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Six-year outcomes in neovascular age-related macular degeneration with ranibizumab

International Journal of Ophthalmology(English edition) 2017年第1期10卷 81-90页

作者： Julie Jacob Heidi brié Anita Leys Laurent Levecq Filip Mevgaerts Kris Denhaerynck Stefaan Vancayzeele Eline Van Craeyveld Ivo Abraham Karen MacDonald Leuven University Eye Hospital Kapucijnenvoer 33Leuven B-3000Belgium Novartis Pharma Medialaan 40Vilvoorde B-1800Belgium Catholic University of Louvain CHU UCL NamurYvoirB-5530Belgium Medisch Centrum Aarschot Langdorpsesteenweg 129Aarschot B-3200Belgium Matrix45 6159 W Sunset RdTucsonAZ 85743USA Center for Health Outcomes and Pharmacoeconomic Research University of ArizonaTucsonAZ 85721USA

AIM： To evaluate the outcomes of （6y ranibizumab therapy in neovascular age-related macular degeneration （AMD）.METHODS： HELIX was a retrospective, observational effectiveness study using medical records of patients treated in three clinics in Belgium. Patients had neovascular AMD and were initially treated with intravitreal ranibizumab （0.5 mg） between November 1, 2007 and October 31, 2008, had （6y of data available, and were treated on an ongoing, as-needed basis. Outcomes included best-corrected visual acuity （BCVA） and central retinal thickness （CRT）.RESULTS： The sample consisted of 88 eyes from 69 patients. Mean age was 76.4±6.5y, most patients were female （62.3%）. Most eyes （62.5%） were treatment-naive, 33 previously treated eyes had received predominantly other anti-vascular endothelial growth factor agents and verteporfin. Mean baseline BCVA was 57.4±12.7 ETDRS letters and CRT was 291.5±86.1 （m. On average, patients received 20.6±11.9 ranibizumab injections over the （6y. Intervals between injections were on average 12.7±16.1wk. Mean change in BCVA from baseline to last observation for the sample was less than one letter （-0.9±17.3 letters）, with an average loss of -3.2±15.6 letters in previously treated eyes versus a gain of 0.6±18.4 letters in treatment-na？ve eyes. When considering a loss of 〈15 letters over 6y as stabilization of disease, 75.9% of all eyes showed a positive （improvement or stabilization） outcome. Mean change in CRT from baseline to last observation for the sample was -26.9±148.4 （m with the greatest reduction observed in treatment-naive ***： This retrospective study of 69 neovascular AMD patients treated for （6y with ranibizumab demonstrates long-term visual stabilization. In light of the natural evolution of the disease, these data confirm that ranibizumab is effective long-term under real-world conditions of heterogeneity of patients, clinicians, and centers.

关键词： ranibizumab age-related macular degeneration visual acuity central retinal thickness optical coherence tomography visual function, long-term outcome

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Comparison of Circular Sector and Rectangular Patch Antenna Arrays in C-Band

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Journal of Electromagnetic Analysis and Applications 2012年第11期4卷 457-467页

作者： Anouar Dalli Lahbib Zenkouar Seddik bri Electrical Enegenniring Department Ecole Supérieure de Technologie—ESTM Université Moulay Ismail Mek- nes Morocco. Laboratoire d’Electronique et de Communications_LEC Ecole Mohammadia d’Ingénieurs—EMI Université Mohammed V-Agdal Rabat Morocco

The circular sector patch antenna is studied in C-band (4 GHz - 8 GHz). In this paper, we present steps of designing the circular sector antenna then a comparison with a rectangular antenna in literature. High Frequency Structure Simulator (HFSS) software is used to compute the gain, axial ratio, radiation pattern, and return loss S11 of proposed antenna. Based on the designed patch antenna, many phased arrays will be simulated using HFSS. The impact of distance between element, number of element and phase will be checked. Obtained results are analyzed and compared with literature.

