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Field sca.ner design for MUSTa.G of the Green Ba.k Telescope

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Science China.Physics,Mecha.ics & a.tronomy) 2011年第11期54卷 2091-2096页

作者： CHENG JingQua. LI Ya.g LI XinNa. Ma.ON brian Na.iona. Ra.io a.tronomy Observa.ory Charlottesville 22903 USA Na.jing Institute of a.tronomica. Optics a.d Technology Nanjing 210042 China

MUSTa.G (Multiplex SQUID TES a.ra. a. Ninety GHz) is a.bolometer ca.era.for the Green Ba.k Telescope (GBT) working a. a.frequency of 90 *** detector ha. a.field of view of 40 *** ca.cel out ra.dom emission cha.ge from a.mosphere a.d other sources,requires a.fa.t sca.ning reflecting system with a.few a.cminute *** this pa.er,the a.erra.ions of a. off-a.is system a.e *** condition for a. optimized system is *** a. optimized system,a. a.ditiona. ima.e tra.sfer mirrors a.e introduced,new a.erra.ions of the off-a.is system ma. be reintroduced,resulting in a.limited field of *** this pa.er,different sca.ning mirror a.ra.gements for the GBT system a.e a.a.yzed through the ra. tra.ing *** include using the subreflector a. the sca.ning mirror,chopping a.fla. mirror a.d tra.sferring ima.e with a. ellipse mirror,a.d chopping a.fla. mirror a.d tra.sferring ima.e with a.pa.r of fa.e-to-fa.e pa.a.oloid *** system a.a.ysis shows tha. chopping a.fla. mirror a.d using a.well a.igned pa.r of pa.a.oloids ca. genera.e the required field of view for the MUSTa.G detector system,while other systems a.l suffer from la.ger off-a.is a.erra.ions a.ded by the system *** spot dia.ra.s of the well a.igned pa.r of pa.a.oloids produced a.e only a.out one a.ry disk size within a.sca.ning a.gle of a.out 3 a.cmin.

关键词： a.tenna optics off-a.is linea. a.tigma.ism coma reflector sca.ner

Distortion-sta.ilized ordered structures in a.(2)BB’O_(7) mixed pyrochlores

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npj Computa.iona. Ma.eria.s 2019年第1期5卷 1076-1084页

作者： Gha.shya. Pila.ia.brian Pucha.a.Bla. P.Uberua.a Ma.eria.s Science a.d Technology Division Los Alamos National LaboratoryLos AlamosNM 87545USA Ma.eria.s Science a.d Engineering Depa.tment University of MichiganAnn ArborMI 48109USA

Pyrochlore oxides(a.B2O7)a.e interesting for a.number of technologica. a.plica.ions,including ra.ia.ion da.a.e tolera.ce a.d a. ionic *** pyrochlores—conta.ning two a.a.d/or two B site ca.ions—provide even more flexibility for ta.loring properties owing to the diverse chemica. a.d configura.iona. degrees of freedom a.cessible within this chemica. ***,we exa.ine rela.ive sta.ility of different ca.ion orderings in one model double pyrochlore Gd2(Zr_(x)Ti_(1−x))_(2)O_(7),a. a.function of Zr content *** results show tha.,in the presence of some very specific loca. ca.ion a.ra.gements,certa.n ca.ion-ordered compositions in this system a.e highly sta.ilized a. a.result of la.ge oxygen rela.a.ion displa.ements,lea.ing to the forma.ion of a. ordered‘double’pyrochlore *** origins of these a.oma.ous oxygen rela.a.ions a.e tra.ed ba.k to both the loca. ca.ion symmetry a.d a.strong chemica. preference of Zr a.oms towa.ds a.opting a.7-fold coordina.ion environment,a. opposed to a.6-fold coordina.ion a.a.la.le in a.regula. pyrochlore ***,we exa.ine the sta.ility of this type of ordering in 131 other pyrochlore *** of our findings a.e discussed in rela.ion to the observed composition-dependent ionic conductivity in these systems a.d connections with previously reported experimenta. findings a.e ma.e.

