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Research 2023年第1期2022卷 153-167页

作者： Letao Yang brian m.conley Jinho Yoon Christopher Rathnam Thanapat Pongkulapa Brandon Conklin Yannan Hou Ki-Bum Lee Department of Chemistry and Chemical Biology Rutgers UniversityThe State University of New JerseyPiscatawayNJ 08854USA

A systematic investigation of stem cell-derived neural interfaces can facilitate the discovery of the molecular mechanisms behind cell behavior in neurological disorders and accelerate the development of stem cell-based ***,high-throughput investigation of the cell-type-specific biophysical cues associated with stem cell-derived neural interfaces continues to be a significant obstacle to *** this end,we developed a combinatorial nanoarray-based method for high-throughput investigation of neural interface micro-/nanostructures(physical cues comprising geometrical,topographical,and mechanical aspects)and the effects of these complex physical cues on stem cell fate ***,by applying a machine learning(mL)-based analytical approach to a large number of stem cell-derived neural interfaces,we comprehensively mapped stem cell adhesion,differentiation,and proliferation,which allowed for the cell-type-specific design of biomaterials for neural interfacing,including both adult and human-induced pluripotent stem cells(hiPSCs)with varying genetic *** short,we successfully demonstrated how an innovative combinatorial nanoarray and mL-based platform technology can aid with the rational design of stem cell-derived neural interfaces,potentially facilitating precision,and personalized tissue engineering applications.

关键词： overcome neural rational

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Injectable bioorthogonal hydrogel (BIOGEL) accelerates tissue regeneration in degenerated intervertebral discs

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Bioactive materials 2023年第5期23卷 551-562页

作者： Jeffrey Luo Anjani Darai Thanapat Pongkulapa brian conley Letao Yang Inbo Han Ki-Bum Lee Department of Chemistry and Chemical Biology RutgersThe State University of New JerseyPiscatawayNJ08854USA Department of Neurosurgery CHA University School of MedicineCHA Bundang Medical Center59 Yaptap-roBundang-guSeongnam-siGyeonggi-do13496Republic of Korea

Intervertebral disc(IVD)degeneration is a leading cause of back pain and precursor to more severe conditions,including disc herniation and spinal *** traditional growth factor therapies(e.g.,TGFβ)are effective at transiently reversing degenerated disc by stimulation of matrix synthesis,it is increasingly accepted that bioscaffolds are required for sustained,complete IVD *** scaffolds(e.g.,metal/polymer composites,non-mammalian biopolymers)can be improved in one or more IVD regeneration demands:biodegradability,noninvasive injection,recapitulated healthy IVD biomechanics,predictable crosslinking,and matrix repair *** meet these demands,tetrazine-norbornene bioorthogonal ligation was combined with gelatin to create an injectable bioorthogonal hydrogel(BIOGEL).The liquid hydrogel precursors remain free-flowing across a wide range of temperatures and crosslink into a robust hydrogel after 5-10 min,allowing a human operator to easily inject the therapeutic constructs into degenerated ***,BIOGEL encapsulation of TGFβpotentiated histological repair(e.g.,tissue architecture and matrix synthesis)and functional recovery(e.g.,high water retention by promoting the matrix synthesis and reduced pain)in an in vivo rat IVD degeneration/nucleotomy *** BIOGEL procedure readily integrates into existing nucleotomy procedures,indicating that clinical adoption should proceed with minimal *** bioorthogonal crosslinking is essentially non-reactive towards biomolecules,our developed material platform can be extended to other payloads and degenerative injuries.

关键词： Bioorthogonal chemistry Growth factor Injectable hydrogel Intervertebral disc degeneration Tissue engineering

Polar comonomer incorporation using cationic Ni α-diimine olefin polymerization catalysts

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Science China Chemistry 2019年第2期62卷 153-154页

作者： Jordan m.Kaiser brian K.Long Department of Chemistry University of Tennessee

Polyolefins are an indispensable class of materials that have become the most widely produced and utilized polymers *** are readily synthesized from cheap and abundant monomer feedstocks,such as ethylene and propylene,and are capable of achieving a vast array of thermal and mechanical properties based upon their composition and ***,despite their numerous advantages, polyolefins are typically devoid of functional groups which can limit their applicability to many product families,such as coatings,adhesives,and cross-linked polyolefins.