关键词： Circular Sector Microstrip Antenna Rectangular Antenna Antenna Array Gain Directivity HFSS

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Tuberous Sclerosis Complex Associated with Autism Spectrum Features and Bumetanide as a Pharmacological Indication: A Case Report

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Open Journal of Psychiatry 2021年第3期11卷 202-213页

作者： Maria Cristina brió Mariana Fazzina Melina Chindi Independent Author Buenos Aires Argentina Independent Author Bahia Blanca Argentina

A wide variety of genetic and non-genetic pathologies share serious psychiatric symptoms, which determine a poor quality of life for patients and their families. To evaluate whether bumetanide, a drug initially developed as a diuretic and currently analyzed for a new indication in patients with severe neuropsychiatric pathologies, could improve the disruptive and self-injurious behaviors secondary to Tuberous Sclerosis Complex (TSC) and characteristic of the autistic spectrum the case of this 6-year-old patient is considered. Following preclinical and clinical evidence of the efficacy of bumetanide in Tuberous Sclerosis and other neurodevelopmental disorders, the drug may alleviate the psychiatric manifestations (TAND) of Tuberous Sclerosis pathology. This would allow avoiding the excessive prescription of antipsychotic drugs indicated to control disruptive behaviors. Methodology: The Administración Nacional de Medicamentos, Alimentos y Tecnología Médica (ANMAT) approval was requested for compassionate use since it is not an approved drug in Argentina for this indication. The patient was evaluated with laboratory tests at T0, T1, T2, T3 and T4, corresponding to the basal moments, of 7 days, 30 days, 60 days and 90 days after starting the medication. Likewise, behavior was evaluated with the Aberrant Behavior Checklist (ABC) at the same times described. CARS was used for autistic characteristics and TAND Checklist for psychiatric disorders, both at the beginning. Bumetanide was administered at 1 mg/day and increased to 1.5 mg/day one month after the first dose. Results: We observed, in this case, the primary endpoint, irritability, showed moderate improvement. On the contrary, hyperactivity, attention, sociability and better connection through gaze experienced and evident improvement. Regarding isolation scales and stereotyped behaviors, an important improvement was found after 3 months of treatment with bumetanide, an antagon

关键词： Bumetanide Tuberous Sclerosis Complex Autism Spectrum Disorder Antagonist NKCC1

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原发性血小板增多症巨核系祖细胞体外自主性生长及Tpo作用的探讨

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中华血液学杂志 2001年第6期22卷 300-302页

作者：李艳 Jean brière 翟明中国医科大学第一临床学院血液科沈阳110001 DepartmentofHematology BeaujonHospitalFrance

目的　研究原发性血小板增多症 (ET)巨核系祖细胞的体外自主性生长以及Tpo对其生长的作用。方法　用ET患者骨髓纯化CD3 4+ 细胞以及不同浓度的骨髓和外周血单个核细胞进行体外培养 ,检测其对自发性CFU MK形成的影响 ;用RT PCR技术检测... 详细信息

目的　研究原发性血小板增多症 (ET)巨核系祖细胞的体外自主性生长以及Tpo对其生长的作用。方法　用ET患者骨髓纯化CD3 4+ 细胞以及不同浓度的骨髓和外周血单个核细胞进行体外培养 ,检测其对自发性CFU MK形成的影响 ;用RT PCR技术检测液体培养自发性生长细胞的Tpo的自主分泌和旁分泌 ;观察CD3 4+ 细胞培养中加入Tpo对CFU MK形成的影响。结果　体外培养纯化CD3 4+ 细胞无自发性CFU MK形成 ,单个核细胞稀释到一定浓度 (10 4 /ml或 10 3 /ml)时自发性集落消失 ;液体培养自发性生长细胞无TpomRNA的表达 ;CD3 4+ 细胞培养中加入Tpo后可形成CFU MK。结论　ET患者的体外自发性CFU MK形成并非巨核系祖细胞的自主性生长所致 ,与Tpo的自主分泌或旁分泌也无关。

关键词：原发性血小板增多症巨核系祖细胞自主分泌血小板生成素

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Online Learning Effectiveness in Times of Covid-19 for Utesa University Undergraduate Students in the Dominican Republic: A Narrative Research Approach

Online Learning Effectiveness in Times of Covid-19 for Utesa...

