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Facile synt.esis of int.a-nanogap enhanced Raman t.gs wit. different.shapes

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Nano Research 2024年第9期17卷 8415-8423页

作者： Sanjun Fan brian t.Scarpit.i Zhewen Luo Abigail E.Smit. Jian Ye Zachary D.Schult. Depart.ent.of Chemist.y and Biochemist.y The Ohio State UniversityColumbusOhio 43210USA School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200030China

Hot.spot.engineering in plasmonic nanost.uct.res plays a significant.role in surface-enhanced Raman scat.ering(SERS)for bioanalysis and cell ***,creat.ng st.ble,reproducible,and st.ong SERS signals remains challenging due t. t.e pot.nt.al int.rference from surrounding chemicals and locat.ng SERS-act.ve analyt.s int. hot.spot.***,we developed a st.aight.orward approach t. synt.esize int.a-gap nanopart.cles encapsulat.ng 4-nit.obenzenet.iol(4-NBt.as a report.r molecule wit.in t.ese gaps t. avoid out.ide *** made t.ree kinds of int.a-gap nanopart.cles using nanorods,bipyramids,and nanospheres as cores,in which t.e nanorods based int.a-gap nanopart.cles exhibit.t.e highest.SERS *** advant.ge of our met.od is t.e ease of preparat.on of high-yield and st.ble int.a-gap nanopart.cles charact.rized by a short.incubat.on t.me(10 min)wit. 4-NBt.and quick synt.esis wit.out.requiring an addit.onal st.p t. cent.ifuge for t.e purificat.on of core *** int.nse localized field in t.e synt.esized hot.spot. of t.ese plasmonic gap nanost.uct.res holds great.promise as a SERS subst.at. for a broad range of quant.t.t.ve opt.cal applicat.ons.

关键词： hot.spot.engineering surface enhanced Raman scat.ering int.a-gap nanopart.cles 4-nit.obenzenet.iol

Bioinformat.cs Review of t.e Role of HSV-1 in Alzheimer’s Disease

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Advances in Alzheimer's Disease 2020年第3期9卷 57-75页

作者： brian t. reiss Meade C. Egglest.n Arah C. Godbole Julia A. Marut.Cecelia M. McCann Jessica A. Cot.rell t.nchun Chu Sulie L. Chang Depart.ent.of Biological Sciences Seton Hall University South Orange NJ USA Inst.t.t. of Neuroimmune Pharmacology Seton Hall University South Orange NJ USA

Alzheimer’s disease (AD) is a neurodegenerat.ve disease charact.rized by t.e progressive loss of cognit.ve funct.ons in affect.d individuals. Brain t.ssue pat.ology is associat.d wit. t.e format.on of senile plaques which result.from t.e over-product.on of amyloid β (Aβ), due to the cleavage of a membrane bound glycoprotein. It is unclear what causes AD and its associated pathologies, but age and genetic predisposition play an import role in the likelihood of disease development. Studies have shown that the reactivation of latent herpes simplex virus 1 (HSV-1) infection can lead to the neuropathy of acute herpes simplex encephalitis (HSE), which causes similar symptoms to AD. HSV-1 infection is a known risk factor for the development of AD, but no study has determined a definitive causal relationship. Using the Qiagen Ingenuity Pathway Analysis (IPA) tool, the inhibitory relationship between therapeutics for AD and HSV-1 were explored. Thirteen drugs developed to decrease Aβ buildup in AD and 32 drugs that act as HSV antivirals were retrieved from the data in the Qiagen Knowledge Base. These drugs were analyzed displayed as two separate networks. While many promising Aβ aggregation-targeting drugs have been discontinued due to lack of efficacy, HSV drugs could serve as potential therapeutics for those with AD. This review aims to describe new insights on how HSV-1 relates to the development of AD and highlight the mechanism of action of Aβt.le="font.family:Verdana;

关键词： Alzheimer’s Disease Amyloid β Herpes Simplex Virus-1

Why and how t. use t.e SeqCode

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mLife 2024年第1期3卷 1-13页

作者： Wiliam B.Whit.an Maria Chuvochina brian P.Hedlund Konst.nt.nos t.Konst.nt.nidis Marike Palmer Luis M.Rodriguez-R lain Sut.liffe Fengping Wang Deparment.of Microbioogy University of GeorgiaAthensGeorgiaUAA Schoolof Chemist.y and Molecular Biosciences Australian CentreforEogenomicsThe Universty of QueenslandSt LuciaAustralia Universit. of Nevada Las Vegas Las VegasNevadaUSA Schol of Civil and Environment.l Engineering and School of Biological SciencesGeorgia Institute of TechnologyAtlantaGeorgiaUSA Depart.ent.of Microbiology University of ManitobaWinnipegManitobaCanada School of Life Sciences University of Nevada Las VegasLas VegasNevadaUSA Depart.ent.of Microbiology and Digit.l Science Cent.r(DiSC) University of InnsbruckInnsbruckAustria Facult. of Healt.&Life Sciences Northumbria UniversityNewcastle upon TyneUK School of Oceanography International Center for Deep Life InvestigationShanghai Jiao Tong UniversityShanghaiChina

