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Asymmetric reversible structural switching of a diene coordination polymer promoted by UV-visible light

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Science China Chemistry 2024年第2期67卷 536-541页

作者： Yong Wang Qiaoqiao Zhang Yong-Yong Cao Qi Liu brendan F.Abrahams Jian-Ping Lang College of Chemistry Chemical Engineering and MaterialsSoochow UniversitySuzhou215123China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032China College of Biological Chemical Science and EngineeringJiaxing UniversityJiaxing314001China School of Chemistry University of MelbourneVictoria3010Australia

In natural and artificial systems,reversible reactions are commonly asymmetric with respect to the time scale and nature of the stimuli which drive the forward and backward *** applications for which switching behavior is required,it is desirable that the reversible reaction goes as close to symmetric as possible;however,such systems are ***,we report an example of ultraviolet(UV)-visible light-regulated asymmetric reversible structural switching involving a diene-based coordination polymer,CP1 and its monocyclobutane product,*** is possible to cycle at least ten times through a forward [2+2] photocycloaddition reaction and the reverse,photocleavage reaction.A single cycle can be completed within a few *** transformation is accompanied by fast and distinct fluorescence changes,arising from optimisation of the reaction *** functional theory calculations allow rationalisation of the asymmetric reversible transformation between CP1 and CP1a rather than between CP1 and its dicyclobutane product *** work provides a clear illustration of reversible structural switching which approaches symmetric behaviour with respect to reaction rate and *** insights gained from this work also assist in the design of fast,reversible switching materials.

关键词： asymmetrical reversible structural switching coordination polymer photocycloaddition UV-visible light-controlled fluorescence switching

Investigating low dispersion isotope dissolution Lu-Hf garnet dates via in situ Lu-Hf geochronology,Kanchenjunga Himal

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Geoscience Frontiers 2024年第3期15卷 137-145页

作者： Kyle P.Larson John M.Cottle Mark Button brendan Dyck Iva Lihter Sudip Shrestha Department of Earth Environmental and Geographic SciencesUniversity of British ColumbiaOkanaganKelownaCanada Department of Earth Science University of CaliforniaSanta BarbaraUSA Fipke Laboratory for Trace Element Research University of British ColumbiaOkanaganKelownaCanada

Re-examination of three specimens from the Kanchenjunga Himal of Nepal via in situ Lu-Hf garnet geochronology yields evidence of multiple garnet growth *** analyses from grain cores in two specimens define Paleozoic regressions whereas analyses from grain rims in the same specimens define low-precision regressions consistent with the timing of Himalayan *** dates contrast with previously published low dispersion,ca.290 Ma isotope dissolution(ID)Lu-Hf garnet dates for the same *** of Lu and spot age distribution in representative grains from the specimens examined yields calculated dates that approximate the Permian-age regressions through the original ID *** findings demonstrate that it is possible to generate low dispersion ID Lu-Hf data from multigenerational garnet with significantly different-age growth events when approximately equal proportions of the different age reservoirs are included in multi-component aliquots.

关键词： Lu-Hf geochronology In situ Lu-Hf geochronology Kanchenjunga Himal

Post-operative protein supplementation following orthopaedic surgery: A systematic review

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Sports Medicine and Health Science 2024年第1期6卷 16-24页

作者： Andrew George brendan M.Holderread Bradley S.Lambert Joshua D.Harris Patrick C.McCulloch Houston Methodist Orthopedics and Sports Medicine 6445 Main Street Suite 2300HoustonTX77030USA Houston Methodist Orthopedic Biomechanics Research Laboratory 6670 Bertner AveHoustonTX77030USA

Decreased mechanical loading after orthopaedic surgery predisposes patients to develop muscle *** purpose of this review was to assess whether the evidence supports oral protein supplementation can help decrease postoperative muscle atrophy and/or improve patient outcomes following orthopaedic surgery.A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and MetaAnalysis(PRISMA).PubMed(MEDLINE),Embase,Scopus,and Web of Science were searched for randomized controlled trials that assessed protein or amino acid supplementation in patients undergoing orthopaedic *** investigators independently conducted the search using relevant Boolean *** outcomes included functional or physiologic measures of muscle atrophy or *** studies including 611 patients(224 males,387 females)were *** studies evaluated protein supplementation after ACL reconstruction(ACLR),3 after total hip arthroplasty(THA),5 after total knee arthroplasty(TKA),and 3 after surgical treatment of hip *** supplementation showed beneficial effects across all types of *** primary benefit was a decrease in muscle atrophy compared to placebo as measured by muscle cross sectional *** authors also demonstrated improved functional measures and quicker achievement of rehabilitation *** supplementation has beneficial effects on mitigating muscle atrophy in the postoperative period following ACLR,THA,TKA,and surgical treatment of hip *** effects often correlate with improved functional measures and quicker achievement of rehabilitation *** research is needed to evaluate long-term effects of protein supplementation and to establish standardized population-specific regimens that maximize treatment efficacy in the postoperative period.

