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国际医学放射学杂志 2023年第3期 359-360页

作者： W.Kim h.Shin h.lee D.Park J.Kang Y.Nam 王超

摘要使用χ分离成像可以提供与多发性硬化（MS）病变异常变化密切相关的铁和髓鞘检测的一种补充手段。目的评估MS和视神经脊髓炎谱系病（NMOSD）脑病变在χ-分

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h∞ synchronization of chaotic neural networks with time-varying delays

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Chinese Physics B 2013年第11期22卷 244-252页

作者： O. M. Kwon M. J. Park Ju h. Park S. M. lee E. J. Cha School of Electrical Engineering Chungbuk National University Department of Electrical Engineering Yeungnam University School of Electronic Engineering Daegu University Department of Biomedical Engineering School of Medicine Chungbuk National University

In this paper, we investigate the problem of h∞ synchronization for chaotic neural networks with time-varying delays. A new model of the networks with disturbances in both master and slave systems is presented. By constructing a suitable Lyapunov–Krasovskii functional and using a reciprocally convex approach, a novel h∞ synchronization criterion for the networks concerned is established in terms of linear matrix inequalities （LMIs） which can be easily solved by various effective optimization algorithms. Two numerical examples are given to illustrate the effectiveness of the proposed method.

关键词： chaotic neural networks time-varying delays h∞ synchronization Lyapunov method

State-of-the-Art management of knee osteoarthritis

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World Journal of Clinical Cases 2015年第2期3卷 89-101页

作者： Kenton h Fibel howard J hillstrom brian C halpern Department of Medicine Primary Care Sports MedicineHospital for Special Surgery Leon Root Motion Analysis Laboratory Department of RehabilitationHospital for Special Surgery

Osteoarthritis(OA) is the most common type of arthritis found in the United States' population and is also the most common disease of joints in adults throughout the world with the knee being the most frequently affected of all joints. As the United States' population ages along with the increasing trends in obesity prevalence in other parts of the world, it is expected that the burden of OA on the population, healthcare system, and overall economy will continue to increase in the future without making major improvements in managing knee OA. Numerous therapies aim to reduce symptoms of knee OA and continued research has helped to further understand the complex pathophysiology of its disease mechanism attempting to uncover new potential targets for the treatment of OA. This review article seeks to evaluate the current practices for managing knee OA and discusses emerging therapies on the horizon. These practices include non-pharmacological treatments such as providing patient education and self-management strategies, advising weight loss, strengthening programs, and addressing biomechanical issues with bracing or foot orthoses. Oral analgesics and anti-inflammatories are pharmacologicals that are commonly used and the literature overall supports that some of these medications can be helpful for managing knee OA in the short-term but are less effective for long-term management. Additionally, more prolonged use significantly increases the risk of serious associated side effects that are not too uncommon. Diseasemodifying osteoarthritis drugs are being researched as a treatment modality to potentially halt or slow disease progression but data at this time is limited and continued studies are being conducted to further investigate their effectiveness. Intra-articular injectables are also implemented to manage knee OA ranging from corticosteroids to hyaluronans to more recently plateletrich plasma and even stem cells while several other injection therapies are presently b

关键词： Disease-modifying osteoarthritis drugs Knee osteoarthritis Disease-modifying osteoarthritis drugs Osteoarthritis management Non-steroidal antiinflammatory drugs hyaluronic acid Arthroscopy Platelet-rich plasma Corticosteroids Stem cells

Practical Considerations and Limitations of Using Leaf and Canopy Temperature Measurements as a Stomatal Conductance Proxy:Sensitivity across Environmental Conditions,Scale,and Sample Size

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Plant Phenomics 2024年第2期6卷 416-432页

作者： Ismael K.Mayanja Christine h.Diepenbrock Vincent Vadez Tong Lei brian N.Bailey Department of Biological Systems Engineering University of CaliforniaDavisDavisCAUSA Department of Plant Sciences University of CaliforniaDavisDavisCAUSA French National Research Institute for Sustainable Development(IRD) UMR DIADEUniversity of MontpellierMontpellierFrance

Stomatal conductance(gs)is a crucial component of plant physiology,as it links plant productivity and water loss through *** gs indirectly through leaf temperature(Tl)measurement is common for reducing the high labor cost associated with direct gs ***,the relationship between observed Tl and gs can be notably affected by local environmental conditions,canopy structure,measurement scale,sample size,and gs itself.

关键词： environmental temperature conditions canopy sample proxy scale leaf across conductance

h3K36me2 is highly correlated with m6A modifications in plants

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Journal of Integrative Plant Biology 2020年第10期62卷 1455-1460页

作者： Sangrea Shim hong Gil lee hongwoo lee Pil Joon Seo Department of Chemistry Seoul National UniversitySeoul08826Republic of Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul08826Republic of Korea

Various chemical modifications at the nucleosome,including DNA methylation,histone h3 acetylation(h3Ac),and histone h3 mono-/di-/trimethylation at various lysine residues(h3K4me3,h3K9me1/me2,h3K27me3,and h3K36me2/me3),underlie the delicate control of chromatin architecture(Ramirez-Prado et al.2018).These modifications influence gene ex-pression by changing the accessibility of chromatin by RNA PolⅡand chromatin-binding proteins,under-pinning the importance of chromatin landscape in gene regulation(Malapeira et al.2012).

