检索结果-南通市图书馆

Insights into hepatitis E virus epidemiology in Croatia

World Journal of Gastroenterology 2022年第37期28卷 5494-5505页

作者： Pavle Jelicic Thomas Ferenc Anna Mrzljak Lorena Jemersic Natasa Janev-Holcer Milan Milosevic Maja Bogdanic Ljubo Barbic branko kolaric Vladimir Stevanovic Mateja Vujica Zeljka Jurekovic Jadranka Pavicic Saric Maja Vilibic Tatjana Vilibic-Cavlek Department of Environmental Health Croatian Institute of Public HealthZagreb 10000Croatia Department of Radiology Merkur University HospitalZagreb 10000Croatia Department of Gastroenterology and Hepatology University Hospital Center ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Department of Virology Croatian Veterinary InstituteZagreb 10000Croatia Department of Social Medicine and Epidemiology Faculty of Medicine University of RijekaRijeka 51000Croatia Department of Occupational and Environmental Health Andrija Stampar School of Public HealthZagreb 10000Croatia Department of Virology Croatian Institute of Public HealthZagreb 10000Croatia Department of Microbiology and Infectious Diseases with Clinic Faculty of Veterinary Medicine University of ZagrebZagreb 10000Croatia Department of Gerontology and Social Medicine Andrija Stampar Teaching Institute of Public HealthZagreb 10000Croatia Institute of Emergency Medicine of Krapina-Zagorje County Krapina 49000Croatia Department of Nephrology Merkur University HospitalZagreb 10000Croatia Department of Anesthesiology University Hospital MerkurZagreb 10000Croatia Department for Social Psychiatry Psychotherapy and PsychodiagnosticsUniversity Clinical Hospital Center“Sestre Milosrdnice”Zagreb 10000Croatia

BACKGROUND Hepatitis E virus(HEV)is an emerging virus of global health *** seroprevalence rates differ greatly according to geographic region and population *** To analyze the seroprevalence of HEV in exposed(animal-related professions)and nonexposed populations,as well as solid organ and hematopoietic stem cell transplant *** Forestry workers(n=93),hunters(n=74),and veterinarians(n=151)represented the exposed *** general population(n=126)and pregnant women(n=118)constituted the control *** patients included liver transplant recipients(LTRs)(n=83),kidney transplant recipients(KTRs)(n=43),and hematopoietic stem cell transplant recipients(HSCRs)(n=39).HEV immunoglobulin G antibodies were detected using the enzyme-linked immunosorbent assay and confirmed by the immunoblot *** The HEV seroprevalence significantly differed between groups:Veterinarians 15.2%,hunters 14.9%,forestry workers 6.5%,general population 7.1%,and pregnant women 1.7%.In transplant patients,the seropositivity was highest in LTRs(19.3%),while in KTRs and HSCRs,the seroprevalence was similar to the general population(6.9%and 5.1%,respectively).A significant increase in seropositivity with age was observed from 2.9%in individuals less than 30 years to 23.5%in those older than 60 *** characteristics(sex,educational level,area of residence,and number of household members),eating habits(game meat,offal,and pork products consumption),and environmental and housing conditions(drinking water supply,type of water drainage/sewer,waste disposal,domestic animals)were not associated with HEV ***,individuals who reported a pet ownership were more often seropositive compared to those who did not have pet animals(12.5%vs 7.0%).CONCLUSION The results of this study showed that individuals in professional contact with animals and LTRs are at higher risk for HEV *** addition,age is a significant risk factor for HEV

关键词： Hepatitis E virus Seroprevalence Veterinarians Hunters Forestry workers Transplant patients Croatia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Backstepping approach for design of PID controller with guaranteed performance for micro-air UAV

引用

Control Theory and Technology 2020年第1期18卷 19-33页

作者： Yusuf KARTAL Patrik kolaric Victor LOPEZ Atilla DOGAN Frank LEWIS University of Texas at Arlington Research Institute Forth Worth 76118TXU.S.A. ZDepartment of Mechanical and Aerospace Engineering University of Texas at ArlingtonTKU.S.A.

