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Surface energy-mediated fibronectin adsorption and osteoblast responses on nanostructured diamond

Journal of Materials Science & Technology 2019年第5期35卷 817-823页

作者： Yixing Tian Huiling Liu brian w.sheldon Thomas J.webster Sichen Yang Huilin Yang Lei Yang Orthopaedic Institute and Department of Orthopaedics The First Affiliated Hospital Soochow University Suzhou Jiangsu 215006 China School of Engineering Brown University Providence RI 02912 USA Department of Chemical Engineering Northeastern University Boston MA. 02115 USA International Research Center for Translational Orthopaedics (IRCTO) Soochow University Suzhou Jiangsu 215006 China UwC Changshu China Changshu Jiangsu 215500 China

Nanostructured diamond have potential applications in many biomedical related fields and demonstrated extraordinary capacity to influence cellular responses. Studying the surface property of nanodiamond and its influence to protein adsorption and subsequent cellular responses along with the mechanism behind such capacity becomes more important. Here the role of surface energy associated with nanostructured diamond in modulating fibronectin and osteoblast(OB, bone forming cells) responses was investigated. Nanocrystalline diamond(NCD) and submicron crystalline diamond(SMCD) films with controllable surface energy were prepared by microwave-enhanced plasma chemical vapor deposition(MPCVD) techniques. Fibronectin adsorption on the diamond films with varied surface energy values was measured via the enzyme-linked immunosorbent assay(ELISA) and the relationship between the surface energy and fibronectin adsorption was studied. The result indicated that fibronectin adsorption on nanostructured surfaces was closely related to both surface energy and material microstructures. The spreading and migration of OB aggregates(each containing 30–50 cells) on the NCD with varied surface energy values were also studied. The result indicates a correlation between the cell spreading and migration on nanodiamond and the surface energy of nanostructured surface.

关键词： Nanostructure Diamond films Surface characteristics Protein adsorption Cell responses

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Radiative-coupled evaporative cooling:Fundamentals,development,and applications

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Nano Research Energy 2024年第2期3卷 56-68页

作者： Li Yu Yimou Huang weihong Li Changmin Shi brian w.sheldon Zhuo Chen Meijie Chen School of Energy Science and Engineering Central South UniversityChangsha 410083China Department of Mechanical Engineering City University of Hong KongHong Kong 999077China School of Engineering Brown UniversityProvidenceRI 02912USA

As global energy demand continues to rise and climate change accelerates,the need for sustainable and energy-efficient cooling solutions has reached a critical *** air conditioning systems heavily rely on energy-intensive mechanical cooling,which significantly contributes to both electricity demand and greenhouse gas *** cooling strategies,particularly radiative cooling(RC)and evaporative cooling(EC),present an alternative approach by harnessing natural processes for temperature *** standalone RC can be affected by weather conditions and EC relies on water availability,Radiative-coupled EC(REC)offers a versatile and sustainable cooling solution suitable for various *** we summarize an overview of the theoretical foundations and mathematical models of REC,encompassing REC by bulk water(REC-Bw),REC by perspiration(REC-P),and REC by sorbed water(REC-Sw).Moreover,we explore a range of applications,spanning from industrial processes to personal thermal management,and examine the advantages and challenges associated with each REC *** significance of REC lies in its potential to revolutionize cooling technology,reduce energy consumption,and minimize the environmental ***-Bw can conserve water resources in industrial cooling processes,while REC-P offers innovative solutions for wearable electronics and ***-Sw’s adaptability makes it suitable for food preservation and future potable cooling *** addressing the challenges posed by REC,including water consumption,textile design,and optimization of bilayer structures,we can unlock the transformative potential of REC and contribute to sustainable cooling technologies in a warming world.

