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Insight into the effects of electrochemical factors on host-guest interaction induced signature events in a biological nanopore

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纳米技术与精密工程（英文） 2020年第1期3卷 2-8页

作者： XiaojunWei Zehui Zhang XiaoqinWang brian Lenhart Roberto Gambarini jonathan Gray Chang Liu Biomedical Engineering Program University of South CarolinaColumbiaSC 29208USA Department of Chemical Engineering University of South CarolinaColumbiaSC 29208USA

The signature events caused by host-guest interactions in the nanopore system can be used as a novel and characteristic signal in quantitative detection and analysis of various ***,the effect of several electrochemical factors on the host-guest interactions in nanopore still remains ***,we systematically studied host-guest interactions,especially oscillation of DNA-azide adamantane@cucurbit[6]inα-Hemolysin nanopore under varying pH,concentration of electrolytes and counterions(Li+,Na+,K+).Our results indicate correlations between the change of pH and the duration of the oscillation *** addition,the asymmetric electrolyte concentration and the charge of the counterions affects the frequency of signature events in oscillation signals,and even the integrity of the protein *** study provides insight into the design of a future biosensing platform based on signature oscillation signals of the host-guest interaction within a nanopore.

关键词： Nanopore Host-guest interaction Biosensors Electrochemistry

Is thirty-seven years sufficient for full return of the ant biota following restoration?

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Ecological Processes 2013年第1期2卷 183-194页

作者： jonathan D Majer brian Heterick Thomas Gohr Elliot Hughes Lewis Mounsher Andrew Grigg Curtin Institute for Biodiversity and Climate Curtin UniversityPO Box U1987PerthWA 6845Australia Alcoa of Australia Ltd PO Box 172PinjarraWA 6208Australia

Introduction:An assessment of whether rehabilitated mine sites have resulted in natural or novel ecosystems requires monitoring over considerable periods of time or the use of space-for-time substitution(chronosequence)***:To provide an assessment of ecosystem recovery in areas mined for bauxite in 1975,the ant fauna of one area planted with Eucalyptus resinifera,one seeded with mixed native species,one topsoiled but unrestored,and a forest reference was subjected to a‘long-term’study by sampling monthly and latterly annually between 1976 and 1989 using pitfall *** plots were resampled in 2012.A companion‘short-term’chronosequence study was performed in 1979 in 28 bauxite mines of various ages and restored by a range of different methods,plus three forest *** order to examine the assertion that the observed differences between restored areas and forest references will lessen with time,sampling using comparable methods was repeated in 2012 in seven of the original plots,representing progressive advances in rehabilitation technology:planted pines;planted eastern states eucalypts;planted native eucalypts;planted eucalypts over seeded understorey;and planted eucalypts on fresh,double-stripped topsoil,plus two forest reference ***:Ant and other invertebrate richness in the long-term study was initially superior in the seeded plot,with little difference between the planted and unplanted *** was concluded that although composition of the ant fauna had converged on that of the forest over the 14-year period,differences still *** 2012 resampling revealed that ant species richness and composition had deteriorated in the seeded plot,while values in the unplanted plot,which now supported naturally colonised trees and an understorey,had *** between all rehabilitated plots and forest still *** with the long-term study,the rate of fauna return and the type of ants present in the short-term study p

关键词： Bauxite mining Ant bioindicator Long-term study Chronosequence Seeding Planting Succession

Chronic Cholestatic Liver Injury Attributable to Vedolizumab

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Journal of Clinical and Translational Hepatology 2016年第3期4卷 277-280页

作者： jonathan G.Stine Jennifer Wang brian W.Behm Division of Gastroenterology & Hepatology Department of Medicine University of Virginia Charlottesville VA USA Department of Medicine University of Virginia Charlottesville VA USA

Drug-induced liver injury is a rare but clinically important *** is an α4β7 integrin inhibitor recently approved for use in patients with moderate-to-severe inflammatory bowel *** of hepatoxicity due to vedolizumab in the pre-marketing stage were rare,and all cases resolved upon drug *** present here the first reported case of hepatotoxicity attributable to vedolizumab,which despite drug cessation persisted with chronic cholestatic liver injury.

关键词： Hepatotoxicity Integrin inhibitor Primary sclerosing cholangitis Inflammatory bowel disease

When should we give up on expectant management for patients with proximal ureteral stones?

