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Transcranial magnetic stimulation: potential treatment for co-occurring alcohol, traumatic brain injury and posttraumatic stress disorders

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Neural Regeneration Research 2014年第19期9卷 1712-1730页

作者： Amy A.Herrold Sandra l.Kletzel brett C.Harton R.Andrew Chambers Neil Jordan Theresa louise-Bender Pape Edward Hines Jr.VA Hospital Research Service PO Box 5000 (M/C 151H)HinesILUSA The Department of Veterans Affairs (VA) Center for Innovation for Complex Chronic HealthcareEdward Hines Jr.VA HospitalPO Box 5000 (M/C 151H)HinesILUSA Department of Psychiatry & Behavioral Sciences Northwestern University Feinberg School of Medicine446 East Ontario#7-200ChicagoILUSA Chicago Association for Research and Education in Science HinesILUSA Department of Psychiatry Laboratory for Translational Neuroscience of Dual Diagnosis & DevelopmentNeuroscience Research CenterIndiana University School of Medicine320 West 15~(th)StreetIndianapolisINUSA Northwestern University Feinberg School of Medicine Department of Physical Medicine and RehabilitationOffice of Medical Educ.(1574)345 E.Superior St.ChicagoILUSA

Alcohol use disorder （AUD）, mild traumatic brain injury （mTBI）, and posttraumatic stress disorder （PTSD） commonly co-occur （AUD ＋ mTBI ＋ PTSD）. These conditions have overlapping symptoms which are, in part, reflective of overlapping neuropathology. These conditions become problematic because their co-occurrence can exacerbate symptoms. Therefore, treatments must be developed that are inclusive to all three conditions. Repetitive transcranial magnetic stimulation （rTMS） is non-invasive and may be an ideal treatment for co-occurring AUD ＋ mTBI ＋ PTSD. There is accumulating evidence on rTMS as a treatment for people with AUD, mTBI, and PTSD each alone. However, there are no published studies to date on rTMS as a treatment for co-occurring AUD ＋ mTBI ＋ PTSD. This review article advances the knowledge base for rTMS as a treatment for AUD ＋ mTBI ＋ PTSD. This review provides background information about these co-occurring conditions as well as rTMS. The existing literature on rTMS as a treatment for people with AUD, TBI, and PTSD each alone is reviewed. Finally, neurobiological findings in support of a theoretical model are discussed to inform TMS as a treatment for co-occurring AUD ＋ mTBI ＋ PTSD. The peer-reviewed literature was identified by targeted literature searches using PubMed and supplemented by cross-referencing the bibliographies of relevant review articles. The existing evidence on rTMS as a treatment for these conditions in isolation, coupled with the overlapping neuropathology and symptomology of these conditions, suggests that rTMS may be well suited for the treatment of these conditions together.

关键词： transcranial magnetic stimulation traumatic brain injury posttraumatic stress disorder treatment neuroimaging substance use disorders addiction co-morbidity mental health disorders behavioral health neuroimaging non-invasive brain stimulation

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Single nucleotide polymorphisms linked to quantitative trait loci for grain quality traits in wheat

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The Crop Journal 2016年第1期4卷 1-11页

作者： Chunlian li Guihua Bai Shiaoman Chao brett Carver Zhonghua Wang College of Agronomy Northwest A&F University State Key laboratory of Crop Stress Biology for Arid Areas Northwest A&F University Agronomy Department Kansas State University Hard Winter Wheat Genetics Research Unit USDA-ARS Cereal Crops Research Unit USDA-ARS Department of Plant and Soil Science Oklahoma State University

Wheat(Triticum aestivum l.) grain quality traits that are controlled by quantitative traits loci(QTl) define suitable growing areas and potential end-use products of a wheat cultivar. To dissect QTl for these traits including protein content(GPC); test weight(TW); single kernel characterization system(SKCS)-estimated kernel weight(SKW); kernel diameter(KD);kernel hardness measured by near-infrared reflectance spectroscopy(NIRS) hardness index(NHI); and SKCS-hardness index(SHI), a high-density genetic map with single nucleotide polymorphism(SNP) and simple sequence repeat(SSR) markers was developed using recombinant inbred lines(RIls) derived from Ning7840 × Clark. The RIls were evaluated for these quality traits in seven Oklahoma environments from 2001 to 2003. A total of 41 QTl with additive effects on different traits were mapped on most wheat chromosomes,excluding 1A, 2A, 3D, 4D, 6D, and 7B. Seven chromosome regions showed either tightly linked QTl or QTl with pleiotropic effects on two to four traits. Ten pairs of QTl showed additive × additive effects(AA), four QTl were involved in additive × environment(AE)effects, and one was involved in AAE effects. Two to eleven QTl for each of the six traits and139 tightly linked markers to these QTl were identified. The findings shed light on the inheritance of wheat grain quality traits and provide DNA markers for manipulating these important traits to improve quality of new wheat cultivars.

