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Elasto-inertial focusing and particle migration in high aspect ratio microchannels for highthroughput separation

Microsystems & Nanoengineering 2024年第3期10卷 381-394页

作者： Selim Tanriverdi Javier Cruz Shahriar Habibi Kasra Amini Martim Costa Fredrik Lundell Gustaf Mårtensson Luca brandt Outi Tammisola Aman Russom Division of Nanobiotechnology Department of Protein ScienceScience for Life LaboratoryKTH Royal Institute of TechnologySolna 17165Sweden Division of Microsystems Technology Department of Materials Science and EngineeringUppsala UniversityUppsala 75237Sweden FLOW and SeRC(Swedish e-Science Research Centre) Department of Engineering MechanicsRoyal Institute of TechnologyStockholm SE 10044Sweden FLOW and Fluid Physics Laboratory Department of Engineering MechanicsRoyal Institute of TechnologyStockholmSweden Wallenberg Wood Science Center Royal Institute of TechnologyStockholm SE 10044Sweden Department of Energy and Process Engineering Norwegian University of Science and Technology(NTNU)TrondheimNorway AIMES Center for the Advancement of Integrated Medical and Engineering Sciences at Karolinska Institutet and KTH Royal Institute of Technology StockholmSweden

The combination of flow elasticity and inertia has emerged as a viable tool for focusing and manipulating particles using *** there is considerable interest in the field of elasto-inertial microfluidics owing to its potential applications,research on particle focusing has been mostly limited to low Reynolds numbers(Re<1),and particle migration toward equilibrium positions has not been extensively *** this work,we thoroughly studied particle focusing on the dynamic range of flow rates and particle migration using straight microchannels with a single inlet high aspect *** initially explored several parameters that had an impact on particle focusing,such as the particle size,channel dimensions,concentration of viscoelastic fluid,and flow *** experimental work covered a wide range of dimensionless numbers(0.05

关键词： particle separation straight

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Diverse experiences by active travel for carbon neutrality:A longitudinal study of residential context,daily travel and experience types

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Geography and Sustainability 2024年第3期5卷 459-469页

作者： Karl Samuelsson S.Anders brandt Stephan Barthel Noah Linder Nancy Joy Lim David Hallman Matteo Giusti Department of Building Engineering Energy Systems and Sustainability ScienceFaculty of Engineering and Sustainable DevelopmentUniversity of Gävle 80176 GävleSweden ISGlobal Barcelona Biomedical Research ParkDoctor Aiguader 8808003 BarcelonaSpain Department of Computer and Geospatial Sciences Faculty of Engineering and Sustainable DevelopmentUniversity of Gävle 80176 GävleSweden Stockholm Resilience Centre Stockholm University 10691 StockholmSweden Global Economic Dynamics and the Biosphere Royal Swedish Academy of ScienceLilla Frescativägen 4A 11418 StockholmSweden Department of Occupational Health Science and Psychology Faculty of Health and Occupational StudiesUniversity of Gävle 80176 GävleSweden School of Sustainability Civil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildfordSurrey GU27XHUK

Two key goals for sustainable spatial planning are to promote low-carbon travel in daily life and to enhance human wellbeing through diverse human-environment ***,the integration of these goals has been *** study investigates the potential for experiential diversity via active travel in different resi-dential contexts within the Gävle city-region,*** 15 months,we collected spatiotemporal data from 165 participants,analyzing 4,362 reported experiences and 13,192 GPS-derived travel *** analysis uncovered a significant spatial discrepancy:while the travelled distances to locations of positive experiences typ-ically ranged from 1.5 km to 5 km,active travel predominated only within 1.5 *** discrepancy persisted across urban,suburban,and peripheral *** residents in different contexts reported the same types of experiences,urban dwellers travelled about 50%farther for nature experiences compared with other positive experiences,whereas peripheral dwellers travelled twice the distance for urbanicity experiences compared with other positive ***,urban residents mostly relied on active travel for urbanicity experiences and motorised travel for nature experiences,with the reverse trend observed among peripheral *** results illustrate the importance of spatial scale for promoting diverse positive experiences via active travel,re-gardless of residential *** planning strategies may include enhancing environmental diversity near homes and developing infrastructure that favours active over motorised travel for short to moderate distances.

