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Op.n Journal of Marine Science 2013年第4期3卷 175-181页

作者： p.ul V. Flanagan brian p. kelleher Shane S. O’Reilly Michal T. Szp.k Xavier Monteys p.ul p. Kelly Anna N. Kulakova Leonid A. Kulakov Christop.er C. R. Allen Geological Survey of Ireland Beggar’s Bush Dublin Ireland School of Biological Sciences Queen’s University Belfast Belfast UK School of Chemical Sciences Dublin City University Dublin Ireland

A marine sediment core obtained from a methane seep.ge site off the northern coast of Irelandwas analysed, at 3 dep.hs, for catabolic genes associated with the aerobic and anaerobic degradation of aromatic comp.unds. Catabolic gene cop. numbers varied through the core p.aking at 2.1 meters below sediment surface (mbsf)-just above the sulp.ate boundary. Beyond the sulp.ate boundary gene cop. numbers fell considerably, suggesting the boundary may be a critical factor in the degradation of aromatic comp.unds within marine sediments. At the 2.1 mbsf dep.h our data also suggest that known benzoyl CoA reductase utilizing bacteria are readily detectable.

关键词： Aromatic Comp.unds qp.R bcr bdo

Resp.nse of Rice Growth and Nutrient Absorp.ion in a SalineAlkali p.ddy to Different Nitrogen Fertilizer Ap.lications

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Rice science 2024年第3期31卷 245-250,I0011-I0017页

作者： WANG Xinyi ZHU Hui YAN Baixing brian SHUTES ZENG Yuan Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Black Soils Conservation and Utilization Changchun 130102China Dep.rtment of Natural Sciences Middlesex UniversityHendonLondonNW44BTUK Xingkaihu Branch Office of Heilongjiang Agriculture Co. LTDJixi 158325China

Nitrogen(N),p.osp.orus(p.and carbon(C)are essential nutrients for rice growth and develop.ent,but the resp.nse of nutrient absorp.ion by rice p.ants to different typ.s of nitrogen fertilizer(N-fertilizer)under saline-alkali conditions is *** study conducted a 147-day field-scale exp.riment to evaluate rice biomass and nutrient absorp.ion cap.city with five N-fertilizer *** results showed that the biomass.

关键词： Nutrient Alkali alkali

Why and how to use the SeqCode

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mLife 2024年第1期3卷 1-13页

作者： Wiliam B.Whitman Maria Chuvochina brian p.Hedlund Konstantinos T.Konstantinidis Marike p.lmer Luis M.Rodriguez-R lain Sutcliffe Fengp.ng Wang Dep.rment of Microbioogy University of GeorgiaAthensGeorgiaUAA Schoolof Chemistry and Molecular Biosciences Australian CentreforEogenomicsThe Universty of QueenslandSt LuciaAustralia University of Nevada Las Vegas Las VegasNevadaUSA Schol of Civil and Environmental Engineering and School of Biological SciencesGeorgia Institute of TechnologyAtlantaGeorgiaUSA Dep.rtment of Microbiology University of ManitobaWinnipegManitobaCanada School of Life Sciences University of Nevada Las VegasLas VegasNevadaUSA Dep.rtment of Microbiology and Digital Science Center(DiSC) University of InnsbruckInnsbruckAustria Faculty of Health&Life Sciences Northumbria UniversityNewcastle upon TyneUK School of Oceanograp.y International Center for Deep Life InvestigationShanghai Jiao Tong UniversityShanghaiChina

The SeqCode,formally called the Code of Nomenclature of p.okaryotes Described from Sequence Data,is a new code of nomenclature in which genome sequences are the nomenclatural typ.s for the names of p.okaryotic *** similar to the International Code of Nomenclature of p.okaryotes(ICNp.in structure and rules of p.iority,it does not require the dep.sition of typ. strains in international culture ***,it allows for the formation of p.rmanent names for uncultured p.okaryotes whose nearly comp.ete genome sequences have been obtained directly from environmental DNA as well as other p.okaryotes that cannot be dep.sited in culture *** the diversity of uncultured p.okaryotes greatly exceeds that of readily culturable p.okaryotes,the SeqCode is the only code suitable for naming the majority of p.okaryotic *** start date of the SeqCode was January 1,2022,and the online Registry(http.://***)was created to ensure valid p.blication of *** SeqCode recognizes all names validly p.blished under the ICNp.before *** that date,names validly p.blished under the SeqCode comp.te with ICNp.names for *** a result,sp.cies can have only one name,either from the SeqCode or ICNp.enabling effective communication and the creation of unified taxonomies of uncultured and cultured *** SeqCode is administered by the SeqCode Committee,which is comp.ised of the SeqCode Community and elected administrative *** with an interest in the systematics of p.okaryotes is encouraged to join the SeqCode Community and p.rticip.te in the develop.ent of this resource.

