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Resection of isolated liver oligometastatic disease in pancreatic ductal adenocarcinoma:Is there a survival benefit?A systematic review

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1512-1521页

作者： James M Halle-Smith Sarah Powell-brett Keith Roberts Nikolaos A Chatzizacharias Department of HPB and Liver Transplant Queen Elizabeth HospitalUniversity of BirminghamBirmingham B152GWUnited Kingdom

BACKGROUND Presence of liver metastatic disease in pancreatic ductal adenocarcinoma(PDAC),either synchronous or metachronous after pancreatic resection,is a terminal diagnosis that warrants management with palliative intent as per all international practice ***,there is an increasing interest on any potential value of surgical treatment of isolated oligometastatic disease in selected *** To present the published evidence on surgical management of PDAC liver metastases,synchronous and metachronous,and compare the outcomes of these treatments to the current standard of *** A systematic review was performed in line with the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines to compare the outcomes of both synchronous and metachronous liver metastases resection to standard *** 356 studies were identified,31 studies underwent full-text review and of these 10 were suitable for *** synchronous resection of liver metastases was compared to standard care,most studies did not demonstrate a survival benefit with the exception of one study that utilised neoadjuvant ***,resection of metachronous disease appeared to confer a survival advantage when compared to treatment with chemotherapy *** A survival benefit may exist in resection of selected cases of metachronous liver oligometastatic PDAC disease,after disease biology has been tested with time and systemic *** survival benefit is less clear in synchronous cases;however an approach with neoadjuvant treatment and consideration of resection in some selected cases may confer some *** studies should focus on pathways for selection of cases that may benefit from an aggressive approach.

关键词： Pancreas cancer Liver metastases Surgical resection Systematic review

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创伤性脑损伤后的多领域变化模式

中国康复 2024年第5期39卷 285-285页

作者：孙欣(译) 四川大学华西医院

“TRACK-TBI LONG”是一个多中心、前瞻性的纵向研究,旨在评估创伤性脑损伤(TBI)患者在受伤后认知、精神和功能变化的发生率和模式。该研究从受伤后的基线开始,为期7年。这项前瞻性研究招募了在2014年2月26日~2018年7月27日期间因TBI住... 详细信息

“TRACK-TBI LONG”是一个多中心、前瞻性的纵向研究,旨在评估创伤性脑损伤(TBI)患者在受伤后认知、精神和功能变化的发生率和模式。该研究从受伤后的基线开始,为期7年。这项前瞻性研究招募了在2014年2月26日~2018年7月27日期间因TBI住院的患者。在受伤后的最初12个月内进行随访评估,并在受伤后的7年内进行长期评估。所有的参与者都接受了评估,使用成人电话认知简要测试(BTACT)来评估认知功能,格拉斯哥结局量表-扩展版(GOSE)以评估功能性结局指标,以及简明症状评估量表(BSI)以评估心理健康状态。通过短期和长期的评估结果来比较结局指标的变化。

关键词：心理健康状态结局指标创伤性脑损伤 TBI 随访评估认知功能前瞻性研究扩展版

A data-driven framework for medium-term electric vehicle charging demand forecasting

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Energy and AI 2023年第4期14卷 201-211页

作者： Alexander Orzechowski Loren Lugosch Hao Shu Raymond Yang Wei Li brett H.Meyer McGill University Mcconnell Engineering Building3380 University StMontreal QC H2X 2G6Canada Mogile Technologies 16647 Hymus BlvdKirklandQuebec H9H 4R9Canada

The rapid phase-in of electric vehicles(EV)will cause unprecedented issues with managing the supply of electricity and charging *** is in the interest of utility providers and everyday consumers to be able to plan for peak charging times,and related *** past work has been done for localized,short-term forecasting,it has not included longer term forecasting,or considered the relationships between multiple ***,past work has also not offered a framework for dataset construction and evaluated different dataset *** propose a methodology to forecast demand at public EV charging stations,and use it to explore the potential of data-driven models to predict demand up to one week in *** strategy includes selecting parameters for formatting a dataset given a list of charging events,a way to consider flexible prediction horizons,and deployment of deep and supervised learning-based *** the best of our knowledge,ours is the first study to propose machine learning to forecast medium-term public EV charging demand,to exploit weather and other features at public charging stations,and to forecast demand at multiple stations and the entire *** validated our approach using data from eleven stations over three years from Scotland,*** method outperforms the benchmark time series method,and predicts network demand with a symmetric mean absolute percentage error(SMAPE)of 5.9%and a mean absolute error(MAE)of 124.7 kWh,or less than twelve percent of average daily demand.