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Causal Analysis of User Search Query Intent

当代泌尿学（英文） 2022年第1期16卷 9-14页

作者： Igal Shpunt Etay Elbaz Yuval Avda jonathan Modai Dan Leibovici brian Berkowitz Yaniv Shilo Department of Urology Kaplan Medical CenterRehovotIsrael Department of Earth and Planetary Sciences Weizmann Institute of ScienceRehovotIsrael

Background:Proximal ureteral stones(PUS)have relatively low rates of spontaneous ***,some patients do on expectant *** aim was to compare risk factors for surgical intervention in patients with PUS who underwent primary intervention to those subjected to expectant management.Materials and methods:We retrospectively reviewed the medical charts of patients presented to the emergency room with symptoms of renal colic and underwent computerized tomography between August 2016 and August 2017.A total of 97 consecutive patients were identified with up to 10 mm *** collected patient demographics,clinical,and imaging data,and performed binary regression analysis for risk of intervention.Results:The average age was 49years(range 17-97)and average stone size was 7.1 mm(range 3-10).Forty-one patients underwent immediate intervention while the remaining 56 patients were treated *** the 56 patients treated conservatively,26 underwent delayed intervention while 30 reported spontaneous stone *** univariate analysis of all 97 patients,statistically significant risk factors for intervention were found based on stone size,age,serum lymphocyte,platelet counts,and stone *** these risk factors,stone size≥7mm(p=0.012,odds ratio=5.4)and platelet count?230K/mL(p=0.027,odds ratio=4.9)remained statistically significant on multivariate analysis.Conclusion:Stone size and platelet count were found to be risk factors for surgical intervention in patients with up to 10 mm *** findings may assist in identifying patients who are more suitable for conservative approach.

关键词： Nephrolithiasis Renal colic Ureteral calculi Ureterolithiasis Urolithiasis

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Journal of Computer and Communications 2016年第14期4卷 108-131页

作者： Gahangir Hossain James Haarbauer jonathan Abdo brian King Electrical Engineering and Computer Science Texas A & M University-Kingsville Kingsville TX USA Electrical and Computer Engineering Indiana University-Purdue University Indianapolis Indianapolis IN USA

We investigated the application of Causal Bayesian Networks (CBNs) to large data sets in order to predict user intent via internet search prediction. Here, sample data are taken from search engine logs (Excite, Altavista, and Alltheweb). These logs are parsed and sorted in order to create a data structure that was used to build a CBN. This network is used to predict the next term or terms that the user may be about to search (type). We looked at the application of CBNs, compared with Naive Bays and Bays Net classifiers on very large datasets. To simulate our proposed results, we took a small sample of search data logs to predict intentional query typing. Additionally, problems that arise with the use of such a data structure are addressed individually along with the solutions used and their prediction accuracy and sensitivity.

关键词： Causal Bayesian Networks (CBNs) Query Search Intervention Reasoning Inference Mechanisms Prediction Methods

使用HTML、CSS和JavaScript开发Android程序

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Risk assessment of venous thromboembolism in inflammatory bowel disease by inherited risk in a population-based incident cohort

作者： jonathan Stark brian Jepson

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World Journal of Gastroenterology 2023年第39期29卷 5494-5502页

作者： Andrew S Rifkin Zhuqing Shi Jun Wei Siqun Lilly Zheng brian T Helfand jonathan S Cordova Vincent F Biank Alfonso J Tafur Omar Khan Jianfeng Xu Program for Personalized Cancer Care NorthShore University HealthSystemEvanstonIL 60201United States Department of Surgery NorthShore University HealthSystemEvanstonIL 60201United States Pritzker School of Medicine University of ChicagoChicagoIL 60637United States Department of Pediatrics NorthShore University HealthSystemEvanstonIL 60201United States Cardiovascular Institute NorthShore University HealthSystemEvanstonIL 60201United States Department of Medicine NorthShore University HealthSystemEvanstonIL 60201United States

Inflammatory bowel disease(IBD),including Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory disease of the digestive tract with increasing prevalence *** venous thromboembolism(VTE)is a major complication in IBD patients,it is often underappreciated with limited tools for risk *** To estimate the proportion of VTE among IBD patients and assess genetic risk factors(monogenic and polygenic)for *** Incident VTE was followed for 8465 IBD patients in the UK Biobank(UKB).The associations of VTE with F5 factor V leiden(FVL)mutation,F2 G20210A prothrombin gene mutation(PGM),and polygenic score(PGS003332)were tested using Cox hazards regression analysis,adjusting for age at IBD diagnosis,gender,and genetic background(top 10 principal components).The performance of genetic risk factors for discriminating VTE diagnosis was estimated using the area under the receiver operating characteristic curve(AUC).RESULTS The overall proportion of incident VTE was 4.70%in IBD patients and was similar for CD(4.46%),UC(4.49%),and unclassified(6.42%),and comparable to that of cancer patients(4.66%)who are well-known at increased risk for *** carriers of F5/F2 had a significantly increased risk for VTE compared to non-mutation carriers,hazard ratio(HR)was 1.94,95%confidence interval(CI):*** contrast,patients with the top PGS decile had a considerably higher risk for VTE compared to those with intermediate scores(middle 8 deciles),HR was 2.06(95%CI:1.57-2.71).The AUC for differentiating VTE diagnosis was 0.64(95%CI:0.61-0.67),0.68(95%CI:0.66-0.71),and 0.69(95%CI:0.66-0.71),respectively,for F5/F2 mutation carriers,PGS,and *** Similar to cancer patients,VTE complications are common in IBD *** provides more informative risk information than F5/F2 mutations(FVL and PGM)for personalized thromboprophylaxis.