关键词： structure ordered sta.ilized

Bra.sinosteroid biosynthesis a.d signa.ing:Conserved a.d diversified functions of core genes a.ross multiple pla.t species

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Pla.t Communica.ions 2024年第9期5卷 72-100页

作者： brian Zebosi Erik Vollbrecht Norma. B.Best Depa.tment of Genetics Development and Cell BiologyIowa State UniversityAmesIA 50011USA Interdepa.tmenta. Genetics a.d Genomics Gra.ua.e Progra. Iowa State UniversityAmesIA 50011USA USDa.a.S Plant Genetics Research UnitColumbiaMO 65201USA

Bra.sinosteroids(BRs)a.e importa.t regula.ors tha. control myria. a.pects of pla.t growth a.d development,including biotic a.d a.iotic stress responses,such tha. modula.ing BR homeosta.is a.d signa.ing presents a.unda.t opportunities for pla.t breeding a.d crop *** a.d other proteins involved in the biosynthesis a.d signa.ing of BRs a.e well understood from molecula. genetics a.d phenotypic a.a.ysis in a.a.idopsis tha.ia.a.however,knowledge of the molecula. functions of these genes in other pla.t species,especia.ly cerea. crop pla.ts,is *** this ma.uscript,we comprehensively review functiona. studies of BR genes in a.a.idopsis,ma.ze,rice,Seta.ia.Bra.hypodium,a.d soybea. to identify conserved a.d diversified functions a.ross pla.t species a.d to highlight ca.es for which a.ditiona. resea.ch is in *** performed phylogenetic a.a.ysis of gene fa.ilies involved in the biosynthesis a.d signa.ing of BRs a.d re-a.a.yzed publicly a.a.la.le tra.scriptomic *** trees coupled with expression da.a.provide a.va.ua.le guide to supplement future resea.ch on BRs in these importa.t crop species,ena.ling resea.chers to identify gene-editing ta.gets for BR-rela.ed functiona. studies.

关键词： bra.sinosteroids ma.ze rice Seta.ia soybea. Bra.hypodium a.a.idopsis

Vibrioha.veyi: a.serious pa.hogen offish a.d invertebra.es in ma.iculture

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Ma.ine Life Science & Technology 2020年第3期2卷 231-245页

作者： Xia.-Hua.Zha.g Xinxin He brian a.stin MOE Key La.ora.ory of Ma.ine Genetics a.d Breeding College of Marine Lite Sciences.Ocean University of ChinaQingdao 266003China La.ora.ory for Ma.ine Ecology a.d Environmenta. Science Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Frontiers Science Center for Deep Ocea. Multispheres a.d Ea.th System Ocean University of ChinaQingdao 266100China Institute of a.ua.ulture University of StirlingStirling FK94LAScotlandUK

Vibrio ha.veyi,which belongs to fa.ily Vibriona.ea. of cla.s G cunma. rote oba.te ria.includes the species *** cha. ia. a.d *** a. its junior *** orga.ism is a.well-recognized a.d serious ba.teria. pa.hogen of ma.ine fish a.d invertebra.es,including pena.id shrimp,in *** fish ma. exhibit a.ra.ge of lesions,including eye lesions/blindness,ga.tro-enteritis,muscle necrosis,skin ulcers,a.d ta.l rot *** shrimp,*** is rega.ded a. the etiologica. a.ent of luminous vibriosis in which a.fected a.ima.s glow in the *** is a.second condition of shrimp known a. Bolita. negrica.s where the digestive tra.t is filled with spheres of sloughed-off *** is recognized tha. the pa.hogenicity mecha.isms of *** ma. be different in fish a.d pena.id *** shrimp,the pa.hogenicity mecha.isms involved the endotoxin lipopolysa.cha.ide,a.d extra.ellula. protea.es,a.d intera.tion with *** fish,the pa.hogenicity mecha.isms involved extra.ellula. hemolysin(encoded by duplica.e hemolysin genes),which wa. identified a. a.phospholipa.e B a.d could ina.tiva.e fish cells by a.optosis,via.the ca.pa.e a.tiva.ion *** ma. enter the so-ca.led via.le but noncultura.le(VBNC)sta.e,a.d resuscita.ion of the VBNC cells ma. be a. importa.t rea.on for vibriosis outbrea.s in *** control mea.ures center on dieta.y supplements(including probiotics),nonspecific immunostimula.ts,a.d va.cines a.d to a.lesser extent a.tibiotics a.d other a.timicrobia. compounds.

关键词： Vibrio ha.veyi Pa.hogen Fish Invertebra.es a.ua.ulture

Historica. review of the ca.ses of ca.cer

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World Journa. of Clinica. Oncology 2016年第1期7卷 54-86页

作者： Cla.ke brian Bla.ka.a. Depa.tment of Food Science Ontario Agricultural College University of Guelph

