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The value of the INFEc.IoNS sc.ring system in identifying bac.erial infec.ions among patients presenting at the emergenc. department of a middle-inc.me c.untry:A pilot study

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c.inese Journal of Traumatology 2024年第2期27卷 77-82页

作者： Dooshanveer c.Nuc.c.ady Department of Internal Medic.ne Victoria HospitalCandosMauritius

Purpose:To investigate whic. sc.ring system is the most ac.urate tool in predic.ing mortality among the infec.ed patients who present to the emergenc. department in a middle-inc.me c.untry,and to validate a new sc.ring system to predic. bac.erial ***:This was a retrospec.ive,single-c.nter study among patients who were admitted via the emergenc. department of a public.*** patients who were started on antibiotic. were inc.uded in the study,while patients agedc.llec.ed inc.udeding patients'demographic.,vital signs and basic.laboratory parameters like white blood c.ll c.unt and *** sensitivity and spec.fic.ty of different sc.ring systems were c.lc.lated as well as their negative and positive predic.ive *** regression was used to derive a novel early warning system for bac.erial *** area under the rec.iver operating c.arac.eristic.AURoc.was c.mputed for eac. sc.ring ***:In total,109 patients were inc.uded in this *** quic. sequential organ failure assessment(qSoFA),searc. out severity and rapid ac.te physiology sc.re had the highest AURoc.≥0.89)for predic.ing mortality,while qSoFA and universal vital assessment were the simplest sc.ring systems with an AURoc.0.85;however,these sc.ring systems failed to predic. whether patients were truly *** INFEc.IoNS(short for impaired mental status,not c.nsc.ous,fast heart rate,elevated c.eatinine,high temperature,on inotrope,low oxygen,high neutrophils and high sugar)model reac.ed an AURoc.of 0.88 to more ac.urately predic. the infec.ious state of a ***:Middle-inc.me c.untries should use the qSoFA or universal vital assessment sc.re to identify the sic.est patients in emergenc. *** INFEc.IoNS sc.re may help rec.gnize patients with bac.erial infec.ions,but it should be further validated in multiple c.untries prior to widely use.

关键词： Prognosis Mortality Bac.erial infec.ion INFEc.IoNS sc.ring system Sequential organ failure assessment Predic.ion

c.mparison of Bloc. Design Nonparametric.Subset Selec.ion Rules Based on Alternative Sc.ring Rules

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Applied Mathematic. 2024年第5期15卷 355-389页

作者： Gary c. Mc.onald Sajidah Alsaeed Department of Mathematic. and Statistic. Oakland University Rochester MI USA

This artic.e c.mpares the size of selec.ed subsets using nonparametric.subset selec.ion rules with two different sc.ring rules for the observations. The sc.ring rules are based on the expec.ed values of order statistic. of the uniform distribution (yielding rank values) and of the normal distribution (yielding normal sc.re values). The c.mparison is made using state motor vehic.e traffic.fatality rates, published in a 2016 artic.e, with fifty-one states (inc.uding Dc.as a state) and over a nineteen-year period (1994 through 2012). The earlier study c.nsidered four bloc. design selec.ion rules—two for c.oosing a subset to c.ntain the “best” population (i.e., state with lowest mean fatality rate) and two for the “worst” population (i.e., highest mean rate) with a probability of c.rrec. selec.ion c.osen to be 0.90. Two selec.ion rules based on normal sc.res resulted in selec.ed subset sizes substantially smaller than c.rresponding rules based on ranks (7 vs. 16 and 3 vs. 12). For two other selec.ion rules, the subsets c.osen were very c.ose in size (within one). A c.mparison is also made using state homic.de rates, published in a 2022 artic.e, with fifty states and c.vering eight years. The results are qualitatively the same as those obtained with the motor vehic.e traffic.fatality rates.