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作者： Luis Gabriel Pérez Báez 浙江师范大学

学位级别：硕士

Effectiveness refers to the measure of to what extent goals are accomplished,this study will focus on determining how effective online learning is,more specifically how it fares during times of COVID-19 pandemic and focused on undergraduate *** studies have been previously been made regarding online learning effectiveness,however there are not many studies referring to online learning in times of pandemic and even fewer focused on developing nations like the Dominican *** purpose of this study is to determine the effectiveness of online learning in times of COVID-19 of undergraduate students in the Dominican *** research is necessary because of how the country have switched completely,albeit temporarily to a fully online teaching modality due to COVID-19,this sudden change was done without much infrastructure,teaching materials or pacification previously adapted to this particular situation,therefore assessing how effective has online education has been during this period will contribute to the country’s current situation and any future challenge that may arrive and need a similar *** order to understand this problematic as well as to get useful information from the volunteers,undergraduate students from UTESA University,interviews will be used to collect information which will later be analyzed using the qualitative methodology with a narrative inquiry *** conducting this study is expected to provide much needed information in this subject that may serve as guidance for a future reform of the higher education system in the country,putting special focus on the online learning modality.

关键词： Effectiveness Online learning Undergraduate students COVID-19 Dominican Republic

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Boundary of Cretaceous and Paleogene continental deposits in Zeya-Bureya Basin,Amur(Heilongjiang)River region

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Global Geology 2011年第3期14卷 144-159页

作者： Valentina S. Markevich Eugenia V. Bugdaeva Abdul R. Ashraf SUN get Institute of Biology and Soil Science FEB RAS Vladivostok 690022 Russia Institute of Geosciences University of Tuebingen Tuebingen 72074 Germany Key-Lab for Evolution of Past Life MOEC （Jilin University） Changchun 130026 China College of Paleontology Shenyang Normal University Shenyang 110034 China

It was conducted the comparison of palynological assemblages of the Middle Tsagayan,Upper Tsagayan subformations,Furao and Wuyun formations from Zeya-Bureya Basin of Amur (Heilongjiang) River region with assemblages obtained from the marine deposits of Northeast Russia,Sakhalin,Kuril,and Hokkaido Islands,dated by ammonites,foraminifers and other invertebrates. Based on detail correlation,the geological age of the terrestrial beds was defined. The guide fossils are recognized Marsypiletes cretacea,Tricolpites variexi- nus,Aquilapollenites conatus,A. stelkii,A. rombicus,Integricorpus bellum,Pseudointegricorpus clarireticula- tus,Triprojectus amoenus,Orbiculapollis lucidus,Wodehouseia aspera,Quercoidites minor,which had last oc- currence in the late Maastrichtian. The Danian palynofloras usually are dominated by Triatriopollenites plicoides and T. confusus. The species Anacolosidites subtrudens,Aquilapollenites proceros,A. spinulosus have last occurrence in the Danian. The K-T (K-Pg) boundary in the terrestrial deposits is defined in the base of the Upper Tsagayan Subformation and the base of the lower part of the Wuyun Formation. The latter is represented by aleuropelite to fine-grained sandstones. The change of taxonomical composition of palynospectra in similar environments could be determined by real change of flora at the Mesozoic and Cenozoic boundary,but not by changes of lithological facies or depositional environment,generally.

关键词： palynoflore Cretaceous Paleogene boundary Zeya-Bureya Basin

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骨髓增殖性疾病巨核系祖细胞的体外液体培养

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中国医科大学学报 2001年第2期30卷 88-90页

作者：李艳 Jeanbriére 中国医科大学第一临床学院血液科沈阳110001 法国Beaujon医院血液科

目的 :观察有自发性巨核细胞集落 (CFU MK)形成的骨髓增殖性疾病 (MPD)患者 ,其液体培养是否也有自发性巨核细胞生长。方法 :采用末梢血非粘附单个核细胞进行体外无血清液体培养及半固体培养 ,应用RT PCR技术检测液体培养自发性生长细胞... 详细信息

