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Growth.factors for th.rapeutic angiogenesis in h.perch.lesterolemic erectile dysfunction

Asian Journal of Andrology 2008年第1期10卷 23-27页

作者： Dongh.a Xie brian h. annex Craig F. Donatucci Division of Cardiovascular Medicine and Department of Medicine Duke University Medical Center Durham NC 27710 USA Division of Cardiology and Department of Medicine Duke University Medical Center Durham NC 27710 USA Division of Urology Department of Surgery Duke University Medical Center Durham NC 27710 USA

Th. past decade h.s seen an explosion of new information on th. ph.siology of penile erection, and path.ph.siology of erectile dysfunction （ED）. h.perch.lesterolemia is a ch.onic condition th.t can lead to degeneration in th. vasculature bed and can result in ED if th. penile vasculature is involved. Angiogenesis is th. growth.of new blood vessels from preexisting vasculature. Th.rapeutic angiogenesis seeks to h.rness th. mech.nisms of vascular growth.to treat disorders of inadequate tissue perfusion, such.as coronary artery disease and ED. Th.re h.ve been tremendous ch.nges in th. field of th.rapeutic angiogenesis over th. past decade, and th.re is much.promise for th. future. Initial preclinical work with.cytokine growth.factor delivery resulted in a great deal of enth.siasm for th. treatment of isch.mic h.art and/or periph.ral vascular disease, th.ugh.clinical studies h.ve not ach.eved similar success. With.an increased understanding of th. complex mech.nisms involved in angiogenesis, novel th.rapies wh.ch.target multiple different angiogenic path.ays are also being developed and tested. Th. penis is a convenient tissue target for gene th.rapy because of its external location and accessibility, th. ubiquity of endoth.lial lined spaces, and low level of blood flow, especially in th. flaccid state. Th.rapeutic angiogenesis is an exciting field th.t continues to evolve. Th.s review will focus on th. development of growth.factors for h.perch.lesterolemic ED, th. use of various growth.factors for ED th.rapy, th.ir routes of delivery, and th. results in animal studies.

关键词： erectile dysfunction h.perch.lesterolemia angiogenic growth.factors nitric oxide synth.se

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IMPAIRED ANGIOGENESIS FOLLOWING h.ND-LIMB ISCh.MIA IN DIABETES MELLITUS MICE

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Ch.nese Medical Sciences Journal 2007年第4期22卷 232-237页

作者： Yong-jun Li h.ng Guan Surovi h.zarika Ch.ng-wei Liu Brain h.annex Department of Vascular Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Division of Cardiology Department of Medicine Durham VA and Duke University Medical Center Durham North Carolina 27710 USA

Objective To investigate vascular endoth.lial growth.factor(VEGF) and its signaling path.ay spontaneous response in type 2 diabetes mellitus(T2DM) mice to surgery-induced h.nd-limb *** Sixty mice were randomly divided into two groups,one was fed with.normal ch.w as control,and anoth.r was fed with.h.gh.fat diet to induce *** weeks later,mice were surgically induced to h.nd-limb *** flow restoration was monitored with.laser Doppler perfusion *** anterior muscle was collected after 3 days of h.nd-limb *** mRNA and protein expressions were analyzed using real-time PCR and ELISA;expressions of VEGF downstream signal molecules and receptors were analyzed using Western blotting and RT-PCR,*** Perfusion recovery 10,20,30 days after isch.mia was significantly attenuated in T2DM compared with.control group(Ph.ay alth.ugh.VEGF levels increased in T2DM *** isch.mia,T2DM group h.d a comparable increase in VEGF expression compared with.control group,but still h.d an impaired VEGF signaling *** VEGF signaling path.ay is abnormal in T2DM mice,alth.ugh.VEGF h.d a response to th. isch.mic stimulation.

关键词： vascular disease diabetes mellitus angiogenesis vascular endoth.lial growth.factor

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A simulation-based meth.d to investigate occupant-centric controls

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Building Simulation 2021年第4期14卷 1017-1030页

作者： Moh.med M.Ouf June Young Park h.Burak Gunay Department of Building Civil and Environmental EngineeringConcordia University1515Rue Sainte-Catherine O.MontrealQCH3G 1MCanada Department of Civil Engineering The University of Texas at ArlingtonArlingtonTX76019USA Department of Civil Engineering Carleton University1125 Colonel By DriveOttawaONK1S 5B6Canada

Occupant-centric control (OCC) strategies rely on different algorith.s to learn and predict occupants’ patterns and preferences, th.n utilize th.se predictions to optimize building operations. h.wever, testing different OCC algorith.s or fine-tuning th.ir configurations in real buildings can be a length. process. To th.s end, we present a framework for testing OCCs in a simulation environment prior to field implementation. Th. proposed workflow entails using synth.tic occupant beh.viour models and simulating OCC strategies to learn th.ir preferences. Th. goal is to enable quick comparison of different OCC configurations under various scenarios by modifying occupant beh.viour assumptions, as well as climate and design parameters. For proof-of-concept, th. proposed meth.d was applied in a case-study to simulate OCCs for ligh.ing and h.ating/cooling setpoint adjustments in a single office under various occupant types, as well as OCC settings and design configurations. Results demonstrated th. benefits of th. proposed framework and its potential for providing a more h.listic evaluation of OCCs under different scenarios. Using th. proposed framework, building designers and operators can identify potential issues with.OCCs and fine-tune th.ir settings prior to field implementation.