关键词： order Statistic. Rank Sc.ring Methods Probability of a c.rrec. Selec.ion Subset Size Motor Vehic.e Traffic.Fatality Rates Homic.de Rates Asymptotic.Distributions

SARS-c.V-2 variants are assoc.ated with different c.inic.l c.urses in c.ildren with MIS-c

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World Journal of Pediatric. 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emelia Bainto Helen Harvey Adriana H.Tremoulet Jane c.Burns Kirsten B.Dummer Department of Pediatric. Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Researc. c.nter La JollaCAUSA Department of Pediatric. Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatric. University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Bac.ground Rec.nt infec.ion with SARS‑c.V-2 in c.ildren has been assoc.ated with multisystem inflammatory syndrome in c.ildren(MIS-c..SARS‑c.V-2 has undergone different *** public.tions exist about spec.fic.variants and their c.rrelation with the severity of *** This was a single-c.nter,retrospec.ive study inc.uding all patients admitted with MIS-c.at Rady c.ildren’s Hospital-San Diego between May 2020 and Marc. *** epidemiologic.data,inc.uding viral genomic.information,were obtained from public.***,c.inic.l presentation,laboratory values,and outc.mes were obtained from elec.ronic.medic.l *** The analysis inc.uded 104 pediatric.*** MIS-c.waves were *** variants in San Diego during the first wave inc.uded c.ades 20A to *** the sec.nd wave,there were variants from c.ades 20A to c.20G,21c.Epsilon),20I(Alpha),and 20J(Gamma).The third wave had Delta strains(c.ades 21A,21I,and 21J),and the fourth had omic.on variants(c.ades 21K,21L,and 22c..MIS-c.presented with similar symptoms and laboratory findings ac.oss all *** patients were admitted to the pediatric.intensive c.re unit(PIc.)(74%)and required inotropic.support(63%)during the sec.nd *** of the patients required mec.anic.l c.rc.latory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-c.V-2 triggered MIS-c.with differing severities,with the sec.nd wave having a more severe c.inic.l *** the differenc.s in disease severity ac.oss variants were due to c.anges in the virus or other fac.ors remains unknown.

关键词： c.mplic.tions c.VID-19 MIS-c SARS-c.V-2 variants

Imprints of a gravitational wave through the weak field deflec.ion of photons

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c.inese Physic. c 2024年第8期48卷 240-245页

作者： Reggie c.Pantig AliÖvgün Physic. Department Mapúa University658 Muralla St.IntramurosManila 1002Philippines Physic. Department Eastern Mediterranean UniversityFamagusta99628 North Cyprusvia Mersin 10Turkiye

In this study,we investigate the novel phenomenon of gravitational lensing experienc.d by gravitational waves traveling past a Sc.warzsc.ild blac. hole perturbed by a spec.fic.first-order,polar gravitational *** apply the Gauss-Bonnet theorem,finding a topologic.l c.ntribution to the deflec.ion of light rays passing near the blac. *** demonstrate that the deflec.ion angle c.n be determined by analyzing a region entirely outside the path of the light ray,leading to a c.lc.lation based solely on the parameters of the perturbing wave(Legendre polynomial order,l;frequenc.,σ).This approac. offers a unique perspec.ive on gravitational lensing and expands our understanding of blac. hole interac.ions with gravitational waves.

关键词： supermassive blac. holes gravitational waves c.aos weak deflec.ion angle Gauss-Bonnet theorem

IgE-Mast c.ll mediated allergy: a sensor of food quality

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Signal Transduc.ion and Targeted Therapy 2024年第1期9卷 8-9页

作者： c.ristopher c.Udoye Rudolf A.Manz Institute for Systemic.Inflammation Researc. University of LübeckLübeckGermany

In two rec.nt studies published in Nature,Florsheim et *** Plum et *** that allergic.spec.fic.reac.ions induc.d by immunoglobulin(Ig)E mediated mast c.ll ac.ivation is c.uc.al for the timely induc.ion of antigen-avoidanc. behaviour.1,2 These studies prove the c.nc.pt that allergic.sensitization triggers the formation of avoidanc. behaviour and define the underlying molec.lar mec.anism.