关键词： Triticum aestivum Epistasis Grain quality traits QTl×environments interaction SNP

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A Facile Synthesis of ZnCo2O4 Nanocluster Particles and the Performance as Anode Materials for lithium Ion Batteries

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Nano-Micro letters 2017年第2期9卷 79-87页

作者： Yue Pan Weijia Zeng lin li Yuzi Zhang Yingnan Dong Dianxue Cao Guiling Wang brett l.lucht Ke Ye Kui Cheng Key laboratory of Superlight Materials and Surface Technology of Ministry of Education College of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001People’s Republic of China Department of Chemistry University of Rhode IslandKingstonRI 02881USA Department of Chemical Engineering University of Rhode IslandKingstonRI 02881USA

ZnCo_2O_4 nanocluster particles(NCPs) were prepared through a designed hydrothermal method, with the assistance of a surfactant, sodium dodecyl benzene sulfonate. The crystalline structure and surface morphology of ZnCo_2O_4 were investigated by XRD, XPS, SEM, TEM, and BET analyses. The results of SEM and TEM suggest a clear nanocluster particle structure of cubic ZnCo_2O_4(*100 nm in diameter), which consists of aggregated primary nanoparticles(*10 nm in diameter), is achieved. The electrochemical behavior of synthesized ZnCo_2O_4 NCPs was investigated by galvanostatic discharge/charge measurements and cyclic voltammetry. The ZnCo_2O_4 NCPs exhibit a high reversible capacity of 700 mAh g^(-1) over 100 cycles under a current density of 100 mA g^(-1) with an excellent coulombic efficiency of 98.9% and a considerable cycling stability. This work demonstrates a facile technique designed to synthesize ZnCo_2O_4 NCPs which show great potential as anode materials for lithium ion batteries.

关键词： ZnCo2O4 nanocluster particles Hydrothermal method Sodium dodecyl benzene sulfonate lithium ion batteries

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Hybrid Ni_(2)P/CoP Nanosheets as Efficient and Robust Electrocatalysts for Domestic Wastewater Splitting

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Energy & Environmental Materials 2023年第5期6卷 330-339页

作者： Yeshu Tan Jianrui Feng liqun Kang longxiang liu Fangjia Zhao Siyu Zhao Dan J.l.brett Paul R.Shearing Guanjie He Ivan P.Parkin Christopher Ingold laboratory Department of ChemistryUniversity College LondonLondon WC1H 0AJUK Materials and Catalysis laboratory Department of Chemical EngineeringUniversity College LondonLondon WC1E 7JEUK Electrochemical Innovation laboratory Department of Chemical EngineeringUniversity College LondonLondon WC1E 7JEUK School of Chemistry University of LincolnJoseph Banks LaboratoriesLincolnLN67DLUK

The development of low-cost,robust and efficient non-noble metal electrocatalysts is still a pursuit for the hydrogen evolution reaction(HER).Herein,a self-standing electrocatalyst,Ni_(2)P/CoP nanosheet,was fabricated directly on three-dimensional Ni foams by two facile steps,which illustrated both high activity and stability for HER in different *** from the porous structures of nanosheets with large specific surface area and the hybrid Ni_(2)P/CoP,the as-prepared electrocatalyst presented remarkable HER with overpotentials of 65.2 and 87.8 mV to reach a current density of-10 mA cm^(-2)in neutral and alkaline media,*** function theory calculations revealed a lower activation energy of water dissociation and efficient HER steps of hybrid Ni_(2)P/CoP nanosheets compared with mono *** self-standing electrocatalyst maintained excellent chemical ***,the HER process in domestic wastewater was realized with more impressive performance by using Ni_(2)P/CoP nanosheets compared with commercial Pt/*** was continuously generated for 20 h in mildly alkaline dishwashing *** work provides a feasible way to fabricate non-noble metal and self-standing hybrid bimetallic phosphides for HER in neutral and alkaline media,showing great potential for efficient hydrogen production by re-utilizing wastewater resources.

