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High-flow oxygen via oxygenating mouthguard in short upper gastrointestinal endoscopy:A randomised controlled trial

World Journal of Gastrointestinal Endoscopy 2022年第12期14卷 777-788页

作者： Kim Hay Be Leonardo Zorron Cheng Tao Pu brett pearce Matthew Lee Luke Fletcher Rebecca Cogan Philip Peyton Rhys Vaughan Marios Efthymiou Sujievvan Chandran Department of Gastroenterology and Hepatology Austin HealthHeidelberg 3084VictoriaAustralia Department of Anaesthesia and Pain Medicine Austin HealthHeidelberg 3084VictoriaAustralia Faculty of Medicine Dentistry and Health SciencesUniversity of MelbourneParkville 3010VictoriaAustralia

BACKGROUND Anaesthetic care during upper gastrointestinal(GI)endoscopy has the unique challenge of maintaining ventilation and oxygenation via a shared upper *** oxygen is recommended by international society guidelines,however,the optimal route or rate of oxygen delivery is not *** oxygen delivery devices have been investigated to improve oxygenation during upper GI endoscopy,however,these are limited by commercial availability,costs and in some cases,the expertise required for *** at our centre,higher flows of supplemental oxygen can safely be delivered via an oxygenating mouthguard routinely used during upper GI endoscopic *** To assess the incidence of hypoxaemia(SpO2<90%)in patients undergoing upper GI endoscopy receiving supplemental oxygen using an oxygenating mouthguard at 20 L/min flow compared to standard nasal cannula(SNC)at 2 L/min *** A single centre,prospective,randomised clinical trial at two sites of an Australian tertiary hospital between October 2020 and September 2021 was *** undergoing elective upper gastrointestinal endoscopy under deep sedation were randomised to receive supplemental oxygen via high-flow via oxygenating mouthguard(HFMG)at 20 L/min flow or SNC at 2 L/min *** primary outcome was the incidence of hypoxaemia of any duration measured by pulse ***-related,procedural-related,and sedation-related adverse events and patient-reported outcomes were also *** Three hundred patients were *** patients were excluded after randomisation.292 patients were included in the intention-to-treat *** incidence of hypoxaemia was significantly reduced in those allocated *** patients(4.4%)allocated to HFMG experienced an episode of hypoxaemia,compared to thirty-four(22.1%)patients allocated to SNC(P value<0.001).No significant difference was observed in the rates of adverse events or patient-reported outcome meas

关键词： Upper gastrointestinal endoscopy Supplementary oxygen Hypoxaemia Oxygenating mouthguard

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