Flight controllers for micro-air UAVs are generally designed using proportional-integral-derivative(PID)methods,where the tuning of gains is difficult and time-consuming,and performance is not *** this paper,we develop a rigorous method based on the sliding mode analysis and nonlinear backstepping to design a PID controller with guaranteed *** technique provides the structure and gains for the PID controller,such that a robust and fast response of the UAV(unmanned aerial vehicle)for trajectory tracking is ***,the second-order sliding variable errors are used in a rigorous nonlinear backstepping design to obtain guaranteed performance for the nonlinear UAV ***,using a small angle approximation and rigorous geometric manipulations,this nonlinear design is converted into a PID controller whose structure is naturally determined through the backstepping *** gains that guarantee robust UAV performance are finally computed from the sliding mode gains and from stabilizing gains for tracking error *** prove that the desired Euler angles of the inner attitude controller loop are related to the dynamics of the outer backstepping tracker loop by inverse kinematics,which provides a seamless connection with existing built-in UAV attitude *** implement the proposed method on actual UAV,and experimental flight tests prove the validity of these *** is seen that our PID design procedure yields tighter UAV performance than an existing popular PID control technique.

关键词： Quadrotor nonlinear controller trajectory tracking backstepping controller inverse kinematics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Consensus controller for multi-UAV navigation

引用

Control Theory and Technology 2018年第2期16卷 110-121页

作者： Patrik kolaric Ci CHEN Ankur DALAL Frank L. LEWIS UTA Research Institute University of Texas at Arlington 7300 Jack Newell Bird S Fort Worth TX 76118 U.S.A. School of Automation Guangdong University of Technology Guangdong Key Laboratory of loT Information Technology Guangzhou Guangzhou 510006 China State Key Laboratory of Synthetical Automation for Process Industries Northeastern University Shenyang Liaoning 110819 China

In this paper, we design consensus algorithms for multiple unmanned aerial vehicles （UAV）. We mainly focus on the control design in the face of measurement noise and propose a position consensus controller based on the sliding mode control by using the distributed UAV information. Within the framework of Lyapunov theory, it is shown that all signals in the closed-loop multi- UAV systems are stabilized by the proposed algorithm, while consensus errors are uniformly ultimately bounded. Moreover, for each local UAV, we propose a mechanism to define the trustworthiness, based on which the edge weights are tuned to eliminate negative influence from stubborn agents or agents exposed to extremely noisy measurement. Finally, we develop software for a nano UAV platform, based on which we implement our algorithms to address measurement noises in UAV flight tests. The experimental results validate the effectiveness of the proposed algorithms.

关键词： Consensus control multi-agent system quadrotor Lyapunov stability distributed system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mechanisms of Hepatic Cholestatic Drug Injury

引用

Journal of Clinical and Translational Hepatology 2019年第1期7卷 86-92页

作者： Tea Omanovic kolaric Vjera Nincevic Robert Smolic Martina Smolic George Y Wu Department of Pharmacology Faculty of Medicine OsijekOsijekCroatia Department of Pharmacology Faculty of Dental Medicine and HealthOsijekCroatia Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Drug-induced cholestasis represents a form of drug-induced liver disease that can lead to severe impairment of liver *** drugs have been shown to cause cholestasis and consequently bile duct ***,there is still lack of therapeutic tools that can prevent progression to advanced stages of liver *** review focuses on the various pathological mechanisms by which drugs expresstheir hepatotoxic effects,as well as consequences of increased bile acid and toxin accumulation in the hepatocytes.