关键词： hybrid hydrogen evolution reaction Ni_(2)P/CoP nanosheet self-standing wastewater splitting

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Reversible lithium storage in sp^(2) hydrocarbon frameworks

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Journal of Energy Chemistry 2022年第3期31卷 161-167,I0006页

作者： Zhangxiang Hao Junrun Feng Yiyun liu liqun Kang Bolun Wang Junwen Gu lin Sheng Ruoyu Xu Sushila Marlow Dan J.l.brett Yunhui Huang Feng Ryan Wang Materials and Catalysis laboratory Department of Chemical EngineeringUniversity College LondonLondon WC1E 7JEUnited Kingdom School of Materials Science and Engineering Huazhong University of Science and TechnologyWuhan 430074HubeiChina Electrochemical Innovation lab Department of Chemical EngineeringUniversity College LondonLondon WC1E 7JEUnited Kingdom Department of Chemistry University College LondonLondon WC1H 0AJUnited Kingdom

Polymer materials offer controllable structure-dependent performances in separation,catalysis and drug *** molecular structures can be precisely tailored to accept li^(+)for energy storage *** the design of sp^(2)carbon-based polyphenylene(PPH)with high lithium-ion uptakes and long-term stability is ***-PPH(l-PPH)exceeds the performance of crosslink-PPH(C-PPH),due to the fact that it has an ordered lamellar structure,promoting the li^(+)intercalation/deintercalation *** l-PPH cell shows a clear charge and discharge plateau at 0.35 and 0.15 V ***^(+)/li,respectively,which is absent in the C-PPH *** li^(+)storage capacity of l-PPH is five times that of the *** reversible storage capacity is further improved to 261 m Ah g;by functionalizing the l-PPH with the–SO_(3)H *** addition,the li-intercalated structures of C-PPH and l-PPH are investigated via near-edge X-ray absorption fine structure(NEXAFS),suggesting the high reversible li^(+)–C=C bond interaction at *** strategy,based on new insight into sp^(2)functional groups,is the first step toward a molecular understanding of the structure storage-capacity relationship in sp^(2)carbon-based polymer.

关键词： lithium-ions battery Organic anode Topological structure sp^(2)hydrocarbon

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Vinyl chloride monomer production catalysed by gold: A review

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Chinese Journal of Catalysis 2016年第10期37卷 1600-1607页

作者： Catherine J.Davies Peter J.Miedziak Gemma l.brett Graham J.Hutchings 卡迪夫大学

In this review we discuss the history of research into the use of gold for the acetylene hydrochlorin‐ation reaction, and describe the recent developments which have led to its commercialisation. We discuss the use of different precursors and the addition to gold of a secondary metal as methods which attempt to improve these catalysts, and consider the nature of the active gold species. The vast majority of poly vinyl chloride （PVC） produced globally still uses a mercuric chloride as a cata‐lyst, despite the environmental problems associated with it. Due to the agreement by the Chinese government to remove mercury usage in the PVC industry over the course of the next few years there is an obvious need to find a replacement catalyst;the potential use of gold for this process has been well known for several decades and to date gold seems to be the best candidate for this, pri‐marily due to its superior selectivity when compared to other metals.

关键词： Gold Acetylene Hydrochlorination Vinyl chloride monomer Poly vinyl chloride Catalysis

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pHairyRed： A Novel Binary Vector Containing the DsRed2 Reporter Gene for Visual Selection of Transgenic Hairy Roots

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Molecular Plant 2011年第3期4卷 537-545页

作者： Meng-Han lin Peter M. Gresshoff Arief Indrasumunar brett J. Ferguson Australian Research Council Centre of Excellence for Integrative legume Research The University of Queensland St Lucia Brisbane QLD 4072 Australia

We developed a new plant transformation vector, pHairyRed, for enabling high throughput, non-destructive selection of Agrobacterium rhizogenes-mediated ＇hairy-root＇ transformation, pHairyRed allows easy in planta visualiza- tion of transgenic tissue with minimal disturbance to the plant. The DsRed2 reporter gene, encoding a red fluorescent protein, was cloned to yield pHairyRed （harbouring a multiple cloning site）, which was used with the highly efficient K599 A. rhizogenes strain to infect soybean （Glycine max l. Merrill） plants. DsRed2 fluorescence was easily detected in planta for the duration of a 5-week study with negligible levels of background autofluorescence. This enabled visual selection of transformed roots and subsequent excission of non-transformed roots, pHairyRed-transformed roots nodu- lated normally when inoculated with Bradyrhizobiumjaponicum. Within the nodule, DsRed2 fluorescence was plant-spe- cific, being absent in the bacteroid-dominated nodule infected zone. To test the reliability of pHairyRed as a high-fidelity binary vector reporter system, the gene encoding the soybean Nod factor receptor, GmNFRlol, was cloned into the vector for use in a complementation study with a non-nodulating nfrlol mutant of soybean. Complementation was achieved and, without exception, DsRed2 fluorescence was detected in all hairy roots that successfully formed nodules （100%, n = 34）. We anticipate broad application of this reporter system for the further analysis of root-related events in soybean and related legumes.

关键词： Fluorescence imaging genetics molecular biology plant-microbe interactions soybean plant transformation.

