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SARS-CoV-2 productively infects primary human immune system cells in vitro and in Covid-19 patients

Journal of Molecular Cell Biology 2022年第4期14卷 51-64页

作者： Marjorie C.Pontelli italo A.Castro Ronaldo B.Martins Leonardo La Serra Flavio P.Veras daniele C.Nascimento Camila M.Silva Ricardo S.Cardoso Roberta Rosales Rogério Gomes Thais M.Lima Juliano P.Souza brenda C.Vitti diego B.Caetite Mikhael H.F.de Lima Spencer d.Stumpf Cassandra E.Thompson Louis-Marie Bloyet Juliana E Toller-Kawahisa Marcela C.Giannini Leticia P.Bonjorno Marial.F.Lopes Sabrina S.Batah Li Siyuan Rodrigo Luppino-Assad Sergio C.L.Almeida Fabiola R.Oliveira Maira N.Benatti Lorena L.F.Pontes Rodrigo C.Santana Fernando C.Vilar Maria Auxiliadora-Martins Pei-Yong Shi Thiago M.Cunha Rodrigo T.Calado JoséC.Alves-Filho dario S.Zamboni Alexandre T.Fabro Paulo Louzada-Junior Rene d.R.Oliveira Sean P.J.Whelan Fernando Q.Cunha Eurico Arruda Virology Research Center Ribeirao Preto Medical SchoolUniversity of Sao Pauloibeirao PretoSao Paulo 14049-900.Brazil Center of Research in Inflammatory diseases Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil department of Celland Molecular Biology Ribeirao Preto Medical SchoolUniversityof Sao PauloRibeirao PretoSao Paulo 14049-900 Brazil Regional Blood Centerof Ribeirao Preto Ribeirao Preto Medical ScholUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil department of Biochemistry&Molecular Biology the University of Texas Medical BranchGalvestonTX7755USA divisions of Clinical lmmunology Infectious Diseases and Intensive Care UnitRibeirao Preto Medical Schooniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil department of Pathology Ribeirao Preto Medical Scholniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil department of Molecular Microbiology.Washington University in St.Louis Saint LouisMO 63110USA

The severe acute respiratory syndrome coronavirus 2(SARS-CovV-2)infection is associated with a hyperinflammatory state and lymphocytopenia,a hallmark that appears as both signature and prognosis of disease severity *** cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion,it is still unclear whether direct SARS-Cov-2 infection of immune cells could also play a role in this scenario by harboring viral *** found that monocytes,as well as both B and T lymphocytes,were susceptible to SARS-Cov-2 infection in vitro,accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell *** addition,flow cytometry and immunofluorescence analysis revealed that SARS-Cov-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019(CoVId-19)*** rates of SARS-Cov-2-infected monocytes in peripheral blood mononuclear cells from CoVId-19 patients increased over time from symptom onset,with SARS-CoV-2-positive monocytes,B cells,and Cd4+T lymphocytes also detected in postmortem lung *** results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in covId-19 patients might have important implications for disease pathogenesis and progression,immune dysfunction,and virus spread within the host.

关键词： SARS-CoV-2 CoVId-19 lymphocytopenia peripheral blood mononuclear cell(PBMC) lymphocytes monocytes apoptosis

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Is increased water consumption among older adults associated with improvements in glucose homeostasis?

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Open Journal of Preventive Medicine 2013年第5期3卷 363-367页

作者： Adrienne G. Clark Elizabeth A. dennis Parker Jyoti S. Savla Kevin P. davy brenda M. davy department of Human development Virginia Tech Blacksburg USA department of Human Nutrition Foods and Exercise Virginia Tech Blacksburg USA department of Human Nutrition Foods and Exercise Virginia Tech Blacksburg USA Lombardi Comprehensive Cancer Center Georgetown University Medical Center Washington D.C. USA

