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Liver re-transplantation for donor-derived neuroendocrine tumor: A case report

World Journal of Clinical Cases 2019年第18期7卷 2794-2801页

作者： Anna Mrzljak branislav Kocman Anita Skrtic Ivana Furac Jelena Popic Lucija Franusic Renata Zunec Davor Mayer Danko Mikulic Department of Medicine Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Croatia Department of Surgery Merkur University HospitalZagreb 10000Croatia Department of Pathology and Cytology Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Croatia DNA Laboratory Institute of Forensic Medicine and CriminalisticsSchool of MedicineUniversity of ZagrebZagreb 10000Croatia Department of Radiology Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Department for Tissue Typing Clinical Hospital Centre ZagrebZagreb 10000Croatia Institute of Forensic Medicine and Criminalistics School of MedicineUniversity of ZagrebZagreb 10000Croatia

BACKGROUND Donor-origin cancer is a well-recognized but rare complication after liver transplantation (LT). The rise in the use of extended criteria donors due to the current shortage of organs increases the risk. Data on donor-origin neuroendocrine neoplasms (NENs) and the most appropriate treatment are scarce. Here, we report a case of a patient who developed a NEN confined to the liver after LT and was treated with liver re-transplantation (re-LT). CASE SUMMARY A 49-year-old man with no other medical co-morbidities underwent LT in 2013 for alcoholic liver cirrhosis. The donor was a 73-year-old female with no known malignancies. Early after LT, a hypoechogenic (15 mm) lesion was detected in the left hepatic lobe on abdominal ultrasound. The lesion was stable for next 11 mo, when abdominal magnetic resonance identified two hypovascular lesions (20 and 11 mm) with atypical enhancement pattern. Follow-up abdominal ultrasound revealed no new lesions for the next 2.5 years, when magnetic resonance showed a progression in size and number of lesions, also confirmed by abdominal computed tomography. Liver biopsy proved a well-differentiated NEN. Genetic analysis of the NEN confirmed donor origin of the neoplasm. As NEN was confined to liver graft only, in 2018, the patient underwent his second LT. At 12 mo after re-LT the patient is well with no signs of NEN dissemination. CONCLUSION The benefits of graft explantation should be weighed against the risks of re-LT and the likelihood of NEN dissemination beyond the graft.

关键词： Donor-origin tumor Neuroendocrine tumor Liver transplantation Donor Case report

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The Implementation of the Surface Charging Effects in Three-Dimensional Simulations of SiO_(2) Etching Profile Evolution

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Engineering（科研） 2014年第1期6卷 1-6页

作者： branislav Radjenovic Marija Radmilovic-Radjenovic Institute of Physics University of BelgradeZemunSerbia

Refined control of etched profile in microelectronic devices during plasma etching process is one of the most important tasks of front-end and back-end microelectronic devices manufacturing technologies. A comprehensive simulation of etching profile evolution requires knowledge of the etching rates at all the points of the profile surface during the etching process. Electrons do not contribute directly to the material removal, but they are the source, together with positive ions, of the profile charging that has many negative consequences on the final outcome of the process especially in the case of insulating material etching. The ability to simulate feature charging was added to the 3D level set profile evolution simulator described earlier. The ion and electron fluxes were computed along the feature using Monte Carlo method. The surface potential profiles and electric field for the entire feature were generated by solving Laplace equation using finite elements method. Calculations were performed in the case of simplified model of Ar+/CF4 non-equilibrium plasma etching of SiO2.

关键词： Plasma Etching Level Set Method Profile Charging Finite Elements Method

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Application of the Level Set Method in Three-Dimensional Simulation of the Roughening and Smoothing of Substrates in Nanotechnologies

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World Journal of Nano Science and Engineering 2014年第2期4卷 84-89页

作者： branislav Radjenovic Marija Radmilovic-Radjenovic Institute of Physics University of BelgradeZemunSerbia

This paper contains results of the comprehensive studies of the effect of the isotropic etching mode on roughening of the nanocomposite materials and on smoothing of the roughed nanostructure made of homogeneous materials. Three-dimensional simulation results obtained illustrate the influence of the isotropic etch process on dynamics of the roughening and smoothing of the surfaces, indicating the opposite effects of the same etch process on the surfaces made of different materials. It was shown that root mean square roughness obeys simple scaling laws during both roughening and smoothing processes. The exponential time dependences of the rms roughness have been determined.