关键词： al. landscape modification

Biliary endoscopy in the management of primary sclerosing cholangitis and its complications

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Liver Research 2019年第2期3卷 106-117页

作者： brian M.Fung James h.Tabibian University of California Los Angeles-Olive View Internal Medicine Residency Program SylmarCAUSA Division of Gastroenterology Department of MedicineOlive View-University of California Los Angeles Medical CenterSylmarCAUSA

Primary sclerosing cholangitis(PSC)is a chronic,idiopathic,cholestatic liver disease characterized by inflammation and fibrosis of the intrahepatic and/or extrahepatic bile *** can affect individuals of all age groups and gender,has no established pharmacotherapy,and is associated with a variety of neoplastic(***)and non-neoplastic(*** strictures)hepatobiliary *** these considerations,endoscopy plays a major role in the care of patients with *** this review,we discuss and provide updates regarding endoscopic considerations in the management of hepatobiliary manifestations and complications of *** evidence is limited,we suggest pragmatic approaches based on currently available data and expert opinion.

关键词： Primary sclerosing cholangitis(PSC) Biliary tract disease Balloon dilation Cholangioscopy Dominant stricture Cholangiocarcinoma(CCA) Endoscopic retrograde cholangiopancreatography(ERCP)

Phase Formation and Magnetic Properties of Nanocomposite Nd-Fe-B Adjusted by Small Amount of Dy and Co

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Journal of Rare Earths 2004年第z2期22卷 89-94页

作者： T S Jang T W Lim h S Aum D h.lee M B Kim Division of Materials and Chemical Engineering Sun Moon UniversityKorea Division of Materials and Chemical EngineeringSun Moon UniversityKorea Division of Mechanical EngineeringSun Moon University 100 Kalsan LiTangjung MyonAsan CityChoongnam 336-708Korea Division of Materials and Chemical EngineeringSun Moon UniversityKorea Division of Materials and Chemical EngineeringSun Moon UniversityKorea

In order to improve and stabilize the magnetic properties of nanocomposite Nd2Fe14B/α-Fe magnetic alloys by a compositional adjustment, small amount of Dy and/or Co was added to Nd9Fe84B7 alloys. DTA analysis on the amorphous of the alloys took place as the soft magnetic phases were crystallized, and then the hard magnetic Nd2Fe14B was precipitated from them. While α-Fe and a metastable 1:7 (TbCu7-type) phase were formed simultaneously in Dy and Co-free alloys, they were crystallized separately at different temperatures after Dy or Co was added. This phase separation occurred more clearly in the Dy-treated alloys and the other soft magnetic phase Fe3B was also stabilized by Dy and/or Co. The 1: 7 phase that was stabilized by Dy and/or Co was not eliminated at 700 ℃, decreasing magnetic properties of the alloys. It was eventually disappeared above 725 ℃, but Fe3B was not eliminated even at 750 ℃ when Dy was added more than 0.5 at% or Co was added more than 2.0 at%. Amount of Nd2Fe14B in the alloys tended to increase as Dy addition increased,whereas Co addition did not lead to any appreciable change in the ratio of α-Fe and Nd2Fe14B. Moreover, Dy addition apparently increased coercivity of an alloy while Co addition had a beneficial effect on remanence. The grains in the Dytreated alloys were usually finer than those in the Co-treated alloys. The grain size of both α-Fe and Nd2Fe14B in the alloys exhibiting mr ≥ 0.72 was in the range of 20 ～ 40 nm or even larger 50 nm, which is larger than the theoretical optimum size ( ～ 10 nm). Typical magnetic properties obtained from a Nd7.5Dy1.5Fe82.5Co1.5B7 alloy annealed for 12 min at 725 ℃were ihc=4.85 kOe, Br= 11.32 kG, (Bh)max = 15.73 MGOe, and mr=0.73.

