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Anatomy of a eustatic event during the Turonian (Late Cretaceous) hot greenhouse climate

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Science China Earth Sciences 2017年第1期60卷 20-29页

作者： Bilal U. HAQ brian T. HUBER Department of paleobiology MRC-121Smithsonian InstitutionWashington D C 20013USA Sorbonne ISTEP Pierre&Marie Curie UniversityParis 75005France

Sequence stratigraphic studies consider relative change in sea level(as regulated by eustasy,local tectonics and sediment supply)as the main builder of the stratigraphic *** has generally been considered as a consequence of the growth and decay of continental ice sheets that would explain large,rapid changes in sea level,even during periods of relative global climatic ***,such a mechanism has become increasingly difficult to envision during times of extreme global warmth such as the Turonian,when the equator-to-pole temperature gradient was very low and the presence of polar ice seems *** paper investigates the timing and extent of sea level falls during the late Cenomanian through Turonian,especially the largest of those events,sequence boundary KTu4,which occurred during the middle to late Turonian peak of the Cretaceous hot greenhouse *** conclude that the amplitude of the widespread third-order sea level fall in the middle Turonian that is centered at^91.8 Ma varies at different locations depending on the influence of dynamic topography on local tectonics and regional climatic *** volume variations seem unlikely as a mechanism for controlling sea level at this ***,this causal factor cannot be ruled out completely since Antarctic highlands(if they existed in the Late Cretaceous)could sequester enough water as ice to cause eustatic *** ascertain this requires detailed tomographic imaging of Antarctica,followed by geodynamic modeling,to determine whether high plateaus could have existed to accumulate ephemeral ice *** mechanisms for sea level change,such as transference between ground water(a small amplitude shorter time scale effect)and the ocean and entrainment and release of water from the mantle to the oceanic reservoir(a potentially large amplitude and longer time scale process),are intriguing and need to be explored further to prove their efficacy at third-order time scales.

关键词： Eustatic event Turonian Hot greenhouse climate

Significance of Vibrio species in the marine organic carbon cycle-A review

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Science China Earth Sciences 2018年第10期61卷 1357-1368页

作者： Xiaohua ZHANG Heyu LIN Xiaolei WANG brian AUSTIN College of Marine Life Sciences Ocean University of China Qingdao 266003 China Laboratory for Marine Ecology and Environmental Science Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071 China Institute of Aquaculture University of StirlingStirling FK9 4LA UK

The genus Vibrio,belonging to Gammaproteobacteria of the phylum proteobacteria,is a genetically and ecologically diverse group of heterotrophic bacteria,that are ubiquitous in marine environments,especially in coastal *** particular,vibrios dominate,*** to 10%of the readily culturable marine bacteria in these *** distribution of Vibrio *** shaped by various environmental parameters,notably temperature,salinity and dissolved organic *** utilize a wide range of organic carbon compounds,including chitin(this may be metabolized by most Vibrio spp.),alginic acid and *** Vibrio *** very short replication times(as short as～10 min),which could facilitate them developing into high biomass content albeit for relatively short *** *** comprise a minor portion(typically^1%of the total bacterioplankton in coastal waters)of the total microbial population,they have been shown to proliferate explosively in response to various nutrient pulses,e.g.,organic nutrients from algae blooms and iron from Saharan ***,Vibrio *** exert large impacts on marine organic carbon cycling especially in marginal *** and related areas of investigation will reveal more about the molecular components and mechanisms involved in Vibrio-mediated biotransformation and remineralization processes.

关键词： Vibrio Ecology Carbon cycle Marine Organic carbon

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Editorial

Chinese Chemical Letters 2015年第4期26卷 393-394页

作者： Zhan Chen brian p.Coppola Carol A.Fierke Department of Chemistry University of Michigan

We convey our sincere thanks for the publication of this special University of Michigan issue of Chinese Chemical Letters. The idea to publish this special issue came from a meeting between Dr. Zhan Chen （professor of Chemistry at the University of Michigan） and Dr. Huanfang Guo （associate editor-in-chief, Chinese Chemical Letters） when Dr. Guo visited the University of Michigan during May 2014. On behalf of prof. Xuhong Qian, the editor-in-chief of Chinese Chemical Letters, Dr. Guo invited prof. Chen to contact various professors at the University of Michigan to make contributions to a special issue. prof. Chen received many immediate responses, resulting in the eighteen mini-reviews and research papers published in this issue and authored by members of research groups at the University of Michigan. Nineteen professors, their postdoctoral fellows, students, and collaborators contributed to this special issue, including professors associated with College of Literature, Science and Arts （Chemistry, Biophysics, Applied physics）, College of Engineering （Chemical Engineering, Electrical Engineering）, School of Medicine （Radiology, Internal Medicine, Surgery）, School of pharmacy, and School of Dentistry at the University of Michigan. The co-authors for these articles also include many researchers from universities in China such as Nanjing University, China University of Geosciences, Nanjing Medical University, Nanjing College of Chemical Technology, and Southeast University. The research reported in these articles covers many areas in chemistry and related sciences, as well as many interdisciplinary research projects, fitting the nature and scope of Chinese Chemical Letters, which publishes mini-reviews and research articles in all areas of chemistry, satisfying a real and urgent need for the dissemination of new and exciting research results.

