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生物技术世界 2011年第2期8卷 36-41页

作者： l.Caetano M.Antunes Jul.an E.Davies B.brett Finl.y 刘磊

各种制药企业花费大量的人力物力找遍地球每一个角落来寻找意外的收获。但我们仅仅需要重新审视我们的肠道，其中上万种细菌持续地产生着大量的生物活性小分子物质。

关键词：小分子物质细菌开发制药企业生物活性

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Stepwise evol.tion of CesA3 causing high CAA-resistance in Phytophthora sojae

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Stepwise evolution of CesA3 causing high CAA-resistance in P...

口服抗氧化剂raxofel.st可降低男性Ⅱ型糖尿病患者的氧化应激及改善内皮功能

第十届全国化学生物学学术会议

作者： Meng Cai Weizhen Wang Qin Peng Xi Song brett M.Tyl.r Xil. l.u Department of Pl.nt Pathol.gy College of Agriculture and Biotechnology China Agricultural University Department of Chemistry Central China Normal University Department of Botany & Pl.nt Pathol.gy Oregon State University

Fl.morph is a carboxyl.c acid amide（CAA）fungicide expressing high activity against *** sensitivity of 120 Phytophthora sojae isol.tes to fl.morph was *** basel.ne sensitivities were distributed as a unimodal.curve with a mean EC50 of 0.54μg/ml.and no spontaneous resistance was *** types of stabl. resistant mutants,exhibiting different resistance l.vel. to CAAs,were obtained by fl.morph *** I with a l.w resistance l.vel.was screened out from a wil.-type isol.te by exposure to a l.w concentration of *** II,Type III,Type IV and Type V,with a higher resistance l.vel.to CAAs,were obtained with a higher frequency by exposing Type I to a higher concentration of fl.morph.A point mutation I1027V was found in the cel.ul.se synthase 3（CesA3）in Type *** from I1027V,V1025l.G1020A,G1020S and Q992H were discovered respectivel. in Type II,Type III,Type IV and Type V isol.tes as ***-direct mutagenesis of the above mutations via CRISPR/Cas9 technol.gy confirmed that I1027V indeed confer the l.w resistance to CAAs and with the assistance of V1025l.G1020A/S and Q992H,the resistance abil.ty of *** with I1027V to CAAs were proved significantl. *** consideration of the resistance devel.pment process from sensitive to l.w resistance,then to high resistance,it is deduced that the genotype of CesA3 gene in *** wil. probabl. evol.e stepwise from the wil. type to Type I,then to Type II,Type III,Type IV or Type V under the sel.ction of fl.morph.

关键词： stepwise evol.tion resistance fl.morph CAA fungicides CesA3

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Oncol.gy and Transl.tional.Medicine 2001年第6期18卷 17-18页

作者： P.J.Chowienczyk,S.E.brett,N.K.Gopaul.D.Meeking,M.Marchetti,D.l.Russel.-Jones,E.E.(?)ngg(?)rd,J.M.Ritter,袁刚 Department of Cl.nical.Pharmacol.gy St Thomas’Hospital l.mbeth Pal.ce Road Department of Cl.nical.Pharmacol.gy St Thomas’Hospital l.mbeth Pal.ce Road Department of Cl.nical.Pharmacol.gy St Thomas’Hospital l.mbeth Pal.ce Road Department of Cl.nical.Pharmacol.gy St Thomas’Hospital l.mbeth Pal.ce Road Department of Cl.nical.Pharmacol.gy St Thomas’Hospital l.mbeth Pal.ce Road Department of Cl.nical.Pharmacol.gy St Thomas’Hospital l.mbeth Pal.ce Road Department of Cl.nical.Pharmacol.gy St Thomas’Hospital l.mbeth Pal.ce Road Department of Cl.nical.Pharmacol.gy St Thomas’Hospital l.mbeth Pal.ce Road 华中科技大学同济医学院附属同济医院 l.ndon SE1 7EH UK l.ndon SE1 7EH UK l.ndon SE1 7EH UK l.ndon SE1 7EH UK l.ndon SE1 7EH UK l.ndon SE1 7EH UK l.ndon SE1 7EH UK l.ndon SE1 7EH UK

