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Percutaneous coronary intervention of totally occluded coronary venous bypass grafts:An exercise in futility?

World Journal of Cardiology 2021年第9期13卷 493-502页

作者： Evan W Nardone brandon m madsen melissa m mcCarey David L Fischman Nicholas J Ruggiero Paul Walinsky Alec Vishnevsky michael P Savage Department of medicine Thomas Jefferson UniversityPhiladelphiaPA 19107United States Department of Anesthesiology Medstar Georgetown University HospitalWashingtonDC 20007United States Jefferson Clinical Research Institue Thomas Jefferson UniversityPhiladelphiaPA 19107United States

BACKGROUND Percutaneous coronary intervention(PCI)of diseased saphenous vein grafts(SVG)continues to pose a clinical *** PCI guidelines give a class III recommendation against performing PCI on chronically occluded ***,contemporary outcomes after SVG intervention have incrementally improved with distal protection devices,intracoronary vasodilators,drug-eluting stents,and prolonged dual antiplatelet *** To reassess the procedural and long-term outcomes of PCI for totally occluded SVG with contemporary *** This was a retrospective observational study conducted at a single university *** study population consisted of 35 consecutive patients undergoing PCI of totally occluded ***-procedure dual antiplatelet therapy was continued for a minimum of one year and aspirin was continued *** outcomes were assessed at a mean follow-up of 1221±1038 *** primary outcome was freedom from a major adverse cardiac event(mACE)defined as the occurrence of any of the following:death,myocardial infarction,stroke,repeat bypass surgery,repeat PCI,or graft *** The study group included 29 men and 6 women with a mean age of 69±12 *** was present in 14(40%)*** patients had Canadian Heart Classification class III or IV *** presentation was an acute coronary syndrome in 34(97%)*** SVG age was 12±5 *** duration of occlusion was acute(24 h to 30 d)in 26%,and late(>30 d)in 40%.PCI was initially successful in 29/35 SVG occlusions(83%).Total stent length was 52±35 *** complications of distal embolization or no-reflow occurred in 6(17%)*** longer term follow-up,mACE-free survival was only 30%at 3 years and 17%at 5 *** PCI of totally occluded SVG can be performed with a high procedural success ***,its clinical utility remains limited by poor follow-up outcomes.

关键词： Coronary artery bypass grafting Coronary stents Chronic total occlusion Percutaneous coronary intervention Restenosis Saphenous vein grafts

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Evaluation of hand infections in the emergency department using point-of-care ultrasound

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World Journal of Emergency medicine 2024年第4期15卷 283-288页

作者： David Ahmad Haidar David mintz brandon m Wubben Omar Rizvi Srikar Adhikari Department of Emergency medicine Michigan MedicineAnn Arbor 48109-1382USA University of Arizona College of medicine Tucson 85724USA Department of Emergency medicine University of IowaIowa City 52242-1009USA Department of Surgery University of Arizona College of MedicineTucson 85724USA Department of Emergency medicine University of Arizona College of MedicineTucson 85724USA

BACKGROUND:We aimed to evaluate the utility of point-of-care ultrasound(POCUS)in the assessment of hand infections that present to the emergency department(ED)and its impact on medical decision making and patient ***:We conducted a retrospective review of patients who presented to two urban academic EDs with clinical presentations concerning for skin and soft tissue infections(SSTI)of the hand between December 2015 and December *** trained POCUS fellowship physicians reviewed an ED POCUS database for POCUS examinations of the *** then reviewed patients’electronic health records(EHR)for demographic characteristics,history,physical examination findings,ED course,additional imaging studies,consultations,impact of POCUS on patient care and final ***:We included a total of 50 cases(28 male,22 female)in the final *** most common presenting symptoms and exam findings were pain(100%),swelling(90%),and erythema(74%).The most common sonographic findings were edema(76%),soft tissue swelling(78%),and fluid surrounding the tendon(57%).POCUS was used in medical decision making 68%of the time(n=34),with the use of POCUS leading to changes in management 38%of the time(n=19).POCUS use led to early antibiotic use(11/19),early consultation(10/19),and led to the performance of a required procedure(8/19).The POCUS diagnosis was consistent with the discharge diagnosis of flexor tenosynovitis 8/12 times,abscess 12/16 times,and cellulitis 14/20 ***:POCUS is beneficial for evaluating of hand infections that present to the ED and can be used as an important part of medical decision making to expedite patient care.

