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潜在内分泌干扰风险防晒剂的监管及其使用情况分析

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日用化学工业（中英文） 2024年第3期54卷 337-343页

作者：塔娜冯孟鑫高家敏张凤兰王钢力中国食品药品检定研究院北京100062

欧盟对具有潜在内分泌干扰风险的化妆品原料进行筛查并建立了化妆品原料优先评估清单,该清单包含了4个欧盟化妆品指令准用防晒剂。文章以优先评估清单中的防晒剂为研究对象,对其在欧盟、美国等国家(地区)的监管情况和在我国的使用情况... 详细信息

欧盟对具有潜在内分泌干扰风险的化妆品原料进行筛查并建立了化妆品原料优先评估清单,该清单包含了4个欧盟化妆品指令准用防晒剂。文章以优先评估清单中的防晒剂为研究对象,对其在欧盟、美国等国家(地区)的监管情况和在我国的使用情况进行概述和分析,并汇总欧盟消费者安全科学委员会的再评估结果。经研究调查发现,优先评估清单中防晒剂在我国的法规限值与美国、日本和韩国规定基本一致,但部分防晒剂限值较欧盟新修订限值高,可能存在安全风险。建议监管部门综合评估上述防晒剂的安全风险、实际使用情况和行业发展等因素,通过进一步评估和细化法规限值,以期更好地保障民众用妆安全。

关键词：防晒剂内分泌干扰物监管

ＬＯＣＡＬＥＸＡＣＴＢＯＵＮＤＡＲＹＣＯＮＴＲＯＬＬＡＢＩＬＩＴＹＦＯＲＡＣＬＡＳＳＯＦＱＵＡＳＩＬＩＮＥＡＲＨＹＰＥＲＢＯＬＩＣＳＹＳＴＥＭＳ

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Chinese Annals of Mathematics,Series B 2002年第2期23卷 209-218页

作者：ＬＩＴＡ－ＴＳＩＥＮＲＡＯ ВＯＰＥＮＧＤｅｐａｒｔｍｅｎｔｏｆＭａｔｈｅｍａｔｉｃｓＦｕｄａｎＵｎｉｖｅｒｓｉｔｙＩｎｓｔｉｔｕｔｄｅＲｅｃｈｅｒｃｈｅＭａｔｈｅｍａｔｉｑｕｅＡｖａｎｃｅｅＳｈａｎｇｈａｉ２００４３３ＣｈｉｎａＥ－ｍａｉｌ:ｄｑｌｉ＠ｆｕｄａｎ．ｅｄｕ．ｃｎＵｎｉ

For a class of mixed initial-boundary value problem for general quasilinear hyperbolic systems, this paper establishes the local exact boundary controllability with boundary controls only acting on one end. As an application, the authors show the local exact boundary controllability for a kind of nonlinear vibrating string problem.

关键词： Exact boundary controllability Quasilinear hyperbolic system Nonlinear vibrating string equation

Bottomonium Spectrum with Screened Potential

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Communications in Theoretical Physics 2009年第10期52卷 653-661页

作者： LI Bai-Qing CHAO Kuang-ta Department of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100871 China Department of Physics Huzhou Teachers College Huzhou 313000 China

As a sister work of[Phys. Rev. D 79 （2009） 094004], we incorporate the color-screening effect due to light quark pair creation into the heavy quark-antiquark potential, and investigate the effects of screened potential on the spectrum of bottomonimn. We calculate the masses, electromagnetic decays, and E1 transitions of bottomonium states. We find that the fine splittings between χbJ （J = 0, 1, 2） states are in good agreement with experimental data, and the E1 transition rates of γ（2S） → γχbJ（1P） and γ（3S） →γχbJ（2P）（J = 0, 1, 2） all agree with data within experimental errors. In particular, the mass of γ（6S） is lowered down to match that of the γ（11020）, which is smaller than the predictions of the linear potential models by more than 100 MeV. Comparison between charmonium and bottomonium in some related problems is also discussed.

关键词： color-screening effect Bottomonium

Design of Floating Mass Type Piezoelectric Actuator for Implantable Middle Ear Hearing Devices

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Chinese Journal of Mechanical Engineering 2009年第2期22卷 221-226页

作者： LIU Houguang ta Na MING Xiaofeng RAO Zhushi State Key Laboratory of Mechanical System and Vibrations Shanghai Jiao Tong University Shanghai 200240 China