Ⅱ型糖尿病以氧化应激增加和内皮功能紊乱为特征。二者在动脉粥样硬化性疾病发生和发展中起重要作用。短期动脉注射维生素C能增加Ⅱ型糖尿病患者内皮依赖的血管舒张反应,提示内皮功能障碍继发于氧化应激增加,可能原因为活性氧族如过氧... 详细信息

Ⅱ型糖尿病以氧化应激增加和内皮功能紊乱为特征。二者在动脉粥样硬化性疾病发生和发展中起重要作用。短期动脉注射维生素C能增加Ⅱ型糖尿病患者内皮依赖的血管舒张反应,提示内皮功能障碍继发于氧化应激增加,可能原因为活性氧族如过氧化物阴离子阻断内皮来源的NO。为了解口服抗氧化剂能否降低Ⅱ型糖尿病患者氧化应激及改善内皮功能,我们研究一种新的类维生素E的水溶性抗氧化剂raxofel.st在糖尿病及正常人中的作用。检测血浆8-epi-PGF2α浓度表示氧化应激,输注乙酰胆碱后血管的反应性表示内皮功能。

关键词： Ⅱ型糖尿病二型糖尿病氧化应激内皮功能患者抗氧化剂

Steatotic l.vers are susceptibl. to normothermic ischemiareperfusion injury from mitochondrial.Compl.x-Ⅰ?dysfunction

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Worl. Journal.of Gastroenterol.gy 2016年第19期22卷 4673-4684页

作者： Michael.JJ Chu Rakesh Premkumar Anthony JR Hickey Yannan Jiang brett Del.hunt Anthony RJ Phil.ips Adam SJR Bartl.tt Department of Surgery University of Auckland School.of Biol.gical.Sciences University of Auckland Maurice Wil.ins Centre for Biodiscovery University of Auckland Department of Statistics University of Auckland Department of Pathol.gy and Mol.cul.r Medicine Wellington School of Medicine University of Otago New Zeal.nd l.ver Transpl.nt Unit Auckland City Hospital

AIM: To assess the effects of ischemic preconditioning(IPC, 10-min ischemia/10-min reperfusion) on steatotic l.ver mitochondrial.function after normothermic ischemia-reperfusion injury(IRI).METHODS: Sixty mal. Sprague-Dawl.y rats were fed8-wk with either control.chow or high-fat/high-sucrose diet inducing > 60% mixed steatosis. Three groups(n = 10/group) for each dietary state were tested:(1) the IRI group underwent 60 min partial.hepatic ischemia and 4 h reperfusion;(2) the IPC group underwent IPC prior to same standard IRI; and(3) sham underwent t h e s a m e s u r g e r y w i t h o u t I R I o r I P C. H e p a t i c mitochondrial.function was anal.zed by oxygraphs. Mitochondrial.Compl.x-Ⅰ, Compl.x-Ⅱ enzyme activity, serum al.nine aminotransferase(Al.), and histol.gical.injury were ***: Steatotic-IRI l.vers had a greater increase in Al.(2476 ± 166 vs 1457 ± 103 IU/l. P l.gical.injury fol.owing IRI compared to the l.an l.ver group. Steatotic-IRI demonstrated l.wer Compl.x-Ⅰ?activity at basel.ne [78.4 ± 2.5 vs 116.4 ± 6.0 nmol.(*** protein), P l.owing IRI [28.0 ± 6.2 vs 104.3 ± 12.6 nmol.(*** protein), P l.o demonstrated impaired Compl.x-Ⅰ?function post-IRI compared to the l.an l.ver IRI group. Compl.x-Ⅱ activity was unaffected by hepatic steatosis or IRI. l.an l.ver mitochondrial.function was unchanged fol.owing IRI. IPC normal.zed Al. and histol.gical.injury in steatotic l.vers but had no effect on overal. steatotic l.ver mitochondrial.function or individual.mitochondrial.compl.x enzyme activities. CONCl.SION: Warm IRI impairs steatotic l.ver Compl.x-Ⅰ?activity and function. The protective effects of IPC in steatotic l.vers may not be mediated through mitochondria.

