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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage Mark L.Dell’Acqua brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAps).

关键词： function supporting

Distortion-stabilized ordered structures in A_(2)BB’O_(7) mixed pyrochlores

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npj Computational Materials 2019年第1期5卷 1076-1084页

作者： Ghanshyam pilania brian puchala Blas p.Uberuaga Materials Science and Technology Division Los Alamos National LaboratoryLos AlamosNM 87545USA Materials Science and Engineering Department University of MichiganAnn ArborMI 48109USA

pyrochlore oxides(A2B2O7)are interesting for a number of technological applications,including radiation damage tolerance and as ionic *** pyrochlores—containing two A and/or two B site cations—provide even more flexibility for tailoring properties owing to the diverse chemical and configurational degrees of freedom accessible within this chemical ***,we examine relative stability of different cation orderings in one model double pyrochlore Gd2(Zr_(x)Ti_(1−x))_(2)O_(7),as a function of Zr content *** results show that,in the presence of some very specific local cation arrangements,certain cation-ordered compositions in this system are highly stabilized as a result of large oxygen relaxation displacements,leading to the formation of an ordered‘double’pyrochlore *** origins of these anomalous oxygen relaxations are traced back to both the local cation symmetry and a strong chemical preference of Zr atoms towards adopting a 7-fold coordination environment,as opposed to a 6-fold coordination available in a regular pyrochlore ***,we examine the stability of this type of ordering in 131 other pyrochlore *** of our findings are discussed in relation to the observed composition-dependent ionic conductivity in these systems and connections with previously reported experimental findings are made.

关键词： structure ordered stabilized

Harpephyllum caffrum stimulates glucose uptake,abates redox imbalance and modulates purinergic and glucogenic enzyme activities in oxidative hepatic injury

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Asian pacific Journal of Tropical Biomedicine 2022年第1期12卷 9-19页

作者： Kolawole A.Olofinsan Ochuko L.Erukainure Beseni K.brian md.Shahidul Islam Department of Biochemistry School of Life SciencesUniversity of KwaZulu-Natal(Westville Campus)Durban 4000South Africa Department of pharmacology University of the Free StateBloemfontein 9300South Africa

Objective:To investigate the antioxidative and antidiabetic effects of Harpephyllum caffrum bark infusion as well as its effects on glucogenic and nucleotide hydrolyzing enzyme activities in FeSO4-induced oxidative stress in rat hepatic ***:Harpephyllum caffrum infusion was prepared from dried plant materials(40 g)infused in boiling water(400 mL)for 20 min at room *** antioxidative and inhibitory activities against carbohydrate digestive enzymes of the infusion were determined using established *** liver tissues of rats were used for glucose uptake assay and to evaluate the infusion’s effect on endogenous antioxidant,glucogenic,and nucleotide hydrolyzing enzyme activities in FeSO4-induced hepatic ***:The Harpephyllum caffrum infusion significantly reduced ferric iron(FRAp)and free radicals(OH•and DppH)in a dose-dependent *** inhibitedα-amylase andα-glucosidase activities and increased glucose uptake in hepatic ***4 significantly decreased glutathione concentration,catalase,and superoxide dismutase activities while increasing malondialdehyde level,glycogen phosphorylase,fructose-1,6-bisphosphatase,and adenosine triphosphatase ***,treatment with Harpephyllum caffrum infusion reversed FeSO4-induced *** of the infusion revealed the presence of catechol,O-pyrocatechuic acid,mequinol,maltol,and glycoside ***:The Harpephyllum caffrum infusion demonstrates antidiabetic and antioxidative potentials in in vitro models of type 2 diabetes as depicted by its ability to inhibit carbohydrate digestive enzymes,mitigate oxidative imbalance,and regulate glucogenic and nucleotide hydrolyzing enzyme activities in oxidative hepatic injury.

关键词： Harpephyllum caffrum Antioxidant Oxidative injury Carbohydrate dysmetabolism

A Flux Based Approximation to Simulate Coupled Hydromechanical problems for Mines with Heterogeneous Rock Types Using the Material point Method

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Computer Modeling in Engineering & Sciences 2022年第4期131卷 379-409页

作者： Gysbert Basson Andrew p.Bassom brian Salmon Institute of Mine Seismology and University of Tasmania Kingston7050Australia School of Natural Sciences-University of Tasmania Sandy BayHobart7001Australia School of Engineering-University of Tasmania Sandy BayHobart7001Australia

Advances in numerical simulation techniques play an important role in helpingmining engineers understand those parts of the rock mass that cannot be readily *** Material point Method(MpM)is an example of such a tool that is gaining popularity for studying geotechnical *** recent years,the original formulation of MpM has been extended to not only account for simulating the mechanical behaviour of rock under different loading conditions,but also to describe the coupled interaction of pore water and solid phases in *** methods assume that the permeability of mediums is homogeneous,and we show that these MpM techniques fail to accurately capture the correct behaviour of the fluid phase if the permeability of the material is *** this work,we propose a novel implementation of the coupled MpM to address this *** employ an approach commonly used in coupled Finite Volume Methods,known as the Two point Flux Approximation(TpFA).Our new method is benchmarked against two well-known analytical expressions(a one-dimensional geostatic consolidation and the so-called Mandel-Cryer effect).Its performance is compared to existing coupled MpM approaches for homogeneous *** order to gauge the possible effectiveness of our technique in the field,we apply ourmethod to a case study relating to a mine known to experience severe problems with pore water.

