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Immunomodulatory activity of polycaprolactone nanoparticles with calcium phosphate salts against Leishmania infantum infection

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Asian Pacific j.urnal of Tropical Biomedicine 2024年第8期14卷 359-368页

作者： Kübra Kelleci Adil Allahverdiyev Melahat bağırova Murat Ihlamur EmrahŞefik Abamor Department of Bioengineering Yildiz Technical UniversityIstanbulTurkey V.Akhundov National Scientific Research Medical Prophylactic Institute BakuAzerbaijan Department of Electronics and Automation Biruni UniversityIstanbulTurkey

Obj.ctive:To prepare and characterize polycaprolactone(PCL)nanoparticles loaded with sonicator fragmented(SLA)and freeze-thaw Leishmania antigens(FTLA)and to investigate the in vitro immunogenicity of antigen-encapsulated nanoparticles with calcium phosphate ***:The water/oil/water binary emulsion solvent evaporation method was used to synthesize antigen-loaded PCL *** were characterized by scanning electron microscopy and zeta potential *** cytotoxicity in j.74 macrophages in vitro was determined by MTT *** addition,the amount of nitric oxide and the level of cytokines produced by macrophages were determined by Griess reaction and ELISA method,*** protective effect of the developed formulations was evaluated by determining the infection index percentage in macrophages infected with Leishmania ***:Compared to the control group,SLA PCL and FTLA PCL nanoparticles with calcium phosphate adj.vant induced a 6-and 7-fold increase in nitric oxide,***,the vaccine formulations promoted the production of IFN-γand *** PCL and FTLA PCL nanoparticles combined with calcium phosphate adj.vant caused an approximately 13-and 11-fold reduction in infection index,respectively,compared to the control ***:The encapsulation of antigens obtained by both sonication and freeze-thawing into PCL nanoparticles and the formulations with calcium phosphate adj.vant show strong in vitro immune stimulating ***,PCL-based antigen delivery systems and calcium phosphate adj.vant are recommended as a potential vaccine candidate against leishmaniasis.

关键词： Leishmaniasis Calcium phosphate Polycaprolactone Nanoparticle Antigen delivery system Adj.vant Vaccine design

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Woody plant taxonomic,functional,and phylogenetic diversity decrease along elevational gradients in Andean tropical montane forests:Environmental filtering and arrival of temperate taxa

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Plant Diversity 2024年第4期46卷 491-501页

作者： Guillermo bañares-de-Dios Manuel j.Macía Gabriel Arellano Íñigo Granzow-de la Cerda j.lia Vega-álvarez Itziar Arnelas Carlos I.Espinosa Norma Salinas Luis Cayuela Departamento de Biología y Geología Física y Química InorgánicaUniversidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain Departamento de Biología Área de BotánicaUniversidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Ecology and Evolutionary Biology University of MichiganAnn ArborMI 48109USA Oikobit LLC ***AlbuquerqueNM87120USA Real j.rdín Botánico–CSIC Plaza Murillo 2MadridES-28014Spain Departamento de Biología Animal EcologíaParasitologíaEdafología y Química AgrícolaUniversidad de SalamancaCalle Donantes de Sangre s/nSalamancaES-37007Spain Departamento de Biodiversidad Ecología y EvoluciónUniversidad Complutense de MadridCalle JoséAntonio Nováis 12Ciudad UniversitariaES-28040Spain Departamento de Ciencias Biológicas y Agropecuarias Universidad Técnica Particular de LojaA.P.11-01-608 LojaEcuador Sección Química Pontificia Universidad Católica del PerúA.P.Lima 32LimaPeru ECI School of Geography and EnvironmentUniversity of OxfordOX13QYOxfordshireUnited Kingdom Instituto de Investigación en Cambio Global(IICG-URj.) Universidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain

Mountains are paramount for exploring biodiversity patterns due to the mosaic of topographies and climates encompassed over short *** research has traditionally focused on taxonomic diversity when investigating changes along elevational gradients,but other facets should be *** first time,we simultaneously assessed elevational trends in taxonomic,functional,and phylogenetic diversity of woody plants in Andean tropical montane forests and explored their underlying ecological and evolutionary *** investigation covered four transects(traversing ca.2200 m a.s.l.) encompassing 114 plots of 0.1 ha across a broad latitudinal range(ca.10°).Using Hill numbers to quantify abundance-based diversity among 37,869 individuals we observed a consistent decrease in taxonomic,functional,and phylogenetic diversity as elevation increased,although the decrease was less pronounced for higher Hill *** exception was a slight increase in phylogenetic diversity when dominant species were *** decrease in taxonomic and functional diversity might be attributed to an environmental filtering process towards highlands,where the increasingly harsher conditions exclude species and functional ***,the differences in steepness decrease between Hill orders suggest that rare species disproportionately contribute to functional *** phylogenetic diversity the shifting elevational trend between Hill orders indicates a greater than previously considered influence in central Andean highlands of tropical lowlands originated species with strong niche conservatism relative to distantly related temperate *** could be explained by a decreasing presence and abundance of temperate,extratropical taxa towards the central Andes relative to northern or southern Andes,where they are more prevalent.

关键词： Altitudinal gradients Andes Environmentalﬁltering Out of the Tropical Lowlands Functional rarity Tropical Niche Conservatism

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黏声波方程波场模拟的通用格式自适应系数频域有限差分方法

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地球物理学报 2024年第2期67卷 654-669页

作者：徐文豪巴晶 j.M.Carcione 朱鹤松河海大学地球科学与工程学院南京211100 National Institute of Oceanography and Applied Geophysics-OGS Borgo Grotta Gigante 42/cTriesteSgonico 34010Italy

黏声波方程常被用于描述地下介质的黏弹性及波的传播现象,频域有限差分(finite difference frequency domain,FDFD)方法是黏声波和黏弹性波波场模拟的常用工具.目前FDFD黏声波模拟常用的二阶五点方法和优化九点方法在一个波长内的网格... 详细信息

黏声波方程常被用于描述地下介质的黏弹性及波的传播现象,频域有限差分(finite difference frequency domain,FDFD)方法是黏声波和黏弹性波波场模拟的常用工具.目前FDFD黏声波模拟常用的二阶五点方法和优化九点方法在一个波长内的网格点数小于4时误差较大.通过令FDFD系数随一个波长内的网格点数自适应从而提高FDFD方法的精度,本文针对黏声波波场模拟发展了一种适用于不同空间采样间隔之比的通用格式自适应系数FDFD方法.同时,为了验证自适应系数FDFD方法对一般黏声波模型的有效性,本文针对三个典型的黏声波模型,分别采用解析解和基于高阶FDFD的参考解验证了所提出方法的有效性.本方法的FDFD格式通过在传统的二阶FDFD格式的基础上引入相关校正项得到,其中校正项按网格点与中心点的距离进行分类选取,同时校正项对应的自适应FDFD系数不仅和空间采样间隔之比相关,还和一个波长内的采样点数相关.所需的自适应FDFD系数可通过声波方程的数值频散关系和查找表高效给出.数值频散分析表明,在空间采样间隔相等或不等的情况下,以相速度误差不超过1%为标准,通用格式自适应系数FDFD方法所需的一个波长内的采样点数均小于2.5.数值模拟实验表明,对于不同的空间采样间隔之比,相对于常用的二阶五点FDFD方法和优化九点FDFD方法,通用格式自适应系数FDFD方法均可在相似的计算量和内存需求下,有效提高黏声波模拟的精度.