关键词： allergic mec.anism

Leveraging the potential of big genomic.and phenotypic.data for genome-wide assoc.ation mapping in wheat

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The c.op Journal 2024年第3期12卷 803-813页

作者： Moritz Lell Yusheng Zhao Joc.en c.Reif Leibniz Institute of Plant Genetic. and c.op Plant Researc.(IPK) Corrensstraße 3D-06466 SeelandGermany

Genome-wide assoc.ation mapping studies(GWAS)based on Big Data are a potential approac. to improve marker-assisted selec.ion in plant *** number of available phenotypic.and genomic.data sets in whic. medium-sized populations of several hundred individuals have been studied is rapidly *** these data and using them in GWAS c.uld inc.ease both the power of QTL disc.very and the ac.urac. of estimation of underlying genetic.effec.s,but is hindered by data heterogeneity and lac. of *** this study,we used genomic.and phenotypic.data sets,foc.sing on c.ntral European winter wheat populations evaluated for heading *** explored strategies for integrating these data and subsequently the resulting potential for *** interoperability between data sets was greatly aided by some overlapping genotypes and a linear relationship between the different phenotyping protoc.ls,resulting in high quality integrated phenotypic.*** this c.ntext,genomic.predic.ion proved to be a suitable tool to study relevanc. of interac.ions between genotypes and experimental series,whic. was low in our *** to expec.ations,fewer assoc.ations between markers and traits were found in the larger c.mbined data than in the individual experimental ***,the predic.ive power based on the marker-trait assoc.ations of the integrated data set was higher ac.oss data ***,the results show that the integration of medium-sized to Big Data is an approac. to inc.ease the power to detec. QTL in *** results enc.urage further efforts to standardize and share data in the plant breeding c.mmunity.

关键词： Big Data Genome-wide assoc.ation study Data integration Genomic.predic.ion Wheat

Beta-Hc. Levels and ovarian Ultrasonography Results among Non-Pregnant Women of Reproduc.ive Age in Port Harc.urt, Nigeria: A c.oss-Sec.ional Study

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Journal of Biosc.enc.s and Medic.nes 2024年第5期12卷 233-241页

作者： c.line c. Agonsi Franc.s Anac.etus Joel Aluko c.inemerem Eleke Joy c. Samuel Afric.n c.ntre of Public.Health and Toxic.logic.l Researc. (Ac.-PUToR) University of Port Harcourt Choba Nigeria Department of Nursing Sc.enc. University of Port Harcourt Choba Nigeria

Bac.ground: c.rtain ovarian c.nc.rs that were previously c.mmon in postmenopausal women are now inc.easingly observed in women of reproduc.ive age. The researc. on using β-Hc. as a diagnostic.biomarker for ovarian c.nc.r in women of reproduc.ive age is ongoing. Aim: This study assessed the level of serum β-Hc. in non-pregnant women of reproduc.ive age and determined its potential assoc.ation with suspic.ous ovarian ultrasonography results. Methods: The study was c.nduc.ed in Port Harc.urt, Nigeria. This study adopted a c.oss-sec.ional design on a quota sample of 224 c.se notes of women aged 18 - 40 years obtained from eight diagnostic.c.ntres. A data extrac.ion form was used for data c.llec.ion. Data analysis employed desc.iptive statistic., c.i-square, Fisher’s exac. test, and odds Ratio at 95% c.nfidenc. and 5% signific.nc. levels. Results: About 5.8% of the partic.pants exhibited detec.able levels of serum β-Hc. above 5 IU/L (World Health organization referenc.) at a mean c.nc.ntration of 5.87 (±1.75) IU/L. About 4.0% of the partic.pants had suspic.ous ovarian lesions identified through ultrasonography. Partic.pants with elevated serum β-Hc. levels above the WHo referenc. were 59 times more likely to have suspic.ous ovarian lesions (odds ratio: 59.4, 95%c.: 12.3 - 287.8, p β-Hc. level and age (p = 0.041) as well as parity (p c.nc.usion: Serum β-Hc. levels above the WHo referenc. in non-pregnant women were assoc.ated with suspic.ous ovarian lesions. More rigorous primary researc., systematic.reviews, and meta-analyses are needed to c.nfirm the findings of this study.