关键词： Nanocomposite Roughness Smoothing Isotropic Etching

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Constrictive pericarditis as a cause of refractory ascites after liver transplantation:A case report

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World Journal of Clinical Cases 2019年第20期7卷 3266-3270页

作者： Miran Bezjak branislav Kocman Stipislav Jadrijevic Hrvoje Gasparovic Anna Mrzljak Tajana Filipec Kanizaj Darko Vujanic Tomislav Bubalo Danko Mikulic Division of Abdominal Surgery and Organ Transplantation Department of SurgeryUniversity Hospital MerkurZagreb 10000Croatia Division of Cardiology Department of Internal MedicineUniversity Hospital Centre ZagrebZagreb 10000Croatia Division of Gastroenterology Department of Internal MedicineUniversity Hospital MerkurZagreb 10000Croatia Division of Cardiology Department of Internal MedicineUniversity Hospital MerkurZagreb 10000Croatia

BACKGROUND Refractory ascites is a rare complication following orthotopic liver transplantation(OLT).The broad spectrum of differential diagnosis often leads to delay in *** depends on recognition and treatment of the underlying *** pericarditis is a condition characterized by clinical signs of right-sided heart *** the advanced stages of the disease,hepatic congestion leads to formation of *** patients after OLT,cardiac etiology of ascites is easily overlooked and it requires a high degree of clinical *** SUMMARY We report a case of a 55-year-old man who presented with a refractory ascites three months after liver transplantation for alcoholic *** to transplantation the patient had a minimal amount of *** transplant procedure and the early postoperative course were *** posttransplant work up failed to reveal any typical cause of refractory post-transplant *** function of the graft was *** from atrial fibrillation,cardiac status was *** months post transplantation the patient developed dyspnea and severe fatigue with peripheral *** was still *** presenting signs of right-sided heart failure were highly suggestive of cardiac *** paracentesis was suggestive of cardiac ascites,and further cardiac evaluation showed typical signs of constrictive *** was performed followed by complete resolution of *** the follow-up the patient remained symptom-free with no signs of recurrent ascites and with normal function of the liver *** Refractory ascites following liver transplantation is a rare complication with many possible *** differential diagnosis needs to be considered.

关键词： Constrictive pericarditis Liver transplantation Refractory ascites Case report

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Design of a DSLM-based cerebral palsy action rehabilitation training system

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High Technology Letters 2020年第3期26卷 342-348页

作者： Lu Zhenli Ma Zhipeng Shen Xuanlin Borovac branislav Liu Yan Shan Changkao Wang Hong Zhao Yu Koumiana ilieva Bojan Nemec Maijan Memik School of Electrical Engineering and Automation Changshu Institute of TechnologyChangshu 215500P.R.China China University of Mining and Technology Xuzhou 221116P.R.China Department of Rehabilitation Medicine Changshu No.2 People HospitalChangshu 215500P.R.China Faculty of Technical Sciences University of Novi Sad21000-Novi SadSerbia School of Business Changshu Institute of TechnologyChangshu 215500P.R.China Faculty of Management Technical University of SofiaSofia 1000Bulgaria Department of Automatics Biocybemetics and RoboticsJozef Stefan InstituteLjubljanalOOOSlovenia University of Maribor Maribor 2000Slovenia

Based on domain specified language mechanism(DSLM),the architecture of the robotic training system for the rehabilitation of children with cerebral palsy(CP)is *** of human-computer interaction(HCI)motion recognition technology is combined with Kinect to improve the effect of cerebral palsy rehabilitation *** this system,Kinect's bone recognition method is used to judge the patient's training movements,and the collected bone movement information is *** human-computer interaction function is based on the Microsoft foundation classes function of Visual Studio based on DSLM development,which can realize real-time interactive training and evaluation of people and actions,and record the training information of *** system combines the designed small game to train the upper limb movement ability and reaction ability of the cerebral palsy patient,and provides key technology for improving the cerebral palsy rehabilitation training system.