关键词：黏声波频域有限差分自适应系数波场模拟通用格式

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Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation

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World j.urnal of Diabetes 2024年第5期15卷 958-976页

作者： Hong Xu Li-Bo Zhang Yi-Yi Luo Ling Wang Ye-Pin Zhang Pei-Qi Chen Xue-Ying ba j.an Han Heng Luo Department of Ophthalmology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Precision Medicine Center of Chuxiong Yi Autonomous Prefecture The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Department of Endocrinology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Department of Pathology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina

baCKGROUND Synaptotagmins(SYTs)are a family of 17 membrane transporters that function as calcium ion sensors during the release of Ca2+-dependent neurotransmitters and ***,few studies have reported whether members of the SYT family play a role in glucose uptake in diabetic retinopathy(DR)through Ca2+/glucose transporter-1(GLUT1)and the possible regulatory mechanism of *** To elucidate the role of the SYT family in the regulation of glucose transport in retinal pigment epithelial cells and explore its potential as a therapeutic target for the clinical management of *** DR was induced by streptozotocin in C57BL/6j.mice and by high glucose medium in human retinal pigment epithelial cells(ARPE-19).Bioinformatics analysis,reverse transcriptase-polymerase chain reaction,Western blot,flow cytometry,ELISA,HE staining,and TUNEL staining were used for *** Six differentially expressed proteins(SYT2,SYT3,SYT4,SYT7,SYT11,and SYT13)were found between the DR and control groups,and SYT4 was highly *** induces SYT4 overexpression,manipulates Ca2+influx to induce GLUT1 fusion with the plasma membrane,promotes abnormal expression of the glucose transporter GLUT1 and excessive glucose uptake,induces ARPE-19 cell apoptosis,and promotes DR *** deficiency inhibits the proteasomal degradation of SYT4 in DR,resulting in SYT4 accumulation and enhanced GLUT1 fusion with the plasma membrane,and these effects were blocked by oe-Parkin ***,dysregulation of the myelin transcription factor 1(Myt1)-induced transcription of SYT4 in DR further activated the SYT4-mediated stimulus-secretion coupling process,and this process was inhibited in the oe-MYT1-treated *** Our study reveals the key role of SYT4 in regulating glucose transport in retinal pigment epithelial cells during the pathogenesis of DR and the underlying mechanism and suggests potential therapeutic targets for clinical DR.

关键词： Diabetic retinopathy Glucose transporter-1 Synaptotagmin 4 Parkin Myelin transcription factor 1

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轴流压气机叶片与机匣处理一体化优化设计

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航空动力学报 2024年第7期39卷 205-216页

作者：范忠岗巴顿邱佳慧杨晨杜娟中国科学院工程热物理研究所先进燃气轮机实验室北京100190 中国科学院先进能源动力重点实验室北京100190 中国科学院轻型动力创新研究院北京100190 中国科学院大学航空宇航学院北京100049

针对一台低速轴流压气机搭建了叶片与机匣处理一体化优化设计平台,基于自由变形技术关联设计参数与工程参数,实现多目标优化.综合考虑效率和裕度指标,在峰值效率不降的情况下获得了7.21%的裕度拓宽量.针对最优方案,分析了叶顶堵塞及损... 详细信息

针对一台低速轴流压气机搭建了叶片与机匣处理一体化优化设计平台,基于自由变形技术关联设计参数与工程参数,实现多目标优化.综合考虑效率和裕度指标,在峰值效率不降的情况下获得了7.21%的裕度拓宽量.针对最优方案,分析了叶顶堵塞及损失分布,探讨了叶片与机匣处理一体化优化设计的扩稳机理.研究发现:叶片弯掠和机匣处理组合作用下,最大堵塞位置由24.7%叶顶轴向弦长后移至33.6%叶顶轴向弦长,最大损失位置由21.4%叶顶轴向弦长后移至30.6%叶顶轴向弦长,叶顶泄漏涡的抑制和低能堵塞区的消除是一体化优化设计扩稳的主要原因.