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Battery state-of-charge estimation using machine learning analysis of ultrasonic signatures

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能源与人工智能(英文) 2022年第4期10卷 60-72页

作者： Elias Galiounas Tom G.Tranter Rhodri E.Owen James B.Robinson Paul R.Shearing Dan J.l.brett Electrochemical Innovation lab Department of Chemical EngineeringUniversity College LondonLondonWC1E 7JEUK The Faraday Institution Quad OneBecquerel AvenueHarwell CampusDidcotOX11 The Alan Turing Institute British Library96 Euston RoadLondon NW12DB

The potential of acoustic signatures to be used for State-of-Charge(SoC)estimation is demonstrated using artificial neural network regression *** approach represents a streamlined method of processing the entire acoustic waveform instead of performing manual,and often arbitrary,waveform peak *** applications where computational economy is prioritised,simple metrics of statistical significance are used to formally identify the most informative waveform *** alone can be exploited for SoC *** is further shown that signal portions representing both early and late interfacial reflections can correlate highly with the SoC and be of predictive value,challenging the more common peak selection methods which focus on the *** later echoes represent greater through-thickness coverage,and are intuitively more information-rich,their presence is not *** waveform treatment offers a more robust approach to correlating acoustic signatures to electrochemical *** is further demonstrated that transformation into the frequency domain can reduce the dimensionality of the problem significantly,while also improving the estimation *** importantly,it is shown that acoustic signatures can be used as sole model inputs to produce highly accurate SoC estimates,without any complementary voltage *** makes the method suitable for applications where redundancy and diversification of SoC estimation approaches is *** is obtained experimentally from a 210 mAh liCoO2/graphite pouch *** estimation errors as low as 0.75%are achieved on a SoC scale of 0-100%.

关键词： Battery diagnostics Ultrasonic battery monitoring Acoustic battery inspection Mechanical-electrochemical correlation Machine learning Artificial neural networks

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Controlled release of FK506 from micropatterned PlGA films:potential for application in peripheral nerve repair

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Neural Regeneration Research 2018年第7期13卷 1247-1252页

作者： brett Davis Susan Wojtalewicz Pratima labroo Jill Shea Himanshu Sant Bruce Gale Jayant Agarwal Department of Bioengineering University of Utah Department of Surgery University of Utah Department of Mechanical Engineering University of Utah

After decades of research,peripheral nerve injury and repair still frequently results in paralysis,chronic pain and neuropathies leading to severe disability in *** clinically available nerve conduits only provide crude guidance of regenerating axons across nerve gap without additional ***506（Tacrolimus）,an FDA approved immunosuppressant,has been shown to enhance peripheral nerve regeneration but carries harsh side-effects when delivered *** objective of this study was to develop and evaluate a bioresorbable drug delivery system capable of local extended delivery of FK506 that also provides topological guidance cues to guide axon growth via *** was used to create micropatterned poly（lactide-co-glycolic acid）（PlGA） films embedded with ***-patterned,10/10 μm（ridge/groove width）,and 30/30 μm patterned films loaded with 0,1,and 3 μg/cm2 FK506 were manufactured and *** vitro FK506 rate of release testing indicated that the films are capable of an extended（at least 56 days）,controlled,and scalable release of *** extension bioactivity assay indicated that FK506 released from the films（concentration of samples tested ranged between 8.46–19.7 ng/m l） maintained its neural bioactivity and promoted neurite extension similar to control FK506 dosages（10 ng/m l FK506）.The multi-functional FK506 embedded,micropatterned poly（lactide-co-glycolic acid） films developed in this study have potential to be used in the construction of peripheral nerve repair devices.

关键词： nerve regeneration FK506 controlled release micropatterns topological cues PlGA

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Morinda citrifolia （Noni）: A literature review and recent advances in Noni research1

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Acta Pharmacologica Sinica 2002年第12期23卷 74-88页

作者： brett J WEST,CJarakae JENSEN,Diane NOWICKI,SU Chen,Afa K PAlU,Gary ANDERSON Department of R＆D Morinda Inc Provo Utah 84606 USA Department of R＆D Morinda Inc Provo Utah 84606 USA Department of R＆D Morinda Inc Provo Utah 84606 USA Department of R＆D Morinda Inc Provo Utah 84606 USA Department of R＆D Morinda Inc Provo Utah 84606 USA University of Illinois College of Medicine Department of Pathology 1601 Parkview Avenue Rockford Il 61107 USA

Morinda citrifolia l (Noni) has been used in folk remedies by Polynesians for over 2000 years, and is reported to have a broad range of therapeutic effects, including antibacterial, antiviral, antifungal, antitumor, antihelmin, analgesic, hypotensive, anti-inflammatory, and immune enhancing effects. In order to reveal the nutritional and medicinal value of the Noni plant, and to summarize scientific evidence that supports the Polynesians' claim, a literature review and recent advances in Noni research is given below.

关键词： Morinda citrifolia l Noni proxeronine xeronine cancer prevention antioxidants selective COX-2 inhibitor Yin & Yang

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