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Open Journal of Orthopedics 2020年第9期10卷 221-233页

作者： Murilo Barroso Matos José Leonardo Rocha de Faria Douglas Mello Pavão Márcio Liu Sandt breno chaves de almeida pigozzo Pedro Guilme Teixeira de Sousa Filho Rodrigo Pires e Albuquerque CLIFOR-Orthopedics and Fractures Clinic Vitória Brazil Knee Surgery Center National Institute of Traumatology and Orthopedics Rio de Janeiro Brazil Genutarso-Orthopedics Clinic Rio de Janeiro Brazil Genu Surgery Group Fortaleza Brazil

Objective: To evaluate intraobserver and interobserver reliability of the measurement of the mechanical axis of the lower limb by means of the panoramic radiograph of lower limbs by physicians with different levels of medical practice. Method: A retrospective cross-sectional study with preoperative and postoperative radiographic analysis of a group of 100 patients submitted to total knee arthroplasty. Results: It was observed that there is a highly significant intraobserver and interobserver agreement (p Conclusion: The panoramic radiograph of the lower limbs is a reliable method for measuring the mechanical axis of the lower limb in patients submitted to total knee arthroplasty, regardless of the level of medical practice of the evaluator.

关键词： Knee Mechanical Axis Total Knee Arthroplasty

Are there differences in anaerobic relative muscle power between upper and lower limbs in adolescent swimmers:A blinded study

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Sports Medicine and Health Science 2023年第4期5卷 290-298页

作者： Paulo Francisco de almeida-Neto Adam Baxter-Jones Jason Azevedo de Medeiros Paulo Moreira Silva Dantas breno Guilherme de Araújo Tinoco Cabral Health Sciences Center Federal University of Rio Grande do NorteUFRNNatalRNBrazil department of Physical Education Federal University of Rio Grande do NorteUFRNNatalRNBrazil College of Kinesiology University of SaskatchewanSaskatoonSKS7N 5B2Canada

Success in speed swimming depends on the efficiency of the anaerobic system for the production of cellular energy,especially during muscle power *** the adolescent athletes much is unknown with regards to the relationships between relative power of upper and lower limbs with speed swimming *** aim the present study was to identify differences in relative muscle power of upper and lower limbs in adolescent swimmers and relate these to speed swimming *** adolescents,of both sexes(50%female,50%male,30 swimmers and 30 controls),were *** relative upper limb power(ULP[W/kg])was assessed by a medicine ball test and the relative lower limbs power(LLP[W/kg])by a jump test on a jumping *** mass of the upper and lower limbs was assessed by dual-energy X-ray absorptiometry(DXA)(g).Sport performance was assessed during national level competition(50-m swimming time[in seconds]).Biological maturation(BM)was indexed by years from attainment of peak height ***(W/kg)was higher than LLP(W/kg)in both groups(pded that ULP(W/kg)is higher than LLP(W/kg)in adolescent *** and lower limb lean mass and BM were both positively associated with increased ULP(W/kg)and LLP(W/kg).

关键词： Performance Sport Swimming Biological maturation

Streptococcus agalactiae:Identification methods,antimicrobial susceptibility, and resistance genes in pregnant women

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World Journal of Clinical Cases 2020年第18期8卷 3988-3998页

作者： Fabrícia almeida Fernandes Santana Tais Viana Ledo de Oliveira Marcelo Barreto de Souza Filho Lucas Santana Coelho da Silva breno Bittencourt de Brito Fabrício Freire de Melo Cláudio Lima Souza Lucas Miranda Marques Márcio Vasconcelos Oliveira Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Laboratório Oliveira Ltda LABOVitória da Conquista 45020740BahiaBrazil Campus Soane Nazaréde Andrade Universidade Estadual de Santa CruzIlhéus 45662900BahiaBrazil

BACKGROUND Group B Streptococcus(GBS)is a normal component of the gastrointestinal and genital microbiota in humans and can lead to important infections in *** To compare GBS isolation and identification methods as well as to assess the antibiotic susceptibility and to identify resistance genes in GBS strains from pregnant women attended in healthcare services from the city of Vitória da Conquista,in Bahia State,*** From January 2017 to February 2018,vaginorectal swabs were obtained from 186 participants and the samples were seeded onto chromogenic agar for GBS before and after inoculation in selective *** identification using 3 CAMP and latex tests was performed in samples with GBS-suggestive ***,disk diffusion antibiograms were performed in GBS-positive samples,and the detection of the resistance genes ermB,ermTR,mefA,and linB in the clindamycin and/or erythromycin-resistant samples was carried *** Thirty-two samples(17.2%)were *** culture in chromogenic agar after sample incubation in selective broth was the most sensitive method(96.9%)for GBS *** isolates were susceptible to penicillin,ampicillin,cefotaxime,and *** resistance was observed in 6 samples(18.8%),while 8 samples(25%)were *** erythromycin and/or clindamycin-resistant GBS strains had negative *** strains(25%)presented an M phenotype and 6 isolates(75%)presented a cMLSB *** ermB gene was identified in 4 samples(44.4%),the mefA gene was also found in 4 samples(44.4%),the ermTR gene was identified in 1 isolate(11.1%),and the linB gene was not found in any *** This study evidenced that the screening for SGB can be performed by means of various methods,including chromogenic media,and that the chemoprophylaxis for pregnant women who cannot use penicillin must be susceptibility-guided.