关键词： domain specified language mechanism(DSLM) robot-assistant system humancomputer interaction(HCI) cerebral palsy rehabilitation training

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Pre-and intraoperative predictors of acute kidney injury after liver transplantation

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World Journal of Clinical Cases 2020年第18期8卷 4034-4042页

作者： Anna Mrzljak Lucija Franusic Jadranka Pavicic-Saric Tomislav Kelava Zeljka Jurekovic branislav Kocman Danko Mikulic Ivan Budimir-Bekan Mladen Knotek Department of Medicine Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Croatia General Hospital Dubrovnik Dubrovnik 20000Croatia Department of Anesthesiology and Intensive Medicine Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Croatia Laboratory for Molecular Immunology Croatian Institute for Brain ResearchUniversity of ZagrebSchool of MedicineZagreb 10000Croatia Department of Medicine Merkur University HospitalZagreb 10000Croatia Department of Surgery Merkur University HospitalZagreb 10000Croatia

BACKGROUND Acute kidney injury(AKI)after liver transplantation(LT)is a frequent and multifactorial event related to increased morbidity and *** factors for AKI after LT still need to be *** To identify the predictors of acute kidney injury after liver *** The frequency and pre-and intraoperative predictors of AKI within the first 7 d after LT were evaluated in adult liver transplant candidates in a single LT center in *** was defined according to the Kidney Disease:Improving Global Outcomes *** Out of 205 patients(mean age 57±10 years;73.7%males,52.7%with alcoholrelated liver disease)93(45.36%)developed AKI,and the majority of them(58.06%)had stage *** 5.38%of patients required renal replacement therapy after *** majority of patients(82.8%)developed AKI within the first two days after the *** logistic regression identified pre-LT body mass index(OR=1.1,95%CI:1.05-1.24)and red blood cell transfusion(OR=1.66,95%CI:1.09-2.53)as independent predictors of early post-LT AKI occurrence.30-d survival after LT was significantly better for patients without AKI(P=0.01).CONCLUSION Early AKI after LT is a frequent event that negatively impacts short-term *** pathogenesis of AKI is multifactorial,but pre-LT BMI and intraoperative volume shifts are major contributors.

关键词： Acute kidney injury Liver transplant Body mass index Red blood cell Survival

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Development of Pull Strategies in Production Management in Order to Increase Efficiency of Manufacturing Enterprise

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Journal of Mechanics Engineering and Automation 2014年第9期4卷 730-737页

作者： branislav Micieta Libor Kubinec Vladimira Bifiasova Department of Industrial Engineering University of Zilina Zilina 01026 Slovak Republic

The article deals with possible approaches to the management of manufacturing organizations. The authors emphasize the need for integration of lean management with eco-innovation. This integration represents a sustainable development so that environmental impacts are reduced, more effective use of natural resources is achieved and production costs are reduced. Manufacturing organizations based on that approach must use so-called pull production control systems. Pull systems are most often presented in production management system--Kanban. This article also deals with specification of these systems and the development of pull strategies in production management in order to increase efficiency of manufacturing enterprise.

关键词： Production management development trends manufacturing enterprise pull systems.

