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Potential Alzheimer’s disease therapeutic nano-platform: Discovery of amyloid-beta plaque disaggregating agent and brain-targeted delivery system using porous silicon nanoparticles

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Bioactive Materials 2023年第6期24卷 497-506页

作者： Jaehoon Kim Hyeji Um na Hee Kim Dokyoung Kim Department of Biomedical Science Graduate SchoolKyung Hee UniversitySeoul02447Republic of Korea Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute Kyung Hee UniversitySeoul02447Republic of Korea Department of Anatomy and Neurobiology College of MedicineKyung Hee UniversitySeoul02447Republic of Korea Center for Converging Humanities Kyung Hee UniversitySeoul02447Republic of Korea KHU-KIST Department of Converging Science and Technology Kyung Hee UniversitySeoul02447Republic of Korea UC San Diego Materials Research Science and Engineering Center 9500 Gilman Drive La JollaCA92093USA

There has been a lot of basic and clinical research on Alzheimer’s disease(AD)over the last 100 years,but its mechanisms and treatments have not been fully *** some controversies,the amyloid-beta hypothesis is one of the most widely accepted causes of *** this study,we disclose a new amyloid-beta plaque disaggregating agent and an AD brain-targeted delivery system using porous silicon nanoparticles(pSiNPs)as a therapeutic nano-platform to overcome *** hypothesized that the negatively charged sulfonic acid functional group could disaggregate plaques and construct a chemical *** a result of the in vitro assay of amyloid plaques and library screening,we confirmed that 6-amino-2-naphthalenesulfonic acid(Ana)showed the highest efficacy for plaque disaggregation as a hit *** confirm the targeted delivery of Ana to the AD brain,a nano-platform was created using porous silicon nanoparticles(pSiNPs)with Ana loaded into the pore of pSiNPs and biotin-polyethylene glycol(PEG)surface *** resulting nano-formulation,named Biotin-CaCl2-Ana-pSiNPs(BCAP),delivered a large amount of Ana to the AD brain and ameliorated memory impairment of the AD mouse model through the disaggregation of amyloid plaques in the *** study presents a new bioactive small molecule for amyloid plaque disaggregation and its promising therapeutic nano-platform for AD brain-targeted delivery.

关键词： Alzheimer’s disease Plaques disaggregation nanotherapeutics Brain-targeted drug delivery Porous silicon nanoparticles

去卵巢骨质疏松大鼠腹腔注射白藜芦醇及雌二醇的效果评价

维普期刊数据库评论

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中国骨质疏松杂志 2024年第2期30卷 222-227页

作者：黄燕李钰娜宋丽华牛晓红冀菁荃李卿长治医学院基础医学部生化教研室山西长治046000 运城护理职业学院山西运城044000 长治医学院附属和济医院内分泌科山西长治046000 长治医学院基础医学部病生教研室山西长治046000

目的评价腹腔注射白藜芦醇(resveratrol,RSV)、雌二醇(estradiol,E)抗绝经后骨质疏松症的效果,为白藜芦醇作为潜在辅助性治疗药物提供依据。方法将大鼠随机分为正常组、假手术(Sham)组、去卵巢(OVX)组、OVX+RSV组、OVX+雌二醇(OVX+E)组... 详细信息

目的评价腹腔注射白藜芦醇(resveratrol,RSV)、雌二醇(estradiol,E)抗绝经后骨质疏松症的效果,为白藜芦醇作为潜在辅助性治疗药物提供依据。方法将大鼠随机分为正常组、假手术(Sham)组、去卵巢(OVX)组、OVX+RSV组、OVX+雌二醇(OVX+E)组,每组10只。OVX+RSV组腹腔注射RSV[10 mg/(kg·d)],OVX+E组腹腔注射β-雌二醇[0.1 mg/(kg·d)]。Sham组和OVX组注射生理盐水,连用12周。每4周进行全身双能X线测量分析,收集骨密度、体脂率及肌肉含量等数据。12周后,收集心脏、肝脏、胰腺、肾脏等相关数据,计算脏器系数;收集血清,测定尿素氮及肌酐水平;收集两侧股骨,分别行HE及Goldner染色。结果DXA结果显示,白藜芦醇可有效防止骨密度的降低,同时保持与正常组一致的体脂率与肌肉含量,其效果与雌激素相当。脏器系数结果显示,除白藜芦醇组肾脏系数显著降低外,肝脏、胰腺及心脏系数各组之间无显著性差异。与正常组及去卵巢组相比,白藜芦醇组大鼠空腹血清尿素氮和肌酐水平均显著降低,雌激素组肌酐水平显著降低。右侧股骨HE染色显示白藜芦醇组与雌激素组较去卵巢组的骨小梁结构均有改善,并且RSV干预后骨小梁数量和小梁间的连接改善更为明显。左侧股骨Goldner染色结果同样显示,OVX+RSV组股骨小梁数量和小梁厚度显著增加,骨小梁分离度显著降低。结论本研究结果显示RSV的抗骨质疏松作用与雌二醇相当,且未观察到对肝、肾、胰腺及心脏明显的毒副作用,此结果可为其作为临床辅助性用药提供依据。