关键词： Ultrasound Point-of-care ultrasound Cellulitis Abscess Flexor tenosynovitis

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Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

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Bone Research 2024年第1期12卷 180-198页

作者： morten S.Hansen Kaja madsen maria Price Kent Søe Yasunori Omata mario m.Zaiss Caroline m.Gorvin morten Frost Alexander Rauch molecular Endocrinology Laboratory(KmEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of metabolism and Systems Research(ImSR)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for membrane Proteins and Receptors(COmPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of molecular medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from CD14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density SNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(SSTR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating C5AR1 enhanced osteoclast formation,while activating SSTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.Thomas m.brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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A machine learning driven 3D+1D model for efficient characterization of proton exchange membrane fuel cells

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Energy and AI 2024年第3期17卷 281-294页

作者： Yuwei Pan Haijun Ruan Billy Wu Yagya N.Regmi Huizhi Wang Nigel P.brandon Department of Earth Science and Engineering Imperial College LondonLondon SW72AZUK Dyson School of Design Engineering Imperial College LondonLondon SW72AZUK Centre for E-mobility and Clean Growth Coventry UniversityCoventry CV15FBUK manchester Fuel Cell Innovation Centre Department of Natural SciencesManchester Metropolitan UniversityManchester M15GDUK Department of mechanical Engineering Imperial College LondonLondon SW72AZUK

The computational demands of 3D continuum models for proton exchange membrane fuel cells remain substantial. One prevalent approach is the hierarchical model combining a 2D/3D flow field with a 1D sub-model for the catalyst layers and membrane. However, existing studies often simplify the 1D domain to a linearized 0D lumped model, potentially resulting in significant errors at high loads. In this study, we present a computationally efficient neural network driven 3D+1D model for proton exchange membrane fuel cells. The 3D sub-model captures transport in the gas channels and gas diffusion layers and is coupled with a 1D electrochemical sub-model for microporous layers, membrane, and catalyst layers. To reduce computational intensity of the full 1D description, a neural network surrogates the 1D electrochemical sub-model for coupling with the 3D domain. Trained by model-generated large synthetic datasets, the neural network achieves root mean square errors of less than 0.2%. The model is validated against experimental results under various relative humidities. It is then employed to investigate the nonlinear distribution of internal states under different operating conditions. With the neural network operating at 0.5% of the computing cost of the 1D sub-model, the hybrid model preserves a detailed and nonlinear representation of the internal fuel cell states while maintaining computational costs comparable to conventional 3D+0D models. The presented hybrid data-driven and physical modeling framework offers high accuracy and computing speed across a broad spectrum of operating conditions, potentially aiding the rapid optimization of both the membrane electrode assembly and the gas channel geometry.

关键词： Proton exchange membrane fuel cell Hierarchical model Neural network Hybrid model

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Determinants of COVID-19 Face mask Litter in Coastal Urban Parking Lots: Implications for Source modelling of Potential microplastic Pollution

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Journal of Environmental Protection 2024年第8期15卷 874-886页

作者： Robert France brandon Heung Department of Plant Food and Environmental Science Dalhousie University Nova Scotia Canada

Despite cities being recognized as being potential sources of microplastic pollution to the wider environment, most surveys of COVID-19 plastic-based litter have been undertaken through linear transects of marine beaches. For the far fewer number of studies conducted on inland and urban locations, the site-specific focus has primarily been surveys along the length of streets. The present study is the first to specifically assess the standing stock (i.e., moment-in-time) of littered face masks for the entire surface area of urban parking lots. The density of face masks in 50 parking lots in a Canadian coastal town (0.00054 m2 ± 0.00051 m2) was found to be significantly greater than the background level of littering of town streets. Face mask density was significantly related to visitation “usage” of parking lots as gauged by the areal size of the lots and of their onsite buildings, as well as the number of vehicles present. Neither parking lot typology nor estimates of inferred export (various measures of wind exposure) and entrapment (various metrics of obstruction) of face masks had a significant influence on the extent of whole-lot littering. In consequence, modelling of the potential input of mask-derived microplastics to the marine environment from coastal communities can use the areal density of face masks found here in association with the total surface area of lots for individual municipalities as determined through GIS analysis.

关键词： COVID Face masks Parking Lot Litter Prediction Areal Abundance

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可持续混凝土的奇特来源

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空中英语教室（高级版．彭蒙惠英语） 2024年第1期 14-15,41页

作者： Elissaveta m.brandon 不详

08建筑师对不寻常的建筑材料并不陌生:大麻纤维、龙舌兰酒产业的龙舌兰浆、破碎的马桶、不可回收的塑料,现在更有……用过的尿布?日本北九州市立大学的一群研究人员研发出一种混凝土,可以用碎尿布取代多达40%的沙子。

关键词：建筑材料龙舌兰酒马桶大麻纤维可持续混凝土建筑师

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可爱面面观可爱如何演变并影响消费主义

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空中英语教室（高级版．彭蒙惠英语） 2024年第8期 34-35,49,50页

作者： Elissaveta m.brandon 不详

猫咪一直都这么可爱吗?伦敦萨默塞特郡最近的一个展览,尝试通过说明当代文化中可爱的崛起与流行来回答那个问题展览名称就是简单的“可爱”二字,展出数百件毛绒玩具、菲比精灵、护理机器人、宝可梦卡牌、机器狗、拓麻歌子、玩具屋、可... 详细信息