关键词： Walking Biking Experiential diversity GPS data Smartphone app Topodiversity

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Severe SARS-CoV-2 Infection: Late Impact on the Retinal Ganglion Cell Layer Thickness

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Open Journal of Ophthalmology 2024年第3期14卷 339-349页

作者： Rayssa de Fátima Farias da Costa Gabino Carlos Teixeira brandt Sebastião Cronemberger UNIFACISA Campina Grande Paraba Brazil Federal University of Minas Gerais Belo Horizonte Brazil

Purpose: The involvement of the ocular anterior segment by SARS-CoV-2 has been the subject of many studies, however, the repercussions on the posterior segment, particularly on the different layers of the retina and optic nerve, are still little known. The purpose of this study was to evaluate the impact of severe COVID-19 on the retinal ganglion cell layer (RGCL) thickness. Methods: This observational, prospective and analytical study was performed in the Ophthalmology Department of the FACISA University Center, Campina Grande. Three groups were included: group I (control), 29 healthy individuals who had not severe COVID-19;group II (infirmary), 24 individuals who had COVID-19 and were hospitalized in the infirmary;and group III, 25 individuals who had severe COVID-19 and required Intense Care Unit (ICU). All individuals had ophthalmologic examination and assessment of RGCL thickness using Optical Coherence Tomography (OCT). Statistical tests required p ≤ 0.05 to reject the null hypothesis. Results: The mean of RGCL thickness was significantly reduced in individuals from GIII (77.9 ± 8.9 µm), as compared with GII (83.9 ± 10.9 µm) and GI (82.8 ± 6.5 µm) (p = 0.0027). The mean measurements from the retinal neve fiber layer (RNFL) of the optic nerve head were similar. However, when evaluated sectoral, the mean of RNFL at the temporal sector of the optic disc was significantly lower in group GIII (p Conclusion: The RGCL thickness from patients with severe COVID-19 was significantly reduced. This finding supports that the SARS-CoV-2 has systemic action and affinity for nerve cells, including those from the retina and are related to the severity of the infection.

关键词： COVID-19 Post-Acute COVID-19 Syndrome Retinal Ganglion Cell

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难治性高血压患者行肾去交感神经消融术后心肺系统对运动的反应

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中华高血压杂志 2012年第2期20卷 199-199页

作者： Ukena C Mahfoud F Kindermann I Barth C Lenski M Kindermann M brandt mc Hoppe UC Krum H Esler M Sobotka PA Bohm M 林东杰叶鹏

介入性肾脏交感神经消融术（renal sympathetic denervation，RD）可降低难治性高血压患者静息时的血压。该研究旨在探讨RD后心肺系统对运动反应的影响。方法：人选了46例难治性高血压患者进行研究，作为“难治性高血压患者肾交感神经... 详细信息

介入性肾脏交感神经消融术（renal sympathetic denervation，RD）可降低难治性高血压患者静息时的血压。该研究旨在探讨RD后心肺系统对运动反应的影响。方法：人选了46例难治性高血压患者进行研究，作为“难治性高血压患者肾交感神经消融术临床试验”（Symplicity HTN-2）的延伸调查。

关键词：高血压患者去交感神经运动反应心肺系统难治性肾脏术后肾交感神经

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Multifunctional landscapes—perspectives for the future

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Journal of Environmental Sciences 2003年第2期15卷 187-192页

作者： Jesper brandt Department of Geography and International Development Studies Roskilde University

New methods in landscape ecology to study the link between landscape heterogeneity and landscape functionality are needed. Heterogeneity is a basic characteristic of landscape, and landscape function is the capacity to change the structural heterogeneity of a landscape system. In most developed countries the industrialisation of agriculture has in general resulted in a change of agricultural landscapes from a small-grained heterogeneous pattern towards more monotonous and monofunctional landscapes. During the 1990's this trends seems to have changed due to a diversification of rural land use and new trends in urbanisation. Weather these phases of landscape development should be expected in developing countries is a totally open question. Dealing with the study of multifunctionality of landscapes it is proposed to distinguish between ecological functionality of landscape ecosystems, functionality pertaining to land use and social functionality. Further, the relation between function, space and scale is important by the determination of spatial and time segregation as well as spatial and time integration of multifunctionality in landscapes.