关键词：白藜芦醇雌二醇绝经后骨质疏松症腹腔注射

Suitable resolution of EOS tables for neutron star investigations

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chinese Physics C 2019年第5期43卷 93-98页

作者： Houyuan chen Dehua Wen na Zhang School of Physics and Optoelectronics South China University of Technology

Inasmuch as the hydrostatic structure of the interior of neutron stars uniquely depends on the equation of state(EOS), the inverse constraints on EOS from astrophysical observations have been an important method for revealing the properties of high density matter. Currently, most EOS for neutron star matter are given in tabular form,but these numerical tables can have quite different resolution. To guarantee both the accuracy and efficiency in computing the Tolman-Oppenheimer-Volkoff equations, a concise standard for generating EOS tables with suitable resolution is investigated. It is shown that EOS tables with 50 points logarithmic-uniformly distributed in the supra-nuclear density segment [ρ_0, 10_(ρ0)], where ρ_0 is the nuclear saturation density, correspond to the interpolation induced errors of ～0.02% for the gravitational mass M and ～0.2% for the tidal deformability ∧.

关键词： neutron star equation of state TOV equations

Analysis of Rna-Dependent Rna Polymerase Sequence of Infectious Flacherie Virus Isolated in china and Its Expression in BmN Cells

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Agricultural Sciences in china 2009年第7期8卷 872-879页

作者： LI Ming-qian LU Qi-neng WU Xiao-Feng MAN na-na chEN Xiao-xue JIN Wei LU Xing-meng Laboratory of lnvertebrate Pathology College of Animal Sciences Zhejiang University Hangzhou 310029 P.R.China

Full gene sequence of Rna-dependent Rna polymerase （RdRp） from Bombyx mori infectious flacherie virus isolated in Zhejiang Province, china （Zhejiang01/chN/2002） was cloned. The sequence was 1 920 nucleotides in length coding 639 amino acid residues. Sequences comparison of RdRp showed Zhejiang01/chN/2002 was 99.7% nucleotide sequence and 99.1% amino acids sequence homology with Japanese strain. The RdRp sequence was aligned with 8 representative picorna（-like） viruses and 8 highly conserved regions were detected. The result indicated their relevance function. Phylogenetic tree of 14 picorna（-like） viruses which RdRp presumed protein sequences revealed that the viruses from Iflavirus genus formed an independent clade. The RdRp was successfully expressed in BmN cells using Bac-to-Bac expression system.

关键词： infectious flacherie virus Rna-dependent Rna polymerase phylogenetic analysis BmN cells expression

Zircon U-Pb dating of Shuiquangou alkaline complex intrusives, northwestern Hebei Province

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chinese Science Bulletin 1997年第9期42卷 772-775页

作者： Mo, ch Liang, HY Wang, XZ cheng, JP Li, HM Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou China Tianjin Institute of Geology and Mineral Resources Chinese Academy of Geological Sciences Tianjin China

SUPER large gold deposits related to alkaline intrusions have been found in America,Canada,Australia,Papua New Guinea and *** gold deposit with superlarge potentialhas also been found in Shuiquangou alkaline complex intrusions,northwestern Hebei Province,*** of the keys to resolving the possible genetic relationship between gold deposits andore-host alkaline intrusions is to determine their formation *** note dates the Shuiquan-gou intrusions with zircon U-Pb method.

关键词： alkaline intrusions Proterozoic Era zircon U-Pb dating gold deposit.

关于提高慢性气道疾病患者吸入制剂用药依从性的实践与探索

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中国医院药学杂志 2024年第2期44卷 195-199,220页

作者：于小杰杨文明赵艳敏张伟威王娜秦皇岛市第一医院药学部河北秦皇岛066000

目的:探讨慢性气道疾病患者出院后使用吸入制剂依从性的影响因素及回访周期优化,探索提高患者用药依从性的方法。方法:收集秦皇岛市第一医院呼吸与危重症医学科2019年6月至2021年6月出院的医嘱长期使用吸入制剂的慢性气道疾病患者信息,... 详细信息

目的:探讨慢性气道疾病患者出院后使用吸入制剂依从性的影响因素及回访周期优化,探索提高患者用药依从性的方法。方法:收集秦皇岛市第一医院呼吸与危重症医学科2019年6月至2021年6月出院的医嘱长期使用吸入制剂的慢性气道疾病患者信息,通过调查问卷考察患者出院后2周、1个月、2个月、6个月、12个月、18个月使用吸入制剂依从性情况。结果:该研究纳入患者整体依从性较差,logistic回归分析显示文化程度低、无法正确操作装置、同时使用吸入制剂数量多是依从性差的危险因素,事后多重比较分析显示,临床药师分别于患者出院后2周、1个月、2个月、6个月、12个月、18个月持续电话随访可逐步提高用药依从性,12个月和18个月两组间依从性得分相似,可将随访至出院后12个月作为一个回访周期。结论:随访12个月可有效提高患者用药依从性,临床药师在随访过程中应重点关注涉及危险因素人群,加强此类患者的用药教育、用药提醒。

