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*** model of riboflavin transporter deficiency(RTD)disorder reveals deficits in synaptic transmission and movement

Genes & Diseases 2024年第4期11卷 120-123页

作者： Ramesh K.Narayanan Gonzalo Perez-siles Kamila A.Marzec Alexandra Boyling brent Neumann Manoj P.Menezes Marina L.Kennerson Northcott Neuroscience Laboratory ANZAC Research Institute-Sydney Local Health DistrictSydneyNSW 2139Australia Sydney Medical School University of SydneySydneyNSw 2050Australia ANZAC Research Institute-Sydney Local Health District SydneyNSW 2139Australia Neuroscience Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVictoria 3800Australia TY nelson Department of Neurology and Neurosurgery and Kids Neuroscience Children's Hospital at WestmeadWestmeadSydneyNSW2145Australia Paediatrics and Child Health The University of SydneySydneySydneyNSW 2145Australia Molecular Medicine Laboratory Concord General Repatriation HospitalSydneyNSW 2139Australia

Riboflavin transporter deficiency(RTD),previously known as Brown-Vialetto-Van Laere syndrome,is a childhoodonset neurodegenerative disorder characterized by sensory and motor neuron degeneration causing ataxia,muscle weakness,optic atrophy,and respiratory *** in SLC52A2 and SLC52A3,solute carrier family members that encode riboflavin(RF)transporters RFVT2 and RFVT3,are known to cause RTD types 2 and 3,respectively.

关键词： RTD degeneration TD

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Ten questions concerning future buildings beyond zero energy and carbon neutrality

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建筑节能 2017年第7期45卷 27-27页

作者： Na Wang Patrick E. Phelan Jorge G onzalez Chioke Harris G regor P. Henze Robert Hutchinson Jared Langevin Mary Ann Lazarus brent nelson Chris Pyke Kurt Roth David Rouse Karma Sawyer Stephen Selkowitz 侯恩哲 <建筑节能>杂志社

Architects and planners have been at the forefront of envisioning a future built environment for millennia. How ever,fragmental view s that emphasize one facet of the built environment,such as energy,environment,or groundbreaking technologies,often do not achieve expected outcomes. Buildings are responsible for approximately one-third of w orldw ide carbon emissions and account for about 40% of primary energy consumption in the U. S. In addition to achieving the very ambitious goal of reducing building-associated greenhouse gas emissions by75% by 2050,buildings must improve their functionality and performance to meet current and future human,societal,and environmental needs in a changing w orld. In this article,w e introduce a new framew ork to guide potential evolution of the building stock in the next century,based on greenhouse gas emissions as the common thread to investigate the potential implications of new design paradigms,innovative operational strategies,and disruptive technologies. This framew ork emphasizes integration of multidisciplinary know ledge,scalability for mainstream buildings,and proactive approaches considering constraints and unknow *** framew ork integrates the interrelated aspects of the built environment through a series of quantitative metrics that aim to improve environmental outcomes w hile optimizing building performance to achieve healthy,adaptive,and productive buildings.

关键词：建筑节能建筑设计建筑风格建筑材料

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Vitamin A administration at birth promotes calf growth and intramuscular fat development in Angus beef cattle

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Journal of Animal Science and Biotechnology 2018年第4期9卷 991-999页

作者： Corrine L.Harris Bo Wang Jeneane M.Deavila Jan R.Busboom Martin Maquivar Steven M.Parish brent McCann Mark L.nelson Min Du Department of Animal Sciences Washington State University State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University College of Veterinary Medicine Washington State University

Background: Marbling, or intramuscular fat, is an important factor contributing to the palatability of beef. Vitamin A, through its active metabolite, retinoic acid, promotes the formation of new fat cells(adipogenesis). As intramuscular adipogenesis is active during the neonatal stage, we hypothesized that vitamin A administration during the neonatal stage would enhance intramuscular adipogenesis and ***: Angus steer calves(n = 30), in a completely randomized design, were randomly allotted to three treatment groups at birth, receiving 0, 150,000, or 300,000 IU of vitamin A at both birth and one month of age.A biopsy of the biceps femoris muscle was collected at two months of age. After weaning at 210 d of age, steers were fed a backgrounding diet in a feedlot until 308 d of age, when they were transitioned to a high concentrate finishing diet and implanted with trenbolone/estradiol/tylosin mixture. Steers were harvested at an average of 438 d of age. All diets were formulated to meet nutrient ***: Weaning weight and weight during the backgrounding phase were linearly increased(P < 0.05) by vitamin A level, though no difference in body weight was observed at harvest. Intramuscular fat of steers at 308 d of age, measured by ultrasound, quadratically increased(P < 0.05) with vitamin A level from 4.0±0.26 % to 4.9±0.26 %.Similarly, carcass marbling score in the ribeye quadratically increased(P < 0.05).Conclusion: Administration of vitamin A at birth increased weaning weight and enhanced marbling fat ***, vitamin A administration provides a practical method for increasing marbling and early growth of beef cattle.

关键词： Beef Calf Cattle Marbling fat Quality Vitamin A

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