To overcome some of the problems inherent in conventional heating aids such as low gain at high fi＇equencies due to acoustic feedback, discomfort in occlusion of the extemal ear canal and so on, implantable middle ear hearing devices （IMEHDs） have been developed over the past two decades. For such kinds of IMEHDs, this paper presents the design of a floating mass piezoelectric actuator using a PMN-30%PT stack as a new type of vibrator. The proposed piezoelectric actuator consists of only three components of a piezoelectric stack, a metal case and a clamp. For the purpose of aiding the design of this actuator, a coupling biomechanics model of human middle ear and the piezoelectric actuator was constructed. This model was built based on a complete set of computerized tomography section images of a healthy volunteer＇s left ear by reverse engineering technology. The validity of this model was confirmed by comparing the motion of the tympanic membrane and stapes footplate obtained by this model with published experimental measurements on human temporal bones. It is shown that the designed actuator can be implanted on the incus long process by a simple surgical operation, and the stapes footplate displacement by its excitation at 10.5 V root-mean-square（RMS） voltage was equivalent to that from acoustic stimulation at 100 dB sound pressure level（SPL）, which is adequate stimulation to the ossicular chain. The corresponding power consumption is 0.04 mW per volt of excitation at 1 kHz, which is low enough for the transducer to be used in an implantable middle ear device.

关键词： piezoelectric actuator implantable middle ear hearing device floating mass fmite element model

Blood Pressure and Heart Rate Measurements Using Photoplethysmography with Modified LRCN

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Computers, Materials & Continua 2022年第4期71卷 1973-1986页

作者： Chih-ta Yen Cheng-Hong Liao Department of Electrical Engineering Taiwan Ocean UniversityKeelung City202301Taiwan Department of Electrical Engineering National Formosa UniversityYunlin County632Taiwan

In this study,single-channel photoplethysmography(PPG)signals were used to estimate the heart rate(HR),diastolic blood pressure(DBP),and systolic blood pressure(SBP).A deep learning model was proposed using a long-term recurrent convolutional network(LRCN)modified from a deep learning algorithm,the convolutional neural network model of the modified inception deep learning module,and a long short-term memory network(LSTM)to improve the model’s accuracy of BP and HR *** PPG data of 1,551 patients were obtained from the University of California Irvine Machine Learning *** to design a filter of PPG signals and how to choose the loss functions for deep learning model were also discussed in the ***,the stability of the proposed model was tested using a 10-fold cross-validation,with an MAE±SD of 2.942±5.076 mmHg for SBP,1.747±3.042 mmHg for DBP,and 1.137±2.463 bpm for the *** with its existing counterparts,the model entailed less computational load and was more accurate in estimating SBP,DBP,and *** results established the validity of the model.

关键词： Photoplethysmography(PPG)signal deep learning blood pressure systolic blood pressure(SBP) diastolic blood pressure(DBP) heart rate(HR)

On the Non-Commutative Neutrix Product of the Distributions x＋^λ and x^＋μ

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Acta Mathematica Sinica,English Series 2006年第6期22卷 1639-1644页

作者： B.FISHER K.ta■ Department of Mathematics University of Leicester Department of Mathematics Cankaya University

Let f and g be distributions and let gn = （g ＊ δn）（x）, where δn （x） is a certain converging to the Dirac delta function. The non-commutative neutrix product fog of f and g to be the limit of the sequence {fgn }, provided its limit h exists in the sense that sequence is defined N-lim n-∞（f（x）g,, （x）, φ（x）〉 = （h（x）, φ（x）},for all functions p in 2. It is proved that （x^λ＋1n^px＋）0（x^μ＋1n^qx＋）=x＋^λμ1n^p＋qx＋,（x^λ-1n^qx-）=x-^λ＋μ1n^p＋qx-,for λ＋μ〈-1; λ,μ, λ＋μ≠-1,-2…and p,q=0,1,2……

关键词： distribution delta function product of distributions

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儿童肥厚型心肌病治疗的研究进展

中华心血管病杂志 2024年第6期52卷 723-728页

作者：常凌潇李静史晓荷鲁孝楠王静拓胜军刘丽文空军军医大学西京医院超声医学科西安710032

肥厚型心肌病是常见的遗传性心肌病,具有高度异质性和高猝死率的特点,是儿童心原性猝死的最常见原因。该文对儿童肥厚型心肌病的药物及侵入性治疗、心律失常管理、特殊类型肥厚型心肌病治疗等方面的研究进展进行综述,以期为临床治疗及... 详细信息

肥厚型心肌病是常见的遗传性心肌病,具有高度异质性和高猝死率的特点,是儿童心原性猝死的最常见原因。该文对儿童肥厚型心肌病的药物及侵入性治疗、心律失常管理、特殊类型肥厚型心肌病治疗等方面的研究进展进行综述,以期为临床治疗及进一步研究提供参考。

关键词：心肌病,肥厚性儿童药物治疗手术治疗心原性猝死

益生菌结合蒙脱石散对轮状病毒感染乳鼠肠道黏膜、肠道微生物功能相关基因表达的影响

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中国临床药理学杂志 2024年第13期40卷 1903-1907页