关键词：轴流压气机自由变形技术一体化优化设计裕度拓宽堵塞熵产率

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A detailed comparison of the composition of(RE)-ba-Cu-O-Ag bulk superconductors

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Superconductivity 2024年第1期9卷 87-94页

作者： j.V.j.Congreve Y.Shi A.R.Dennis H.Druiff N.C.Tutt D.A.Cardwell j.H.Durrell Department of Engineering University of CambridgeCambridgeUK

The homogeneity of the microstructure and composition are critical in determining the properties of rare earthbarium‐cuprate,single grain bulk superconductors[(RE)BCO].The magnitude of the trapped magnetic field achieveable in these technologically important materials,in particular,is influenced heavily by the size and distribution of(RE)_(2)baCuO_(x)(RE‐211)flux pinning inclusions in the bulk microstructure,whereas the size and distribution of silver agglomerates present within the bulk superconducting matrix correlate directly with improved mechanical *** careful engineering,these materials have significant potential for application in range of devices related to energy storage,medicine,electro‐magnetic machinery and microelectronic *** of(RE)BCO bulk superconductors typically involves heating a powder compact above its peritectic decomposition temperature followed by slow cooling to facilitate the growth of a single ***(RE)BCO composition has a different peritectic temperature and growth rate,which,therefore,necessitates different requirements in the heating *** fabrication temperature and growth rate,for example,may have an effect on the RE‐211 and silver distribution,which may,in turn,affect the superconducting properties of the resulting single *** this work we compare the distributions of silver and RE‐211 in the single grain microstructures of YBCOAg,GdBCO‐Ag,EuBCO‐Ag and SmBCO‐Ag bulk superconductors using optical microscopy,scanning electron microscopy and energy dispersive X‐ray *** observe that the distributions are very similar along both the a/b‐axis and c‐axis of these *** suggests that factors other than the maximum temperature used to achieve peritectic decomposition and the rate of single grain growth are particularly influential in determining the properties of the as‐processed samples in the top seeded melt growth *** observation demonstrates there is freedom to us

关键词： YBCO‐Ag GdBCO‐Ag SmBCO‐Ag EuBCO‐Ag Composition Bulk superconductor

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Modeling the impact of quarantine during an outbreak of Ebola virus disease

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Infectious Disease Modelling 2019年第1期4卷 12-27页

作者： Attila Dénes Abba B.Gumel Bolyai Institute University of SzegedAradi vertanúk tere 1.Szeged H-6720Hungary School of Mathematical and Statistical Sciences Arizona State UniversityTempeAZ 85287-1804USA Other affliation:Department of Mathematics and Applied Mathematics University of PretoriaPretoria 0002South Africa

The quarantine of people suspected of being exposed to an infectious agent is one of the most basic public health measure that has historically been used to combat the spread of communicable diseases in human *** study presents a new deterministic model for assessing the population-level impact of the quarantine of individuals suspected of being exposed to disease on the spread of the 2014e2015 outbreaks of Ebola viral *** is assumed that quarantine is imperfect(i.e.,individuals can acquire infection during quarantine).In the absence of quarantine,the model is shown to exhibit global dynamics with respect to the disease-free and its unique endemic equilibrium when a certain epidemiological threshold(denoted byR 0)is either less than or greater than ***,unlike the full model with imperfect quarantine(which is known to exhibit the phenomenon of backward bifurcation),the version of the model with no quarantine does not undergo a backward *** data relevant to the 2014e2015 Ebola transmission dynamics in the three West African countries(Guinea,Liberia and Sierra Leone),uncertainty analysis of the model show that,although the current level and effectiveness of quarantine can lead to significant reduction in disease burden,they fail to bring the associated quarantine reproduction number(R Q0)to a value less than unity(which is needed to make effective disease control or elimination feasible).This reduction of R Q0 is,however,very possible with a modest increase in quarantine rate and *** is further shown,via sensitivity analysis,that the parameters related to the effectiveness of quarantine(namely the parameter associated with the reduction in infectiousness of infected quarantined individuals and the contact rate during quarantine)are the main drivers of the disease transmission ***,this study shows that the singular implementation of a quarantine intervention strategy can lead to the effective control or

关键词： Ebola virus disease Quarantine Global dynamics

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Alpha-fetoprotein expression is a potential prognostic marker in hepatocellular carcinoma

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World j.urnal of Gastroenterology 2005年第32期11卷 5015-5018页