In the ea.ly 1900 s, numerous semina. publica.ions reported tha. high ra.es of ca.cer occurred in certa.n occupa.ions. During this period, work with infectious a.ents produced only mea.er results which seemed irreleva.t to huma.s. Then in the 1980 s ground brea.ing evidence bega. to emerge tha. a.va.iety of viruses a.so ca.se ca.cer in huma.s. There is now sufficient evidence of ca.cinogenicity in huma.s for huma. T-cell lymphotrophic virus, huma. immunodeficiency virus, hepa.itis B virus, hepa.itis C virus, huma. pa.illoma.irus, Epstein-Ba.r virus, a.d huma. herpes virus 8 a.cording to the Interna.iona. a.ency for Resea.ch on Ca.cer(Ia.C). Ma.y other ca.ses of ca.cer ha.e a.so been identified by the Ia.C, which include: Sunlight, toba.co, pha.ma.eutica.s, hormones, a.cohol, pa.a.ites, fungi, ba.teria. sa.ted fish, wood dust, a.d herbs. The World Ca.cer Resea.ch Fund a.d the a.erica. Institute for Ca.cer Resea.ch ha.e determined a.ditiona. ca.ses of ca.cer, which include beta.ca.otene, red mea., processed mea.s, low fibre diets, not brea.t feeding, obesity, increa.ed a.ult height a.d sedenta.y lifestyles. In brief, a.historica. review of the discoveries of the ca.ses of huma. ca.cer is presented with extended discussions of the difficulties encountered in identifying vira. ca.ses of ca.cer.

关键词： Infections Ca.ses Ca.cer Ca.cinogens Historica. Etiology Interna.iona. a.ency for resea.ch on ca.cer

La.el-free detection of single na.opa.ticles a.d biologica. molecules using microtoroid optica. resona.ors

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Light(Science & a.plica.ions) 2016年第1期5卷 863-868页

作者： Judith Su a.exa.der FG Goldberg brian M Stoltz Division of Biology a.d Biologica. Engineering California Institute of TechnologyPasadenaCAUSA Divison of Chemistry a.d Chemica. Engineering California Institute of TechnologyPasadenaCAUSA

Single-molecule detection is one of the funda.enta. cha.lenges of modern *** experiments often use la.els tha. ca. be expensive,difficult to produce,a.d for sma.l a.a.ytes,might perturb the molecula. events being *** size pla.s a. importa.t role in determining *** we use la.er-frequency locking in the context of sensing to improve the signa.-to-noise ra.io of microtoroid optica. resona.ors to the extent tha. single na.opa.ticles 2.5 nm in ra.ius,a.d 15.5 kDa.molecules a.e detected in a.ueous solution,thereby bringing these detectors to the size limits needed for detecting the key ma.romolecules of the *** results,covering severa. orders of ma.nitude of pa.ticle ra.ius(100 nm to 2 nm),a.ree with the‘rea.tive’model prediction for the frequency shift of the resona.or upon pa.ticle *** confirms tha. the ma.n contribution of the frequency shift for the resona.or upon pa.ticle binding is a. increa.e in the effective pa.h length due to pa.t of the eva.escent field coupling into the a.sorbed *** a.ticipa.e tha. our results will ena.le ma.y a.plica.ions,including more sensitive medica. dia.nostics a.d funda.enta. studies of single receptor–liga.d a.d protein–protein intera.tions in rea. time.

关键词： biosensing frequency locking la.el-free microtoroid single molecule

Identifica.ion of two a.erra.t tra.scripts derived from a.hybridoma.with a.plifica.ion of functiona. immunoglobulin va.ia.le genes

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Cellula. & Molecula. Immunology 2010年第5期7卷 349-354页

作者： Guipeng Ding Ximin Chen Jin Zhu brian Ca. Depa.tment of Pa.hology Nanjing Medical UniversityNanjingChina Hua.ong Medica. Institute of Biotechniques NanjingChina La.ora.ory of a.tibody Technology Van Andel Research InstituteGrand RapidsMIUSA

Murine monoclona. a.tibodies(ma.s)a.e widely used but ha.e limita.ions if a.ministered in *** use of chimeric or huma.ized ma.s ca. reduce *** first step in producing such ma.s is to clone murine va.ia.le genes from a.hybridoma.but it is possible to a.plify both functiona. a.d a.erra.t va.ia.le genes,a. they coexist in the *** the development of a.murine–huma. chimeric a.tibody,we ha.e cloned from a.hybridoma.the functiona. hea.y cha.n va.ia.le region(VH)a.d light cha.n va.ia.le region(VL)genes of a.ma. tha. blocks the binding of a.thra. letha. fa.tor to protective *** this study,we report the detection of two a.erra.t tra.scripts from a.hybridoma.produced using myeloma.cell line OUR-1,the development of a.method to distinguish between the functiona. a.d a.unda.t a.erra.t VL tra.scripts,a.d the origins of these a.erra.t *** a.erra.t VL gene is derived from OUR-1 cells,while the a.erra.t VH gene might derive from a.tibody repertoires in B cells or from gene rea.ra.gement in the hybridoma.*** a.erra.t VH a.d VL genes in this study ma. fa.ilita.e discrimina.ion between the functiona. a.d a.erra.t va.ia.le genes from hybridoma.cells.

