检索结果-南通市图书馆

Journal of Cancer Therapy 2013年第3期4卷 797-803页

作者： Dominic E. Sanford Matthew R. Porembka Roheena Z. Panni jonathan B. Mitchem brian A. Belt Stacey M. Plambeck-Suess Goldie Lin David G. DeNardo Ryan C. Fields William G. Hawkins Steven M. Strasberg Craig Lockhart Andrea Wang-Gillam Simon Peter Goedegebuure David C. Linehan Alvin J. Siteman Cancer Center St. Louis USA Department of Medicine School of Medicine Washington University St. Louis USA Department of Surgery School of Medicine Washington University St. Louis USA

Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by abundant granulocytic myeloid-derived suppressor cells (G-MDSC = CD45+/Lin﹣/CD33+/CD11b+/CD15+), which infiltrate tumors and suppress anti-tumor immunity. We have previously demonstrated in a murine model of PDAC that zoledronic acid (ZA) depletes G-MDSC resulting in decreased tumor growth and improved survival. We report here the results of a phase 1 clinical trial (NCT00892242) using ZA as neo-adjuvant, perioperative therapy in patients with non-metastatic, resectable pancreatic adenocarcinoma. Methods: Eligible PDAC patients received ZA (4 mg) IV 2 weeks prior to surgery. Patients then received 2 additional doses of ZA 4 weeks apart. Blood and bone marrow were obtained from patients prior to treatment with ZA and 3 months after surgery for analysis of G-MDSC by flow cytometry. Results: Twenty-three patients received pre-operative ZA with at least 6 months of follow-up. Only 15 PDAC patients had nonmetastatic PDAC, which was amenable to resection. ZA was well tolerated, and all adverse events were grade 1 or 2. The most common adverse events were fatigue, abdominal pain/discomfort, anorexia, and arthralgia. Of resected PDAC patients treated with ZA, 1- and 2-year overall survival (OS) was 85.7% and 33.3%, respectively, with a median OS of 18 months. This group had a 1- and 2-year progression-free survival (PFS) of 26.9% and 8.9%, respectively, with a median PFS of 12 months. The prevalence of G-MDSC was unchanged in the blood and bone marrow of PDAC patients pre- and post-treatment with ZA. Conclusion: ZA is safe and well tolerated as neo-adjuvant, peri-operative therapy in PDAC patients. In this small study, we did not observe a difference in OS or PFS compared to historical controls. Also, there was no difference in the prevalence of G-MDSC in the blood and bone marrow of PDAC patients pre- and post-treatment with ZA.

关键词： Pancreatic Cancer Zoledronic Acid Myeloid-Derived Suppressor Cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

我国海岸带保护存在关键大型野生动物空缺

我国海岸带保护存在关键大型野生动物空缺

REVIEW OF RECENT PROGRESS IN TROPICAL CYCLONE TRACK FORECASTING AND EXPRESSION OF UNCERTAINTIES

第十六届全国野生动物生态与资源保护学术研讨会

作者：李心诚王翰臣 Douglas J.McCauley Andrew H.Altieri brian R.Silliman jonathan S.Lefcheck 吴纪华李博贺强 School of Life Sciences Fudan University Marine Science Institute University of California Santa Barbara Department of Environmental Engineering Sciences University of Florida Nicholas School of the Environment Duke University University of Maryland Center for Environmental Science College of Ecology Lanzhou University School of Ecology and Environmental Science Yunnan University

盐沼、红树林、海草床等海岸带生态系统在渔业资源供给、碳汇等方面具有极高的生态服务功能,但由于地处人口经济高度密集的海岸带区域,人类活动干扰也尤为强烈。保护修复海岸带生态系统对生态文明建设和实现联合国可持续发展目标具有重...

盐沼、红树林、海草床等海岸带生态系统在渔业资源供给、碳汇等方面具有极高的生态服务功能,但由于地处人口经济高度密集的海岸带区域,人类活动干扰也尤为强烈。保护修复海岸带生态系统对生态文明建设和实现联合国可持续发展目标具有重要意义。当前,保护修复海岸带生态系统正在快速推进。虽然大型野生动物往往在调控生态系统结构和功能中发挥关键作用,但海岸带保护修复对大型野生动物的涵括在全球许多国家均仍不明确。本研究以中国为例,系统分析了海岸带大型野生动物的多样性及保护状况。研究首先基于多源数据,构建了我国大陆海岸带大型野生动物数据集,分析了其多样性及在不同类型海岸带生态系统中的分布特征。研究发现,我国盐沼、红树林、海草床、珊瑚礁、河口、近海水域等海岸带生态系统是众多大型野生动物的栖息生境,现存最大体重超过10千克的野生动物218种,超过45千克的野生动物120种,全生活史周期均以海岸带为主要生境的海岸带特有大型野生动物96种。通过分析受胁状况并构建大型野生动物功能多样性区域格局,研究还发现,在上述218种海岸带大型野生动物中,78%的灭绝风险尚未在中国生物多样性红色名录中得到评估,这些大多为海岸带特有物种和海岸带/远洋共有物种;已评估的物种在中国的濒危等级普遍高于世界自然保护联盟(IUCN)红色名录中评定的全球濒危等级;除中华鲟、中华白海豚、儒艮等明星物种外,73%的物种尚未被列入国家重点保护动物名录;超过90%的保护优先生境尚未被纳入我国海岸带/海洋保护地体系。研究进一步提出,纳入大型野生动物将从立法与激励措施、保护地设计与管理、修复工程设计与评估等多个方面提升海岸带生态系统保护修复成效。该研究可为进一步提升我国海岸带海洋生态保护修复提供新思路,也可为昆明-蒙特利尔全球生物多样性框架中海岸带保护与修复目标的实现提供科学支撑。