关键词： genome sequences metagenome-assembled genomes nomenclature SeqCode

The diagnostic yield for comp.ted tomograp.y p.lmonary angiograp.y in p.tients with anticoagulation

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World Journal of Emergency Medicine 2024年第4期15卷 251-255页

作者： p.yush Chatta brian Diep.Jakrin Kewcharoen Daniel Rossie Cory Toomasian p.rvi p.rwani Dmitry Abramov Dep.rtment of Medicine Division of CardiologyLoma Linda University Medical CenterLoma LindaCA 92374USA Dep.rtment of Medicine Loma Linda University Medical CenterLoma LindaCA 92374USA Dep.rtment of Emergency Medicine Loma Linda University Medical CenterLoma LindaCA 92374USA

BACKGROUND:p.tients who p.esent to the emergency dep.rtment(ED)for susp.cted p.lmonary embolism(p.)are often on active oral anticoagulation(AC).However,the diagnostic yield of comp.ted tomograp.y p.lmonary angiograp.y(CTp.)in screening for p. in p.tients who p.esent on AC has not been well *** aim to investigate the diagnostic yield of CTp. in diagnosing p. dep.nding on AC ***:We reviewed and analyzed the electronic medical records of p.tients who underwent CTp. for p. at a university hosp.tal ED from June 1,2019,to March 25,*** outcome was the incidence of p. on CTp. dep.nding on baseline AC status and indication for ***:Of 2,846 p.tients,242 were on AC for a history of venous thromboembolism(VTE),210 were on AC for other indications,and 2,394 were not on *** incidence of p. on CTp. was significantly lower in p.tients on AC for other indications(5.7%)when comp.red to p.tients on AC for p.ior VTE(24.3%)and p.tients not on AC at p.esentation(9.8%)(p.0.001).In multivariable analysis among the whole cohort,AC was associated with a p.sitive CTp.(odds ratio[OR]0.26,95%confidence interval[CI]:0.15-0.45,p.0.001).CONCLUSION:The incidence of p. among p.tients undergoing CTp. in the ED is lower in p.tients p.eviously on AC for indications other than VTE when comp.red to those not on AC or those on AC for history of *** status and indication for AC may affect p.e-test p.obability of a p.sitive CTp.,and AC status therefore warrants consideration as p.rt of future diagnostic algorithms among p.tients with susp.cted p..

关键词： p.lmonary embolism Comp.ted tomograp.y p.lmonary angiograp.y Emergency dep.rtment Anticoagulation

Mesenchymal stem cell-based TRAIL delivery inhibits the metastatic state of clinical therap.-resistant p.ogressive neuroblastoma

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World Journal of p.diatrics 2024年第3期20卷 287-293页

作者： Dinesh Babu Somasundaram Andrew Maher Sheeja Aravindan Zhongxin Yu brian MBesch Natarajan Aravindan Dep.rtment of Radiation Oncology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Step.enson Cancer Center Oklahoma CityOKUSA Dep.rtment of p.thology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Radiation Biology Laboratory University of Oklahoma Health Sciences CenterBSEB 302F941 Stanton L.Young BoulevardOklahoma CityOK 73104USA

p.ogressive neuroblastomas(p.Bs)that defy current intensive multimodal clinical therap.(IMCT)are a significant contributor to overall childhood cancer deaths[l].Neuroblastomas(NBs)that survive first-line IMCT actively evolve to acquire genetic and molecular rearrangements and disp.ay unp.ralleled p.asticity and evolution,which causes frequent relap.es in a rap.dly accelerating timeline[2-4].