关键词： Orthopaedic surgery Protein supplementation Systematic review Muscle atrophy

iDEAL-CIO: Instant Digital Express Advocated “Magic Lamp” for Cloud Intelligence Outlet

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Intelligent Information Management 2024年第1期16卷 35-63页

作者： Sheldon Liang Paul Anthony Miller brendan Shane Rowe Alexis Rainbow Digital Innovation for Music Education Library and STEM Lane College Jackson TN USA

Instant Digital Express iDEAL-CIO The “Magic Lamp” for Cloud Intelligence Outlet, which has been recommended, combines innovations to satisfy modern users’ needs and efficiently sift through the ever-expanding amount of intelligent content stored in the cloud. One such innovation introduces a ground-breaking concept to remove superfluous and outdated sequential search patterns that overwhelm the user and computer in order to better serve the user in an eclectic & elastic and multidimensional approach to finding, grouping, assimilation, organizing, and delivering archival content. The cloud intelligence outlet (CIO) is presented in this article as the perfect magic lamp option for quick digital express advocacy. The grouping, indexing, folding, and targeting (GIFT) method of multidimensional online synthetic/analytical intelligent content (MOSAIC) for adaptive intelligence is the fundamental intelligent aggregation and automated process of the Magic Lamp. Three perspectives above this new ideal framework are available to observe: The Magic Lamp proposes contextual and multiple analytical tracks to improve cloud intelligence services conceptually. Technically speaking, MOSAIC combines domain-specific services for a wide range of international users, and through the usage of Cloud Intelligence Outlet, GIFT operationally activates grouping, indexing, folding, and targeting to promote decent experience and in-depth research on target for users’ wants. Because of this, iDEAL-CIO works in tandem with cloud extraction, digital transformation, and archival loading to provide improved service through the readily accessible cloud intelligence outlet.

关键词： iDEAL-CIO MOSAIC Multidimensional Online Synthetic/Analytical Intelligent Content

Evaluating the Efficacy of Cervical Tactile Ultrasound Technique as a Predictive Tool for Spontaneous Preterm Birth

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 832-846页

作者： Vladimir Egorov Todd Rosen Jennifer Hill Meena Khandelwal Victors Kurtenoks brendan Francy Noune Sarvazyan Advanced Tactile Imaging Inc. Ewing New Jersey USA Department of Obstetrics Gynecology and Reproductive Sciences Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA Department of Maternal-Fetal Medicine Cooper Medical School of Rowan University Camden New Jersey USA

Background: Premature cervical softening and shortening may be considered an early mechanical failure that predispose to preterm birth. Purpose: This study aims to explore the applicability of an innovative cervical tactile ultrasound approach for predicting spontaneous preterm birth (sPTB). Materials and Methods: Eligible participants were women with low-risk singleton pregnancies in their second trimester, enrolled in this prospective observational study. A Cervix Monitor (CM) device was designed with a vaginal probe comprising four tactile sensors and a single ultrasound transducer operating at 5 MHz. The probe enabled the application of controllable pressure to the external cervical surface, facilitating the acquisition of stress-strain data from both anterior and posterior cervical sectors. Gestational age at delivery was recorded and compared against cervical elasticity. Results: CM examination data were analyzed for 127 women at 240/7 - 286/7 gestational weeks. sPTB was observed in 6.3% of the cases. The preterm group exhibited a lower average cervical stress-to-strain ratio (elasticity) of 0.70 ± 0.26 kPa/mm compared to the term group’s 1.63 ± 0.65 kPa/mm with a p-value of 1.1 × 10−4. Diagnostic accuracy for predicting spontaneous preterm birth based solely on cervical elasticity data was found to be 95.0% (95% CI, 88.5 - 100.0). Conclusion: These findings suggest that measuring cervical elasticity with the designed tactile ultrasound probe has the potential to predict spontaneous preterm birth in a cost-effective manner.

关键词： Cervical Elasticity Spontaneous Preterm Birth Tactile Ultrasound Probe

RANKL inhibition reduces lesional cellularity and Gαs variant expression and enables osteogenic maturation in fibrous dysplasia

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Bone Research 2024年第1期12卷 165-179页

作者： Luis F.de Castro Jarred M.Whitlock Zachary Michel Kristen Pan Jocelyn Taylor Vivian Szymczuk brendan Boyce Daniel Martin Vardit Kram Rebeca Galisteo Kamran Melikov Leonid V.Chernomordik Michael T.Collins Alison M.Boyce Skeletal Disorders and Mineral Homeostasis Section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Section on Membrane Biology Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMDUSA Metabolic Bone Disorders Unit National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Department of Plastic and Reconstructive Surgery The Johns Hopkins Medical InstitutionsBaltimoreMDUSA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA NIDCR Genomics and Computational Biology Core National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA

Fibrous dysplasia(FD)is a rare,disabling skeletal disease for which there are no established *** evidence supports inhibiting the osteoclastogenic factor receptor activator of nuclear kappa-B ligand(RANKL)as a potential treatment *** this study,we investigated the mechanisms underlying RANKL inhibition in FD tissue and its likely indirect effects on osteoprogenitors by evaluating human FD tissue pre-and post-treatment in a phase 2 clinical trial of denosumab(NCT03571191)and in murine in vivo and ex vivo preclinical *** analysis of human and mouse tissue demonstrated increased osteogenic maturation,reduced cellularity,and reduced expression of the pathogenic Gαs variant in FD lesions after RANKL *** sequencing of human and mouse tissue supported these *** interaction between osteoclasts and mutant osteoprogenitors was further assessed in an ex vivo lesion model,which indicated that the proliferation of abnormal FD osteoprogenitors was dependent on *** results from this study demonstrated that,in addition to its expected antiosteoclastic effect,denosumab reduces FD lesion activity by decreasing FD cell proliferation and increasing osteogenic maturation,leading to increased bone formation within *** findings highlight the unappreciated role of cellular crosstalk between osteoclasts and preosteoblasts/osteoblasts as a driver of FD pathology and demonstrate a novel mechanism of action of denosumab in the treatment of bone disease.

关键词： dysplasia treatment finding

Sticking together:Mechanisms of quartz synneusis in high-silica magma

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Geoscience Frontiers 2023年第2期14卷 40-46页

作者： brendan Dyck Department of Earth Environmental and Geographic SciencesThe University of British Columbia4237 University WayKelownaBC V1V 1V7Canada

The formation of crystal clusters by synneusis(magmatic sintering)affects a wide range of magmatic systems from olivine clusters in komatiite to quartz clusters in high-silica granite.A common feature of synneusis in any mineral phase is the alignment of neighbouring crystals in certain lower-energy orientation ***,the underlying mechanisms involved with both the alignment of crystals in lower-energy orientations and the binding of crystal clusters are not well *** the absence of mechanisms that bind crystals together upon contact,the same hydrodynamic forces that may bring crystals together can in theory also serve to disaggregate *** I use cathodoluminescence imaging and crystal orientation data from quartz clusters in high-silica granite to show that i)rapid crystalline neck growth along attachment surfaces and ii)grain rotation are two mechanisms that reduce the grain boundary energy of crystal clusters while increasing clusters’shear *** continued crystallization of sintered phases as the magmatic body cools further cements crystal pairs and resists cluster *** these mechanisms underpin both the formation and preservation of large crystal clusters in dynamic magmatic environments.

关键词： Synneusis Granite Magmatic behaviour EBSD Cathodoluminescence Quartz

Incidence Category of the Young Lattice,Injections Between Finite Sets,and Koszulity

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Algebra Colloquium 2021年第2期28卷 195-212页

作者： brendan Dubsky Jie Xiao Department of Mathematics Uppsala UniversityUppsalaSweden 不详

We study the quadratic quotients of the incidence category of the Young lattice defined by the zero relations corresponding to adding two boxes to the same row,or to the same column,or *** show that the last quotient corresponds to the Koszul dual of the original incidence category,while the first two quotients axe,in a natural way,Koszul duals of each other and hence they axe in particular Koszul *** of these two quotients are known to be basic representatives in the Morita equivalence class of the category of injections between finite *** also present a new,rather direct,argument establishing this Morita equivalence.

关键词： Young lattice Koszulity category of injections Koszul duality

Exploring the metamorphic consequences of secular change in the siliciclastic compositions of continental margins

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Geoscience Frontiers 2018年第4期9卷 967-975页

作者： Gautier Nicoli brendan Dyck Department of Earth Sciences University of Cambridge Department of Earth Sciences Simon Fraser University

Shale and greywacke compositions from the Archean to Phanerozoic record a secular change in the siliciclastic material that comprises much of Earth＇s continental margins, past and present. This study explores the metamorphic consequence of these compositional changes, by comparing phase equilibrium models constructed for average Archean, Proterozoic, and Phanerozoic shale and greywacke compositions equilibrated along two Barrovian-type geotherms： 1330℃/GPa（A） and 800 ℃/GPa（B）. Our models show that Archean siliciclastic rocks can retain up to 4 vol.% water at middle to lower crustal conditions, nearly twice that of Proterozoic and Phanerozoic compositions. The increased ferromagnesium content of Archean siliciclastic rocks stabilizes chlorite to higher temperatures and results in a biotite-rich assemblage at solidus temperatures. Accordingly, water-absent biotite dehydration melting is predicted to play a greater role in the generation of melt in the metamorphism of Archean aged units,and water-absent muscovite dehydration melting is of increasing importance through the Proterozoic and Phanerozoic. This secular variation in predicted mineral assemblages demonstrates the care with which metamorphic facies diagrams should be applied to Archean compositions. Moreover, secular changes in the composition of shale and greywacke is reflected in the evolution of anatectic melt towards an increasingly less viscous, Ca-rich, and Mg-poor monzogranite.

关键词： Secular change Shale Greywacke Dehydration melting Thermodynamic modelling Perple_X