关键词： Folate binding protein Serum protein Drug delivery Folate conjugate Folic acid

Robotic lobectomy-the future of minimally invasive lobectomy?

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Chinese Journal of Cancer Research 2013年第1期25卷 1-3页

作者： brian E. Louie Co-Director Minimally Invasive Thoracic Surgery Program Swedish Cancer Institute and Medical Center WA 98104 USA

It has been almost 20 years since the first reports of minimally invasive lobectomies appeared. Despite the tremendous amounts of research performed on VATS lobectomy showing its benefit over open thoracotomy, a mere 32% of all lobectomies are performed via this technique in the Society for Thoracic Surgeons database and only 6% in the Nationwide Inpatient Sample （1）. So, why is it that in a recent review of clinical stage I lung cancers over 70% were still completed using open thoracotomy？（2）. Advocates of an open approach still cite the ability to sample and perform a ＂more thorough＂ lymphadenectomy, the instability of the VATS platform and the lack of precision with the fissure-less-dissection VATS technique as reasons to maintain the status quo.

关键词： VATS Robotic lobectomy-the future of minimally invasive lobectomy

Metabolomic and elemental profiling of blood serum in bladder cancer

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Journal of pharmaceutical Analysis 2022年第6期12卷 889-900页

作者： Krzysztof Ossolinski Tomasz Ruman Valerie Copie brian p.Tripet Leonardo B.Nogueira Katiane O.p.C.Nogueira Artur Kołodziej Aneta płaza-Altamer Anna Ossolinska Tadeusz Ossolinski Joanna Nizioł Department of Urology John Paul II Hospital36-100KolbuszowaPoland Rzeszow University of Technology Faculty of Chemistry35-959RzeszowPoland The Department of Chemistry and Biochemistry Montana State UniversityBozemanMT59717USA Department of Geology Federal University of Ouro Preto35400-000Ouro PretoBrazil Department of Biological Sciences Federal University of Ouro Preto35400-000Ouro PretoBrazil Doctoral School of Engineering and Technical Sciences at the Rzeszow University of Technology 35-959RzeszowPoland

Bladder cancer(BC)is one of the most frequently diagnosed types of urinary *** advances in treatment methods,no specific biomarkers are currently in *** and untargeted profiling of metabolites and elements of human blood serum from 100 BC patients and the same number of normal controls(NCs),with external validation,was attempted using three analytical methods,i.e.,nuclear magnetic resonance,gold and silver-109 nanoparticle-based laser desorption/ionization mass spectrometry(LDI-MS),and inductively coupled plasma optical emission spectrometry(ICp-OES).All results were subjected to multivariate statistical *** potential serum biomarkers of BC,namely,isobutyrate,pyroglutamate,choline,and acetate,were quantified with proton nuclear magnetic resonance,which had excellent predictive ability as judged by the area under the curve(AUC)value of *** elements,Li and Fe,were also found to distinguish between cancer and control samples,as judged from ICp-OES data and AUC of 0.807(in validation set).Twenty-five putatively identified compounds,mostly related to glycans and lipids,differentiated BC from NCs,as detected using *** serum metabolites were found to discriminate between tumor grades and nine metabolites between tumor *** results from three different analytical platforms demonstrate that the identified distinct serum metabolites and metal elements have potential to be used for noninvasive detection,staging,and grading of BC.

关键词： Bladder cancer Biomarkers Human serum Metallomics Metabolomics

Managing malignant biliary obstruction in pancreas cancer: Choosing the appropriate strategy

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World Journal of Gastroenterology 2014年第28期20卷 9345-9353页

作者： brian R Boulay Mayur parepally Division of Gastroenterology and Hepatology University of Illinois Hospital and Health Sciences System

Most patients with pancreatic cancer develop malignant biliary *** of obstruction is generally indicated to relieve symptoms and improve morbidity and ***-line therapy consists of endoscopic biliary stent *** data comparing plastic stents to self-expanding metallic stents(SEMS)has shown improved patency with *** decision of whether to treat obstruction and the means for doing so depends on the clinical *** patients with resectable disease,preoperative biliary decompression is only indicated when surgery will be delayed or complications of jaundice *** patients with locally advanced disease,self-expanding metal stents are superior to plastic stents for long-term *** patients with advanced disease,the choice of metallic or plastic stent depends on life *** endoscopic stent placement fails,percutaneous or surgical treatments are *** therapy or surgical approach can be used to treat concomitant duodenal and biliary obstruction.