关键词： landscape heterogeneity monotonisation multifunctionality spatial segregation time segregation landscape development

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Bootstrap Algebraic Multigrid: Status Report, Open Problems, and Outlook

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Numerical Mathematics(Theory,Methods and Applications) 2015年第1期8卷 112-135页

作者： Achi brandt James Brannick Karsten Kahl Ira Livshits Department of Applied Mathematics&Computer Science The Weizmann Institute of Science76100 RehovotIsrael Department of Mathematics The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Mathematics University of WuppertalWuppertalGermany Department of Mathematical Sciences Ball State UniversityMuncieIN 47306USA

This paper provides an overview of the main ideas driving the bootstrap algebraic multigrid methodology,including compatible relaxation and algebraic dis-tances for defining effective coarsening strategies,the least squares method for com-puting accurate prolongation operators and the bootstrap cycles for computing the test vectors that are used in the least squares *** review some recent re-search in the development,analysis and application of bootstrap algebraic multigrid and point to open problems in these *** from our previous research as well as some new results for some model diffusion problems with highly oscillatory diffusion coefficient are presented to illustrate the basic components of the BAMG algorithm.

关键词： Bootstrap algebraic multigrid compatible relaxation algebraic distance least squares interpolation

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Saussure’s Prolegomena——Toward a Semiotics of the Mind

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Language and Semiotic Studies 2022年第1期8卷 91-104页

作者： Per Aage brandt 不详

The study of language is based either on the word or on the sentence as basic *** de Saussure opted for the word;other linguists later preferred the sentence or chose to ignore the difference between word and ***,however,have extra-linguistic functions related to the topologies of thought,the spontaneous geometrical imageries of meaningful mental figuration,as we know them from sign posts,from verbal descriptions,and from the semiotics of *** words,rather than sentences,are in this sense the essential connectors of language and thought,then the general architecture of linguistic structures,including semantics and syntax,should be centered around this lexical“window”into the thinking mind,and the semiotic modes of language and signs may then be described by similar architectures directly connected to the figurative mind *** paper offers tentative connected models of the architectures of language,signs,and the figurative mind,and suggests the possibility of interpreting Ferdinand de Saussure’s semiological intuitions in the sense of a semiotics of the mind along these cognitive-semiotic lines.

关键词： word-based linguistics mental architecture cognitive semiotics sign categories

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Exercise immunology:Future directions

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Journal of Sport and Health Science 2020年第5期9卷 432-445页

作者： David C.Nieman brandt D.Pence Human Performance Laboratory Appalachian State UniversityNorth Carolina Research CampusKannapolisNC 28081USA School of Health Studies University of MemphisMemphisTN 38152USA

Several decades of research in the area of exercise immunology have shown that the immune system is highly responsive to acute and chronic exercise *** exercise bouts enhance immunosurveillance and when repeated over time mediate multiple health *** of the studies prior to 2010 relied on a few targeted outcomes related to immune *** the past decade,technologic advances have created opportunities for a multi-omics and systems biology approach to exercise *** article provides an overview of metabolomics,lipidomics,and proteomics as they pertain to exercise immunology,with a focus on *** review also summarizes how the composition and diversity of the gut microbiota can be influenced by exercise,with applications to human health and ***-induced improvements in immune function may play a critical role in countering immunosenescence and the development of chronic diseases,and emerging omics technologies will more clearly define the underlying *** review summarizes what is currently known regarding a multi-omics approach to exercise immunology and provides future directions for investigators.