关键词： Public EV charging Forecasting Energy consumption Smart grid Time-series Multi-task learning Deep learning

Structure-guided Capacitance Relationships in Oxidized Graphene Porous Materials Based Supercapacitors

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Energy & Environmental Materials 2023年第4期6卷 58-69页

作者： Srinivas Gadipelli Hanieh Akbari Juntao Li Christopher A.Howard Hong Zhang Paul R.Shearing Dan J.L.brett College of Physics Sichuan UniversityChengdu 610064China Electrochemical Innovation Lab Department of Chemical EngineeringUniversity College LondonLondonWC1E 7JEUK Department of Physics and Astronomy University College LondonLondonWC1E 6BTUK

Supercapacitors formed from porous carbon and graphene-oxide(GO)materials are usually dominated by either electric double-layer capacitance,pseudo-capacitance,or *** to these combined features,reduced GO materials have been shown to offer superior capacitance over typical nanoporous carbon materials;however,there is a significant variation in reported values,ranging between 25 and 350 F g^(−1).This undermines the structure(e.g.,oxygen functionality and/or surface area)-performance relationships for optimization of cost and scalable *** work demonstrates important structure-controlled charge storage *** this,a series of exfoliated graphene(EG)derivatives are produced via thermal-shock exfoliation of GO precursors and following controlled graphitization of EG(GEG)generates materials with varied amounts of porosity,redox-active oxygen groups and graphitic *** results show significantly varied capacitance values between 30 and 250 F g^(−1)at 1.0 A g^(−1)in GEG structures;this suggests that for a given specific surface area the redox-active and hydrophilic oxygen content can boost the capacitance to 250–300%higher compared to typical mesoporous carbon *** with identical oxygen functionality show a surface area governed *** allows to establish direct structure-performance relationships between 1)redox-active oxygen functional concentration and capacitance and 2)surface area and capacitance.

关键词： electric double-layer capacitance graphene-oxide pseudocapacitance structure-performance relationships supercapacitors

Environment-dependent attack rates of cryptic and aposematic butterflies

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Current Zoology 2018年第5期64卷 663-669页

作者： brett M. SEYMOURE Andrew RAYMUNDO Kevin J. MCGRAW W. OWEN MCMILLAN Ronald L, RUTOWSKI Department of Biology Colorado State University Fort Collins CO 80523 USA School of Life Sciences Arizona State University Tempe AZ 85287 USA Smithsonian Tropical Research Institute Panama City Panama

Many organisms have evolved adaptive coloration that reduces their risk of predation. Cryptic colo- ration reduces the likelihood of detection/recognition by potential predators, while warning or aposematic coloration advertises unprofitability and thereby reduces the likelihood of attack. Although some studies show that aposematic coloration functions better at decreasing attack rate than crypsis, recent work has suggested and demonstrated that crypsis and aposematism are both successful strategies for avoiding predation. Furthermore, the visual environment （e.g., ambient lighting, background） affects the ability for predators to detect prey. We investigated these 2 related hypoth- eses using 2 well-known visually aposematic species of Heliconius butterflies, which occupy differ- ent habitats （open-canopy vs. closed-canopy）, and one palatable, cryptic, generalist species Junonia coenia. We tested if the differently colored butterflies differ in attack rates by placing plasti- cine models of each of the 3 species in 2 different tropical habitats where the butterflies naturally occur： disturbed, open-canopy habitat and forested, closed-canopy habitat. The cryptic model had fewer attacks than one of the aposematic models. Predation rates differed between the 2 habitats, with the open habitat having much higher predation. However, we did not find an interaction between species and habitat type, which is perplexing due to the different aposematic phenotypes naturally occurring in different habitats. Our findings suggest that during the Panamanian dry sea- son avian predation on perched butterflies is not a leading cause in habitat segregation between the 2 aposematic species and demonstrate that cryptically colored animals at rest may be better than aposematic prey at avoiding avian attacks in certain environments.