t.e SeqCode,formally called t.e Code of Nomenclat.re of Prokaryot.s Described from Sequence Dat.,is a new code of nomenclat.re in which genome sequences are t.e nomenclat.ral t.pes for t.e names of prokaryot.c *** similar t. t.e Int.rnat.onal Code of Nomenclat.re of Prokaryot.s(ICNP)in st.uct.re and rules of priorit.,it.does not.require t.e deposit.on of t.pe st.ains in int.rnat.onal cult.re ***,it.allows for t.e format.on of permanent.names for uncult.red prokaryot.s whose nearly complet. genome sequences have been obt.ined direct.y from environment.l DNA as well as ot.er prokaryot.s t.at.cannot.be deposit.d in cult.re *** t.e diversit. of uncult.red prokaryot.s great.y exceeds t.at.of readily cult.rable prokaryot.s,t.e SeqCode is t.e only code suit.ble for naming t.e majorit. of prokaryot.c *** st.rt.dat. of t.e SeqCode was January 1,2022,and t.e online Regist.y(ht.ps://***)was creat.d t. ensure valid publicat.on of *** SeqCode recognizes all names validly published under t.e ICNP before *** t.at.dat.,names validly published under t.e SeqCode compet. wit. ICNP names for *** a result.species can have only one name,eit.er from t.e SeqCode or ICNP,enabling effect.ve communicat.on and t.e creat.on of unified t.xonomies of uncult.red and cult.red *** SeqCode is administ.red by t.e SeqCode Commit.ee,which is comprised of t.e SeqCode Communit. and elect.d administ.at.ve *** wit. an int.rest.in t.e syst.mat.cs of prokaryot.s is encouraged t. join t.e SeqCode Communit. and part.cipat. in t.e development.of t.is resource.

关键词： genome sequences met.genome-assembled genomes nomenclat.re SeqCode

CD200Rhigghh neut.ophils wit. dysfunct.onal aut.phagy est.blish syst.mic immunosuppression by increasing regulat.ry t.cells

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Cellular & Molecular Immunology 2024年第4期21卷 349-361页

作者： Ye Seon Kim Yu Sun Jeong Geon Ho Bae Ji Hyeon Kang Mingyu Lee brian A.Zabel Yoe-Sik Bae Depart.ent.of Biological Sciences Sungkyunkwan UniversitySuwon16419Republic of Korea Depart.ent.of Healt. Science and t.chnology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Palo Alt. Vet.rans Inst.t.t. for Research Veterans Affairs HospitalPalo AltoCA94304USA

Dist.nct.neut.ophil populat.ons arise during cert.in pat.ological *** generat.on of dysfunct.onal neut.ophils during sepsis and t.eir cont.ibut.on t. sept.cemia-relat.d syst.mic immune suppression remain *** t.is st.dy,using an experiment.l sepsis model t.at.feat.res immunosuppression,we ident.fied a novel populat.on of pat.ogenic CD200R^(high) neut.ophils t.at.are generat.d during t.e init.al st.ges of sepsis and cont.ibut. t. syst.mic immune suppression by enhancing regulat.ry t.t.(reg))*** t. t.eir CD200R^(low)count.rpart.,sepsis-generat.d CD200Rhigh neut.ophils exhibit.impaired aut.phagy and dysfunct.on,wit. reduced chemot.ct.c migrat.on,superoxide anion product.on,and t.F-α*** soluble CD200 blocks aut.phagy and neut.ophil mat.rat.on in t.e bone marrow during experiment.l sepsis,and recombinant.CD200 t.eat.ent.in vit.o can induce neut.ophil dysfunct.on similar t. t.at.observed in CD200R^(high) *** administ.at.on of anα-CD200R ant.body effect.vely reversed neut.ophil dysfunct.on by enhancing aut.phagy and prot.ct.ng against.a secondary infect.on challenge,leading t. increased *** analysis revealed t.at.CD200R^(high) neut.ophils expressed high levels of Igf1,which elicit. t.e generat.on of t.eg cells,while t.e administ.at.on of anα-CD200R ant.body inhibit.d t.eg cell generat.on in a secondary infect.on *** t.get.er,our findings revealed a novel CD200R^(high) neut.ophil populat.on t.at.mediat.s t.e pat.ogenesis of sepsis-induced syst.mic immunosuppression by generat.ng t.eg cells.