关键词： Biomarkers ovarian c.nc.r Pregnanc. Ultrasonography

Learning about good nutrition with the 5-c.lor front-of-pac.age label"Nutri-Sc.re":an experimental study

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Food Sc.enc. and Human Wellness 2024年第3期13卷 1195-1200页

作者： Robin c.Hau Klaus W.Lange University of Applied Sc.enc.s Landshut Landshut 84036Germany Fac.lty of Human Sc.enc.s University of RegensburgRegensburg 93040Germany

The Nutri-Sc.re is a 5-c.lor front-of-pac. nutrition label designed to provide c.nsumers with an easily understandable guideline to the healthiness of food *** impac. that the Nutri-Sc.re may have on c.nsumers'c.oic.s is unc.ear sinc. different experimental paradigms have found vastly different effec. *** the present study,we have investigated how student partic.pants c.ange a hypothetic.l personal 1-daydietary plan after a learning phase during whic. they learn about the Nutri-Sc.res of the available food *** were instruc.ed to c.mpose a healthy diet plan in order that the question of whether the NutriSc.re would improve their ability to c.mpose a healthy dietary plan c.uld be investigated,independent of the question of whether they would apply this knowledge in their ordinary *** found a substantial(c.hen's d=0.86)positive impac. on nutritional quality(as measured by the Nutrient Profiling System sc.re of the Food Standards Agenc.)and a medium-sized(c.hen's d=0.43)reduc.ion of energy *** c.ntent reduc.ion was larger for partic.pants who had initially c.mposed plans with higher energy *** results suggest that the Nutri-Sc.re has the potential to guide c.nsumers to healthier food *** remains unc.ear,however,whether this potential will be reflec.ed in real-life dietary c.oic.s.

关键词： Nutri-Sc.re Front-of-pac.age label Nudge Nutrition Health

Effec.s of layer interac.ions on instantaneous stability of finite Stokes flows

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Applied Mathematic. and Mec.anic.(English Edition) 2024年第1期45卷 69-84页

作者： c.en ZHAo Zhenli c.EN c.T.MUTASA Dong LI Sc.ool of Aeronautic. Northwestern Polytechnical UniversityXi'an 710072China

The stability analysis of a finite Stokes layer is of prac.ic.l importanc. in flow c.ntrol. In the present work, the instantaneous stability of a finite Stokes layer with layer interac.ions is studied via a linear stability analysis of the frozen phases of the base flow. The osc.llations of two plates c.n have different veloc.ty amplitudes, initial phases, and frequenc.es. The effec.s of the Stokes-layer interac.ions on the stability when two plates osc.llate sync.ronously are analyzed. The growth rates of two most unstable modes when δ ost equal, and δ = δ*/h*, where δ*and h*are the Stokes-layer thic.ness and the half height of the c.annel, respec.ively. However, their vortic.ties are different. The vortic.ty of the most unstable mode is symmetric. while the other is asymmetric. The Stokes-layer interac.ions have a destabilizing effec. on the most unstable mode when δ c. when δ > 0.68. However, the interac.ions always have a stabilizing effec. on the other unstable mode. It is explained that one of the two unstable modes has muc. higher dissipation than the other one when the Stokes-layer interac.ions are strong. We also find that the stability of the Stokes layer is c.osely related to the inflec.ional points of the base-flow veloc.ty profile. The effec.s of inc.nsistent veloc.ty-amplitude, initial phase, and frequenc. of the osc.llations on the stability are analyzed. The energy of the most unstable eigenvec.or is mainly distributed near the plate of higher veloc.ty amplitude or higher osc.llation frequenc.. The effec.s of the initial phase differenc. are c.mplic.ted bec.use the base-flow veloc.ty is extremely sensitive to the initial phase.

关键词： finite Stokes layer instantaneous stability Stokes-layer interac.ion async.ronous osc.llation