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Comparative effectiveness of traditional chemoembolization with or without sorafenib for hepatocellular carcinoma

World Journal of Hepatology 2013年第7期5卷 364-371页

作者： Adnan Muhammad Manish Dhamija Gitanjali Vidyarthi Donald Amodeo William Boyd branko miladinovic Ambuj Kumar Department of Gastroenterology University of South Florida Department of Gastroenterology James A Haley VA Hospital Department of Internal Medicine Morsani College of Medicine Center for Evidence Based Medicine

AIM: To compare the overall survival (OS) and progression-free survival (PFS) with associated adverse events (AE) in patients with unresectable hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE) + sorafenib vs TACE alone. METHODS: In this retrospective cohort study we collected data on all consecutive patients with a diagnosis of unresectable HCC between 2007 and 2011 who had been treated with TACE + sorafenib or TACE alone. We hypothesized that the combination therapy is superior to TACE alone in improving the survival in these patients. Data extracted included patient's demographics, etiology of liver disease, histology of HCC, stage of liver disease with respect to model of end stage liverdisease score and Child-Turcotte-Pugh (CTP) classification and Barcelona Clinic Liver Cancer (BCLC) staging for HCC. Computed tomography scan findings, alpha fetoprotein levels, number of treatments and related AE were also recorded and analyzed. RESULTS: Of the 43 patients who met inclusion criteria, 13 were treated with TACE + sorafenib and 30 with TACE alone. There was no significant difference in median survival: 20.6 mo (95%CI: 13.4-38.4) for the TACE + sorafenib and 18.3 mo (95%CI: 11.8-32.9) for the TACE alone (P = 0.72). There were also no statistically significant differences between groups in OS (HR = 0.82, 95%CI: 0.38-1.77; P = 0.61), PFS (HR = 0.93, 95%CI: 0.45-1.89; P = 0.83), and treatment-related toxicities (P = 0.554). CTP classification and BCLC staging for HCC were statistically significant (P = 0.001, P = 0.04 respectively) in predicting the survival in patients with HCC. The common AE observed were abdominal pain, nausea, vomiting and mild elevation of liver enzymes. CONCLUSION: Combination therapy with TACE + sorafenib is safe and equally effective as TACE alone in patients with unresectable HCC. CTP classification and BCLC staging were the significant predictors of survival. Future trials with large number of patients are nee

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sorafenib Survival Adverse events

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Behavior of the relativistic angular and energy distributions of atoms exposed to a strong and low-frequency circularly polarized laser field

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Chinese Optics Letters 2015年第7期13卷 14-17页

作者： Tatjana B.miladinovic Violeta M.Petrovic Department of Physics Faculty of Science Kragujevac University

In this Letter, we focus on the theoretical analysis of the relativistic energy and angular distributions of the ejected photoelectrons during the relativistic tunnel ionization of atoms by intense, circularly polarized light. We make a small modification of the general analytical expressions for these distributions. The role of the initial momentum, the ponderomotive potential, and the Stark shift are considered. We also present the maximal angle of electron emission.

关键词： Stark Behavior of the relativistic angular and energy distributions of atoms exposed to a strong and low-frequency circularly polarized laser field

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Optimization and kinetic modeling of waste lard methanolysis in a continuous reciprocating plate reactor

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Chinese Journal of Chemical Engineering 2019年第10期27卷 2481-2490页

作者： Marija R.miladinovic Ivan J.Stojkovic Ana V.Velickovic Olivera S.Stamenkovic Ivana B.Bankovic-Ilic Vlada B.Veljkovic University of Nis Faculty of TechnologyBulevar osloboaenja 124Leskovac 16000Serbia University of Belgrade Faculty of Technology and MetallurgyKarnegijeva 4Belgrade 11000Serbia Serbian Academy of Sciences and Arts(SASA) Knez Mihailova 35Belgrade 11000Serbia

Continuous biodiesel production from a waste pig-roasting lard,methanol and KOH was carried out in a reciprocating plate reactor(RPR)using a factorial design containing three process factors,namely methanol/lard molar ratio,catalyst loading,and normalized height of the *** main goals were to optimize the influential process factors with respect to biodiesel purity using the response surface methodology and to model the kinetics of the transesterification reaction in order to describe the change of triacylglycerols(TAG)and fatty acid methyl esters(FAME)concentrations along the RPR *** first-order rate law was proved for both the reaction and the mass *** model of the changing reaction mechanism and mass transfer of TAG was also *** kinetic models agreed with the experimental concentrations of TAG and FAME determined along the RPR height.

关键词： Biodiesel Kinetics Optimization Reciprocating plate reactor Waste lard

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酶可减少制粒过程中的电耗

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国外畜牧学（猪与禽） 2014年第10期34卷 10-12页

作者：陈国营陈琳 Dejan miladinovic 挪威生命科学大学

饲料制粒过程会消耗大量的能量。减少所需能量的一个方法是使用酶。众所周知,酶能加快反应,减少环模的摩擦力。全世界的畜禽养殖场是为了满足人类对动物蛋白日益增长的需要而建立的。消费者对可持续发展的认识,迫使全球饲料工业证明畜... 详细信息

饲料制粒过程会消耗大量的能量。减少所需能量的一个方法是使用酶。众所周知,酶能加快反应,减少环模的摩擦力。全世界的畜禽养殖场是为了满足人类对动物蛋白日益增长的需要而建立的。消费者对可持续发展的认识,迫使全球饲料工业证明畜禽的生产是安全且环境可持续性的。动物饲料制粒过程中的电耗及温室气体的释放。

关键词：制粒过程饲料工业环模环境可持续性畜禽养殖场饲料颗粒所需能量制粒机饲料加工厂混合原料

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Student-Teacher Communication in University Teaching

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Sino-US English Teaching 2013年第1期10卷 65-71页

作者： Radmila Suzic Tijana Dabic Ivana Cirkovic miladinovic "Bijeljina" University Bijeljina Bosnia and Herzegovina "Sinergij a" University Bijeljina Bosnia and Herzegovina University of Kragujevac Kragujevac Serbia

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