关键词： Ni α-diimine olefin polymerization catalysts

Emerging role of galectin 3 in neuroinflammation and neurodegeneration

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Neural Regeneration Research 2024年第9期19卷 2004-2009页

作者： brian m.Lozinski Khanh Ta Yifei Dong Department of Clinical Neuroscience University of CalgaryCalgaryABCanada Deparment of Biochemistry Microbiology&ImmunologyUniversity of SaskatchewanSaskatoonSKCanada

Neuroinflammation and neurodegeneration are key processes that mediate the development and progression of neurological ***,the mechanisms modulating these processes in different diseases remain incompletely *** in single cell based multi-omic analyses have helped to identify distinct molecular signatures such as Lgals3 that is associated with neuroinflammation and neurodegeneration in the central nervous system(CNS).Lgals3 encodes galectin-3(Gal3),aβ-galactoside and glycan binding glycoprotein that is frequently upregulated by reactive microglia/macrophages in the CNS during various neurological *** Gal3 has previously been associated with non-CNS inflammatory and fibrotic diseases,recent studies highlight Gal3 as a prominent regulator of inflammation and neuroaxonal damage in the CNS during diseases such as multiple sclerosis,Alzheimer’s disease,and Parkinson’s *** this review,we summarize the pleiotropic functions of Gal3 and discuss evidence that demonstrates its detrimental role in neuroinflammation and neurodegeneration during different neurological *** also consider the challenges of translating preclinical observations into targeting Gal3 in the human CNS.

关键词： Alzheimer’s disease Galectin 3 microglia multiple sclerosis neurodegeneration neuroinflammation Parkinson’s disease therapeutics

Real-time hybrid simulation for structural control performance assessment

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Earthquake Engineering and Engineering Vibration 2009年第4期8卷 481-492页

作者： Juan E Carrion BF Spencer Jr brian m Phillips Skidmore Owings & Merrill LLP Civil and Environmental Engineering Department University of Illinois

Real-time hybrid simulation is an attractive method to evaluate the response of structures under earthquake loads. The method is a variation of the pseudodynamic testing technique in which the experiment is executed in real time, thus allowing investigation of structural systems with rate-dependent components. Real-time hybrid simulation is challenging because it requires performance of all calculations, application of displacements, and acquisition of measured forces, within a very small increment of time. Furthermore, unless appropriate compensation for actuator dynamics is implemented, stability problems are likely to occur during the experiment. This paper presents an approach for real-time hybrid simulation in which compensation for actuator dynamics is implemented using a model-based feedforward compensator. The method is used to evaluate the response of a semi-active control of a structure employing an mR damper. Experimental results show good agreement with the predicted responses, demonstrating the effectiveness of the method for structural control performance assessment.

关键词： real-time hybrid simulation mR damper semi-active control actuator dynamics

Label-free detection of single nanoparticles and biological molecules using microtoroid optical resonators

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Light(Science & Applications) 2016年第1期5卷 863-868页

作者： Judith Su Alexander FG Goldberg brian m Stoltz Division of Biology and Biological Engineering California Institute of TechnologyPasadenaCAUSA Divison of Chemistry and Chemical Engineering California Institute of TechnologyPasadenaCAUSA

Single-molecule detection is one of the fundamental challenges of modern *** experiments often use labels that can be expensive,difficult to produce,and for small analytes,might perturb the molecular events being *** size plays an important role in determining *** we use laser-frequency locking in the context of sensing to improve the signal-to-noise ratio of microtoroid optical resonators to the extent that single nanoparticles 2.5 nm in radius,and 15.5 kDa molecules are detected in aqueous solution,thereby bringing these detectors to the size limits needed for detecting the key macromolecules of the *** results,covering several orders of magnitude of particle radius(100 nm to 2 nm),agree with the‘reactive’model prediction for the frequency shift of the resonator upon particle *** confirms that the main contribution of the frequency shift for the resonator upon particle binding is an increase in the effective path length due to part of the evanescent field coupling into the adsorbed *** anticipate that our results will enable many applications,including more sensitive medical diagnostics and fundamental studies of single receptor–ligand and protein–protein interactions in real time.