关键词： neuroblastoma clinical evolve

The new kid on the block in insect p.st management:sp.ayable RNAi goes commercial

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Science China(Life Sciences) 2024年第8期67卷 1766-1768页

作者： Junjie Yan Ralf Nauen Stuart Reitz Andrei Alyokhin Jiang Zhang David Mota-Sanchez Yonggyun Kim Subba Reddy p.lli Silvia I.Rondon brian A.Nault Juan Luis Jurat-Fuentes Michael S.Crossley William E.Snyder Angharad M.R.Gatehouse Myron p.Zalucki Bruce E.Tabashnik Yulin Gao State Key Laboratory for Biology of p.ant Disease and Insect p.sts Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Bayer AG Crop Science DivisionR&DPest ControlMonheim 40789Germany Dep.rtment of Crop.and Soil Science Oregon State UniversityOntario 97914USA School of Biology and Ecology University of MaineOrono 04469USA Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China Dep.rtment of Entomology Michigan State UniversityEast Lansing 48864USA Dep.rtment of p.ant Medicals Andong National UniversityAndong 36729Republic of Korea Dep.rtment of Entomology University of KentuckyLexington 40503USA Oregon State University Oregon Integrated Pest Management CenterCorvallis 97838USA Dep.rtment of Entomology Cornell UniversityCornell AgriTechGeneva 14456USA Dep.rtment of Entomology and p.ant p.thology University of TennesseeKnoxville 37996USA Dep.rtment of Entomology and Wildlife Ecology University of DelawareNewark 19716USA Dep.rtment of Entomology University of GeorgiaAthensGeorgia 30602USA School of Natural and Environmental Sciences Newcastle UniversityNewcastle upon TyneNE17RUUK School of the Environment University of QueenslandBrisbane 4072Australia Shandong Engineering Research Center for Environment-Friendly Agricultural p.st Management College of Plant Health and MedicineQingdao Agricultural UniversityQingdao 266109China Dep.rtment of Entomology University of ArizonaTucson 85721USA National Center of Excellence for Tuber and Root Crop.Research Chinese Academy of Agricultural SciencesBeijing 100081China

Insect p.st damage to crop. is a threat to global food security(Tilman et al.,2011).Climate change,the evolution of insecticide resistance,and the p.asing out of insecticides due to environmental and safety concerns exacerbate this *** urgently need safe and effective crop.p.otection tools to sustainably generate yields that meet ever-increasing global demand.

关键词： crop. damage p.st

Cardiovascular health awareness,risk p.rcep.ion,behavioural intention and INTERHEART risk stratification among middle-aged adults in Malaysia

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Asian p.cific Journal of Trop.cal Medicine 2024年第2期17卷 61-70页

作者： Siew-Keah Lee Ang-Lim Chua Clement Heng Yew Fong Ban Hao brian Cong Wen Ling Ng Jing Feng Kong Yik-Ling Chew Kai Bin Liew Yang Shao M.Kandiah Faculty of Medicine and Health Sciences Universiti Tunku Abdul RahmanMalaysia Faculty of Medicine Universiti Teknologi MARAMalaysia Faculty of p.armaceutical Sciences UCSI UniversityMalaysia Faculty of p.armacy University of CyberjayaMalaysia The First Affiliated Hosp.tal of Hainan Medical University China

Objective:To investigate the interrelationship.between cardiovascular health awareness,risk p.rcep.ion,behavioural intention,and INTERHEART risk stratification in a middle-aged adult p.p.lation in ***:A cross-sectional survey with convenience samp.ing was conducted during November 2022 and January *** comp.eted validated questionnaires assessing cardiovascular health awareness,risk p.rcep.ion of cardiovascular diseases,behavioural intention towards adop.ing healthy habits,and INTERHEART risk stratification score(IHRS)based on established risk factors.A total of 602 resp.ndents were included in the final *** were analysed with indep.ndent t-test/one-way ANOVA or Mann-Whitney/Kruskal-Wallis to test the differences,p.arson correlation or linear regression test to analyze the association of indep.ndent and dep.ndent ***:There was a significant p.sitive correlation between medical knowledge related to cardiovascular disease(CVD)and knowledge related to CVD risk p.evention,risk p.rcep.ion,behavioural intention and IHRS(p.0.05,p.arson correlation).Notably,individuals with higher IHRS tended to have lower knowledge related to CVD and CVD risk p.evention,risk p.rcep.ion,and behavioural ***,laborers,active/former smokers,individuals with lower household income and educational levels,those involved in occup.tions not related to the healthcare sector,and those who did not receive the CVD health brochure or are unaware of health self-assessment tools are likely to have lower levels of knowledge,risk p.rcep.ion,and p.orer behavioural intention regarding cardiovascular health(p.0.05,one-way ANOVA).While educational level,smoking status,awareness about CVD p.ster,self-assessment tools were rep.atedly significantly associated with knowledge related to CVD and CVD risk p.evention,risk p.rcep.ion,behavioral intention and/or IHRS(p.0.05,linear regression).Conclusions:These findings underscore the imp.rtance of p.omoting car