关键词： Drug-induced liver injury Bile acids Cholestasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Drug-induced Fatty Liver Disease:Pathogenesis and Treatment

引用

Journal of Clinical and Translational Hepatology 2021年第5期9卷 731-737页

作者： Tea Omanovic kolaric Vjera Nincevic Lucija Kuna Kristina Duspara Kristina Bojanic Sonja Vukadin Nikola Raguz-Lucic George Y Wu Martina Smolic University of Osijek Faculty of MedicineOsijekCroatia University of Osijek Faculty of Dental Medicine and HealthOsijekCroatia Health Center Osijek OsijekCroatia Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Metabolic dysfunction-associated fatty liver disease(commonly known as MAFLD)impacts global health in epidemic proportions,and the resulting morbidity,mortality and economic burden is *** much attention has been given to metabolic syndrome and obesity as offending factors,a growing incidence of polypharmacy,especially in the elderly,has greatly increased the risk of drug-induced liver injury(DILI)in general,and drug-induced fatty liver disease(DIFLD)in *** review focuses on the contribution of DIFLD to DILI in terms of epidemiology,pathophysiology,the most common drugs associated with DIFLD,and treatment strategies.

关键词： Metabolic dysfunction-associated fatty liver disease Drug-induced liver injury Reactive oxygen species Free fatty acids Pharmacogenetics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Targeting the Wnt Signaling Pathway in Liver Fibrosis for Drug Options:An Update

引用

Journal of Clinical and Translational Hepatology 2021年第6期9卷 960-971页

作者： Kristina Duspara Kristina Bojanic Josipa Ivanusic Pejic Lucija Kuna Tea Omanovic kolaric Vjera Nincevic Robert Smolic Aleksandar Vcev Marija Glasnovic Ines Bilic Curcic Martina Smolic Department of Pharmacology and Biochemistry Faculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijekCroatia Department of Pharmacology Faculty of Medicine OsijekJ.J.Strossmayer University of OsijekOsijekCroatia Department of Biophysics and Radiology Faculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijekCroatia Department of Biophysics and Radiology Faculty of Medicine OsijekJ.J.Strossmayer University of OsijekOsijekCroatia Department of Radiology Health Center OsijekOsijekCroatia Department of Medi-cine Division of Gastroenterology/HepatologyUniversity Hospital OsijekOsijekCroatia Department of Pathophysiology Physiology and ImmunologyFaculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijekCroatia Department of Pathophysiology Faculty of Medicine OsijekJ.J.Strossmayer University of OsijekOsijekCroatia Department of Medicine Family Medicine and History of MedicineFaculty of Medicine OsijekJ.J.Strossmayer University of OsijekOsijekCroatia Department of Medicine Division of EndocrinologyUniversity Hospital OsijekOsijekCroatia

morbidity and mortality for healthcare systems *** imparts an enormous economic burden to societies,making continuous research and informational updates about its pathogenesis and treatment *** review′s focus is on the current knowledge about the Wnt signaling path-way,serving as an important pathway in liver fibrosis development and activation of hepatic stellate cells(HSCs).Two types of Wnt pathways are distinguished,namely the ß-catenin-dependent canonical and non-canonical Ca^(2+) or planar cell polarity(PCP)-dependent *** dynamic balance of physiologically healthy liver and hepatocytes is disturbed by repeated liver *** of theß-catenin Wnt pathway prevents the regeneration of hepatocytes by the replacement of extracellular matrix(ECM),leading to the appearance of scar tissue and the formation of regenerated nodular hepatocytes,lacking the original function of healthy ***,liver function is reduced due to the severely advanced *** inhibition ofß-catenin inhibits inflammatory processes(since chemokines and pro-inflammatory cytokines are produced during Wnt activation),reduces growth of activated HSCs and reduces collagen synthesis and angiogenesis,thereby reducing the progression of liver fibrosis in *** the canonical Wnt pathway is usually inactive in a physiologically healthy liver,it shows activity during cell regeneration or renewal and in certain pathophysiological conditions,such as liver diseases and *** blocking of some of the basic components of the Wnt path-way is a therapeutic *** include the frizzled transmembrane receptor(Fz)receptors using the secreted frizzled-related protein family(sFRP),Fz-coreceptors low-density LRP 5/6 through dickkopf-related protein 1(DKK1)or niclosamide,glycogen kinase-3 beta(GSK-3β)using SB-216763,cyclic-AMP response element-binding protein(CBP)using PRI-724 and ICG-001,the lymphoid enhancer binding factor(LEF)/T cell-spec

关键词： Liver fibrosis Wnt signaling pathway Hepatic stellate cell Therapeutic solutions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：