关键词： nanocomposite Nd-Fe-B magnetic properties remanence coercivity

Macrophage depletion and Schwann cell transplantation reduce cyst size after rat contusive spinal cord injury

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Neural Regeneration Research 2018年第4期13卷 684-691页

作者： Yee-Shuan lee Lucy h.Funk Jae K.lee Mary Bartlett Bunge The Miami Project to Cure Paralysis University of Miami Miller School of Medicine Department of Neurological Surgery University of Miami Miller School of Medicine Department of Cell Biology University of Miami Miller School of Medicine

Schwann cell transplantation is a promising therapy for the treatment of spinal cord injury（SCI） and is currently in clinical *** our continuing efforts to improve Schwann cell transplantation strategies,we sought to determine the combined effects of Schwann cell transplantation with macrophage *** macrophages are major inflammatory contributors to the acute spinal cord injury,and are the major phagocytic cells,we hypothesized that transplanting Schwann cells after macrophage depletion will improve cell survival and integration with host tissue after *** test this hypothesis,rat models of contusive SCI at thoracic level 8 were randomly subjected to macrophage depletion or *** rat subjected to macrophage depletion,liposomes filled with clodronate were intraperitoneally injected at 1,3,6,11,and 18 days post *** not subjected to macrophage depletion were intraperitoneally injected with liposomes filled with phosphate buffered *** cells were transplanted 1 week post injury in all *** dextran amine（BDA） was injected at thoracic level 5 to evalute axon *** Basso,Beattie,and Bresnahan locomotor test,Gridwalk test,and sensory test using von Frey filaments were performed to assess functional *** was used to detect glial fibrillary acidic protein,neurofilament,and green fluorescent protein（GFP）,and also to visulize BDA-labelled *** GFP labeled Schwann cell and cyst and lesion volumes were quantified using stained *** numbers of BDA-positive axons were also *** 8 weeks after Schwann cell transplantation,there was a significant reduction in cyst and lesion volumes in the combined treatment group compared to Schwann cell transplantation *** changes were not associated,however,with improved Schwann cell survival,axon growth,or locomotor *** combining Schwann cell transplantation with macrophage depletion does improve histopathology of the in

关键词： Schwann cell Iiposome clodrosome clodronate axon regeneration Schwann cell survival neuroprotection glial scar cyst cell transplantation

Is endoscopic ultrasound examination necessary in the management of esophageal cancer?

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World Journal of Gastroenterology 2017年第5期23卷 751-762页

作者： Tomas DaVee Jaffer A Ajani Jeffrey h.lee Department of Gastroenterology Hepatology and NutritionDivision of Internal MedicineThe University of Texas MD Anderson Cancer Center Department of Gastrointestinal Medical Oncology Division of Cancer MedicineThe University of Texas MD Anderson Cancer Center

Despite substantial efforts at early diagnosis, accurate staging and advanced treatments, esophageal cancer(EC) continues to be an ominous disease worldwide. Risk factors for esophageal carcinomas include obesity, gastroesophageal reflux disease, hard-alcohol use and tobacco smoking. Five-year survival rates have improved from 5% to 20% since the 1970 s, the result of advances in diagnostic staging and treatment. As the most sensitive test for locoregional staging of EC, endoscopic ultrasound(EUS) influences the development of an optimal oncologic treatment plan for a significant minority of patients with early cancers, which appropriately balances the risks and benefits of surgery, chemotherapy and radiation. EUS is costly, and may not be available at all centers. Thus, the yield of EUS needs to be thoughtfully considered for each patient. Localized intramucosal cancers occasionally require endoscopic resection(ER) for histologic staging or treatment; EUS evaluation may detect suspicious lymph nodes prior to exposing the patient to the risks of ER. Although positron emission tomography(PET) has been increasingly utilized in staging EC, it may be unnecessary for clinical staging of early, localized EC and carries the risk of false-positive metastasis(over staging). In EC patients with evidence of advanced disease, EUS or PET may be used to define the radiotherapy field. Multimodality staging with EUS, crosssectional imaging and histopathologic analysis of ER, remains the standard-of-care in the evaluation of early esophageal cancers. herein, published data regarding use of EUS for intramucosal, local, regional and metastatic esophageal cancers are reviewed. An algorithm to illustrate the current use of EUS at The University of Texas MD Anderson Cancer Center is presented.

关键词： Esophageal squamous cell carcinoma Endosonography Echoendoscope Esophagus cancer Esophageal adenocarcinoma

Computational Analysis of a Variable Ejector Flow

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Journal of Thermal Science 2006年第2期15卷 140-144页

作者： h.D. KIM J.h. lee T. SETOGUChI S.MATSUO School of Mechanical Engineering Andong National University 388 Songchun-dong Andong 760-749 Korea Department of Mechanical Engineering Saga University 1 Honjo Saga 840-8502 Japan

The present study addresses a variable ejector which can improve the ejector efficiency and control the re-circulation ratio under a fixed operating pressure ratio. The variable ejector is a facility to obtain specific recirculation ratio under a given operating pressure ratio by varying the ejector throat area ratio. The numerical simulations are carried out to provide an understanding of the flow characteristics inside the variable ejector. The sonic and supersonic nozzles are adopted as primary driving nozzles in the ejector system, and a movable cone cylinder, inserted into a conventional ejector-diffuser system, is used to change the ejector throat area ratio. The numerical simulations are based on a fully implicit finite volume scheme of the compressible, Reynolds-Averaged Navier-Stokes equations. The results show that the variable ejector can control the recirculation ratio at a fixed operating pressure ratio.

关键词： variable ejector ejector throat area ratio re-circulation ratio