. morris Cornerstone Therapy & Recovery Center St. Paul USA CircFacts Warrington UK School of Medical Sciences and Bosch Institute University of Sydney Sydney Australia

We critically evaluate an online “Global survey of circumcision harm” that gauged beliefs of men who thought that their neonatal circumcision had harmed them. Sequential evaluation of the survey data and claims reveal numerous serious flaws that are at odds with strong scientific evidence. Moreover, the one-sided study design and “loaded” survey title meant the findings were not representative of the general population of circumcised males. None of the participants’ claimed physical problems were confirmed by a health practitioner. Belief in this seriously flawed survey has potential to cause psychological harm to vulnerable men influenced by anti-circumcision claims, and as such has serious detrimental implications for male sexual health. The survey appears driven less by empiricism and more by psychological forces, as we show in de-tail. The overwhelming body of high quality medical scientific evidence finds no adverse effect of male circumcision on sexual function and pleasure, but strong evidence for a wide array of lifetime benefits in protection against infections, dermatological problems, and genital cancers. Consistent with the United Nations Convention on the Rights of the Child, children are entitled to low risk procedures that are beneficial to their health. In conclusion, the survey and its uncritical presentation do a disservice to evidence-based medicine, sexual health, mental health, public health, human rights, and pediatric policy development. It should therefore be dismissed as unreliable.

关键词： Sexual Function Psychology Male Health Anti-Circumcision

Critical evaluation of unscientific arguments disparaging affirmative infant male circumcision policy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Clinical Pediatrics 2016年第3期5卷 251-261页

作者： brian j morris john N Krieger jeffrey D Klausner School of Medical Sciences University of Sydney Section of Urology VA Puget Sound Health Care System and School of MedicineUniversity of Washington Division of Infectious Diseases Department of MedicineDavid Geffen School of MedicineUniversity of California Los Angeles

We evaluate recent claims opposing infant male circumcision,a procedure now supported by the evidencebased policy of the American Academy of *** find those criticisms depend on speculative claims about the foreskin and obfuscation of the strong scientific evidence supporting pediatric policy *** argument that circumcision should be delayed to allow a boy to make up his own mind as an adult fails to appreciate the psychological,scheduling and financial burdens later circumcision entails,so reducing the likelihood that it will *** contrast,early infant circumcision is convenient,safer,quicker,lower risk,healing is faster,cosmetic outcome is routinely good and the lifetime benefits accrue *** include reduction in urinary tract infections,inflammatory skin conditions,foreskin problems,and,when older,substantial protection against sexually transmitted infections and genital cancers in the male and his female sexual *** authorities regard the failure to offer parents early infant circumcision as unethical,just as it would be unethical to fail to encourage the vaccination of *** conclusion,the criticisms of evidence-based infant male circumcision policy are seriously flawed and should be dismissed as unhelpful to evidence-based development and implementation of pediatric policy intended to improve public health and individual wellbeing.

关键词： Male circumcision Policy American Academy of Pediatrics Newborn Foreskin

Tye &Sardi’s Psychological, Psychosocial, and Psychosexual Aspects of Penile Circumcision*

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Sexual Medicine 2022年第3期12卷 65-83页

作者： Stefan A. Bailis Stephen Moreton john N. Krieger brian j. morris Cornerstone Therapy & Recovery Center St. Paul Minnesota USA CircFacts Warrington UK Department of Urology University of Washington School of Medicine Seattle USA School of Medical Sciences University of Sydney Sydney Australia

Tye and Sardi recently reviewed the evidence purporting to implicate male circumcision, especially when performed early in infancy, in psychological problems in men. Here we provide a critical evaluation to determine the veracity of their evidence and claims. Missing from their review were critiques pointing out fundamental flaws in key studies. We argue that psychological stress in some men may be caused by anti-circumcision propaganda telling them that they are victims of “genital mutilation”, a term adopted from dissimilar female practices in particular ethnic groups. Sexual dissatisfaction results. We critically discuss claims about foreskin “gliding”, the eccentric foreskin-related sexual practice of “docking”, and the use of lubricant in masturbation. We further find that a study claiming to show numerous differences in socio-affective processing in men circumcised as neonates stem from statistically flawed and one-sided data that has been misinterpreted, and in fact shows the opposite of the hypothesis that psychological problems in some men can be attributed to the pain of their circumcision as newborns. Importantly, since the brain regions responsible for empathy, namely subcortical gray matter and white matter in frontal and parietal regions, were similar in neonatally circumcised and uncircumcised men, the null hypothesis remains null. In conclusion, we find no compelling evidence to support newborn circumcision pain being responsible for psychological problems in neonatally circumcised men. Men who come to believe that they are victims of their infant circumcision are in actual fact likely victims of false claims perpetrated by activist community groups with trenchant opposition to circumcision.