关键词： radiative cooling evaporative cooling passive cooling thermal radiation mass transfer

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage Mark L.Dell’Acqua brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

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Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

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Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

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Gene-modified neural progenitor cells for the treatment of neuropathic lysosomal storage diseases

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Neural Regeneration Research 2023年第9期18卷 1954-1955页

作者： Oriana Mandolfo brian w.Bigger Stem Cell and Neurotherapies Faculty of BiologyMedicine and HealthUniversity of ManchesterManchesterUK

Lysosomal storage diseases:Lysosomal storage diseases(LSDs) are a family of about 70 disorders,with an overall incidence of 1:7000 live *** are caused by dysfunctional lysosomal hydrolases,eventually leading to the accumulation of undegraded substrate into the *** results in a wide array of symptoms,which may include:the presence of dysmorphic features,cardio-respiratory disease,bone and joint disease,organomegaly,developmental delay and neurocognitive *** majority of these diseases have a neurological component and in the absence of treatment.

关键词： diseases progenitor eventually

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Prime gradient noise

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Computational Visual Media 2021年第3期7卷 349-362页

作者： sheldon Taylor Owen Sharpe Jiju Peethambaran Graphics&Spatial Computing Lab Dept.of Math&CSSaint Mary’s UniversityHailifaxNSCanadaB3H3C3

Procedural noise functions are fundamental tools in computer graphics used for synthesizing virtual geometry and texture ***,a procedural noise function should be compact,aperiodic,parameterized,and randomly *** lattice noise functions such as Perlin noise,however,exhibit periodicity due to the axial correlation induced while hashing the lattice vertices to the *** this paper,we introduce a parameterized lattice noise called prime gradient noise(PGN)that minimizes discernible periodicity in the noise while enhancing the algorithmic *** utilizes prime gradients,a set of random unit vectors constructed from subsets of prime numbers plotted in polar coordinate *** map axial indices of lattice vertices to prime gradients,PGN employs Szudzik pairing,a bijection F:N2→*** of Szudzik pairing functions are used in higher *** the core of PGN is the ability to parameterize noise generation though prime sequence offsetting which facilitates the creation of fractal noise with varying levels of heterogeneity ranging from homogeneous to hybrid multifractals.A comparative spectral analysis of the proposed noise with other noises including lattice noises show that PGN significantly reduces axial correlation and hence,periodicity in the noise *** demonstrate the utility of the proposed noise function with several examples in procedural modeling,parameterized pattern synthesis,and solid texturing.

关键词： procedural noise procedural texture Perlin noise prime numbers

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Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 123-138页

作者： Chentong GAO Huiyu SUN Jianping GU w.M.HUANG College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics School of Mechanical and Aerospace Engineering Nanyang Technological University Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology

Currently, there are a limited number of dynamic models available for braided composite plates with large overall motions, despite the incorporation of three-dimensional(3D) braided composites into rotating blade components. In this paper, a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established. Based on Kirchhoff's plate assumptions, the displacement variables of the plate are expressed. By incorporating the braiding directions into the constitutive equation of the braided composites, the dynamic model of the plate considering braiding directions is obtained. The effects of the speeds, braiding directions, and braided angles on the responses of the plate with fixed-axis rotation and translational motion, respectively, are investigated. This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions. It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.

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Study on semi-active control of mega-sub controlled structure by MR damper subject to random wind loads

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Earthquake Engineering and Engineering Vibration 2008年第3期7卷 285-294页

作者： Qin Xiangjun Zhang Xun＇an sheldon Cherry Department of Mechanics and Civil Engineering Northwestern Polytechnical University Xi ＇an 710072 China Department of Civil Engineering University of British Columbia Vancouver Canada

The recently proposed mega-sub controlled structure （MSCS）, a new type of structure associated with the design and construction of super-tall buildings, has attracted the attention of designers for use in enhancing the control effectiveness in mega-frame buildings. In this paper, a dynamic equation and method to assemble parameter matrixes for a mega-sub controlled structure under random wind loads is presented. Semi-active control using magnetorheological dampers for the MSCS under random wind loads is investigated, and is compared with a corresponding system without dampers. A parametric study of the relative stiffness ratio and relative mass ratio between the mega-frame and the substructures, as well as the additional column stiffness ratio that influences the response control effectiveness of the MSCS, is discussed. The studies reveal, for the first time, that different control mechanisms exist. The results indicate that the proposed structure employing semi-active control can offer an effective control mechanism. Guidelines for selecting parameters are provided based on the analytical study.

关键词： mega-sub controlled structure (MSCS) semi-active control magnetorheological damper relative stiffness ratio relative mass ratio additional column stiffness ratio wind load

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