关键词： avian attacks camouflage Heliconius Junonia light environment plasticine models predation warning coloration.

Molecular Characterization of Atlas 66-Derived Wheat Near-Isogenic Lines Contrasting in Aluminum (Al) Tolerance

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Agricultural Sciences in China 2007年第5期6卷 522-528页

作者： GUO Pei-guo BAI Gui-hua LI Rong-hua brett Carver Michael Baum College of Life Science Guangzhou University Guangzhou 510006 P.R.China USDA-ARS-PIant Science and Entomology Research Unit 4008 Throckmorton Hall Kansas State University Manhattan KS 66506 USA Department of Plant and Soil Sciences Oklahoma State University 0K74078 USA International Center for Agricultural Research in the Dry Areas （ICARDA） P.O.Box 5466 Aleppo Syria

Aluminum （Al） toxicity is the major limiting factor for wheat growth in acidic soils. Genetic improvement of Al tolerance is one of the most cost-effective solutions to improve wheat productivity. The objective of this study was to characterize near isogenic lines （NILs） contrasting in Al tolerance derived from Atlas 66 in the backgrounds of Al-sensitive cultivars Chisholm and Century using amplified fragment length polymorphism （AFLP） and simple sequence repeat （SSR）. A total of 200 AFLP and 88 SSR primer pairs were screened and 12 markers （11 AFLPs and one SSR） were associated with Al-tolerance in NILs of at least one recurrent parental background. Among them, nine were linked to A1 tolerance in the Chisholm-derived NILs, seven were associated with Al-tolerance in the Century-derived NILs, and three AFLPs derived from the primer combinations of pAG/mGCAG, pCAG/mAGC and pGTG/mGCG, and one SSR, Xwmc331 on chromosome 4D, associated with A1 tolerance in NILs of both recurrent parental backgrounds. Those common markers across two backgrounds may be the major marker loci associated with Al-tolerance in Atlas 66 and could be useful for marker-assisted breeding to improve Al tolerance in wheat. In addition, evaluation of Al tolerance among different genotypes using hematoxylin stain and relative root growth revealed that Atlas 66 was more tolerant to Al stress than the NILs, therefore suggested that the Al-tolerant NILs might not carry all Al-tolerance loci from Arias 66 and inheritance of Al tolerance in Arias 66 is more likely multigenic.

关键词： aluminum (Al) tolerance Triticum aestivum L. molecular marker

The role of the molecular chaperone heat shock protein A2 （HSPA2） in regulating human sperm-egg recognition

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Asian Journal of Andrology 2015年第4期17卷 568-573页

作者： brett Nixon Elizabeth G Bromfield Matthew D Dun Kate A Redgrove Eileen A McLaughlin R John Aitken priority Research Centre in Reproductive Science School of Environmental and Life Sciences Discipline of Biological Sciences University of Newcastle CallaghanNSW 2308 Australia Priority Research Centre in Chemical Biology School of Environmental and Life Sciences Discipline of Biological Sciences University of NewcastleCallaghan NSW 2308 Australia Hunter Cancer Research Alliance School of Biomedical Sciences and Pharmacy Faculty of Health and Medicine NSW Australia

One of the most common lesions present in the spermatozoa of human infertility patients is an idiopathic failure of sperm-egg recognition. Although this unique cellular interaction can now be readily by-passed by assisted reproductive strategies such as intracytoplasmic sperm injection （ICSI）, recent large-scale epidemiological studies have encouraged the cautious use of this technology and highlighted the need for further research into the mechanisms responsible for defective sperm-egg recognition. Previous work in this field has established that the sperm domains responsible for oocyte interaction are formed during spermatogenesis prior to being dynamically modified during epididymal maturation and capacitation in female reproductive tract. While the factors responsible for the regulation of these sequential maturational events are undoubtedly complex, emerging research has identified the molecular chaperone, heat shock protein A2 （HSPA2）, as a key regulator of these events in human spermatozoa. HSPA2 is a testis-enriched member of the 70 kDa heat shock protein family that promotes the folding, transport, and assembly of protein complexes and has been positively correlated with in vitro fertilization （IVF） success. Furthermore, reduced expression of HSPA2 from the human sperm proteome leads to an impaired capacity for cumulus matrix dispersal, sperm-egg recognition and fertilization following both IVF and ICSI. In this review, we consider the evidence supporting the role of HSPA2 in sperm function and explore the potential mechanisms by which it is depleted in the spermatozoa of infertile patients. Such information offers novel insights into the molecular mechanisms governing sperm function.