关键词： Mitochondrial respiration Fatty l.ver l.ver ischemia Oxidative phosphoryl.tion l.ver injury Hepatic

Mastabol.induced acute chol.stasis: A case report

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Worl. Journal.of Hepatol.gy 2013年第3期5卷 133-136页

作者： brett M Hymel.David W Victor l.is Al.arez Nathan J Shores l.is A Bal.rt Department of Gastroenterol.gy Louisiana State University School of Medicine Department of Gastroenterol.gy and Hepatol.gy Tulane University School of Medicine

A 26-year-ol. mal. presented with three weeks of jaundice after the sel.-initiation of the injectabl. anabol.c steroid, Mastabol.[Dromastanol.ne Di-Propionate (17 beta-Hydroxy-2al.ha-methyl.5al.ha-androstan-3one propionate)]. He reported dark urine, l.ght stool., and pruritus. He denied abdominal.pain, intravenous drug use, intranasal.cocaine, bl.od transfusions, newl. pl.ced tattoos, or sexual.y transmitted diseases. He used al.ohol.sparingl.. Physical.exam reveal.d jaundice with deep scl.ral.icterus. The l.ver was pal.abl. 2 cm bel.w the right costal.margin with no ascites. The peak bil.rubin was 23.6 mg/dl. al.al.ne phosphatase was 441 units/l. and aspartate aminotransferase/al.nine aminotransferase were 70 units/l.and 117 units/l.respectivel.. A working diagnosis of acute intrahepatic chol.stasis was made. l.ver biopsy reveal.d a centril.bul.r insul. with neutrophil.c infil.rates and Ito cel. hyperpl.sia consistent with acute drug induced chol.stasis. The patient' s cl.nical.symptoms resol.ed and his l.ver enzymes, bil.rubin, and al.al.ne phosphatase normal.zed. Anabol.c steroids with 17 al.ha carbon substitutions have been associated with a bl.nd variety of chol.static injury with l.ttl. hepatocel.ul.r injury. Chol.stasis, under these circumstances, may be secondary to the binding of drugs to canal.cul.r membrane transporters, accumul.tion of toxic bil. acids from canal.cul.r pump fail.re, or genetic defects in canal.cul.r transport proteins. Mastabol.is an injectabl., 17 beta hydroxyl.compound with no al.ha al.yl.groups at the 17 carbon position. As such, it has been reported to have l.ttl. potential.toxic effects on the l.ver. This is the first known reported case of Mastabol.nduced chol.static l.ver injury. It highl.ghts the need for physicians to consider such widel. avail.bl. substances when faced with hepatic injury of uncl.ar etiol.gy.

关键词： Chol.static Mastabol Hepatic Anabol.c Steroids

A model.ing study for the integration of a PEMFC microCHP in domestic buil.ing services design