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Tropical Cyclone Research and Review 2019年第4期8卷 181-218页

作者： Julian T.Heming Fernando Prates Morris A.Bender Rebecca Bowyer John Cangialosi Phillippe Caroff Thomas Coleman James D.Doyle Anumeha Dube Ghislain Faure Jim Fraser brian C.Howell Yohko Igarashi Ron McTaggart-Cowan M.Mohapatra jonathan R.Moskaitis Jim Murtha Rabi Rivett M.Sharma Chris J.Short Amit A.Singh Vijay Tallapragada Helen A.Titley Yi Xiao 不详

The Ninth International Workshop on Tropical Cyclones(IWTC-9) took place in Hawaii, USA in December 2018. This review paper was presented at the Workshop under the Tropical Cyclone Track *** forecasting of tropical cyclone(TC) track has seen significant improvements in recent decades both by numerical weather prediction models and by regional warning centres who issue forecasts having made use of these models and other forecasting techniques. Heming and Goerss(2010) gave an overview of forecasting techniques and models available for TC forecasting, including evidence of the improvement in performance over the years. However, the models and techniques used for TC forecasting have continued to develop in the last decade. This presentation gives an updated overview of many of the numerical weather prediction models and other techniques used for TC track prediction. It includes recent performance statistics both by the models and the regional warning centres.

关键词： Tropical Cyclone World Meteorological Organization Workshop Numerical Models Track Forecasting

儿科日间手术中超重（或肥胖症）与胃液特性的关系：在禁食指南和误吸风险评估方面的意义

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

麻醉与镇痛 2010年第6期6卷 38-49页

作者： Scott D. Cook-Sather Paul R. Gallagher Lydia E. Kruge jonathan M. Beus brian P. Ciampa Kevin Conor Welch Sina Shah-Hosseini Jieun S. Choi Reshma Pachikara Kim Minger Ronald S. Litman Mark S. Schreiner 周洁(译) 李士通(校) Departments of Anesthesiology and Critical Care Medicine Departments of Biostatistics and Epidemiology Nursing The Children's Hospital of Philadelphia The University of Pennsylvania School of Medicine Philadelphia Pennsylvania 不详

背景超重或肥胖的日间手术儿科患者手术前2小时禁水的安全性尚未得到证实。健康的儿童和肥胖的成人在手术前禁水2小时后残留胃液量（GFVs）并不多，因此认为误吸风险并不高。因此我们将测算日间手术患者中超重症或肥胖症的患病率，并假... 详细信息