关键词：吸入制剂用药依从性影响因素回访周期用药教育方式

Forecasting promising technology using analysis of patent information:Focused on next generation mobile communications

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Journal of Central South University 2014年第11期21卷 4303-4310页

作者： chOI Seung-Wook YOU Yen-Yoo na Kwan-Sik Department of Knowledge Service & Consulting Hansung UniversitySeoul Korea Department of Management Information Systems Seowon UniversityCheongju Korea

In order to forecast promising technologies in the field of next generation mobile communication, various patent indicators were analyzed such as citation per patent, patent family information, patent share, increase rate, and patent activity. These indicators were quantified into several indexes and then integrated into an evaluation score to provide promising technologies. As a result of the suggested patent analysis, four technologies out of twenty two in details classification were selected, which showed outstanding technology competitiveness, high patent share and increasing rates as well as high recent-patent-ratios and triad-patent-family-ratios. Each of the selected technologies scored more than 10 points in total, and the following four technologies were suggested as promising ones in the field of next generation mobile communication: 1) 3GPP based mobile communication, 2) beyond 4G mobile communication, 3) IEEE 802.16 based mobile communication, which are in medium classification of broadband mobile communication system, and 4) testing/certification system of mobile communication, which is in medium classification of mobile communication testing/certification system.

关键词： next generation mobile communication promising technology forecasting patent information patent analysis patent indicators

玉米青霉穗腐病接种方法及玉米新品种抗性分析

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玉米科学 2024年第4期32卷 102-109页

作者：那明慧赵睿杰陈晓旭王作英高增贵丹东农业科学院辽宁凤城118100 沈阳农业大学植物保护学院沈阳110161

近年由青霉Penicillium spp.引起的穗腐病逐年加重。抗病玉米品种的选育和利用是控制穗腐病的经济、安全和有效措施。本研究开展玉米抗青霉穗腐病的接种鉴定,连续3年(2020-2022)在不同环境下比较分析花丝喷雾法、花丝通道注射法、子粒... 详细信息

近年由青霉Penicillium spp.引起的穗腐病逐年加重。抗病玉米品种的选育和利用是控制穗腐病的经济、安全和有效措施。本研究开展玉米抗青霉穗腐病的接种鉴定,连续3年(2020-2022)在不同环境下比较分析花丝喷雾法、花丝通道注射法、子粒注射法、牙签法等接种方法对玉米青霉穗腐病抗性鉴定的效果。结果表明,子粒注射法、牙签法发病强度适中,能够使得不同品种在人工接种后表现出不同水平的抗性反应,较适合用于玉米抗青霉穗腐病鉴定接种,接种后发病稳定、抗感差异明显、鉴定结果准确。2021-2022年接种鉴定的玉米新品种中,对青霉穗腐病表现高抗、抗性、中抗、感病和高感的品种分别占7.8%、24.1%、28.6%、24.5%、15.0%。

关键词：玉米青霉穗腐病接种方法抗性鉴定

TT viral infection through blood transfusion:retrospective investigation on patients in a prospective study of post-transfusion hepatitis

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World Journal of Gastroenterology 2000年第1期6卷 70-73页

作者： Yang SS Wu ch chen TH Huang YY Huang CS Department of Gastroenterology china Medical College TaichungTaiwanChina Cathay General HospitalTaipei and Medical Faculty China Medical CollegeTaichungTaiwanChina Department of Gastroenterology china Medical College TaichungTaiwanChina Department of Laboratory Medicine china Medical College TaichungTaiwanChina

AIM To investigate the role of bloodtransfusion in TT viral infection(TTV).METHODS We retrospectively studied serumsamples from 192 transfusion recipients whounderwent cardiovascular surgery and bloodtransfusion between July 1991 and June *** had a follow-up every other week for atleast 6 months after *** received blood before screeningdonors for hepatitis C antibody(anti-HCV),and112 recipients received screened *** with alanine aminotransferase level>2.5 times the upper normal limit were testedfor serological markers for viral hepatitis A,B,C,G,Epstein-Barr virus and *** infection was defined by the positivity forserum TTV Dna using the polymerase chainreaction *** Eleven and three patients,whoreceived anti-HCV unscreened and screened'blood,respectively,had serum ALT levels>90 IU/*** patients(HCV and TTV:1;HCV,HGV,and TTV:1;TTV:2;and CMV and TTV:1)were positive for TTV Dna,and four of them hadsero-conversion of TTV *** TTV can be transmitted viablood *** recipients infected byTTV alone may be associated with the ***,whether TTV was the causal agentremains unsettled,and further studies arenecessary to define the role of TTV infection inchronic hepatitis.

关键词： Subject headings blood transfusion TT viral infection hepatitis C antibody viral