作者：赵林徐沙沙郭伟胜刘鹏席作武河南省中医院、河南中医药大学第二附属医院普外二科河南郑州450002 河南省中医院、河南中医药大学第二附属医院肛肠科河南郑州450002 河南省儿童医院呼吸内科河南郑州450018

目的分析益生菌结合蒙脱石散对轮状病毒(RV)感染乳鼠肠道黏膜、肠道微生物功能相关基因表达的影响。方法用灌胃SA11株轮状病毒构建RV感染模型。将48只乳鼠随机分为正常组(0.9%NaCl)、模型组(0.9%NaCl)、实验组(0.06 g·mL^(-1)蒙脱石散... 详细信息

目的分析益生菌结合蒙脱石散对轮状病毒(RV)感染乳鼠肠道黏膜、肠道微生物功能相关基因表达的影响。方法用灌胃SA11株轮状病毒构建RV感染模型。将48只乳鼠随机分为正常组(0.9%NaCl)、模型组(0.9%NaCl)、实验组(0.06 g·mL^(-1)蒙脱石散)和联合组(0.06 g·mL^(-1)蒙脱石散+6.5×10~7 CFU·mL^(-1)布拉氏酵母菌散),每组12只。4组乳鼠每天给药1次,连续给药5 d。收集粪便进行评价,用酶联免疫吸附试验法检测血清肿瘤坏死因子α(TNF-α)、白细胞介素-1β(IL-1β)和IL-17水平,用实时荧光定量聚合酶链反应法检测肠道组织中水通道蛋白(AQP)水平,用细菌16srDNA荧光定量聚合酶链反应法检测粪便中双歧杆菌和大肠埃希菌含量。结果正常组、模型组、实验组和联合组的粪便评分分别为(1.01±0.10)、(2.97±0.08)、(2.84±0.03)和(2.77±0.03)分,TNF-α水平分别为(132.54±14.63)、(185.66±19.64)、(165.25±17.63)和(149.95±15.76)pg·mL^(-1),IL-1β水平分别为(172.32±18.68)、(265.34±27.72)、(202.34±21.34)和(186.24±19.46)pg·mL^(-1),IL-17水平分别为(118.62±12.44)、(173.24±18.25)、(152.32±16.72)和(122.54±13.58)pg·mL^(-1),AQP2 mRNA表达水平分别为1.02±0.05、0.72±0.07、0.89±0.08和1.21±0.12,AQP4 mRNA表达水平分别为1.04±0.07、0.42±0.05、0.78±0.08和1.19±0.12,AQP8 mRNA表达水平分别为1.00±0.06、0.63±0.06、0.91±0.09和1.30±0.13,双歧杆菌含量分别为(6.35±0.64)、(4.31±0.44)、(4.93±0.50)和(5.34±0.54)CFU·g^(-1),大肠埃希菌含量分别为(6.14±0.62)、(8.78±0.88)、(8.46±0.85)和(8.12±0.83)CFU·g^(-1)。模型组的上述指标和实验组、联合组、正常组比较,在统计学上差异均有统计学意义(均P<0.05)。结论蒙脱石散联合益生菌干预RV感染乳鼠可改善粪便性状,降低血清炎症因子水平,纠正肠道菌群紊乱,其可能是通过改善肠道AQP2、AQP4和AQP8表达实现的。

关键词：益生菌蒙脱石散轮状病毒肠道黏膜肠道微生物

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温室传热水道与土壤换热强度影响的数值分析

农机化研究 2024年第9期46卷 257-263页

作者：甄琦杜嘉玮塔娜闫彩霞孙云峰内蒙古农业大学能源与交通工程学院呼和浩特010018

以呼和浩特市某日光温室铺设的传热水道为研究对象,为提供传热水道在土壤中铺设间距、深度的准确依据,利用CFD数值模拟技术对传热水道在不同供水温度(30、40、50℃)、不同埋管深度(30、40、50cm)、不同管道间距(20、40、50cm)的情况时... 详细信息

以呼和浩特市某日光温室铺设的传热水道为研究对象,为提供传热水道在土壤中铺设间距、深度的准确依据,利用CFD数值模拟技术对传热水道在不同供水温度(30、40、50℃)、不同埋管深度(30、40、50cm)、不同管道间距(20、40、50cm)的情况时对温室土壤的换热强度进行研究与分析。结果表明:埋管深度越深对土壤地面温度影响越小,管道间距越宽则土壤的温度分布越分散,使土壤不容易达到温度扩散的饱和值,管温越高对管道以下的土壤影响越大,造成资源浪费;当埋管深度为30cm、管间距为20cm时,土壤的换热效果最佳。研究结果可为温室传热水道对土壤加热提供理论参考。

关键词：土壤计算流体力学传热水道换热强度日光温室