猫咪一直都这么可爱吗?伦敦萨默塞特郡最近的一个展览,尝试通过说明当代文化中可爱的崛起与流行来回答那个问题展览名称就是简单的“可爱”二字,展出数百件毛绒玩具、菲比精灵、护理机器人、宝可梦卡牌、机器狗、拓麻歌子、玩具屋、可爱小雕像——还有,数量极大的猫咪。最后以Hello Kitty装置结尾,庆祝Hello Kitty诞生50周年。

关键词：毛绒玩具机器狗萨默塞特消费主义可爱当代文化

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变废为宝:“蓝色循环”海洋塑料废物管理新策略

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Science Bulletin 2024年第8期69卷 993-996页

作者：余灏轩 Izni Zahidi Chow ming Fai 梁东方 DagØivind madsen Department of Civil Engineering School of EngineeringMonash University MalaysiaBandar Sunway 47500Malaysia monash Climate-Resilient Infrastructure Research Hub(m-CRInfra) School of EngineeringMonash University MalaysiaBandar Sunway 47500Malaysia Department of Engineering University of CambridgeCambridge CB21PZUK Davis School of Business Colorado Mesa UniversityGrand Junction 81501-3122USA

The"Blue Circle"vision,initiated by Zhejiang Province in China,represents a groundbreaking advancement in addressing marine plastic *** more than just an innovative concept,it embodies a future-forward approach to managing marine plastic waste,revealing the untapped potential in what was previously considered mere *** initiative,marrying scientific innovation with advanced technology,has been rightfully acknowledged with the prestigious2023 United Nations"Champions of the Earth"award,recognizing its innovative strategy in environmental stewardship(https://***/a/202310/31/***).

关键词： breaking debris initiated

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RNA m^(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

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Genes & Diseases 2024年第1期11卷 382-396页

作者： Zheng Zhang Keren Zhou Li Han Andrew Small Jianhuang Xue Huilin Huang Hengyou Weng Rui Su brandon Tan Chao Shen Wei Li Zhicong Zhao Ying Qing Xi Qin Kitty Wang Keith Leung mark Boldin Chun-Wei Chen David Ann Zhijian Qian Xiaolan Deng Jianjun Chen Zhenhua Chen Department of Systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA Irell and manella Graduate School of Biological Sciences Beckman Research Institute of City of HopeDuarteCA 91010USA Gehr Family Center for Leukemia Research City of HopeDuarteCA 91010USA Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060China Guangzhou Laboratory GuangzhouGuangdong 510005China Bioland Laboratory GuangzhouGuangdong 51005China Department of Liver Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Diabetes Complications and metabolism Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Biochemistry and molecular Biology University of FloridaGainesvilleFL 32603USA Tongji Hospital Affiliated to Tongji University Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China School of Pharmacy China Medical UniversityShenyangLiaoning 110001China

As the most common internal modification of mRNA,Ne-methyladenosine(m^(6)A)and its regulators modulate gene expression and play critical roles in various biological and patholog-ical processes including *** was reported previously that m^(6)A methyltransferase(writer),methyltransferase-like 3(mETTL3)adds m^(6)A in primary microRNAs(pri-miRNAs)and fa-cilitates its processing into precursor miRNAs(pre-miRNAs).However,it is unknown whether m^(6)A modification also plays a role in the maturation process of pre-miRNAs and(if so)whether such a function contributes to ***,we found that YTHDF2 is aberrantly overexpressed in acute myeloid leukemia(AmL)patients,especially in relapsed patients,and plays an onco-genic role in ***,YTHDF2 promotes expression of miR-126-3p(also known as miR-126,as it is the main product of precursor miR-126(pre-miR-126)),a miRNA that was reported as an oncomiRNA in AmL,through facilitating the processing of pre-miR-126 into mature ***,YTHDF2 recognizes m^(6)A modification in pre-miR-126 and recruits AGO2,a regulator of pre-miRNA processing,to promote the maturation of ***2 posi-tively and negatively correlates with miR-126 and miR-126's downstream target genes,respec-tively,in AmL patients,and forced expression of miR-126 could largely rescue YTHDF2/Ythdf2 depletion-mediated suppression on AmL cell growth/proliferation and leukemogenesis,indi-cating that miR-126 is a functionally important target of YTHDF2 in ***,our studies not only reveal a previously unappreciated YTHDF2/miR-126 axis in AmL and highlight the ther-apeutic potential of targeting this axis for AmL treatment,but also suggest that m^(6)A plays a role in pre-miRNA processing that contributes to tumorigenesis.

关键词： AmL miR-126 N^(6)-methyladenosine Pre-miRNA maturation YTHDF2

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