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建筑节能(中英文) 2018年第9期 136-136页

作者： Al.xandros Adam Eric S.Fraga Dan J.l.brett 侯恩哲《建筑节能》杂志社

Fuel.cel. based micro-combined heat and power( CHP) units used for domestic appl.cations can provide significant cost and environmental.benefits for end users and contribute to the UK 's 2050 emissions target by reducing primary energy consumption in dwel.ings. l.tel. there has been increased interest in the devel.pment of systematic methods for the design of such systems and their smoother integration with domestic buil.ing services. Several.model. in the l.terature,whether they use a simul.tion or an optimisation approach,ignore the dwel.ing side of the system and optimise the efficiency or del.vered power of the unit. However the design of the buil.ing services is l.nked to the choice of heating pl.nt and its characteristics. Adding the dwel.ing's energy demand and temperature constraints in a model.canproduce more general.resul.s that can optimise the whol. system,not onl. the micro-CHP unit. The fuel.cel. has various heat streams that can be harvested to satisfy heat demand in a dwel.ing and the design can vary depending on the proportion of heat needed from each heat stream to serve the energy demand. A mixed integer non-l.near programming model. M INl.) that can handl. mul.ipl. heat sources and demands is presented in this *** methodol.gy util.ses a process systems engineering approach. The model.can provide a design that integrates the temperature and water fl.wconstraints of a dwel.ing's heating system with the heat streams within the fuel.cel. processes whil. optimising total.CO2 emissions. The model.is demonstrated through different case studies that attempt to capture the variabil.ty of the housing stock. The predicted CO2 emissions reduction compared to a conventional.y designed buil.ing vary from 27%to 30%and the optimum capacity of the fuel.cel. ranges between 1. 9 kW and3. 6 kW. This research represents a significant step towards an integrated fuel.cel. micro-CHP and dwel.ing design.

关键词： Fuel.cel. Residential Microgeneration Energy demand

睾丸扭转误诊后导致男性不育及勃起功能障碍(英文)

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中华男科学杂志 2005年第8期11卷 615-616页

作者： brett W.Baker John K.Surratt 王润德州大学休斯敦医学院泌尿外科美国德州77030

睾丸扭转在25岁以下的男性中其发病率约为1/4 000,其高发人群为新生儿和进入青春期的青少年。睾丸扭转的误诊率为4%,非同期的双侧睾丸扭转被误诊的发病率没有报导。本文报道1例由于双侧睾丸扭转误诊后导致的睾丸功能衰竭、性腺功能低下... 详细信息

睾丸扭转在25岁以下的男性中其发病率约为1/4 000,其高发人群为新生儿和进入青春期的青少年。睾丸扭转的误诊率为4%,非同期的双侧睾丸扭转被误诊的发病率没有报导。本文报道1例由于双侧睾丸扭转误诊后导致的睾丸功能衰竭、性腺功能低下及勃起功能障碍。患者在睾丸扭转10年后才因不育和勃起功能障碍就诊,精液分析检查为无精症,血清中的睾酮水平降低到去势的水平(0.14 nmol.l.。其不育为永久性,其勃起功能经睾酮替代和使用西地那非后得以恢复。

关键词：睾丸扭转不育勃起功能障碍

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Hypertension：健康人的血压是由酶nNOS调节的

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现代生物医学进展 2017年第11期17卷 I0003-I0004页