目的 :观察有自发性巨核细胞集落 (CFU MK)形成的骨髓增殖性疾病 (MPD)患者 ,其液体培养是否也有自发性巨核细胞生长。方法 :采用末梢血非粘附单个核细胞进行体外无血清液体培养及半固体培养 ,应用RT PCR技术检测液体培养自发性生长细胞的c mpl及GPⅡb的表达。结果 :只有在半固体培养基上形成自发性巨核细胞集落的患者 ,其无血清液体培养才有自发性生长的细胞 ,且两者为正相关 (r =0 .79,P <0 .0 1) ,同时这些自发性生长的细胞有巨核细胞所特异的c mpl和GPⅡbmRNA的平行表达。结论 :无血清液体培养自发性生长的细胞中有巨核细胞的存在 ,与自发性CFU MK来源于相同的巨核祖细胞 ,提示可利用前者代替集落细胞研究MPD自发性巨核细胞造血的机制。

关键词：骨髓增殖性疾病巨核细胞液体培养

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过敏性肺疾病的免疫学检查

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国际呼吸杂志 1989年第2期21卷 81-83页

作者： Akoun get al 刘崇智

本文提出皮试、血液检查、BAL 检查、激发试验和组织免疫学检查5种简单易行的免疫学检查方法,供临床医师用以诊断过敏性肺疾病。

关键词：过敏性肺疾病免疫学检查激发试验 BAL

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get-iae China国际教育交流峰会圆满落幕 “严肃”+“娱乐”搭建行业交流平台

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留学 2019年第22期 48-52页

作者：汝元昕 get-iae China(图) get-iae China

海外院校、代理顾问、机构同仁……一年一度的get-iae China峰会成为国际教育领域从业者对话交流的盛会。2019年11月4日,第五届get-iae China国际教育交流峰会在厦门万豪酒店及会议中心拉开帷幕。来自海外的国际教育项目合作方,以及国... 详细信息

海外院校、代理顾问、机构同仁……一年一度的get-iae China峰会成为国际教育领域从业者对话交流的盛会。2019年11月4日,第五届get-iae China国际教育交流峰会在厦门万豪酒店及会议中心拉开帷幕。来自海外的国际教育项目合作方,以及国内的一线渠道合作伙伴与优秀顾问参加了此次峰会。峰会为期四天,旨在为海外院校和院校代理、留学顾问搭建交流平台,为留学行业从业人员提供最新信息与便捷帮助,从而推动行业在沟通合作中实现互利共赢。

关键词：渠道合作伙伴国际教育交流对话交流互利共赢万豪酒店沟通合作合作方代理

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Violent and Risk-Taking Behaviors Associated with Intake of Energy Drinks Mixed with Alcohol and Perceptions of This Consumption among Children and Adolescents in Costa Rica

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Food and Nutrition Sciences 2020年第8期11卷 836-853页

作者： Núñez-Rivas Hilda Holst-Schumacher Ileana Campos-Saborío Natalia Costa Rican Institute of Research and Education in Health and Nutrition (INCIENSA) Tres Ríos Costa Rica University of Costa Rica (UCR) San Pedro Montes de Oca Costa Rica State University at Distance (UNED) Sabanilla Costa Rica

Introduction: The consumption of energy drinks and its mix with alcohol has been associated with negative and violent behaviors in youngsters. Objective: To determine the risk-taking behaviors associated with the consumption of energy drinks mixed with alcohol in Costa Rican adolescents. Methods: A mixed cross-sectional study was performed with a population of 2667 students of 64 educative centers in 2016. Descriptive statistics were performed with the program SPSS 20.0 and a value of p 0.05 was considered significant. Results: The third part of the study population is usually a consumer of energy drinks (30%) and 3% make use of drinks mixed with alcohol. The children and adolescents, who consume energy-alcohol mixed drinks, are more likely to present risk-taking behaviors than those who do not consume these mixed beverages: combined use of medicines to get high;cocaine consumption, consumption of cement/glue, consumption of marijuana, physical violence (fighting), use of weapons, suicidal ideation, deliberate self-harm, low educational expectation, sexual intercourses, cyberbullying and school apathy. The students perceived the intake of energy beverages as of low risk for their health. They also agr

关键词： Energy Drinks Energy-Alcohol Mix Drinks Children Adolescents Costa Rica

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