Obesity and impaired glucose homeostasis in older adults place these individuals at risk for diabetes. dehydration, glucose homeostasis, and insulin resistance are related;while aging and dehydration are associated with decreased glucose tolerance, weight loss can improve glycemia. For older adults following hypocaloric diets, additional water consumption may lead to greater weight loss. Further more, research suggests an association between insulin resistance and the body water retention hormone, arginine vasopressin (AVP). Analysis of the association between plasma copeptin (an AVP derivative) and fasting glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) may provide further insight into the relationship between dehydration and diabetes risk. Our objective was to investigate the possibility that increased water consumption among older adults (n = 29, BMI = 31 ± 1 kg/m2, age = 62 ± 1 years) could improve glucose homeostasis beyond that observed with weight loss, as well as associations between plasma copeptin and diabetes risk. This retrospective analysis utilized data from a previous investigation, in which obese/overweight older adults were assigned to one of two groups: 1) Water: consume 500 ml of water prior to three daily meals over a 12-week hypocaloric diet intervention, or 2) Non-water: hypocaloric diet alone. In the present analysis, fasting plasma glucose and insulin, HOMA-IR, and plasma copeptin were evaluated, and compared to urinary specific gravity (USG), drinking water consumption, and body weight. Analyses performed using group assignment, volume of drinking water consumed or among a subgroup pair-matched for weight loss and sex did not reveal significant differences between groups. However in the full sample, plasma insulin concentration was associated with USG (r = 0.512,

关键词： Older Adults diabetes Glucose Water Consumption Hydration

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Optimal length of triple therapy for H pylori eradication in a population with high prevalence of infection in Chile

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World Journal of Gastroenterology 2007年第21期13卷 2967-2972页

作者： Arnoldo Riquelme Alejandro Soza Cesar Pedreros Andrea Bustamante Felipe Valenzuela Francisco Otarola Eduardo Abbott Marco Arellano brenda Medina Alejandro Pattillo douglas Greig Marco Arrese Antonio Rollan department of Gastroenterology Pontificia Universidad Católica de Chile Hospital de Urgencia Asistencia Pública SantiagoChile department of Internal Medicine Pontificia Universidad Católica de Chile

AIM:To compare the efficacy of 7-d versus 14-d triple therapy for the treatment of H pylori infection in Chile,with a prevalence of 73% in general population. METHOdS:H pylori-infected patients diagnosed by rapid urease test,with non-ulcer dyspepsia or peptic ulcer disease were randomized to receive omeprazole 20 mg bid,amoxicillin 1 g bid,and clarithromycin 500 mg bid for 7 (OAC7) or 14 (OAC14) d. Primary outcome was eradication rate 6 wk after the treatment. Subgroup analysis was carried out considering the eradication rate among patients with or without peptic ulcer disease and eradication rate among smokers or non-smokers. RESULTS:One hundred and thirty-one patients were randomized to OAC7 (n = 69) or OAC14 (n = 62). The overall eradication rate (intention-to-treat) was 78.3% in OAC7 and 85.5% in OAC14 groups,without a significant difference (P =0.37). No significant difference in the eradication rate was found among the patients with peptic ulcer disease (n = 31) between the OAC7 group (85.7%) and OAC14 group (87.5%). However,smokers had an obviously lower eradication rate compared to non-smokers,particularly in the OAC7 group (57.1% in smokers vs 83.6% in non-smokers; P = 0.06). Adverse effects rate were similar between both groups. CONCLUSION:Short-term efficacy of triple therapy with OAC for 7 d is comparable to 14 d in this high-prevalence population. Longer follow-up,and studies focused to some subgroups of patients (smokers and non-ulcerpatients) are necessary to support widespread use of 7-d instead of 10-14-d triple therapy in a developing country like Chile.

关键词：智利幽门螺杆菌病抗生素治疗疗程

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君主制的历史

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作者： (英)布伦达·拉尔夫·刘易斯(brenda Ralph Lewis)

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价值演变与美国国家公园体系的发展

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中国园林 2018年第11期34卷 10-14页

作者：凯莉.高切丝若兰.米切尔布兰登.布兰特毕雪婷李璟昱美国乔治亚大学文化景观实验室美国国家公园管理局奥姆斯特德景观保护中心美国国家公园管理局华盛顿d.C.国家遗产区同济大学建筑与城市规划学院