作者： Dénes Grg j.nos Regly-Mérei Sándor Paku László Kopper Péter Nagy Department of Transplantation and SurgerySemmelweis University BudapestHungary Third Department of SurgerySemmelweis University BudapestHungary j.int Research Organization of the Hungarian Academy of Sciences and Semmelweis UniversityBudapest Hungary First Department of Pathology and Experimental Cancer ResearchSemmelweis University BudapestHungary

AIM： To characterize the alpha-fetoprotein （AFP） positive and negative hepatocellular carcinoma （HCC） samples. METHODS： Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for the following antigens： AFP,β-catenin, p53, CD44, MSH-2, MLH-1, and HNF-4. The tumors were divided into two groups based on the AFP expression. The immunophenotypic data and important clinical parameters were studied between the two groups. RESULTS： Twenty-one of the thirty-seven examined HCCs were AFP positive. Seven with nudear p53 staining were AFP positive, while seven tumors with nuclear β-catenin staining were AFP negative. CD44 staining and high histological tumor grade were more frequent among the AFP-positive HCCs. The other immunophenotypical and dinical parameters did not show statistically significant difference in their distribution between the AFP positive and negative samples. CONCLUSION： AFP expression in HCC correlates with unfavorable prognostic factors, while nuclear β-catenin positivity is more common among the AFP-negative liver tumors. This observation supports the microarray data on in vivo human tumors.

关键词： Hepatocellular carcinoma Alpha-fetoprotein p53 β-catenin CD44

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祁连山北坡沙尘天气气溶胶特征的飞机观测

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应用气象学报 2024年第3期35卷 311-322页

作者：奚立宗把黎庞朝云李宝梓黄山甘肃省人工影响天气办公室兰州730020

了解沙尘天气下气溶胶的垂直分布特征对于进一步认识气溶胶-云相互作用及其天气、气候效应至关重要。基于2023年9月6日沙尘天气下的飞机观测数据,分析祁连山北坡沙尘气溶胶的垂直分布特征。结果表明:此次沙尘天气是在高空锋区及地面冷... 详细信息

了解沙尘天气下气溶胶的垂直分布特征对于进一步认识气溶胶-云相互作用及其天气、气候效应至关重要。基于2023年9月6日沙尘天气下的飞机观测数据,分析祁连山北坡沙尘气溶胶的垂直分布特征。结果表明:此次沙尘天气是在高空锋区及地面冷高压的共同作用下形成。受沙尘天气影响,气溶胶粒径谱宽增宽;气溶胶数浓度较背景可上升约2~3倍,且气溶胶数浓度大值区呈悬垂状态分布,粒子数浓度大值层位于4000~4500 m和3000~4000 m高度;对沙尘气溶胶数浓度贡献最大的细粒子和粗粒子粒径分别为1.2~1.8μm和6.5~16.6μm,且气溶胶数浓度的增大在粗粒子段更为明显。气溶胶来源及输送层、以及气象要素垂直分布演变在气溶胶垂直分布及谱分布中发挥了重要作用。

关键词：沙尘气溶胶飞机观测祁连山北坡垂直分布

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On the Space bv_p(F) of Sequences of p-bounded Variation of Fuzzy Numbers

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Acta Mathematica Sinica,English Series 2008年第7期24卷 1205-1212页

作者： zer TALO Feyzi ba■AR Fatih niversitesi Fen-Edebiyat FakltesiMatematik BlmBykekmece Kamps 34500-stanbulTrkiye

Recently, the space bvp of real or complex numbers consisting of all sequences whose differences are in the space lp has been studied by basar, Altay [Ukrainian Math. j. 55（1）（2003）, 136-147], where 1 ≤ p ≤ ∞. The main purpose of the present paper is to introduce the space bvp（F） of sequences of p-bounded variation of fuzzy numbers. Moreover, it is proved that the space bvp（F） includes the space lp（F） and also shown that the spaces bvp（F） and lp（F） axe isomorphic for 1 ≤ p ≤∞. Furthermore, some inclusion relations have been given.

关键词： sequence of fuzzy numbers space of difference sequences isomorphic spaces and inclusion relations

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