关键词： a.erra.t gene rea.ra.gement non-functiona. immunoglobulin OUR-1 va.ia.le gen

Mea.les-mumps-rubella.va.cina.ion timing a.d a.tism a.ong young a.rica. a.erica. boys: a.rea.a.ysis of CDC da.a

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Tra.sla.iona. Neurodegenera.ion 2014年第1期3卷 119-124页

作者： brian S Hooker Simpson University ReddingCAUSA

Ba.kground:a.significa.t number of children dia.nosed with a.tism spectrum disorder suffer a.loss of previously-a.quired skills,suggesting neurodegenera.ion or a.type of progressive encepha.opa.hy with a. etiologica. ba.is occurring a.ter *** purpose of this study is to investiga.e the effectof the a.e a. which children got their first Mea.les-Mumps-Rubella.MMR)va.cine on a.tism *** is a.rea.a.ysis of the da.a.set,obta.ned from the U.S.C enters for Disea.e C ontrol a.d Protection(CDC),used for the Destefa.o et a..2004 publica.ion on the timing of the first MMR va.cine a.d a.tism ***:The a.thor emba.ked on the present study to eva.ua.e whether a.rela.ionship exists between child a.e when the first MMR va.cine wa. a.ministered a.ong ca.es dia.nosed with a.tism a.d controls born between 1986 through 1993 a.ong school children in metropolita. *** Pea.son's chisqua.ed method wa. used to a.sess rela.ive risks of receiving a. a.tism dia.nosis within the tota. cohort a. well a. a.ong different ra.e a.d gender ***:When compa.ing ca.es a.d controls receiving their first MMR va.cine before a.d a.ter 36 months of a.e,there wa. a.sta.istica.ly significa.t increa.e in a.tism ca.es specifica.ly a.ong a.rica. a.erica. ma.es who received the first MMR prior to 36 months of *** risks for ma.es in genera. a.d a.rica. a.erica. ma.es were 1.69(p=0.0138)a.d 3.36(p=0.0019),***,a.rica. a.erica. ma.es showed a. odds ra.io of 1.73(p=0.0200)for a.tism ca.es in children receiving their first MMR va.cine prior to 24 months of a.e versus 24 months of a.e a.d ***:The present study provides new epidemiologic evidence showing tha. a.rica. a.erica. ma.es receiving the MMR va.cine prior to 24 months of a.e or 36 months of a.e a.e more likely to receive a. a.tism dia.nosis.

关键词： a.tism Mea.les-mumps-rubella.MMR)va.cine

Geologica. cycling of pota.sium a.d the K isotopic response:insights from loess a.d sha.es

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a.ta.Geochimica 2019年第4期38卷 508-516页

作者： Weiqia.g Li Shilei Li brian L.Bea.d Sta.e Key La.ora.ory for Minera. Deposits Resea.ch School of Earth Sciences and EngineeringNanjing UniversityNanjing 210046People's Republic of China MOE Key La.ora.ory of Surficia. Geochemistry School of Earth Sciences and EngineeringNanjing UniversityNanjing 210046People's Republic of China Depa.tment of Geoscience University of Wisconsin- Madison1215W Dayton StreetMadisonWI 53706USA Na.a.a.trobiology Institute University of Wisconsin- MadisonMadisonWI 53706USA

Sha.es a.e a.ma.or sink for K into sea.a.er delivered from continenta. wea.hering,a.d a.e potentia. recorders of K *** precision K isotope a.a.yses revea. a.0.6%va.ia.ion in δ^41K va.ues(41K/39K rela.ive to NIST SRM 3141a.from a.set of well cha.a.terized posta.chea. a.stra.ia. sha.e(Pa.S)*** contra.t,loess sa.ples ha.e rela.ively homogenous δ^41K va.ues(-0.5±0.1%),which ma. represent the a.era.e K composition of upper continenta. *** of the sha.es a.a.yzed in this study ha.e experienced K enrichment rela.ive to a.era.e continenta. crust,a.d the ma.ority of them define a.trend of decrea.ing δ^41K va.ue(from-0.5to-0.7%)with increa.ing K content a.d K/Na.ra.io,indica.ing ca.ion excha.ge in cla.s minera.s is a.compa.ied by K isotope *** sha.e sa.ples do not follow the trend a.d ha.e eleva.ed δ^41K va.ues up to-0.1%,a.d these sa.ples a.e cha.a.terized by va.ia.le Fe isotope compositions,which reflect post-depositiona. *** K isotope va.ia.ility observed in sha.es,in combina.ion with recent findings a.out K isotope fra.tiona.ion during continenta. wea.hering,indica.es tha. K isotopes fra.tiona.e during cycling of K between different reservoirs,a.d K isotopes in sediments ma. be used to tra.e geologica. cycling of K.

关键词： K isotopes Loess Sha.e K cycle