作为设立最早且最知名的公园系统之一,美国国家公园体系对世界各国公园系统的发展具有全球性影响,但人们对美国国家公园体系的认识往往局限于美国西部的大型公园。事实上,美国第一批设立的国家公园深受19世纪风景如画的大型城市公园影响... 详细信息

作为设立最早且最知名的公园系统之一,美国国家公园体系对世界各国公园系统的发展具有全球性影响,但人们对美国国家公园体系的认识往往局限于美国西部的大型公园。事实上,美国第一批设立的国家公园深受19世纪风景如画的大型城市公园影响,其后的国家公园类型却随着社会价值观的演变而改变。通过考察美国国家公园体系的发展历程,以文化景观的概念诠释了自19世纪末以来的景观价值演变以及对当今创新保护战略的贡献。在美国国家公园体系的发展过程中,国际交流在促进文化和自然之间的关联性理解及其有效保护中起到了关键性作用。

关键词：风景园林美国国家公园管理局(NPS) 美国国家公园体系文化景观景观价值文化和自然之间的相互联系

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Resilience indicators support valuation of estuarine ecosystem restoration under climate change

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Ecosystem Health and Sustainability 2017年第4期3卷 15-33页

作者： L.A.Wainger d.H.Secor C.Gurbisz W.M.Kemp P.M.Glibert E.d.Houde J.Richkus M.C.Barber Chesapeake Biological Laboratory University of Maryland Center for Environmental ScienceP.O.Box 38SolomonsMaryland 20688 USA Horn Point Laboratory University of Maryland Center for Environmental ScienceP.O.Box 775CambridgeMaryland 21613 USA National Socio-Environmental Synthesis Center 1 Park PlaceSuite 300AnnapolisMD 21401 USA RTI International 70113th St.NWSuite 750WashingtonD.C.20005 USA

Economic valuation of ecological restoration most often encompasses only the most tangible ecosystem service benefits,thereby omitting many difficult-to measure benefits,including those derived from enhanced reliability of ecosystem *** climate change is likely to impose novel ecosystem stressors,a typical approach to valuing benefits may fail to capture the contribution of ecosystem resilience to sustaining long-term ***,we generally lack predictive probabilistic models that would enable measurement and valuation of ***,alternative measures are needed to complement monetary values and broaden understanding of restoration *** use a case study of Chesapeake Bay restoration(total maximum daily load)to show that ecosystem service benefits that are typically monetized leave critical information *** address these gaps,we review evidence for ecosystem services that can be quantified or described,including changes in harmful algal bloom *** further propose two integrative indicators of estuarine resilience-the extent of submerged aquatic vegetation and spatial distribution of *** aquatic vegetation extent is indicative of qualities of ecosystems that promote positive feedbacks to water *** distributed fish populations reduce risk by promoting diverse responses to spatially heterogeneous *** synthesis and new analyses for the Chesapeake Bay suggest that resilience metrics improve understanding of restoration benefits by demonstrating how nutrient and sediment load reductions will alleviate multiple sources of stress,thereby enhancing the system’s capacity to absorb or adapt to extreme events or novel stresses.

关键词： benefit-relevant indicators climate change economic valuation ecosystem services non-monetary benefit indicators resilience total maximum daily load water quality.

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北美松材线虫概述(续)

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林业科技通讯 1990年第7期 30-33页

作者： L.d.Winell W.R.Nickle 陈超林业部保护司

四、北美的松材线虫的两个类型*** 近来,北美的***的种群被归成两个类型,“R”(圆尾)和“M”(尖尾)类。“R”类被认为是松枯萎病的病原。wingfield和Blanchtte在1983年报道松材线虫的“M”类是由香枞墨天牛和白点墨天牛携带的,胶枞是香... 详细信息

四、北美的松材线虫的两个类型*** 近来,北美的***的种群被归成两个类型,“R”(圆尾)和“M”(尖尾)类。“R”类被认为是松枯萎病的病原。wingfield和Blanchtte在1983年报道松材线虫的“M”类是由香枞墨天牛和白点墨天牛携带的,胶枞是香枞墨天牛的专有寄主,而白点墨天牛被发现干松属、冷杉属、落叶松属和云杉属的许多针叶树上。例如。

关键词：松材线虫综述北美

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