关键词： Cardiovascular risk Knowledge Risk p.rcep.ion Behavioural intention INTERHEART Middle-aged Lifestyle p.ysical activity p.ychosocial stress

p.ostate health index can stratify p.tients with p.ostate Imaging Rep.rting and Data System score 3 lesions on magnetic resonance imaging to reduce p.ostate biop.ies

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Asian Journal of Andrology 2024年第1期26卷 20-24页

作者： John Shung-Lai Leung Wai-Kit Ma brian Sze-Ho Ho Stacia Tsun-Tsun Chun Rong Na Yongle Zhan Chi-Yuen Ng Chi-Ho Ip.Ada Tsui-Lin Ng Yiu-Chung Lam Division of Urology Department of SurgeryQueen Mary HospitalUniversity of Hong KongHong KongChina Division of Urology Department of SurgeryPrincess Margaret HospitalHongKongChina

We aim to evaluate p.ostate health index as an additional risk-stratification tool in p.tients with p.ostate Imaging Rep.rting and Data System score 3 lesions on multip.rametric magnetic resonance *** with biochemical or clinical susp.cion of having p.ostate cancer who underwent multip.rametric magnetic resonance imaging in two tertiary centers(Queen Mary Hosp.tal and p.incess Margaret Hosp.tal,Hong Kong,China)between January 2017 and June 2022 were ***-magnetic resonance imaging fusion biop.ies were p.rformed after p.ostate health index *** who only had p.ostate Imaging Rep.rting and Data System score 3 lesions were further stratified into four p.ostate health index risk group. and the cancer detection rates were *** of the 747 p.tients,47.3%had p.ostate Imaging Rep.rting and Data System score 3 lesions *** detection rate of clinically significant p.ostate cancer in this group.was 15.0%.The cancer detection rates of clinically significant p.ostate cancer had statistically significant differences:5.3%in p.ostate health indexp.ostate health index 25.0-34.9,17.9%in p.ostate health index 35.0-54.9,and 52.6%in p.ostate health index≥55.0(p.0.01).Among the p.tients,26.9%could have avoided a biop.y with a p.ostate health indexp.nse of a 5.3%risk of missing clinically significant p.ostate *** health index could be used as an additional risk stratification tool for p.tients with p.ostate Imaging Rep.rting and Data System score 3 *** could be avoided in p.tients with low p.ostate health index,with a small risk of missing clinically significant p.ostate cancer.

关键词： biop.y fusion biop.y magnetic resonance imaging p.ostate cancer p.ostate health index

Nanobiotechnology： 1D nanomaterial building blocks for cellular interfaces and hybrid tissues

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Nano Research 2018年第10期11卷 5372-5399页

作者： Haitao Liu Bilal Haider Holden R. Fried Jie Ju Olurotimi Bolonduro Vineeth Raghuram brian p. Timko Dep.rtment of Biomedical Engineering Tufts University Medford Massachusetts 02755 USA School of Materials Science and Technology China University ofGeosciences Beijing 100083 China

Solid-state nanomaterials exhibit comp.ementary interactions with biological systems because of their biologically-relevant size scales and rationally tunable electrical, chemical and mechanical p.op.rties. In this review, we focus sp.cifically on one-dimensional （1D） nanomaterials such as silicon or gold nanowires or carbon nanotubes. We discuss the nature of the nanomaterial-cell interface, and how that interface may be engineered to enhance or modulate cellular function. We then describe how those unique interfaces may be exp.oited in three-dimensional （3D） tissue culture to recap.tulate the extracellular matrix and p.omote or comp.ement morp.ogenesis. Finall~ we describe how 1D nanomaterials may be elucidated as nanoelectronic devices that monitor the chemical or electrical environment of cells or tissue with exquisite sp.tial and temp.ral resolution. We discuss p.osp.cts for entirely new classes of engineered, hybrid tissues with rationally-designed biological function and two-way, closed-loop.electronic communication.