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Three-Dimensional Simulations with Fields and Particles in Software and Inflector Designs

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Journal of Software Engineering and Applications 2013年第8期6卷 390-395页

作者： branislav Radjenovic Marija Radmilovic-Radjenovic Petar Belicev Institute of Physics University of BelgradeBelgradeSerbia Vinca Institute of Nuclear Science University of BelgradeBelgradeSerbia

Particles and fields represent two major modeling paradigms in pure and applied science at all. In this paper a methodology and some of the results for three-dimensional (3D) simulations that include both field and particle abstractions are presented. Electromagnetic field calculations used here are based on the discrete differential form representation of the finite elements method, while the Monte Carlo method makes foundation of the particle part of the simulations. The first example is the simulation of the feature profile evolution during SiO2 etching enhanced by Ar + /CF4 non-equilibrium plasma based on the sparse field method for solving level set equations. Second example is devoted to the design of a spiral inflector which is one of the key devices of the axial injection system of the VINCY Cyclotron.

关键词： Fields Particles Simulations Finite Elements Inflector Profile Evolution Level Set Method

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Advanced Industrial Engineering in Next Generation of Manufacturing Systems

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Journal of Mechanics Engineering and Automation 2014年第4期4卷 311-317页

作者： branislav Micieta Vladimira Bifiasovit Michal Haluska Department of lndustrial Engineering Faculty of Mechanical Engineering University of Zilina Zilina 010 26 Slovak Republic

The article deals with possible approaches to the development trends in the industrial engineering in manufacturing organizations. The authors emphasize the need for integration of advanced industrial engineering in the next generation of manufacturing systems, which responds to new trends of production, innovation and advanced technology. This integration represents a sustainable development, so that humanization of work are increased, more effective use of natural and energy resources are achieved and production costs are reduced. Trends in the products manufacturing must meet both industrial engineering as well as production management. The development trends in the industrial engineering in manufacturing organizations must use methods and tools of advanced industrial engineering to achieve competitiveness. The second part of this article deals with specification of these approaches in next generation of production systems.

关键词： Advanced industrial engineering development trends manufacturing enterprise intelligent agent autonomous control.

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Influence of donor age on liver transplantation outcomes: A multivariate analysis and comparative study

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 331-344页

作者： Miran Bezjak Ivan Stresec branislav Kocman Stipislav Jadrijević Tajana Filipec Kanizaj Miro Antonijević Bojana Dalbelo Bašić Danko Mikulić Department of Surgery University Hospital MerkurZagreb 10000Croatia Department of Electronics MicroelectronicsComputer and Intelligent SystemsFaculty of Electrical Engineering and ComputingZagreb 10000Croatia Department of Gastroenterology University Hospital MerkurZagreb 10000Croatia Development of Software Nanobit Ltd.Zagreb 10000Croatia

BACKGROUND The growing disparity between the rising demand for liver transplantation(LT)and the limited availability of donor organs has prompted a greater reliance on older liver ***,utilizing livers from elderly donors has been associated with outcomes inferior to those achieved with grafts from younger *** accounting for additional risk factors,we hypothesize that the utili-zation of older liver grafts has a relatively minor impact on both patient survival and graft *** To evaluate the impact of donor age on LT outcomes using multivariate analysis and comparing young and elderly donor *** In the period from April 2013 to December 2018,656 adult liver transplants were performed at the University Hospital *** multivariate Cox propor-tional hazards models were developed to independently assess the significance of donor *** age was treated as a continuous *** approach involved univariate and multivariate analysis,including variable selection and assessment of interactions and ***,to exemplify the similarity of using young and old donor liver grafts,the group of 87 recipients of elderly donor liver grafts(≥75 years)was compared to a group of 124 recipients of young liver grafts(≤45 years)from the *** rates of the two groups were estimated using the Kaplan-Meier method and the log-rank test was used to test the differences between *** Using multivariate Cox analysis,we found no statistical significance in the role of donor age within the constructed *** when retained during the entire model development,the donor age's impact on survival remained insignificant and transformations and interactions yielded no substantial effects on *** insigni-ficance and low coefficient values suggest that donor age does not impact patient survival in our ***,there was no statistical evidence that the five developed models did not adhe

关键词： Liver transplantation Elderly donors Survival analysis Postoperative complications Cox proportional hazard models

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