关键词： Fluid permeability Material point Method mining faults

Leveraging quasi-periodic orbits for trajectory design in cislunar space

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Astrodynamics 2021年第2期5卷 139-165页

作者： brian p.McCarthy Kathleen C.Howell School of Aeronautics and Astronautics Neil Armstrong Hall of EngineeringWest LafayetteIN47907-2045USA

Incorporating quasi-periodic orbits into the preliminary design process offers a wide range of options to meet mission constraints and address the challenges in a complex trade *** this investigation,linear stability and quasi-periodic orbit family continuation schemes are examined to meet various types of *** in eclipse avoidance and transfer design are examined by leveraging quasi-periodic orbits and their associated hyperbolic manifolds in the lunar *** are transitioned to an ephemeris model to validate that geometries are maintained in higher-fidelity *** the natural dynamical structures associated with quasi-periodic orbits are leveraged,novel trajectory solutions can emerge.

关键词： multi-body dynamical systems quasi-periodic orbits trajectory analysis cislunar trajectory design near rectilinear halo orbit ephemeris dynamical model

Rhus longipes (Engl.) infusions improve glucose metabolism and mitigate oxidative biomarkers in ferrous sulfate-induced renal injury

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Asian pacific Journal of Tropical Biomedicine 2022年第11期12卷 453-465页

作者： brian K.Beseni Kolawole AOlofinsan Veronica F.Salau Ochuko L.Erukainure md.Shahidul Islam Department of Biochemistry University of KwaZulu-NatalWestville CampusDurban 4000South Africa Department of pharmacology University of the Free StateBloemfontein 9300South Africa

Objective:To explore the antioxidant and antidiabetic activities of Rhus longipes(***)leaf and stem bark aqueous ***:*** leaf and stem bark infusions were characterized via gas-chromatography mass-spectroscopy(GC-MS)*** vitro antioxidant and carbohydrate and lipid digestive enzyme inhibitory activities of *** infusions were ***,the modulatory effects of *** infusions on intestinal glucose absorption,muscle glucose uptake,and biomarkers of renal oxidative injury were *** docking was performed to determine the binding affinities of the identified compounds from the leaf and stem bark infusions on carbohydrate and lipid digestive ***:GC-MS analysis revealed the presence of several phytocompounds,including palmitoleic acid,octadecanamide,24,25-dihydroxyvitamin D and L-ascorbic *** bark infusion had significantly higher total phenolic contents compared with the leaf infusion,with better DppH scavenging[IC_(50):(10.50±1.03)μg/mL]and ferric reducing[IC_(50):(9.85±0.32)μg/mL]activities(pptake in yeast suspension and rat psoas muscle with marked suppression of glucose absorption in the rat jejunum(ppid peroxidation,increased cellular reduced glutathione concentration,and the activities of superoxide dismutase and catalase in renal homogenate treated with FeSO_(4).Conclusions:*** shows antioxidant and antidiabetic activities and could be a potential therapeutic candidate for diabetes.

关键词： Antioxidant Oxidative biomarkers Enzyme inhibition Antidiabetic Rhus longipes Searsia longipes

Editorial comment on: surgical outcomes of two-stage hepatectomy for colorectal liver metastasis: comparison to a benchmark procedure

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 570-572页

作者： Zhongkai Wang brian K.p.Goh Department of Hepatopancreatobiliary and Transplant Surgery Singapore General HospitalSingaporeSingapore Duke-National University of Singapore Medical School SingaporeSingapore

With advancements in surgical techniques,locoregional therapy and systemic therapy,patients suffering from colorectal cancer with liver metastasis now have numerous therapeutic options for local and systemic disease *** resection of the primary cancer and all metastases remains the primary objective,offering patients the best chance for long-term survival.

关键词： metastasis colorectal surgical

Necking of anisotropic micro-films with strain-gradient effects

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Acta Mechanica Sinica 2008年第5期24卷 557-567页

作者： brian Nyvang Legarth Department of Mechanical Engineering Solid MechanicsTechnical University of Denmark2800 Kgs LyngbyDenmark

Necking of stubby micro-films of aluminum is investigated numerically by considering tension of a specimen with an initial imperfection used to onset localisation. plastic anisotropy is represented by two different yield criteria and strain-gradient effects are accounted for using the visco-plastic finite strain model. Furthermore, the model is extended to isotropic anisotropic hardening （evolving anisotropy）. For isotropic hardening plastic anisotropy affects the predicted overall nominal stress level, while the peak stress remains at an overall logarithmic strain corresponding to the hardening exponent. This holds true for both local and nonlocal materials. Anisotropic hardening delays the point of maximum overall nominal stress.

关键词： Micro-film Finite strain Nonlocal anisotropic visco-plasticity Anisotropic hardening

potential Vorticity and the pV perspective

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Advances in Atmospheric Sciences 2015年第1期32卷 2-9页

作者： brian HOSKINS Department of Meteorology University of Reading Grantham Institute for Climate Change Imperial College London

This paper highlights some theoretical aspects of potential vorticity（pV） and discusses some of the insights the pV perspective has given us. The topics covered include the nature of pV, its controlling role in the symmetric stability of the atmosphere, its inversion to give the flow field, Rossby waves and their coupling to give baroclinic instability, pV and midlatitude weather systems and, finally, insights into tropical motions.

关键词： circulation stability Rossby waves tropopause