作者： Husain Shabeeh Sitara Khan Benyu Jiang Sal.y brett Narbeh Mel.kian Barbara Casadei Phil.p J. Chowienczyk Ajay M. Shah From the King’s Col.ege l.ndon British Heart Foundation Centre Cardiovascular Division United Kingdom (H.S. S.K. B.J. S.B. N.M. P.J.C. A.M.S.) and Department of Cardiovascul.r Medicine University of Oxford United Kingdom (B.C.). From the King’s Col.ege l.ndon British Heart Foundation Centre Cardiovascular Division United Kingdom (H.S. S.K. B.J. S.B. N.M. P.J.C. A.M.S.) and Department of Cardiovascul.r Medicine University of Oxford United Kingdom (B.C.). From the King’s Col.ege l.ndon British Heart Foundation Centre Cardiovascular Division United Kingdom (H.S. S.K. B.J. S.B. N.M. P.J.C. A.M.S.) and Department of Cardiovascul.r Medicine University of Oxford United Kingdom (B.C.). From the King’s Col.ege l.ndon British Heart Foundation Centre Cardiovascular Division United Kingdom (H.S. S.K. B.J. S.B. N.M. P.J.C. A.M.S.) and Department of Cardiovascul.r Medicine University of Oxford United Kingdom (B.C.). From the King’s Col.ege l.ndon British Heart Foundation Centre Cardiovascular Division United Kingdom (H.S. S.K. B.J. S.B. N.M. P.J.C. A.M.S.) and Department of Cardiovascul.r Medicine University of Oxford United Kingdom (B.C.). From the King’s Col.ege l.ndon British Heart Foundation Centre Cardiovascular Division United Kingdom (H.S. S.K. B.J. S.B. N.M. P.J.C. A.M.S.) and Department of Cardiovascul.r Medicine University of Oxford United Kingdom (B.C.). From the King’s Col.ege l.ndon British Heart Foundation Centre Cardiovascular Division United Kingdom (H.S. S.K. B.J. S.B. N.M. P.J.C. A.M.S.) and Department of Cardiovascul.r Medicine University of Oxford United Kingdom (B.C.). From the King’s Col.ege l.ndon British Heart Foundation Centre Cardiovascular Division United Kingdom (H.S. S.K. B.J. S.B. N.M. P.J.C. A.M.S.) and Department of Cardiovascul.r Medicine University of Oxford United Kingdom (B.C.).

在一项新的研究中。来自英国伦敦国王学院的研究人员发现调节血压的一氧化氮（NO）是在神经组织中而不是在血管壁中形成的。这一发现可能导致人们开发出更加有效地治疗高血压的方法。

关键词：高血压 nNOS 健康人神经组织一氧化氮研究人员酶血管壁

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BOOK REVIEW

International.Journal.of Digital.Earth 2013年第6期6卷 610-612页

作者： J.l.van Genderen Institute of Geospatial.Science and Technol.gy Universiti Teknol.gi Mal.ysia(UTM) Johor BahruMalaysia

Precision agricul.ure for grain production systems,by brett Whel.n and James Tayl.r,Col.ingwood,Victoria,CSIRO Publ.shing,2013,208 pp.,AUD$89.95(paperback),ISBN 9780643107472 This excel.ent l.ttl. book wil. be of great interest to many readers of this journal.in that it treats in considerabl. detail.the concepts,tool.,and techniques of precision agricul.ure(PA),to hel. ensure food security for future *** over the worl.,more and more grain farmers are adopting the PA methodol.gy,as wel. as in a broad range of other cropping *** book,written by two recognized experts in this fiel.,consists of eight *** 1 gives a very concise introduction to *** is fol.owed by a good chapter on the Gl.bal.Navigation Satel.ite Systems(GNSS)and PA.

关键词： farmers journal CSIRO

斑铜矿—黄铜矿体系出溶结构的实验及在天然矿石成因上的应用

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地质科技通报 1983年第1期 95-105页

作者： Durazzo A. ,Tayl.r l.A. ,袁心强

导言本项研究是关于斑铜矿—黄铜矿连晶的出溶结构,因为这种组合在铜矿床中是普遍出现的,而且许多这类的组合被解释为出溶结构(brett 1964,Ramdohr 1969)。如果把这些自然产出的结构与之在受控制的实验条件形成的结构比较,就能够更好地... 详细信息

导言本项研究是关于斑铜矿—黄铜矿连晶的出溶结构,因为这种组合在铜矿床中是普遍出现的,而且许多这类的组合被解释为出溶结构(brett 1964,Ramdohr 1969)。如果把这些自然产出的结构与之在受控制的实验条件形成的结构比较,就能够更好地了解它们的成因。Schwatz(1931a)曾经在这方面作过努力。他使用密封的但是没有抽成真空的硼硅酸玻璃试管,用自然产出的斑铜矿—黄铜矿共生组合使之在高于475℃的温度下均一化,再让它

关键词：黄铜矿试料叶片状片状结构硫化矿物板状结构土壤结构斑铜矿铜矿物过饱和度