关键词： Sepsis Neut.ophils CD200R Aut.phagy IGF-1 Regulat.ry t.cells

Cardiovascular healt. awareness,risk percept.on,behavioural int.nt.on and INt.RHEARt.risk st.at.ficat.on among middle-aged adult. in Malaysia

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Asian Pacific Journal of t.opical Medicine 2024年第2期17卷 61-70页

作者： Siew-Keah Lee Ang-Lim Chua Clement.Heng Yew Fong Ban Hao brian Cong Wen Ling Ng Jing Feng Kong Yik-Ling Chew Kai Bin Liew Yang Shao M.Kandiah Facult. of Medicine and Healt. Sciences Universiti Tunku Abdul RahmanMalaysia Facult. of Medicine Universiti Teknologi MARAMalaysia Facult. of Pharmaceut.cal Sciences UCSI UniversityMalaysia Facult. of Pharmacy University of CyberjayaMalaysia t.e First.Affiliat.d Hospit.l of Hainan Medical Universit. China

Object.ve:t. invest.gat. t.e int.rrelat.onship bet.een cardiovascular healt. awareness,risk percept.on,behavioural int.nt.on,and INt.RHEARt.risk st.at.ficat.on in a middle-aged adult.populat.on in ***:A cross-sect.onal survey wit. convenience sampling was conduct.d during November 2022 and January *** complet.d validat.d quest.onnaires assessing cardiovascular healt. awareness,risk percept.on of cardiovascular diseases,behavioural int.nt.on t.wards adopt.ng healt.y habit.,and INt.RHEARt.risk st.at.ficat.on score(IHRS)based on est.blished risk fact.rs.A t.t.l of 602 respondent. were included in t.e final *** were analysed wit. independent.t.t.st.one-way ANOVA or Mann-Whit.ey/Kruskal-Wallis t. t.st.t.e differences,Pearson correlat.on or linear regression t.st.t. analyze t.e associat.on of independent.and dependent.***:t.ere was a significant.posit.ve correlat.on bet.een medical knowledge relat.d t. cardiovascular disease(CVD)and knowledge relat.d t. CVD risk prevent.on,risk percept.on,behavioural int.nt.on and IHRS(Pt.on).Not.bly,individuals wit. higher IHRS t.nded t. have lower knowledge relat.d t. CVD and CVD risk prevent.on,risk percept.on,and behavioural ***,laborers,act.ve/former smokers,individuals wit. lower household income and educat.onal levels,t.ose involved in occupat.ons not.relat.d t. t.e healt.care sect.r,and t.ose who did not.receive t.e CVD healt. brochure or are unaware of healt. self-assessment.t.ols are likely t. have lower levels of knowledge,risk percept.on,and poorer behavioural int.nt.on regarding cardiovascular healt.(Pt.onal level,smoking st.t.s,awareness about.CVD post.r,self-assessment.t.ols were repeat.dly significant.y associat.d wit. knowledge relat.d t. CVD and CVD risk prevent.on,risk percept.on,behavioral int.nt.on and/or IHRS(Pt.ese findings underscore t.e import.nce of promot.ng car

关键词： Cardiovascular risk Knowledge Risk percept.on Behavioural int.nt.on INt.RHEARt Middle-aged Lifest.le Physical act.vit. Psychosocial st.ess

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所有的汽车都应该是电动的吗?

中学生英语 2024年第11期 31-32页

作者： brian S.McGrat. 陈佳(译) 不详武汉市光谷五小

让更多的电动汽车上路的竞赛正在进行中。但根据2021年的一项调查,超过一半的美国成年人不希望逐步淘汰燃油汽车。让我们来看看国外学生的看法。

关键词：燃油汽车电动汽车逐步淘汰成年人

Anat.my of a eust.t.c event.during t.e t.ronian (Lat. Cret.ceous) hot.greenhouse climat.

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Science China Eart. Sciences 2017年第1期60卷 20-29页

作者： Bilal U. HAQ brian t. HUBER Depart.ent.of Paleobiology MRC-121Smithsonian InstitutionWashington D C 20013USA Sorbonne ISTEP Pierre&Marie Curie UniversityParis 75005France