关键词： Streptococcus agalactiae Pregnancy Antimicrobial susceptibility

Flight performance and wing morphology in the bat Carollia perspicillata:biophysical models and energetics

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Integrative Zoology 2023年第5期18卷 876-890页

作者： Lucas de Oliveira CARNEIRO breno MELLADO Marcelo Rodrigues NOGUEIRA Ariovaldo Pereira da CRUZ-NETO Leandro Rabello MONTEIRO Laboratório de Ciências Ambientais Centro de Biociências e BiotecnologiaUniversidade Estadual do Norte FluminenseCampos dos GoytacazesRio de JaneiroBrasil departamento de Biodiversidade Universidade Estadual PaulistaRio ClaroSão PauloBrasil

Studies on functional performance are important to understand the processes responsible for the evolution of *** trait variation within species influences the energetic cost of locomotion and impacts life history traits,with ecological and evolutionary *** study examined wing morphology correlates of flight performance measured by energetic expenditure in the Seba’s short-tailed bat,Carollia *** the flight experiments,nature caught bats(59 females,57 males)were allowed to fly for 3 min in a *** each flight,thermographic images were taken to measure body temperature,and biophysical models were used to calculate sensible heat loss as a measure of energetic *** morphological traits were measured for each individual and associated with heat loss and power required to fly on performance *** morphological traits explained 7-10%of flight energetic cost,and morphologies with the best performance would save the energy equivalent to 9-30%of total daily *** optimal performance areas within the *** morphospace were consistent with predicted selection trends from the literature.A trade-off between demands for flight speed and maneuverability was *** loading and camber presented sexual *** morphological differences are likely associated with more economical but less maneuverable flight in females,leading them to fly more often in open areas along the forest *** findings demonstrate how small scale changes in wing morphology can affect life history strategies and fitness.

关键词： aerodynamics Chiroptera infrared thermography performance surfaces Phyllostomidae wing morphometrics

Role of polymorphisms in genes that encode cytokines and Helicobacter pylori virulence factors in gastric carcinogenesis

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World Journal of Clinical Oncology 2018年第5期9卷 83-89页

作者： breno Bittencourt de Brito Filipe Ant?nio Fran?a da Silva Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da Bahia

The Helicobacter pylori(H. pylori) infection is a determinant factor in gastric cancer(GC) development. However, the infection outcomes are variable and depend on both host and bacterial characteristics. Some host cytokines such as interleukin(IL)-1β, IL-1 Ra, IL-8, IL-10 and tumor necrosis factor-α play important roles in the host immune system response to the pathogen, in the development of gastric mucosal lesions and in cell malignant transformation. Therefore, these host factors are crucial in neoplastic processes. Certain polymorphisms in genes that encode these cytokines have been associated with an increased risk of GC. On the other hand, various virulence factors found in distinct H. pylori bacterial strains, including cytotoxinassociated antigen A, vacuolating cytotoxin, duodenal ulcer promoting gene A protein, outer inflammatory protein and blood group antigen binding adhesin, have been associated with the pathogenesis of different gastric diseases. The virulent factors mentioned above allow the successful infection by the bacterium and play crucial roles in gastric mucosa lesions, including malignant transformation. Moreover, the role of host polymorphisms and bacterial virulence factors in gastric carcinogenesis seems to vary among different countries and populations. The identification of host and bacterium factors that are associated with an increased risk of GC development may be useful in determining the prognosis of infection in patients, what could help in clinical decision-making and in providing of an optimized clinical approach.