关键词： biosensing frequency locking label-free microtoroid single molecule

INTRINSIC FLUORESCENCE CHANGES IN NERVE TERmINALS,EVOKED BY ACTION POTENTIALS,ARE mODULATED BY KREBS CYCLE SUBSTRATES

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Journal of Innovative Optical Health Sciences 2011年第2期4卷 209-214页

作者： PAUL KOSTERIN ANA LIA OBAID brian m.SALZBERG Department of Neuroscience University of Pennsylvania School of medicine Philadelphia PA 19104USA Department of Physiology University of Pennsylvania School of medicine Philadelphia PA 19104USA

Electrical stimulation of the mammalian neurohypophysial infundibular stalk evokes the entry of Nat and Ca^(2+) into the neurosecretory terminals during the action *** events,in turn,increase intracellular Ca^(2+) and activate NaK-and Ca-ATPases,prompting the mitochondria to increase oxidative phosphorylation which can be monitored by recording the changes in FAD and *** paper reflects our efforts to determine whether or not modulating the capacity of mitochondria to produce ATP,by changing the concentrations of two important substrates of the Krebs cycle of the nerve terminal mitochondria,pyruvate and glucose,has an effect on the intrinsicfluorescence changes triggered by action potential stimulation.

关键词： Fluorescence FAD NADH action potential metabolism

Adult neurogenesis from reprogrammed astrocytes

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Neural Regeneration Research 2020年第6期15卷 973-979页

作者： brian B.Griffiths Anvee Bhutani Creed m.Stary Department of Anesthesiology Pain & Perioperative Medicine Stanford University School of Medicine

The details of adult neurogenesis,including environmental triggers,region specificity,and species homology remain an area of intense *** or halting age-related cognitive dysfunction,or restoring neurons lost to disease or injury represent just a fraction of potential therapeutic *** neurons can derive from stem cells,pluripotent neural progenitor cells,or non-neuronal glial cells,such as *** must be epigenetically"reprogrammed"to become neurons,which can occur both naturally in vivo,and via artificial exogenous *** neural progenitor cells are localized to a few neurogenic zones in the adult brain,astrocytes populate almost every brain *** this review,we will summarize recent research into neurogenesis that arises from conversion of post-mitotic astrocytes,detail the genetic and epigenetic pathways that regulate this process,and discuss the possible clinical relevance in supplementing stem-cell neurogenic therapies.

关键词： astrocyte brain dedifferentiation development disease glia injury neurogenesis

Quantum photonics: feature introduction

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Photonics Research 2019年第12期7卷 I0001-I0002页

作者： XIAN-mIN JIN m.S.KIm brian J.SmITH School of Physics and Astronomy and State Key Laboratory of Advanced Optical Communication Systems and Networks Shanghai Jiao Tong UniversityShanghai 200240China QOLS Blackett LaboratoryImperial College LondonLondon SW72AZUK Department of Physics and Oregon Center for Optical Molecularand Quantum ScienceUniversity of OregonEugeneOregon 97403USA

Photons,the individual quanta of the light field,are what the science of quantum photonics is dedicatedly *** manipulation and coherent control of photons in quantum photonics enables the exploration of various quantum phenomena of high fundamental *** the meantime,due to the fast speed and a lack of the interaction with the environment,photons are now regarded as a promising platform for the emerging quantum information processing(QIP)***,there is a growing number of works on quantum computing,quantum communication,and quantum metrology that are solidly based on the techniques of quantum photonics.

关键词： quantum coherent enable