检索结果-南通市图书馆

Formation conditions of Sinian–Cambrian large lithologic gas reservoirs in the north slope area of central Sichuan Basin,SW China

在线全文

学校读者我要写书评

暂无评论

Petroleum Exploration and Development 2022年第5期49卷 963-976页

作者： WEI guoqi XIE Zengye YANG Yu LI Jian YANG Wei ZHAO Luzi YANG Chunlong ZHANG Lu XIE Wuren JIANG Hua LI Zhisheng LI Jin guo Jianying PetroChina Research Institute of Petroleum Exploration&Development Beijing 100083China Key Laboratory of Gas Reservoir Formation and Development CNPCLangfang 065007China PetroChina Southwest Oil&Gas Field Company Chengdu 610051China

Based on analyses of characteristics,hydrocarbon charging history and geological conditions for the formation of Sinian-Cambrian reservoirs in the north slope area of central Sichuan paleo-uplift,the natural gas origin,accumulation evolution,accumulation pattern and formation conditions of large lithologic gas reservoirs have been *** comprehensive analyses of natural gas composition,carbon and hydrogen isotopic compositions,fluid inclusions,reservoir bitumen,and geological conditions such as lithofacies paleogeography and beach body characterization,it is concluded that:(1)The natural gas in the Sinian-Cambrian of the north slope area is mainly oil cracking gas,and different contribution ratios of multiple sets of source rocks lead to different geochemical characteristics of natural gas in different reservoirs.(2)Although the both Sinian and Cambrian gas reservoirs in this area are lithologic gas reservoirs under monocline background,the former has normal-pressure and the latter has *** are three types of source-reservoir-caprock combinations:single source with lower generation and upper reservoir,double sources with lower generation and upper reservoir or with side source and lateral reservoir,double sources with lower generation and upper reservoir or with upper generation and lower *** Permian-Triassic is the main generation period of oil,Early-Middle Jurassic is the main generation period of oil cracking gas and wet gas,and Late Jurassic-Cretaceous is the main generation period of dry gas.(3)The Sinian-Cambrian system of the north slope area has two favorable conditions for formation of large lithologic gas reservoirs,one is that the large scale beach facies reservoirs are located in the range of ancient oil reservoirs or near the source rocks,which is conducive to the"in-situ"large-scale accumulation of cracked gas in the paleo-oil reservoirs,the other is that the large scale mound-beach complex reservoirs and sealing

关键词： lithologic gas reservoir cracking gas accumulation pattern geochemical characteristics Sinian System Cambrian System Sichuan Basin

Shank3 Deficiency of Anterior Cingulate Cortex Underlies Social Deficits Behaviors in Autistic Mouse Model

在线全文

学校读者我要写书评

暂无评论

Shank3 Deficiency of Anterior Cingulate Cortex Underlies Soc...

中国神经科学学会第十二届全国学术会议

作者： Baolin guo Jing Chen Qian Chen Keke Ren Dayun Feng Han Yao Yingying Liu Qing Liu Wenting Wang Shengxi Wu Department of Neurobiology and Collaborative Innovation Center for brian Science School of Basic Medicine Fourth Military Medical University Department of Anatomy and K.K. Leung Brain Research Center Fourth Military Medical University McGovern Institute for Brain Research Department of Brain and Cognitive Science Massachusetts Institute of Technology (MIT) Wuhan Institute of Physics and Mathematics CAS Center for Excellence in Brain Science Chinese Academy of Science

Objective Social deficits is typically the most featured symptoms among the other core symptoms of autism spectrum disorder（ASD）, however, the mechanisms underlying this behavioral impairments are still not well understood. Studies have revealed that deficiency of Shank3, a postsynaptic scaffold protein, contributes to ASD, which may be caused by the abnormal synaptic development, function and plasticity, but how Shank3 deficiency affects specific brain areas and how it leads to social deficits remains elusive. Recently, abnormal development of anterior cingulate cortex（ACC） has been found in some ASD individuals, which may be highly relative to social behavior impairments. Here, we investigate the critical role of ACC plays in social deficits of Shank3 mutant mouse. Methods We utilized virus-based sparse labeling methods, patch clamp, electron microscope and immunohistochemistry to explore the morphological and functional changes in ACC pyramidal neurons. We also conducted optogenetic activation, CRISPR/Cas9 system based conditional knockout methods and a conditional knock-in mouse model to manipulate synaptic function and rescued social behaviors. Results（1） Shank3 deficiency impaired synaptic transmission and plasticity, morphologically and functionally.（2） Optical activation of ACC pyramidal neurons could rescue social behavior impairment temporarily.（3） Adult conditional knock out Shank3 in ACC could induce social interaction deficit behaviors.（4） Adult restoration of Shank3 in ACC could rescue social behavior impairments. Conclusion Our findings demonstrate the significant morphological and functional changes of ACC in a mouse model of autism and using multiple strategies to modulate autistic-like social behaviors in Shank3 mutant mouse.

关键词： Shank3 Anterior cingulate cortex Optogenetics CRISPR/Cas9 Social behaviors

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

合作的起源——浅析斯科姆斯的合作演化观

延安大学学报（社会科学版） 2019年第1期41卷 21-25,46页

作者：赵斌郭虹山西大学科学技术哲学研究中心山西太原030006

合作是生物界普遍存在的行为,以至于我们忽略了对它更深层的研究,即合作何以可能的问题。斯科姆斯在合作演化的博弈模型基础上,提出了促进合作演化的三种机制:本地互动、信号和联合,为人们如何组织行动以实现共同利益的假设辩护。斯科... 详细信息

合作是生物界普遍存在的行为,以至于我们忽略了对它更深层的研究,即合作何以可能的问题。斯科姆斯在合作演化的博弈模型基础上,提出了促进合作演化的三种机制:本地互动、信号和联合,为人们如何组织行动以实现共同利益的假设辩护。斯科姆斯的合作演化观进一步丰富了进化理论,成为现代进化理论中不可或缺的重要组成部分。

关键词：斯科姆斯合作演化机制

在线全文

学校读者我要写书评

暂无评论

高校吸引与留住人才问题探析

苏州市职业大学学报 2008年第3期19卷 96-99页

作者：仇国阳苏州大学科技处江苏苏州215021

高校作为人才聚集的地方,由于外部环境的变化,人才自身价值追求的差异,以及高校内部管理、环境等因素的影响,导致人才的外流。高校要吸引人才、留住人才,必须营造宽松的政治环境、自由的学术环境、良好的工作环境、舒适的生活环境以及... 详细信息

高校作为人才聚集的地方,由于外部环境的变化,人才自身价值追求的差异,以及高校内部管理、环境等因素的影响,导致人才的外流。高校要吸引人才、留住人才,必须营造宽松的政治环境、自由的学术环境、良好的工作环境、舒适的生活环境以及创造公平竞争、奖惩分明的用人环境,增强教师的凝聚力;还须建立和完善科学的评价体系、人才培养机制、开放灵活的人才流动机制、激励机制等,并建设好一批高素质的高校人才管理工作队伍。

关键词：高等院校吸引与留住人才对策

LAMOST Experiment for Galactic Understanding and Exploration (LEGUE)——The survey's science plan

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2012年第7期12卷 735-754页

作者： Li-Cai Deng Heidi Jo Newberg Chao Liu Jeffrey L. Carlin Timothy C. Beers Li Chen Hsu-Tai Lee Carl J. Grillmair Puragra Guhathakurta] Zhan-Wen Han Jin-Liang Hou Sebastien Lepine Jing Li Xiao-Wei Liu Kai-Ke Pan J. A. Sellwood Bo Wang Hong-Chi Wang Fan Yang brian Yanny Hao-Tong Zhang Yue-Yang Zhang Zheng Zheng Zi Zhu Key Lab for Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China licai@*** Department of Physics Applied Physics and Astronomy Rensselaer Polytechnic Institute 1108th Street Troy NY 12180 USA National Optical Astronomy Observatory Tucson AZ 85719 USA Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Astronomy and Astrophysics Academia Sinica EO. Box 23-141 Taipei 106 China University of Heidelberg Landessternwarte K6nigstuhl 12 D-69117 Heidelberg Germany Spitzer Science Center 1200 E. California Blvd. Pasadena CA 91125 USA Department of Astronomy and Astrophysics University of California Santa Cruz 1156 HighStreet Santa Cruz CA 95064 USA Yunnan Astronomical Observatory Chinese Academy of Sciences Kunming 650011 China American Museum of Natural History Central Park West at 79th Street New York NY 10024USA School of Physics and Electronic Information China West Normal University Nanchong637000 China ' Department of Astronomy & Kavli Institute of Astronomy and Astrophysics Peking University Beijing 100871 China Apache Point Observatory PO Box 59 Sunspot NM 88349 USA Department of Physics and Astronomy Rutgers University 136 Frelinghuysen RoadPiscataway NJ 08854-8019 USA Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China Fermi National Accelerator Laboratory Batavia IL 60510 USA Department of Physics and Astronomy University of Utah Salt Lake City UT 84112 USA School of Astronomy and Space Science Nanjing University Nanjing 210008 China

We describe the current plans for a spectroscopic survey of millions of stars in the Milky Way galaxy using the guo Shou Jing Telescope （GSJT, formerly calledthe Large sky Area Multi-Object fiber Spectroscopic Telescope -- LAMOST）. The survey will obtain spectra for 2.5 million stars brighter than r 〈 19 during dark/grey time, and 5 million stars brighter than r 〈 17 or J 〈 16 on nights that are moonlit or have low transparency. The survey will begin in the fall of 2012, and will run for at least four years. The telescope＇s design constrains the optimal declination range for observations to 10~ 〈 di 〈 50~, and site conditions lead to an emphasis on stars in the direction of the Galactic anticenter. The survey is divided into three parts with different target selection strategies： disk, anticenter, and spheroid. The resulting dataset will be used to study the merger history of the Milky Way, the substructure and evolution of the disks, the nature of the first generation of stars through identification of the lowest metallicity stars, and star formation through study of open clusters and OB associations. Detailed design of the LAMOST Experiment for Galactic Understanding and Exploration （LEGUE） survey will be completed in summer 2012, after a review of the results of the pilot survey.

关键词： techniques: spectroscopic -Galaxy: structure - Galaxy: evolution -Galaxy: kinematics and dynamics -- Galaxy: disk -- Galaxy: halo -- spectroscopy

An algorithm for preferential selection of spectroscopic targets in LEGUE

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2012年第7期12卷 755-771页

作者： Jeffrey L. Carlin Sebastien Lepine Heidi Jo Newberg Li-Cai Deng Timothy C. Beers Yu-Qin Chen Norbert Christlie Xiao-Ting Fu Shuang Gao Carl J. Grillmair PuragraGuhathakurta Zhan-Wen Han Jin-Liang Hou Hsu-Tai Lee Jing Li Chao Liu Xiao-Wei Liu Kai-Ke Pan J. A. Sellwood Hong-Chi Wang Fan Yang brian Yanny Yue-Yang Zhan Zheng Zheng Zi Zhu Department of Physics Applied Physics and Astronomy Rensselaer Polytechnic Institute 110 8th Street Troy NY 12180 USA carlij@rpi.edu Department of Astrophysics American Museum of Natural History Central Park West at 79thStreet New York NY 10024 USA City University of New York 365 Fifth Avenue New York NY 10016 USA National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China National Optical Astronomy Observatory Tucson AZ 85719 USA Center for Astronomy University of Heidelberg Landesstemwarte Ktinigstuhl 12 D-69117Heidelberg Germany Spitzer Science Center 1200 E. California Blvd. Pasadena CA 91125 USA JCO/Lick Observatory Department of Astronomy and Astrophysics University of CaliforniaSanta Cruz CA 95064 USA Yunnan Astronomical Observatory Chinese Academy of Sciences Kunming 650011 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanglai 200030 China Institute of Astronomy and Astrophysics Academia Sinica EO. Box 23-141 Taipei 106 China Department of Astronomy & Kavli institute of Astronomy and Astrophysics Peking UniversityBeijing 100875 China Apache Point Observatory PO Box 59 Sunspot NM 88349 USA Department of Physics and Astronomy Rutgers University 136 Frelinghuysen RoadPiscataway NJ 08854-8019 USA Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China Fermi National Accelerator Laboratory EO. Box 500 Batavia IL 60510 USA Department of Physics and Astronomy University of Utah Salt Lake City UT 84112 USA Department of Astronomy Nanjing University Nanjing 210011 China

We describe a general target selection algorithm that is applicable to any survey in which the number of available candidates is much larger than the number of objects to be observed. This routine aims to achieve a balance between a smoothly- varying, well-understood selection function and the desire to preferentially select cer- tain types of targets. Some target-selection examples are shown that illustrate differentpossibilities of emphasis functions. Although it is generally applicable, the algorithm was developed specifically for the LAMOST Experiment for Galactic Understanding and Exploration （LEGUE） survey that will be carried out using the Chinese guo Shou Jing Telescope. In particular, this algorithm was designed for the portion of LEGUE targeting the Galactic halo, in which we attempt to balance a variety of science goals that require stars at fainter magnitudes than can be completely sampled by LAMOST. This algorithm has been implemented for the halo portion of the LAMOST pilot sur- vey, which began in October 2011.

关键词： surveys: LAMOST -- Galaxy: halo -- techniques: spectroscopic

神经节苷脂联合脑蛋白水解物治疗新生儿重度窒息后脑损伤的疗效观察

在线全文

学校读者我要写书评

暂无评论

国际医药卫生导报 2014年第7期20卷 991-993页

作者：郭丹苗张翔高要市人民医院 526040

目的探讨神经节苷脂联合脑蛋白水解物治疗新生儿重度窒息后脑损伤的临床疗效及用药安全性.方法将46例因重度窒息后致脑损伤的新生儿随机分为对照组与观察组.对照组使用常规治疗方法,观察组在常规方法上加用神经节苷脂联合脑蛋白水解... 详细信息

目的探讨神经节苷脂联合脑蛋白水解物治疗新生儿重度窒息后脑损伤的临床疗效及用药安全性.方法将46例因重度窒息后致脑损伤的新生儿随机分为对照组与观察组.对照组使用常规治疗方法,观察组在常规方法上加用神经节苷脂联合脑蛋白水解物治疗,对比两组的临床疗效及药物不良反应.结果观察组患儿各项症状、体征、神经行为及影像学的恢复时间都较对照组短,观察组影像学恢复效果较好,两组对比差异有统计学意义（P＜0.05）.结论神经节苷脂联合脑蛋白水解物治疗新生儿重度窒息后脑损伤临床疗效显著,病情症状恢复时间短,近远期后遗症少,治愈率高.

关键词：神经节苷脂脑蛋白水解物联合治疗重度窒息后脑损伤

在线全文

学校读者我要写书评

暂无评论

动物健康和福利传感器数据:现状和未来应用

中国乳业 2024年第11期 74-79页

作者：徐源(编译) 郭凯军北京农学院北京100096

测量个体动物行为、生理参数的传感器技术越来越多用于奶牛场,以提高繁殖能力和健康管理。这些技术在每头牛的水平上产生了大量高分辨率的数据,因此对使用这些数据的兴趣超出了对牛群管理。这项研究属于ICAR的brian Wickham青年交流计划... 详细信息

测量个体动物行为、生理参数的传感器技术越来越多用于奶牛场,以提高繁殖能力和健康管理。这些技术在每头牛的水平上产生了大量高分辨率的数据,因此对使用这些数据的兴趣超出了对牛群管理。这项研究属于ICAR的brian Wickham青年交流计划(BWPEX),采访ICAR5个成员组织、研究机构,以深入了解传感器数据超出预期用途的使用带来好处和挑战。本次采访话题有:使用传感器数据的最大潜力,特别是对于受访组织;传感器数据目前在受访组织如何使用,以及计划在未来使用;存在哪些挑战以及如何克服这些挑战;传感器数据如何用于改善动物健康、福利以及育种;传感器数据对未来奶业的重要性。本次访谈合作人员都认为传感器数据在牛群管理之外有巨大潜力,并有兴趣在他们组织中使用它。然而,关于大家已经认同的几个挑战,尽管存在克服这些挑战的想法,但最终得出的结论是,基于传感器数据的第三方应用程序或其他产品的开发尚未准备好。本次采访还提及如何应用这些数据提高动物健康、福利和育种,大家一致认为这些数据未来对奶业发挥重要作用。

关键词：奶牛传感器数据动物健康福利育种访谈

同方期刊数据库博看期刊

基于IMRT时代的第八版AJCC／UICC鼻咽癌临床分期建议

在线全文

学校读者我要写书评

暂无评论

中华放射肿瘤学杂志 2016年第3期25卷 197-206页

作者：潘建基 Wai Tong Ng 宗井凤 Lucy L.K.Chan brian O' Sullivan 林少俊 Henry C.K.Sze 陈韵彬 Horace C.W.Choi 郭巧娟 Wai Kuen Kan 肖友平 Xu Wei Quynh Thu Le Christine M.Glastonbury A.Dimtrios Colevas Randal S.Weber Jatin P.Shah Anne W.M.Lee 福建省肿瘤医院放疗科福建医科大学省立临床医学院福州350014 福建省肿瘤医院影像科福州350014 香港东区尤德夫人那打素医院临床肿瘤科多伦多玛格丽特公主癌症中心放疗科香港玛丽医院临床肿瘤科香港城市大学系统工程和工程管理系香港东区尤德夫人那打素医院影像科多伦多玛格丽特公主癌症中心生物统计学部美国斯坦福大学放疗科美国加利福尼亚大学临床肿瘤科美国斯坦福癌症研究所斯坦福大学临床肿瘤科美国德克萨斯大学MD Anderson癌症中心头颈外科美国纪念斯隆-凯特林癌症中心头颈外科香港大学深圳医院临床肿瘤中心

目的准确的分期系统对癌症的治疗至关重要。随着癌症分期和治疗方法的演变，需要不断评价分期的适用性和改进性。方法基于第7版AJCC／UICC分期回顾性分析香港和中国大陆2个肿瘤中心收治的1609例接受调强放射治疗的首诊无转移鼻咽癌患者... 详细信息

目的准确的分期系统对癌症的治疗至关重要。随着癌症分期和治疗方法的演变，需要不断评价分期的适用性和改进性。方法基于第7版AJCC／UICC分期回顾性分析香港和中国大陆2个肿瘤中心收治的1609例接受调强放射治疗的首诊无转移鼻咽癌患者临床资料，所有患者治疗前均行核磁共振分期评估。结果无其他T3、T4期解剖结构受侵患者中，伴有咀嚼肌间隙（翼内肌和／或翼外肌）侵犯、椎前肌侵犯及咽旁间隙侵犯的三组患者之间0s相近。伴广泛软组织（上述侵犯结构以外的软组织）受侵患者OS与伴有颅内侵犯或颅神经侵犯相似。仅2％患者锁骨上窝以上淋巴结转移者直径〉6cm，其0s率与下颈淋巴结转移者类似。用下颈（环状软骨尾侧缘水平以下）代替锁骨上窝并不影响N分期之间的风险差异性。采用推荐的T、N分期，T。N。、T。N，期0s相近。结论经AJCC／UICC分期筹备委员会审阅后，建议第8版分期应将翼内肌／翼外肌从T。降到T：期，增加椎前肌为L期，用下颈取代锁骨上窝，将淋巴结最大直径〉6cm合并归为N，期，将T。、N，期统一归为Ⅳ。期。这些改变不仅使得相邻分期间风险差异性更好，而且使得临床实践性与全球适用性之间达到最佳平衡。

关键词：鼻咽肿瘤/放射疗法预后 TNM分期