关键词： Exercise Immunology Lipidomics Metabolomics Proteomics

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Involvement of CYP347W1 in neurotoxin 3-nitropropionic acid-based chemical defense in mustard leaf beetle Phaedon cochleariae

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Insect Science 2022年第2期29卷 453-466页

作者： Nanxia Fu Tobias Becker Wolfgang brandt Maritta Kunert Antje Burse Wilhelm Boland Department of Bioorganic Chemistry Max Planck Institute for Chemical EcologyJenaGermany Key Laboratory of Tea Biology and Resource Utilization Tea Research InstituteChinese Academy of Agricultural SciencesHangzhouChina Department of Bioorganic Chemistry Leibniz Institute of Plant BiochemistryHalle(Saale)Germany Department of Natural Product Biosynthesis Max Planck Institute for Chemical EcologyJenaGermany Department of Medical Technology and Biotechnology Ernst Abbe Hochschule JenaJenaGermany

Chrysomelina beetlesstore 3-nitropropionic acid in form of a pretoxin,isoxazolin-5-one glucoside-conjugated ester,to protect themselves against *** we identified a cytochrome P450 monooxygenase,CYP347W1,to be involved in the production of the 3-nitropropionic acid moiety of the isoxazolin-5-one glucoside *** down CYP347W1 led to a significant depletion in the concentration of the isoxazolin-5-one glucoside ester and an increase in the concentration of the isoxazolin-5-one glucoside in the larval *** assays with the heterologously expressed CYP347W1 showed freeβ-alanine was not the direct *** modeling indicated thatβ-alanine-CoA ester can fit into CYP347W1’s active ***,we proved that Phaedon cochleariae eggs are not able to de novo synthesize 3-NPA,although both isoxazolin-5-one glucoside and its 3-NPA-conjugated ester are present in the *** results provide direct evidence for the involvement of CYP347W1 in the biosynthesis of a *** chemical defense compound.

关键词： chemical defense isoxazolin-5-one glucoside isoxazolin-5-one glucoside ester leaf beetles P450 3-nitropropionic acid(3-NPA)

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Satellite Remote Sensing of Savannas:Current Status and Emerging Opportunities

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Journal of Remote Sensing 2022年第1期2022卷 162-181页

作者： Abdulhakim M.Abdi Martin brandt Christin Abel Rasmus Fensholt Department of Geosciences and Natural Resource Management University of CopenhagenCopenhagenDenmark Centre for Environmental and Climate Science Lund UniversityLundSweden

Savannas cover a wide climatic gradient across large portions of the Earth’s land surface and are an important component of the terrestrial *** have been undergoing changes that alter the composition and structure of their vegetation such as the encroachment of woody vegetation and increasing land-use *** the spatial and temporal dynamics of savanna ecosystem structure(e.g.,partitioning woody and herbaceous vegetation)and function(e.g.,aboveground biomass)is of high *** challenges include misclassification of savannas as forests at the mesic end of their range,disentangling the contribution of woody and herbaceous vegetation to aboveground biomass,and quantifying and mapping fuel ***,we review current(2010–present)research in the application of satellite remote sensing in savannas at regional and global *** identify emerging opportunities in satellite remote sensing that can help overcome existing *** provide recommendations on how these opportunities can be leveraged,specifically(1)the development of a conceptual framework that leads to a consistent definition of savannas in remote sensing;(2)improving mapping of savannas to include ecologically relevant information such as soil properties and fire activity;(3)exploiting high-resolution imagery provided by nanosatellites to better understand the role of landscape structure in ecosystem functioning;and(4)using novel approaches from artificial intelligence and machine learning in combination with multisource satellite observations,e.g.,multi-/hyperspectral,synthetic aperture radar(SAR),and light detection and ranging(lidar),and data on plant traits to infer potentially new relationships between biotic and abiotic components of savannas that can be either proven or disproven with targeted field experiments.

关键词： structure Remote lidar

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