关键词： Helicobacter pylori Virulence factors Cytokines Gene polymorphisms Gastric cancer

Long-term outcomes of hepatocellular carcinoma that underwent chemoembolization for bridging or downstaging

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World Journal of Gastroenterology 2019年第37期25卷 5687-5701页

作者： breno Boueri Affonso Francisco Leonardo Galastri Joaquim Mauricio da Motta Leal Filho Felipe Nasser Priscila Mina Falsarella Rafael Noronha Cavalcante Marcio Dias de almeida Guilherme Eduardo Goncalves Felga Leonardo Guedes Moreira Valle Nelson Wolosker department of Interventional Radiology Hospital Israelita Albert EinsteinSao Paulo 05651-901Sao PauloBrazil department of Liver Transplant Hospital Israelita Albert EinsteinSao Paulo 05651-901Sao PauloBrazil department of Vascular Surgery Hospital Israelita Albert EinsteinSao Paulo 05651-901Sao PauloBrazil

BACKGROUND Prospective study of 200 patients with hepatocellular carcinoma(HCC)that underwent liver transplant(LT)after drug-eluting beads transarterial chemoembolization(deB-TACE)for downstaging versus *** survival and tumor recurrence rates were calculated,eligibility for LT,time on the waiting list and radiological response were *** TACE,only patients within Milan Criteria(MC)were *** patients underwent LT in bridging ***-year post-transplant overall survival,recurrence-free survival has no difference between the *** response was observed more frequently in bridging *** in DS group can achieve posttransplant survival and HCC recurrence-free probability,at five years,just like patients within MC in patients undergoing *** To determine long-term outcomes of patients with HCC that underwent LT after deB-TACE for downstaging vs *** Prospective cohort study of 200 patients included from April 2011 through June *** group included patients within *** group(out of MC)was divided in 5 subgroups(G1 to G5).Total tumor diameter was≤8 cm for G1,2,3,4(n=42)and was>8 cm for G5(n=22).Downstaging(n=64)and bridging(n=136)populations were not significantly *** survival and tumor recurrence rates were calculated by the Kaplan-Meier ***,eligibility for LT,time on the waiting list until LT and radiological response were *** After TACE,only patients within MC were *** patients underwent LT in bridging group 65.9%(P=0.001).Downstaging population presented:higher number of nodules 2.81(P=0.001);larger total tumor diameter 8.09(P=0.001);multifocal HCC 78%(P=0.001);more post-transplantation recurrence 25%(P=0.02).Patients with maximal tumor diameter up to 7.05 cm were more likely to receive LT(P=0.005).Median time on the waiting list was significantly longer in downstaging group 10.6 mo(P=0.028).Five-year posttransplant over

关键词： Hepatocellular carcinoma Down-staging Liver transplantation Localregional therapy Bridging

Computing Paradigms in Emerging Vehicular Environments:A Review

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IEEE/CAA Journal of Automatica Sinica 2021年第3期8卷 491-511页

作者： Lion Silva Naercio Magaia breno Sousa Anna Kobusińska António Casimiro Constandinos X.Mavromoustakis George Mastorakis Victor Hugo C.de Albuquerque department of Computer Science Faculty of SciencesUniversity of LisbonLisbon 1749-016Portugal Laboratory of Computing Science PoznańUniversity of TechnologyPoznan 60-965Poland department of Computer Science University of NicosiaNicosia CY-2417Cyprus department of Management Science and Technology Hellenic Mediterranean UniversityAgios Nikolaos 72100Greece LAPISCO Federal Institute of EducationScience and Technology of CearáFortaleza 60750-740 ARMTEC Tecnologia em Robótica Fortaleza 60150000Brazil

determining how to structure vehicular network environments can be done in various ***,we highlight vehicle networks’evolution from vehicular ad-hoc networks(VANET)to the internet of vehicles(Io Vs),listing their benefits and *** also highlight the reasons in adopting wireless technologies,in particular,IEEE 802.11 p and 5 G vehicle-toeverything,as well as the use of paradigms able to store and analyze a vast amount of data to produce intelligence and their applications in vehicular *** also correlate the use of each of these paradigms with the desire to meet existing intelligent transportation systems’*** presentation of each paradigm is given from a historical and logical *** particular,vehicular fog computing improves on the deficiences of vehicular cloud computing,so both are not exclusive from the application point of *** also emphasize some security issues that are linked to the characteristics of these paradigms and vehicular networks,showing that they complement each other and share problems and *** these networks still have many opportunities to grow in both concept and application,we finally discuss concepts and technologies that we believe are *** this work,we emphasize the crucial role of these concepts for the well-being of humanity.

关键词： Computing paradigm cloud edge fog internet of vehicle(IoV) vehicular networks

Adipose tissue,systematic inflammation,and neurodegenerative diseases

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Neural Regeneration Research 2023年第1期18卷 38-46页

作者： Ana Paula de A.Boleti Pedro Henrique de O.Cardoso breno Emanuel F.Frihling Patrícia Souza e Silva Luiz Filipe R.Nde Moraes Ludovico Migliolo S-Inova Biotech Programa de Pós-Graduação em BiotecnologiaUniversidade Católica Dom BoscoCampo GrandeMSBrazil Programa de Pós-Graduação em Biologia Celular e Molecular Programa de Pós-Graduação em BioquímicaUniversidade Federal do Rio Grande do NorteNatalBrazil