关键词： Sexual Function Psychology Male Sexual Health Anti-Circumcision

Expertise and Ideology in Statistical Evaluation of Circumcision for Protection against HIV Infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of AIDS 2017年第3期7卷 179-203页

作者： brian j. morris Gia Barboza Richard G. Wamai john N. Krieger School of Medical Sciences and Bosch Institute University of Sydney Sydney Australia Department of Cultures Societies and Global Studies School of Criminology and Criminal Justice Northeastern University Boston MA USA Department of African-American Studies Northeastern University Boston MA USA School of Medicine University of Washington Seattle WA USA Section of Urology VA Puget Sound Health Care System Seattle WA USA

Aim: To critically evaluate data and arguments by Van Howe defending his stance opposing male circumcision (MC), in particular his meta-regression analyses evaluating the ability of MC to reduce HIV infection risk in heterosexual populations within and outside Africa. Methods: We performed metaregression analysis of log odds of HIV infection between uncircumcised and circumcised men using a single covariate (MC prevalence) in the meta-regression model involving the metareg package in STATA 13 for 103 populations worldwide and for populations within Africa. The meta-regression of log odds and MC prevalence was fitted to a line, as were empirical Bayes estimates resulting from post-estimation. Results: Our critical evaluation of Van Howe’s arguments attempting to undermine the scientific evidence in support of the benefits of MC in protection of men against HIV during heterosexual intercourse, as well as other infections and conditions, together with his use of statistics to support his beliefs, revealed serious flaws, obfuscation and missing data. We therefore performed our own meta-regression analysis using a trivariate model. Doing so revealed that for MC prevalences of 50%, 75% and 100% for general populations within Africa, odds ratios for HIV risk in uncircumcised vs. circumcised men were 1.35, 1.58 and 1.85, respectively. Our meta-regression analysis of data for all countries yielded similar findings. For a general population outside Africa with 100% MC prevalence, OR was 1.5. Van Howe failed to acknowledge that since MC prevalence in US whites (91%) and blacks (76%) exceeds 75% his results support MC having a protective effect in those population groups. Conclusions: The protective effect of MC against HIV infection during heterosexual intercourse applies to populations both within and outside Africa. The debate engineered by MC opponents, and led by Van Howe, now appears to have run its course. The scientific evidence has prevailed.

关键词： Male Circumcision Human Immunodeficiency Virus HIV Prevalence Prevention Meta-Regression Global Health

Early infant male circumcision:Systematic review,risk-benefit analysis,and progress in policy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Clinical Pediatrics 2017年第1期6卷 89-102页

作者： brian j morris Sean E Kennedy Alex D Wodak Adrian Mindel David Golovsky Leslie Schrieber Eugenie R Lumbers David j Handelsman john B Ziegler School of Medical Sciences and Bosch Institute University of Sydney School of Women’s and Children’s Health University of New South Wales St Vincent’s Hospital and Kirby Institute for Infection and Immunity in Society University of New South Wales IVF Australia Department of Medicine Sydney Medical SchoolRoyal North Shore Hospital School of Biomedical Sciences and Pharmacy Mothers and Babies Research CentreHunter Medical Research InstituteUniversity of Newcastle Department of Medicine and ANZAC Research Institute Concord Hospital Department of Immunology and Infectious Diseases Sydney Children’s Hospital

AIM To determine whether recent evidence-based United States polices on male circumcision(MC) apply to comparable Anglophone countries,Australia and New *** Articles in 2005 through 2015 were retrieved from PubM ed using the keyword "circumcision" together with 36 relevant subtopics.A further PubM ed search was performed for articles published in *** of the EMBASE and Cochrane databases did not yield additional citable *** were assessed for quality and those rated 2+ and above according to the Scottish Intercollegiate Grading System were studied *** most relevant andrepresentative of the topic were *** were examined to retrieve further key *** controlled trials,recent high quality systematic reviews or meta-analyses(level 1++ or 1+ evidence) were prioritized for inclusion.A risk-benefit analysis of articles rated for quality was *** efficiency and reliability,recent randomized controlled trials,metaanalyses,high quality systematic reviews and large welldesigned studies were used if *** searches were conducted for other relevant information,including policies and Australian data on claims under Medicare for *** Evidence-based policy statements by the American Academy of Pediatrics(AAP) and the Centers for Disease Control and Prevention(CDC) support infant and later age male circumcision(MC) as a desirable public health *** systematic review of relevant literature over the past decade yielded 140 journal articles that met our inclusion ***,these showed that early infant MC confers immediate and lifelong benefits by protecting against urinary tract infections having potential adverse long-term renal effects,phimosis that causes difficult and painful erections and "ballooning" during urination,inflammatory skin conditions,inferior penile hygiene,candidiasis,various sexually transmissible infections in both sexes,genital ulcers,and penil

关键词： Male circumcision Evidence-based policy Infants Adults Urinary tract infections Adverse events Sexually transmitted infections Genital cancers Riskbenefit analysis Cost-benefit

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting