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Mesenchymal stem cell-based TRAIL delivery inhibits the metastatic state of clinical therapy-resistant progressive neuroblastoma

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World Journal of Pediatrics 2024年第3期20卷 287-293页

作者： Dinesh Babu Somasundaram Andrew Maher Sheeja Aravindan Zhongxin Yu brian MBesch Natarajan Aravindan Department of Radiation Oncology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Stephenson Cancer Center Oklahoma CityOKUSA Department of Pathology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Radiation Biology Laboratory University of Oklahoma Health Sciences CenterBSEB 302F941 Stanton L.Young BoulevardOklahoma CityOK 73104USA

Progressive neuroblastomas(pNBs)that defy current intensive multimodal clinical therapy(IMCT)are a significant contributor to overall childhood cancer deaths[l].Neuroblastomas(NBs)that survive first-line IMCT actively evolve to acquire genetic and molecular rearrangements and display unparalleled plasticity and evolution,which causes frequent relapses in a rapidly accelerating timeline[2-4].

关键词： neuroblastoma clinical evolve

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肺PET图像的定量分析:挑战和机遇

中华核医学与分子影像杂志 2019年第11期39卷 698-704页

作者：陈聪霞(译) 李文婵(译) 郭悦(译) 姚稚明(审校者) Delphine L.Chen Joseph Cheriyan Edwin R.Chilvers Gourab Choudhury Christopher Coello Martin Connell Marie fisk Ashley M.Groves Roger N.Gunn Beverley f.Holman brian f.hutton Sarah Lee William MacNee Divya Mohan David Parr Deepak Subramanian Ruth Tai-Singer Kris Thielemans Edwin J.R.van Beek Laurence Vass Jeremy W.Wellen Ian Wilkinson frederick J.Wilson 北京医院核医学科、国家老年医学中心 100730 Mallinckrodt Institute of Radiology Washington University School of MedicineSt.LouisMissouri Department of Medicine University of CambridgeCambridgeUnited Kingdom Cambridge University Hospitals NHS foundation Trust CambridgeUnited Kingdom Queen's Medical Research Institute University of EdinburghEdinburghUnited Kingdom Imanova Ltd. London y United Kingdom Institute of Nuclear Medicine University College LondonLondonUnited Kingdom Department of Medicine Imperial College LondonLondonUnited Kingdom Medical Image Analysis Consultant LondonUnited Kingdom Clinical Discovery Respiratory Therapy Area UnitGlaxoSmithKline R&DKing of PrussiaPennsylvania University Hospitals Coventry and Warwickshire CoventryUnited Kingdom Derby Teaching Hospitals NHS foundation Trust DerbyUnited Kingdom Worldwide Research and Development PfizerInc.CambridgeMassachusetts Experimental Medicine Imaging GlaxoSmithKlineStevenageUnited Kingdom

数百万人受呼吸系统疾病的影响,导致巨大的全球性健康困扰。由于目前对导致呼吸系统疾病发展和进展的潜在机制认识不足,治疗选择仍然有限。为克服此局限和理解相关分子变化,将无创影像技术如PET和SPECT用于探索生物标志物,其中18f-脱氧... 详细信息

数百万人受呼吸系统疾病的影响,导致巨大的全球性健康困扰。由于目前对导致呼吸系统疾病发展和进展的潜在机制认识不足,治疗选择仍然有限。为克服此局限和理解相关分子变化,将无创影像技术如PET和SPECT用于探索生物标志物,其中18f-脱氧葡萄糖(fDG)PET显像的研究最多。由于肺内组织、气体、血液和水的构成比变异,定量分析肺的分子影像数据仍具挑战性。这些成分的比例随着肺部疾病的不同而不同,因此有不同的定量分析方法来显示这种变化,但迄今为止还没有开发出对数据标准化的方法。该文回顾了肺部疾病中18f-fDG PET定量分析方法的数据,聚焦于解释肺内成分变化的方法,解读衍生参数。分析的疾病包括急性呼吸窘迫综合征、慢性阻塞性肺疾病、肺间质性疾病如特发性肺纤维化。基于对既往文献、进行中的研究以及作者间讨论的回顾,作者提出了建议性的注意事项,以协助解读从这些方法及未来研究设计中衍生的参数。

关键词：肺肺部炎症分子成像正电子发射计算机断层显像

Sex-biased autophagy as a potential mechanism mediating sex differences in ischemic stroke outcome

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Neural Regeneration Research 2023年第1期18卷 31-37页

作者： brian Noh Louise D.McCullough Jose f.Moruno-Manchon Department of Neurology McGovern Medical School at the University of Texas Health Science Center at HoustonHoustonTXUSA

Stroke is the second leading cause of death and a major cause of disability worldwide,and biological sex is an important determining factor in stroke incidence and *** childhood through adulthood,men have a higher incidence of stroke compared with *** research has confirmed the beneficial effects of estrogen in experimental ischemic stroke but genetic factors such as the X-chromosome complement can also play an important role in determining sex differences in *** is a self-degrading cellular process orchestrated by multiple core proteins,which leads to the engulfment of cytoplasmic material and degradation of cargo after autophagy vesicles fuse with lysosomes or *** levels and the activity of components of these signaling pathways and of autophagy-related proteins can be altered during ischemic *** stroke activates autophagy,however,whether inhibiting autophagy after stroke is beneficial in the brain is still under a *** is a potential mechanism that may contribute to differences in stroke progression between the ***,the effects of manipulating autophagy may also differ between the *** that regulate autophagy in a sex-dependent manner in ischemic stroke remain *** this review,we summarize clinical and pre-clinical evidence for sex differences in *** briefly introduce the autophagy process and summarize the effects of gonadal hormones in autophagy in the brain and discuss X-linked genes that could potentially regulate brain ***,we review pre-clinical studies that address the mechanisms that could mediate sex differences in brain autophagy after stroke.

关键词： autophagy brain estrogen gonadal hormones neurodegeneration neuron stroke X-chromosome

Spatial cluster mapping and environmental modeling in pediatric inflammatory bowel disease

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World Journal of Gastroenterology 2023年第23期29卷 3688-3702页

作者： Mielle Michaux Justin M Chan Luke Bergmann Luis f Chaves brian Klinkenberg Kevan Jacobson Department of Pediatrics Division of GastroenterologyHepatology and NutritionFaculty of MedicineBritish Columbia Children’s HospitalUniversity of British ColumbiaVancouver V6H 3V4British ColumbiaCanada British Columbia Children’s Hospital Research Institute British Columbia Children’s HospitalVancouver V5Z 4H4British ColumbiaCanada Department of Geography University of British ColumbiaVancouver V6T 1Z2British ColumbiaCanada Department of Environmental and Occupational Health School of Public HealthIndiana UniversityBloomingtonIN 47405United States Department of Cellular and Physiological Sciences University of British ColumbiaVancouver V6T 1Z3British ColumbiaCanada

BACKGROUND Geographical(geospatial)clusters have been observed in inflammatory bowel disease(IBD)incidence and linked to environmental determinants of disease,but pediatric spatial patterns in North America are *** hypothesized that we would identify geospatial clusters in the pediatric IBD(PIBD)population of British Columbia(BC),Canada and associate incidence with ethnicity and environmental *** To identify PIBD clusters and model how spatial patterns are associated with population ethnicity and environmental *** One thousand one hundred eighty-three patients were included from a BC Children’s Hospital clinical registry who met the criteria of diagnosis with IBD≤age 16.9 from 2001–2016 with a valid postal code on file.A spatial cluster detection routine was used to identify areas with similar *** ecological analysis employed Poisson rate models of IBD,Crohn’s disease(CD),and ulcerative colitis(UC)cases as functions of areal population ethnicity,rurality,average family size and income,average population exposure to green space,air pollution,and vitamin-D weighted ultraviolet light from the Canadian Environmental Health Research Consortium,and pesticide *** Hot spots(high incidence)were identified in Metro Vancouver(IBD,CD,UC),southern Okanagan regions(IBD,CD),and Vancouver Island(CD).Cold spots(low incidence)were identified in Southeastern BC(IBD,CD,UC),Northern BC(IBD,CD),and on BC’s coast(UC).No high incidence hot spots were detected in the densest urban *** results were represented as incidence rate ratios(IRR)with 95%*** risk factors for PIBD included fine particulate matter(PM2.5)pollution(IRR=1.294,CI=1.113-1.507,Pf petroleum oil to orchards and grapes(IRR=1.135,CI=1.007-1.270,P=0.033).South Asian population(IRR=1.020,CI=1.011-1.028,Pfactor and Indigenous population(IRR=0.956,CI=0.941-0.971,Pfamily size(IRR=0.467,CI=0.268-0.81

关键词： Inflammatory bowel diseases Crohn disease Ulcerative colitis Pesticides Air pollution South Asian people

Rollback,scissor-like closure of the Mongol-Okhotsk Ocean and formation of an orocline:magmatic migration based on a large archive of age data

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National Science Review 2022年第5期9卷 167-178页

作者： Tao Wang Ying Tong Wenjiao Xiao Lei Guo brian f.Windley Tatiana Donskaya Shan Li Narantsetseg Tserendash Jianjun Zhang Beijing SHRIMP Center Institute of Geology Chinese Academy of Geological Sciences Key Laboratory of Earth Probe and Geodynamics Chinese Academy of Geological Sciences Xinjiang Research Center for Mineral Resources Xinjiang Institute of Ecology and GeographyChinese Academy of Sciences School of Geography Geology and the EnvironmentUniversity of Leicester Institute of the Earth's Crust Siberian Branch Russian Academy of Sciences Institute of Geology Mongolian Academy of Sciences

Tracing the closure of oceans with irregular margins and the formation of an orocline are crucial for understanding plate reconstruction and continental *** eastern Central Asian Orogenic Belt,where the Mongol-Okhotsk orocline is situated,is one of the world’s largest magmatic *** a large data set of U-Pb zircon ages,we updated the timing of many published igneous rocks,which allowed us to recognize tightly ’folded’ linear Carboniferous-Jurassic magmatic belts that wrap around the Mongol-Okhotsk suture and their migrations both sutureward and *** new successive magmatic belts reveal a rollback,scissor-like(or zipper-like) closure of the Mongol-Okhotsk Ocean that was fundamentally controlled by coeval subduction rollback and rotation of the Siberian and Mongolian-Erguna *** study also demonstrates the complex mechanisms and processes of the closure of an ocean with irregular margins and the formation of a consequent orocline.

关键词： magmatic migration ocean closure orocline Mongol-Okhotsk Ocean

Rhus longipes (Engl.) infusions improve glucose metabolism and mitigate oxidative biomarkers in ferrous sulfate-induced renal injury

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Asian Pacific Journal of Tropical Biomedicine 2022年第11期12卷 453-465页

作者： brian K.Beseni Kolawole AOlofinsan Veronica f.Salau Ochuko L.Erukainure Md.Shahidul Islam Department of Biochemistry University of KwaZulu-NatalWestville CampusDurban 4000South Africa Department of Pharmacology University of the Free StateBloemfontein 9300South Africa

Objective:To explore the antioxidant and antidiabetic activities of Rhus longipes(***)leaf and stem bark aqueous ***:*** leaf and stem bark infusions were characterized via gas-chromatography mass-spectroscopy(GC-MS)*** vitro antioxidant and carbohydrate and lipid digestive enzyme inhibitory activities of *** infusions were ***,the modulatory effects of *** infusions on intestinal glucose absorption,muscle glucose uptake,and biomarkers of renal oxidative injury were *** docking was performed to determine the binding affinities of the identified compounds from the leaf and stem bark infusions on carbohydrate and lipid digestive ***:GC-MS analysis revealed the presence of several phytocompounds,including palmitoleic acid,octadecanamide,24,25-dihydroxyvitamin D and L-ascorbic *** bark infusion had significantly higher total phenolic contents compared with the leaf infusion,with better DPPH scavenging[IC_(50):(10.50±1.03)μg/mL]and ferric reducing[IC_(50):(9.85±0.32)μg/mL]activities(Pfusions at their highest concentrations significantly increased glucose uptake in yeast suspension and rat psoas muscle with marked suppression of glucose absorption in the rat jejunum(Pfusions lowered lipid peroxidation,increased cellular reduced glutathione concentration,and the activities of superoxide dismutase and catalase in renal homogenate treated with feSO_(4).Conclusions:*** shows antioxidant and antidiabetic activities and could be a potential therapeutic candidate for diabetes.

关键词： Antioxidant Oxidative biomarkers Enzyme inhibition Antidiabetic Rhus longipes Searsia longipes

Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage:roles of microglia/macrophages

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Stroke & Vascular Neurology 2023年第6期8卷 486-502,I0073-I0080页

作者： Ruiyi Zhang Yifei Dong Yang Liu Dorsa Moezzi Samira Ghorbani Reza Mirzaei brian M Lozinski Jeff f Dunn V Wee Yong Mengzhou Xue Department of Cerebrovascular Diseases The Second Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Academy of Medical Science Zhengzhou UniversityZhengzhouHenanChina Hotchkiss Brain Institute and Department of Clinical Neurosciences University of CalgaryCalgaryAlbertaCanada Department of Biochemistry Microbiology&ImmunologyCollege of MedicineUniversity of SaskatchewanSaskatoonSaskatchewanCanada Department of Radiology University of CalgaryCalgaryAlbertaCanada

background Inflammation-exacerbated secondary brain injury and limited tissue regeneration are barriers to favourable prognosis after intracerebral haemorrhage(ICH).As a regulator of inflammation and lipid metabolism,Liver X receptor(LXR)has the potential to alter microglia/macrophage(M/M)phenotype,and assist tissue repair by promoting cholesterol efflux and recycling from *** support potential clinical translation,the benefits of enhanced LXR signalling are examined in experimental *** Collagenase-induced ICH mice were treated with the LXR agonist GW3965 or *** tests were conducted at multiple time *** and haematoma volume,and other brain parameters were assessed using multimodal MRI with T2-weighted,diffusion tensor imaging and dynamic contrast-enhanced MRI *** fixed brain cryosections were stained and confocal microscopy was applied to detect LXR downstream genes,M/M phenotype,lipid/cholesterol-laden phagocytes,oligodendrocyte lineage cells and neural stem *** blot and real-time qPCR were also ***3CR1^(CreER):Rosa26^(iDTR) mice were employed for M/M-depletion *** GW3965 treatment reduced lesion volume and white matter injury,and promoted haematoma *** mice upregulated LXR downstream genes including ABCA1 and Apolipoprotein E,and had reduced density of M/M that apparently shifted from proinflammatory interleukin-1β+to Arginase1+CD206+regulatory *** cholesterol crystal or myelin debris-laden phagocytes were observed in GW3965 *** activation increased the number of Olig2+PDGfRα+precursors and Olig2+CC1+mature oligodendrocytes in perihaematomal regions,and elevated SOX2+or nestin+neural stem cells in lesion and subventricular *** results supported better lesion recovery by GW3965,and this was corroborated by return to pre-ICH values of functional rotarod *** therapeutic effects of GW3965 were abrogated by M/M depletion in CX3CR1^(CreER):Ros

关键词： metabolism injury depletion

Rapidly Estimating Natural Gas Compressibility factor

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Journal of Natural Gas Chemistry 2007年第4期16卷 349-353页

作者： Alireza Bahadori Saeid Mokhatab brian f.Towler Department of Chemical Engineering Curtin University of Technology GPO Box 1987PerthWA 6845Australia Process Technology Department Tehran Raymand Consulting Engineers TehranIran Chemical and Petroleum Engineering Department University of Wyoming Laramie.WYUSA

Natural gases containing sour components exhibit different gas compressibility factor （Z） behavior than do sweet gases. Therefore, a new accurate method should be developed to account for these differences. Several methods are available today for calculating the Z-factor from an equation of state. However, these equations are more complex than the foregoing correlations, involving a large number of parameters, which require more complicated and longer computations. The aim of this study is to develop a simplified calculation method for a rapid estimating Z-factor for sour natural gases containing as much as 90% total acid gas. In this article, two new correlations are first presented for calculating the pseudo- critical pressure and temperature of the gas mixture as a function of the gas specific gravity. Then, a simple correlation on the basis of the standard gas compressibility factor chart is introduced for a quick estimation of sweet gases＇ compressibility factor as a function of reduced pressure and temperature. finally, a new corrective term related to the mole fractions of carbon dioxide and hydrogen sulfide is developed.

关键词： natural gas compressibility factor sour gas critical pressure critical temperature

On the homogenization of metal matrix composites using strain gradient plasticity

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Acta Mechanica Sinica 2014年第2期30卷 175-190页

作者： Reza Azizi Christian f.Niordson brian Nyvang Legarth Department of Mechanical Engineering Solid Mechanics Technical University of Denmark

The homogenized response of metal matrix composites（MMC） is studied using strain gradient *** material model employed is a rate independent formulation of energetic strain gradient plasticity at the micro scale and conventional rate independent plasticity at the macro scale. free energy inside the micro structure is included due to the elastic strains and plastic strain gradients. A unit cell containing a circular elastic fiber is analyzed under macroscopic simple shear in addition to transverse and longitudinal loading. The analyses are carried out under generalized plane strain condition. Micro-macro homogenization is performed observing the Hill-Mandel energy condition,and overall loading is considered such that the homogenized higher order terms vanish. The results highlight the intrinsic size-effects as well as the effect of fiber volume fraction on the overall response curves, plastic strain distributions and homogenized yield surfaces under different loading conditions. It is concluded that composites with smaller reinforcement size have larger initial yield surfaces and furthermore,they exhibit more kinematic hardening.

关键词： Metal matrix composite(MMC) Strain gradient plasticity Homogenization Yield surface