Obesity is associated with several diseases,including mental *** tissue is distributed around the internal organs,acting in the regulation of metabolism by storing and releasing fatty acids and adipokine in the *** nutritional intake results in hypertrophy and proliferation of adipocytes,leading to local hypoxia in adipose tissue and changes in these adipokine *** leads to the recruitment of immune cells to adipose tissue and the release of pro-inflammatory *** presence of high levels of free fatty acids and inflammatory molecules interfere with intracellular insulin signaling,which can generate a neuroinflammatory *** this review,we provide an up-to-date discussion of how excessive obesity can lead to possible cognitive *** also address the idea that obesity-associated systemic inflammation leads to neuroinflammation in the brain,particularly the hypothalamus and hippocampus,and that this is partially responsible for these negative cognitive *** addition,we discuss some clinical models and animal studies for obesity and clarify the mechanism of action of anti-obesity drugs in the central nervous system.

关键词： adiposity anti-obesity drugs hypothalamic inflammation metabolic disease neurodegenerative disease neuroinflammation

Influence of biological maturation on cardiac autonomic recovery in female volleyball players during&after repeated sprints training:An experimental trial

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Sports Medicine and Health Science 2024年第3期6卷 279-286页

作者： Paulo Francisco de almeida-Neto Fernanda Cristina Silva de Oliveira Jose Marcondes de Oliveira-Júnior Júlio Cesar Medeiros Alves Matheus de Lima Rocha Iago Medeiros da Silva Roberto Felipe Camara Rocha Paulo Moreira Silva Dantas breno Guilherme de Araújo Tinoco Cabral Health Sciences Center Federal University of Rio Grande do NorteCCS-UFRNNatal59012-570RNBrazil department of Physical Education Federal University of Rio Grande do NorteDEF-UFRNNatal59078-970RNBrazil

Previously,it was suggested that biological maturation(BM)could be linked to cardiac autonomic recovery(CAR)in the pediatric ***,this influence hasn’t been confirmed *** aim was to investigate the impact of BM on CAR in female volleyball *** study with a sample of 38 volleyball players,comprising 20 girls(age:[11.62.1]years)and 18 women(age:[24.55.5]years),we analyzed BM,comparing maturing subjects(girls)with mature subjects(women).Additionally,we assessed peak height velocity(PHV)in *** conducted a training session involving repeated sprints(3 rounds of 6 sprints interspersed by 5 min[min]of passive rest).Using short-range radio telemetry,we analyzed CAR during(at the end of the 1st and 2nd rounds)and after(following the 3rd round)the training session of repeated sprints by applying the 60-s to 300-s heart rate recovery index(HRR-Index).Girls exhibited superior CAR compared to women(round 2:60-s,120-s,240-s,and 300-s,pdemonstrated superior CAR compared to those in the Early-PHV and During-PHV groups.(60-s to 300-s,η2p>0.4,p0.4,pded that biological maturation has a significant impact on cardiac autonomic recovery.

关键词： Exercise Sport Volleyball Heart rate Pediatric

Species composition and diversity of woody communities along an elevational gradient in tropical Dwarf Cloud Forest

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Journal of Mountain Science 2021年第6期18卷 1489-1503页

作者： breno MOREIRA Pedro Manuel VILLA Carlos Mariano ALVEZ-VALLES Fabricio Alvim CARVALHO Botanical Garden Federal University of Juiz de ForaJuiz de Fora36045-500Brazil department of Forest Engineering Federal University of ViçosaViçosa36570-900Brazil department of Veterinary Medicine National University Major of San MarcosPucallpa25001Peru departament of Botany Federal University of Juiz de ForaJuiz de Fora36036-900 Brazil

Elucidating woody community diversity and structure change along environmental gradients is still a central issue of tropical forest ecology. We have evaluated changes in alpha and beta diversity, community composition and structure of woody communities along an elevational gradient in Dwarf Cloud Forests, Southeast Brazil. We selected five areas along an elevational gradient(1,300-1,600 m asl), and randomly allocated 10 plots(10 m × 20 m) in each area in the Ibitipoca State Park(ISP), Serra da Mantiqueira, southeastern Brazil. All woody species(diameter at breast height ≥ 5.0 cm) were collected for taxonomic identification. Thus, we analysed the woody communities based on a phytosociological approach. Overall, 147 species and 37 families were recorded, distributed in 2,303 individuals. No differences in the species richness pattern were observed between areas using the rarefaction and extrapolation curves. Significant differences in species composition and structure between areas were observed. The high beta diversity observed, corroborated by the Jaccard coefficient, increases with decreasing altitude. Our results showed that woody communities in the studied Dwarf Cloud Forests have a higher diversity and structural variability along elevational gradient.

关键词： Atlantic Forest Forest structure Ibitipoca State Park Serra da Mantiqueira