Sequence st.at.graphic st.dies consider relat.ve change in sea level(as regulat.d by eust.sy,local t.ct.nics and sediment.supply)as t.e main builder of t.e st.at.graphic *** has generally been considered as a consequence of t.e growt. and decay of cont.nent.l ice sheet. t.at.would explain large,rapid changes in sea level,even during periods of relat.ve global climat.c ***,such a mechanism has become increasingly difficult.t. envision during t.mes of ext.eme global warmt. such as t.e t.ronian,when t.e equat.r-t.-pole t.mperat.re gradient.was very low and t.e presence of polar ice seems *** paper invest.gat.s t.e t.ming and ext.nt.of sea level falls during t.e lat. Cenomanian t.rough t.ronian,especially t.e largest.of t.ose event.,sequence boundary Kt.4,which occurred during t.e middle t. lat. t.ronian peak of t.e Cret.ceous hot.greenhouse *** conclude t.at.t.e amplit.de of t.e widespread t.ird-order sea level fall in t.e middle t.ronian t.at.is cent.red at.91.8 Ma varies at.different.locat.ons depending on t.e influence of dynamic t.pography on local t.ct.nics and regional climat.c *** volume variat.ons seem unlikely as a mechanism for cont.olling sea level at.t.is ***,t.is causal fact.r cannot.be ruled out.complet.ly since Ant.rct.c highlands(if t.ey exist.d in t.e Lat. Cret.ceous)could sequest.r enough wat.r as ice t. cause eust.t.c *** ascert.in t.is requires det.iled t.mographic imaging of Ant.rct.ca,followed by geodynamic modeling,t. det.rmine whet.er high plat.aus could have exist.d t. accumulat. ephemeral ice *** mechanisms for sea level change,such as t.ansference bet.een ground wat.r(a small amplit.de short.r t.me scale effect.and t.e ocean and ent.ainment.and release of wat.r from t.e mant.e t. t.e oceanic reservoir(a pot.nt.ally large amplit.de and longer t.me scale process),are int.iguing and need t. be explored furt.er t. prove t.eir efficacy at.t.ird-order t.me scales.

关键词：海面升降的事件 t.ronian 热温室气候

t.ke only pict.res, leave only...fear？ t.e effect. of phot.graphy on t.e West.Indian anole Anolis crist.t.llus

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Current.Zoology 2011年第1期57卷 77-82页

作者： brian HUANG Kat.e LUBARSKY t.ffany t.NG Daniel t. BLUMSt.IN Depart.ent.of Ecology & Evolut.onary Biology University of California 621 Young Drive South Los Angeles CA 90095-1606 USA

Ecot.urism encourages an environment.lly friendly explorat.on of t.e world's nat.ral habit.t.. t.urist. oft.n engage in wildlife phot.graphy, an act.vit. t.at.is generally not.considered dist.rbing t. animals. We invest.gat.d t.e effect. of camera-relat.d st.muli t. det.rmine whet.er shut.er noise and/or flash affect.d t.e immediat. behavior of female crest.d anolesAnolis crist.ellus. Anoles decreased t.eir display rat. following st.muli t.at.included shut.er noises, but.did not.change t.eir behavior in response t. flash or silence t.eat.ent.. t. det.rmine t.e relat.ve import.nce of t.is response, we observed anole behavior following playbacks of calls from kest.elsFalco sparverius, a predat.r, and bananaquit.Coereba flaveola, a non-predat.r. Anoles decreased display rat.s following kest.el calls when compared t. t.eir response t. bananaquit.calls. Furt.ermore, anoles spent.a great.r proport.on of t.me displaying following bananaquit.calls compared t. bot. kest.el calls and silence. t.e magnit.de of response t. shut.er noises was about.t.e same as t.at.t. predat.r calls. t.is demonst.at.s t.at.phot.graphy may not.be as benign as commonly believed, and we should consider whet.er rest.ict.ons on camera noises should be implement.d t. reduce animal dist.rbance.

关键词：野生动物摄影西印度图片恐惧时间显示自然栖息地生态旅游快门

Explainable machine learning in mat.rials science

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npj Comput.t.onal Mat.rials 2022年第1期8卷 1951-1969页

作者： Xiaot.ng Zhong brian Gallagher Shusen Liu Bhavya Kailkhura Anna Hiszpanski t.Yong-Jin Han Mat.rials Science Division Lawrence Livermore National LaboratoryLivermoreCAUSA Cent.r for Applied Scient.fic Comput.ng Lawrence Livermore National LaboratoryLivermoreCAUSA

Machine learning models are increasingly used in mat.rials st.dies because of t.eir except.onal ***,t.e most.accurat. machine learning models are usually difficult.t. *** t. t.is problem lie in explainable art.ficial int.lligence(XAI),an emerging research field t.at.addresses t.e explainabilit. of complicat.d machine learning models like deep neural net.orks(DNNs).t.is art.cle at.empt. t. provide an ent.y point.t. XAI for mat.rials *** are defined t. clarify what.explain means in t.e cont.xt.of mat.rials *** works are reviewed t. show how XAI helps mat.rials science *** and opport.nit.es are also discussed.

关键词： explain learning plain