关键词： Inflammatory bowel disease Venous thromboembolism Polygenic score Factor V leiden Prothrombin gene mutation

Rem蛋白表达对胚胎心室肌细胞Ca^(2+)通道功能的影响

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临床心血管病杂志 2006年第2期22卷 97-99页

作者：魏毅东魏经汉 brian Finlin Douglas Andres jonathan Satin 美国肯塔基大学Chandler医院郑州大学第一附属医院心内科

目的:研究RGK家族中Rem微小蛋白对胚胎小白鼠心室肌细胞Ca^(2+)通道功能的影响。方法:用含有相同浓度正常的Rem(Ad-RemWT)和反转的Rem蛋白(Ad-CTRrem)的两组重组腺病毒(1012/ml)分别感染培养的怀孕18d胚胎小白鼠(ED18)心室肌细胞。12h后... 详细信息

目的:研究RGK家族中Rem微小蛋白对胚胎小白鼠心室肌细胞Ca^(2+)通道功能的影响。方法:用含有相同浓度正常的Rem(Ad-RemWT)和反转的Rem蛋白(Ad-CTRrem)的两组重组腺病毒(1012/ml)分别感染培养的怀孕18d胚胎小白鼠(ED18)心室肌细胞。12h后,用整个细胞的电压嵌技术来记录ED18心室肌细胞膜L-型Ca^(2+)电流,细胞质Ca^(2+)转运用荧光光度测定法测定。结果:Rem可以很好地在ED18心室肌细胞中表达。在整个细胞的电压嵌技术下,对照组(Ad-CTRrem)能记录到L-型Ca^(2+)电流的细胞为83·3%,实验组(Ad-Rem-WT)为6·6%。Rem有效阻断了ED18心室肌细胞膜Ca^(2+)通道电流。通过荧光光度测定法,测定Rem显著减低了ED18心室肌细胞质Ca^(2+)的转运。结论:外源的RGK家族中Rem蛋白的表达,通过与心室肌细胞Ca^(2+)通道蛋白的β亚单位(Cavβ)相结合改变了Ca^(2+)通道功能,限制了Ca^(2+)的内流。

关键词： Rem蛋白心肌钙通道

The Practice of Physical Medicine and Rehabilitation in subSaharan Africa and Antarctica：A White Paper or a Black Mark？

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中国康复医学杂志 2009年第5期24卷 385-389页

作者： Andrew J. Haig MD jonathan Im Ayodeji Adewole, MD Virgina S. Nelson, MD, M.P.H brian Krabak, MD, M.B.A. Department of Physical Medicine and Rehabilitation University of Michigan Ann Arbor Michigan USA. College of Liberal Arts and Sciences Wayne State University Detroit Michigan USA. SOS International Accra Ghana. Department of Physical Medicine and Rehabilitation University of Michigan Ann Arbor Michigan USA. Department of Rehabilitation Medicine University of WashingtonSeattle Washington USA.

Objective:To explore the practice of PM&R in subSaharan Africa and ***:Medline searches,membership data searches,fax survey of medical schools,Internet searches,and interviews with ***:The continents are dissimilar in terms of climate and *** both Antarctica and subSaharan Africa have no PM&R training programs,no professional organizations,no specialty board requirements,and no practicing physicians in the *** there is no known disabled child on Antarctica and adults are airlifted to world-class health care,the consequences of this deficit are minimal *** the 788,000,000 permanent residents of subSaharan Africa including approximately 78 million persons with disability are left ***:Antarctica is doing *** is in a *** medical schools,hospitals doctors,and persons with disability;along with foreign volunteers,aid groups,and policymakers can impact the *** government-specifically national ministries of health-is ultimately responsible for the health and wellbeing of citizens.

关键词：体格检查医学文献资料因特网