背景超重或肥胖的日间手术儿科患者手术前2小时禁水的安全性尚未得到证实。健康的儿童和肥胖的成人在手术前禁水2小时后残留胃液量（GFVs）并不多，因此认为误吸风险并不高。因此我们将测算日间手术患者中超重症或肥胖症的患病率，并假设不管是体重指数还是禁食时间均不会对GFV或胃液pH值产生显著的影响。所有受试儿童均于手术前禁清水2小时，并假设超重或肥胖患儿的GFV不会多于偏瘦或正常体重患儿，而呕吐或误吸的风险也很低。方法本研究中连续纳入了1000例2－12岁行日间手术的患儿，记录人口统计学资料、病史、身高和体重。另外纳入1000例需全麻插管的日间手术患儿（2。12岁）进行研究。气管插管后，经口插入一根14—18F的胃管，抽空胃内容物。用药情况、禁食时间、GFV、pH值和呕吐事件均被详细记录。采用疾病预防及控制中心的生长图表（2000）评定理想体重（IBW=第50个百分位数），并对患儿进行分层：偏瘦或正常体重（BMI在第25—75个百分位数）、超重（第95个百分位数〈BMI≥第85个百分位数）、肥胖（BMI≥第95个百分位数）。结果在所有的日间手术患儿中有14％属于超重，13．3％属于肥胖。肥胖儿按公斤体重算出的GFV较低（P〈0．001）。当我们用IBW进行校正后，所有BMI组中GFV（mw校正后）的容量都相等（均值为0．96ml／kg，SD为0．71；中位数为0．86ml／kg，IQR为0．96）。手术前使用对乙酰氨基酚和咪达唑仑均导致GFV（1BW校正后）增加（P=0．025和P=0．001）。而ASA11I级（P=0．024）、男性（P=0．012）、胃食管反流性疾病（P=0．049）和使用质子泵抑制剂（P=0．018）患儿的GFV（mw校正后）较低。GFV（IBw校正后）与禁食时间和年龄无关。胃液酸度较低与年龄较小（P=0．005）、BMI较高（P=0．036）和美国非洲裔（P=0．033）患儿等因素相关。有8例患儿在全麻诱导时发生了呕吐（其中50％有肥胖症，P=0．052，75％患有阻塞性睡眠呼吸暂停症，P=0．061）。呕吐与ASA分级较高有关，但却与禁食时间的长短无关。研究中没有出现误吸事件。结论27％的儿科日闻手术患儿属超重或肥胖儿童。无论进食时间长短或BMI如何，GFV（IBw校正后）均为1ml／kg，因此这些患儿均可以在手术前2小时饮清水。在此研究群体中，罕见的呕吐事件与禁食时间的缩短并无相关性。

关键词：禁食时间儿科患者风险评估肥胖症超重症胃液量误吸阻塞性睡眠呼吸暂停症

局部麻醉药浓度和剂量对持续锁骨下神经阻滞的影响：一项多中心、随机、单盲、对照研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

麻醉与镇痛 2010年第1期6卷 60-66页

作者： brian M. Ilfeld Linda T. Le Joanne Ramjohn Vanessa J. Loland Anupama N. Wadhwa J. C. Gerancher Elizabeth M. Renehan Daniel I. Sessler jonathan J. Shuster Douglas W. Theriaque Rosalita C. Maldonado Edward R. Mariano 周璐璐(译) 包睿(译) 邓小明(校) Department of Anesthesiology University of California San Diego San Diego California Department of Anesthesiology University of Florida Gainesville Florida Department of Anesthesiology University of Louisville Louisville Kentucky Department of Anesthesiology Wake Forest Medical Center Winston-Salem North Carolina Department of Anesthesiology University of Ottawa Ottawa Ontario Canada Department of Outcomes Research Cleveland Clinic Cleveland Ohio Department of Epidemiology and Health Policy Research University of Florida Gainesville Florida General Clinical Research Center University of Florida Gainesville Florida 不详

背景目前尚不明确局部麻醉药浓度或药物总剂量是否是连续外周神经阻滞效果最主要的决定性因素。此前仅有一项关于胭窝坐骨神经阻滞的研究，该研究报道了使用高容量较低浓度罗哌卡因发生肢体感觉完全阻滞的概率远远高于低容量较高浓度罗... 详细信息

背景目前尚不明确局部麻醉药浓度或药物总剂量是否是连续外周神经阻滞效果最主要的决定性因素。此前仅有一项关于胭窝坐骨神经阻滞的研究，该研究报道了使用高容量较低浓度罗哌卡因发生肢体感觉完全阻滞的概率远远高于低容量较高浓度罗哌卡因，但上述现象是否仅限于腘窝处的坐骨神经，或者说是否因解剖部位变化而异尚不清楚。因此，本研究的检验假设定为：在连续锁骨下臂丛阻滞中，以不同的浓度和速率注射总量相等的罗哌卡因，可以产生相似的阻滞效果。方法选择拟行肘关节远端、中等疼痛骨科手术患者，经喙突入路放置锁骨下臂丛阻滞导管。患者经随机分组确定手术后第2天应用罗哌卡因神经周围镇痛的方法：浓度0．2％组（背景剂量8ml／h，单次追加量4ml）或0．4％组（背景剂量4ml／h，单次追加量2ml）。两组患者每小时持续注入罗哌卡因的总量均为16mg，每30分钟可能还有患者自控的追加剂量8mg。主要观察指标为自手术后次日早晨开始的24小时内患侧肢体完全无感觉的发生率，次要观察指标是镇痛效果和患者的满意度。结果给予0．4％罗哌卡因（n=27）的患者发生肢体无感觉的平均次数（标准差）为1．8（1．6）次，而给予0．2％罗哌卡因（n=23）的患者为0．6（0．9），评估差异为1．2次，95％可信区间0．5～1．9次（P=0．001）。手术后镇痛满意度（评分0—10分，10分为最高分）在0．2％罗哌卡因组得分的中位数（25％～75％百分位数）为10．0分（8．0～10．0），0．4％罗哌卡因组为7．0分（5．3～8．9）。镇痛效果两组相近。结论在连续锁骨下神经阻滞时，除了注射局麻药物总量之外，药物的浓度和容量是另两种影响神经周围镇痛辫果的因素。容量偏小而浓度略高的罗哌卡因产生肢体完全无感觉的概率较高，这一结果与此前关于连续胭窝坐骨神经阻滞的研究结果相反。局麻药浓度与容量之间的关系相当复杂，且随置管部位的不同而异。