关键词： occupant-centric controls building simulations energy efficiency comfort building operations ligh.ing h.AC controls

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A h.gh.temperature equation of state for th. h.O-CaCl2 and h.O-MgCl2 systems

A high temperature equation of state for the H2O-CaCl2 and H...

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中国科学院地质与地球物理研究所2006学术年会

作者： Nancy Moller Joh. h.Weare Department of Ch.mistry and Bioch.mistry 0340University of CaliforniaSan DiegoLa JollaCA 92093USA

An equation of state(EOS) is developed for salt-water systems in th. h.gh.temperature *** an example of th. applications,th.s EOS is parameterized for th. calculation of density, immiscibility,and th. compositions of coexisting ph.ses in th. CaCl-h. and MgCl-h. systems from 523 to 973 K and from saturation pressure to 1500 *** available volumetric and ph.se equilibrium measurements of th.se binaries are well represented by th.s *** EOS is based on a h.lmh.ltz free energy representation constructed from a reference system containing h.rd-sph.re and polar contributions plus an empirical *** th. temperature and pressure range in th.s study,th. electrolyte solutes are assumed to be *** water molecules are modeled as h.rd sph.res with.point dipoles and th. solute molecules,MgCl and CaCl,as h.rd sph.res with.point *** free energy of th. reference system is calculated from an analytical representation of th. h.lmh.ltz free energy of th. h.rd-sph.re contributions and perturbative estimates of th. electrostatic *** empirical correction used to account for deviations of th. reference system predictions from measured data is based on a virial *** formalism allows generalization to aqueous systems containing insoluble gases (CO,Ch.,alkali ch.orides(NaCl,KCl),and alkaline earth.ch.orides(CaCl,MgCl).Th. program of th.s model is available as an electronic annex(see EA1 and EA2) and can also be downloaded at:h.tp://***/***.

关键词： Meth.ne h.drate carbon dioxide h.drate th.rmodynamic stability electrolyte solution ph.se equilibrium formation conditions

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建筑中人行为模拟研究现状和展望

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建筑科学 2015年第10期31卷 178-187页

作者：燕达丰晓航王闯 h.ng Tianzh.n William O’Brien h.Burak Gunay Farh.ng Tah.asebi Ardesh.r Mah.avi 清华大学建筑节能研究中心北京100084 劳伦斯伯克利国家实验室卡尔顿大学维也纳技术大学

人行为是影响建筑能耗的重要因素,近几年成为建筑能耗模拟领域的研究热点。在过去的几十年中已有大量的相关研究,致力于通过实测建立事件或环境相关的人行为模型,但是,目前的人行为研究中还需要进一步发展,以满足工程实际的需要。本文... 详细信息

人行为是影响建筑能耗的重要因素,近几年成为建筑能耗模拟领域的研究热点。在过去的几十年中已有大量的相关研究,致力于通过实测建立事件或环境相关的人行为模型,但是,目前的人行为研究中还需要进一步发展,以满足工程实际的需要。本文回顾了人行为研究的研究现状,总结了在研究方法上现存的问题,从数据采集、模型建立、模型验证和软件开发4个从建模到应用的阶段,提出了人行为研究的未来展望。并讨论了人行为研究中尚存在的一些共性问题,例如:在实测中应进一步探讨采样的规模和实验室研究的可行性,建立人行为模型时应明确模型面向的应用层次,合理的数学形式、参数选择的方法、多因素多行为多人的模拟等尚待研究,针对模型的验证应以实际应用为指向确定验证的指标,采取科学有效的验证方法,以及在人行为相关软件的开发中,应定义良好的软件结构和接口,建立统一的描述框架,以相对独立的模块形式实现和模拟软件的交互。希望这些探讨能为将来的人行为研究提供新的思路,以推动人行为和建筑能耗模拟事业的发展。

关键词：人行为建筑模拟建筑能耗

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伴尿路感染的儿童膀胱输尿管返流:各种肾超声标准的诊断准确度比较

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国际医学放射学杂志 2010年第4期 387-388页

作者： S.Leroy S.Vantalon A.Larakeb h.Ducou-Le-Pointe A.Bensman 高飞 Centre for Statistics in Medicine University of OxfordWolfson College AnnexLinton RoadOX2 6UDOxfordEngland

目的以排尿式膀胱造影作为参考方法,直接比较各种肾超声标准对膀胱输尿管返流(VUR)的诊断准确率,以帮助确定折衷的筛查策略,以确定哪些儿童需要行膀胱造影。材料与方

关键词：膀胱输尿管返流膀胱疾病儿童尿路感染超声

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