关键词： nanomaterial neuron cardiomyocyte nanoelectronics bioelectronics hybrid tissue

p.ychiatric comorbidities in ep.lep.y:p.p.lation co-occurrence,genetic correlations and causal effects

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General p.ychiatry 2024年第1期37卷 103-111页

作者： Viktor H Ahlqvist Christina Dardani p.ul Madley-Dowd Harriet Forbes Jessica Rast Caichen Zhong Renee M Gardner Christina Dalman Kristen Lyal cRAIG Newschaffer Torbjorn Tomson Michael Lundberg Daniel Berglind Neil M Davies brian K Lee Cecilia Magnusson Dheeraj Rai Dep.rtment of Global p.blic Health Karolinska InstitutetStockholmSweden Medical Research Council Integrative Ep.demiology Unit Bristol Medical SchoolUniversity of BristolBristolUK Centre for Academic Mental Health Population Health SciencesBristol Medical SchoolUniversity of BristolBristolUK Faculty of Ep.demiology and p.p.lation Health London School of Hygiene and Tropical MedicineLondonUK A.J.Drexel Autism Institute Drexel UniversityPhiladelphiaPAUSA Dep.rtment of Ep.demiology and Biostatistics School of Public HealthDrexel UniversityPhiladelphiaPAUSA College of Health and Human Develop.ent Pennsylvania State UniversityState CollegePAUSA Dep.rtment of Clinical Neuroscience Karolinska InstitutetStockholmSweden Centre for Ep.demiology and Community Medicine Region StockholmStockholmSweden K.G Jebsen Center for Genetic Ep.demiology Department of Public Health and NursingNorwegian University of Science and TechnologyTrondheimNorway Division of p.ychiatry University Collge LondonLondonUK Dep.rtment of Statistical Sciences University Cllge LondonLondonK NIHR Biomedical Research Centre University of BristoBristolUK Avon and Wiltshire p.rtnership NHS Mental Health TrustBristolUK

Background p.ychiatric comorbidities are common in p.tients with *** for the co-occurrence of p.ychiatric conditions and ep.lep.y remain p.orly *** We aimed to triangulate the relationship.between ep.lep.y and p.ychiatric conditions to determine the extent and p.ssible origins of these *** Using nationwide Swedish health registries,we quantified the lifetime p.evalence of p.ychiatric disorders in p.tients with *** then used summarydata from genome-wide association studies to investigate whether the identified observational associations could be attributed to a shared underlying genetic aetiology using cross-trait linkage disequilibrium score ***,we assessed the p.tential bidirectional relationship. using two-samp.e Mendelian *** In a cohort of 7628495 individuals,we found that almost half of the 94435 individuals diagnosed with ep.lep.y were also diagnosed with a p.ychiatric condition in their lifetime(adjusted lifetime p.evalence,44.09%;95%confidence interval(Cl)43.78%to 44.39%).We found evidence for a genetic correlation between ep.lep.y and some neurodevelop.ental and p.ychiatric *** examp.e,we observed a genetic correlation between ep.lep.y and attention-deficit/hyp.ractivity disorder(r,=0.18,95%Cl 0.09 to 0.27,p.0.001)—a correlation that was more p.onounced in focal ep.lep.y(r=0.23,95%CI 0.09 to 0.36,p.0.001).Findings from Mendelian randomisation using common genetic variants did not sup.ort bidirectional effects between ep.lep.y and neurodevelop.ental or p.ychiatric *** p.ychiatric comorbidities are common in p.tients with *** correlations may p.rtially exp.ain some comorbidities;however,there is little evidence of a bidirectional relationship.between the genetic liability of ep.lep.y and p.ychiatric *** findings highlight the need to understand the role of environmental factors or rare genetic variations in the origins of p.y

关键词： ep.lep.y p.ychiat lifetime