关键词： egg fertilization heat shock protein A2 molecular chaperone sperm sperm-egg interactions

Professionalism education of OB/GYN resident physicians: What makes a difference?

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Open Journal of Obstetrics and Gynecology 2013年第1期3卷 137-141页

作者： brett Worly Department of OB/GYN Thomas Jefferson University Philadelphia USA

Objective: The aim of this study was to evaluate the efficacy of a new Professionalism curriculum in an Obstetrics and Gynecology (OB/GYN) residency after introducing Narrative Medicine and Professional Development/Support Group (PDSG) programs. Methods: 32 OB/GYN residents participated in this IRB approved pilot study. Twenty residents were assessed with the Barry Challenges to Professionalism Questionnaire (Barry), the Jefferson Scale of Empathy-Physician Version (JSE), and the Jefferson Scale of Attitudes Toward Physician-Nurse Collaboration (JSAT) in August 2010, as controls. Five Narrative Medicine sessions and four PDSG sessions were then used from August 2010-May 2011, for resident physician professionalism education. Seventeen residents then underwent post-testing with the Barry, JSE, and JSAT in May 2011. Results: The pre-test/post-test Barry comparison showed an improvement in scores after introduction of the new Narrative Medicine and PDSG curriculum (7.6 +/- 2.1 versus 8.4 +/- 1.6;p = 0.10) though this was not statistically significant. Pre-test/post-test comparison of JSAT scores showed a statistically significant decline in collaboration (52.3 +/- 4.1 versus 49.7 +/- 3.7;p = 0.028) while JSE scores showed a downward trend in empathy (109.3 +/- 10.0 versus 104.8 +/- 9.2;p = 0.086). Conclusion: Narrative Medicine and PDSG small group sessions could be an effective component of OB/GYN resident physician Professionalism curriculum. This pilot project was underpowered, due to limited resources.

关键词： Curriculum Development Education Medicine Narrative OB/GYN Physician Professionalism Resident

Consumer Perceptions of Noni Juice Health Benefits during a 90-Day In-Home Use Test

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Health 2023年第3期15卷 266-279页

作者： brett J. West Research and Development Department Partner.co American Fork Utah USA

Noni juice, made from the fruit of Morinda citrifolia, is a health-promoting food from the Pacific Islands with an extensive history of traditional use. Human clinical trials have revealed that noni juice has antioxidant, immunomodulatory and anti-inflammatory properties. Previously, regular noni juice consumers in Europe and traditional healers in Fiji were surveyed to identify potential noni juice health benefits. But to better understand the perception of its health benefits among those with no previous experience with noni juice, an in-home study was conducted in the United States. Three hundred and nineteen adults with untreated chronic health conditions were provided with a 90-day supply of a blinded (unlabeled) commercial noni juice product (Tahitian Noni® Juice), instructed to consume 4 fluid ounces (1/2 cup) each day, and responded to a questionnaire given on days 30, 60 and 90 to evaluate product appeal and perceived effectiveness. A total of 299 people (94%) felt that their health improved in some way after drinking TNJ for 90 days. More than 80% of the subjects reported feeling better or healthier in general. Most participants also concurred with more than two dozen additional positive health perception statements, especially on days 60 and 90. More than 70% of consumers also indicated that noni juice helped them feel better than other wellness supplements they had tried in the past, including other so-called “super fruit” products. These findings seem to corroborate the results of clinical trials and previous consumer surveys regarding the potential for noni juice to provide discernable health benefits when used consistently over time. Such findings may help guide additional placebo-controlled clinical trials in which specific effects may be evaluated more rigorously.

关键词： Morinda citrifolia Noni Juice In-Home Use Test Consumer Perception Perceived Health Benefits