关键词： pancreatic neoplasms Cholestasis Extrahepatic Stents Biliary tract diseases

partial Volume Correction in SpECT Using Anatomical Information and Iterative FBp

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Tsinghua Science and Technology 2010年第1期15卷 50-55页

作者： Kjell Erlandsson brian F Hutton The Institute of Nuclear Medicine University College LondonLondonNW12BUUnited Kingdom

The ability to correctly quantify activity concentration with single photon emission computed tomography （SpECT） is limited by its spatial resolution. Blurring of data between adjacent structures, which is known as partial volume effects, can be compensated for by utilizing high resolution structural information from other imaging modalities such as CT or MRI. previously developed partial volume correction （pVC） methods normally assume a spatially invariant point spread function. In SpECT this is not a good approximation, since the resolution varies with the distance from the collimator. A new method, p-pVC, was developed in this paper, which takes into account the distance dependent blurring. The method operates in projection space and is combined with filtered back-projection （FBp） reconstruction. Results from simulations show that similar quantitative results could be obtained with p-pVC＋FBp as with OSEM with resolution recovery, although with better structural definition and an order of magnitude faster.

关键词： partial volume effect (pVE) partial volume correction (pVC) SpECT

Evolving role of the endoscopist in management of gastrointestinal neuroendocrine tumors

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World Journal of Gastroenterology 2017年第27期23卷 4847-4855页

作者： Cemal Yazici brian R Boulay Division of Gastroenterology and Hepatology Department of MedicineUniversity of Illinois Hospital and Health Sciences System

Neuroendocrine tumors(NETs) are uncommon gastrointestinal neoplasms but have been increasingly recognized over the past few decades. Luminal NETs originate from the submucosa of the gastrointestinal tract and careful endoscopic exam is a key for accurate diagnosis. Despite their reputation as indolent tumors with a good prognosis,some NETs may have aggressive features with associated poor long-term survival. Management of NETs requires full understanding of tumor size,depth of invasion,local lymphadenopathy status,and location within the gastrointestinal tract. Staging with endoscopic ultrasound or cross-sectional imaging is important for determining whether endoscopic treatment is feasible. In general,small superficial NETs can be managed by endoscopic mucosal resection and endoscopic submucosal dissection(ESD). In contrast,NETs larger than 2 cm are almost universally treated with surgical resection with lymphadenectomy. For those tumors between 11-20 mm in size,careful evaluation can identify which NETs may be managed with endoscopic resection. The increasing adoption of ESD may improve the results of endoscopic resection for luminal NETs. However,enthusiasm for endoscopic resection must be tempered with respect for the more definitive curative results afforded by surgical treatment with more advanced lesions.

关键词： Carcinoid Gastrointestinal Endoscopy Endoscopic submucosal dissection Neuroendocrine tumor

Malignant biliary obstruction:From palliation to treatment

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World Journal of Gastrointestinal Oncology 2016年第6期8卷 498-508页

作者： brian R Boulay Aleksandr Birg Division of Gastroenterology and Hepatology Department of MedicineUniversity of Illinois Hospital and Health Sciences System Department of Medicine University of Illinois Hospital and Health Sciences System

Malignant obstruction of the bile duct from cholan-giocarcinoma,pancreatic adenocarcinoma,or other tumors is a common problem which may cause debilitating symptoms and increase the risk of subsequent *** optimal treatment-including the decision whether to treat prior to resection-depends on the type of malignancy,as well as the stage of *** biliary drainage is generally discouraged due to the risk of infectious complications,though some situations may *** who require neoadjuvant therapy will require decompression for the prolonged period until attempted surgical *** pancreatic cancer patients,self-expanding metallic stents are superior to plastic stents for achieving lasting decompression without stent *** cholangiocarcinoma patients,treatment with percutaneous methods or nasobiliary drainage may be superior to endoscopic stent placement,with less risk of infectious complications or *** patients of either malignancy who have advanced disease with palliative goals only,the choice of stent for endoscopic decompression depends on estimated survival,with plastic stents favored for survival of pic techniques may actually extend stent patency and patient survival for these patients by achieving local control of the obstructing *** photodynamic therapy and radiofrequency ablation may play a role in extending survival of patients with malignant biliary obstruction.

关键词： pancreatic neoplasms Cholangiocarcinoma Extrahepatic cholestasis Stents Catheter ablation