关键词：坐骨神经阻滞麻醉药浓度背景剂量随机分组锁骨下低浓度罗哌卡因多中心手术后镇痛

Nat Genet:单基因突变导致过敏性皮炎的发生

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

现代生物医学进展 2017年第27期17卷 I0004-I0004页

作者： Chi A Ma, Yuan Zhang, Michael A Weinreich, jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, jonathan Zaiat, Marcelo A Marti brian Kim Megan A Cooper Neil Romberg Laboratory of Allergic Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland USA Department of Pharmacology and Molecular Therapeutics Uniformed Services University of the Health Sciences Bethesda Maryland USA Immunodeficiency Diagnosis and Treatment Program Department of Pediatrics National Jewish Health Denver Colorado USA Department of Translational Medicine University of Piemonte Orientale Novara Italy Department of Immunobiology Yale University School of Medicine New Haven Connecticut USA Immunology Service Department of Laboratory Medicine NIH Clinical Center National Institutes of Health Bethesda Maryland USA Human Immunological Disease Section National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland USA Merck Research Laboratories Merck and Co. Inc. Boston Massachusetts USA Clinical Research Directorate/Clinical Monitoring Research Program Leidos Biomedical Research Inc. NCI Campus at Frederick Frederick Maryland USA Servicio de Immunología y Reumatología Hospital Nacional de Pediatría Prof. Dr. Juan P. Garrahan Buenos Aires Argentina Division of Dermatology Department of Medicine Washington University School of Medicine St. Louis Missouri USA Department of Pediatrics Division of Rheumatology and Department of Pathology and Immunology Washington University School of Medicine St. Louis Missouri USA Department of Pediatrics Children’s Hospital of Philadelphia Philadelphia Pennsylvania USA.

最近，研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变：CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析，发现了这一导致疾病产生的基因、

关键词：过敏性皮炎基因突变 Nat 神经性皮炎血缘关系研究所传染病 NIH

Nature:研究利用单细胞分析阐明癌症干细胞在脑癌中的关键角色

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

现代生物医学进展 2017年第6期17卷 I0003-I0003页

作者： Itay Tirosh, Andrew S. Venteicher, Christine Hebert, Leah E. Escalante, Keren Yizhak, jonathan M. Fisher, Christopher Rodman, Mariella G. Filbin, Cyril Neftel, Jackson Nyman, Benjamin Izar, Joshua M. Francis, Kenneth J. Livak, Dave Gennert, Rahul Satija, Todd R. Golub, Miguel N. Rivera, Gad Getz, Orit Rozenblatt-Rosen, Bradley E. Bernstein, Aviv Regev Mario L. Suv agrave Andrew S. Venteicher, Christine Hebert, Leah E. Escalante, Keren Yizhak, Mariella G. Filbin, Cyril Neftel, Niyati Desai, Christina C. Luo, Aanand A. Patel, Maristela L. Onozato, Nicolo Riggi, Ravindra Mylvaganam, A. John Iafrate, Matthew P. Frosch, Miguel N. Rivera, Gad Getz, Bradley E. Bernstein, David N. Louis Mario L. Suv agrave Andrew S. Venteicher, Anoop P. Patel, brian V. Nahed, William T. Curry, Robert L. Martuza Daniel P. Cahill Christopher Mount Michelle Monje Mariella G. Filbin Todd R. Golub Joshua M. Francis Todd R. Golub Aviv Regev Broad Institute of Harvard and MIT Cambridge Massachusetts 02142 USA Department of Pathology and Center for Cancer Research Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Department of Neurosurgery Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Departments of Neurology Neurosurgery Pediatrics and Pathology Stanford University School of Medicine Stanford California 94305 USA Department of Pediatric Oncology Dana-Farber Cancer Institute and Children’s Hospital Cancer Center Boston Massachusetts 02215 USA Department of Medical Oncology Dana-Farber Cancer Institute Boston Massachusetts 02215 USA Howard Hughes Medical Institute Koch Institute Department of Biology MIT Cambridge Massachusetts 02139 USA

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研... 详细信息

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研究刊登于Nature杂志上。同时研究者还首次在人类脑瘤样本中鉴别出了癌症干细胞及其分化的后代细胞。

关键词：干细胞单细胞分析癌症脑瘤神经胶质瘤键角利用研究人员