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Mechanisms of vascular injury in neurotrauma: A critical review of the literature

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World Journal of Meta-Analysis 2024年第3期12卷 6-16页

作者： Jonathan Willman Annu Lisa Kurian brandon lucke-wold College of Medicine University of FloridaGainesvilleFL 32610United States College of Medicine Florida State UniversityTallahasseeFL 32304United States Department of Neurosurgery University of FloridaGainesvilleFL 32611United States

One in every two individuals will experience a traumatic brain injury in their lifetime with significant impacts on the global economy and healthcare system each *** injury is a key aspect of neurotrauma to both the brain and the spinal cord and an important avenue of current and future research seeking innovative *** this paper,we discuss primary and secondary neurotrauma,mechanisms of injury,the glymphatic system,repair and *** of these topics are directly connected to the vasculature of the central ner-vous system,affecting severity of injury and ***,neurova-scular injury in trauma represents a promising target for future therapeutics and innovation.

关键词： Neurotrauma Neurovascular injury Primary neurotrauma Secondary neurotrauma Traumatic brain injury Traumatic spinal cord injury Glymphatic system Vascular Injury

T lymphocyte proportion in Alzheimer’s disease prognosis

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World Journal of Clinical Cases 2024年第26期12卷 6001-6003页

作者： Matthew Willman Gopi Patel brandon lucke-wold College of Medicine University of FloridaGainesvilleFL 32610United States Department of Neurosurgery University of FloridaGainesvilleFL 32611United States

Bai et al investigate the predictive value of T lymphocyte proportion in Alzheimer's disease(AD)*** a retrospective study involving 62 AD patients,they found that a decrease in T lymphocyte proportion correlated with a poorer prognosis,as indicated by higher modified Rankin scale *** the study highlights the potential of T lymphocyte proportion as a prognostic marker,it suggests the need for larger,multicenter studies to enhance generalizability and ***,future research could use cognitive exams when evaluating prognosis and delve into immune mechanisms underlying AD *** limitations inherent in retrospective designs,Bai et al's work contributes to understanding the immune system's role in AD prognosis,paving the way for further exploration in this under-researched area.

关键词： Alzheimer's disease T lymphocyte T lymphocyte proportion Alzheimer's disease prognosis Modified rankin scale Immune cell count Electroencephalogram Immune function

Overview of emerging therapies for demyelinating diseases

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World Journal of Clinical Cases 2024年第30期12卷 6361-6373页

作者： Robert Medina Ann-Marie Derias Maria Lakdawala Skye Speakman brandon lucke-wold University of Florida College of Medicine University of FloridaGainesvilleFl 32610United States Department of Neurosurgery University of FloridaGainesvilleFL 32611United States

This paper provides an overview of autoimmune disorders of the central nervous system,specifically those caused by *** explore new research regarding potential therapeutic interventions,particularly those aimed at inducing *** is a detailed process,involving many cell types–oligodendrocyte precursor cells(OPCs),astrocytes,and microglia–and both the innate and adaptive immune *** discussion of this process includes the differentiation potential of neural stem cells,the function of adult OPCs,and the impact of molecular mediators on myelin *** therapies are also explored,with mechanisms of action including the induction of OPC differentiation,the transplantation of mesenchymal stem cells,and the use of molecular ***,we discuss current medical advancements in relation to many myelin-related disorders,including multiple sclerosis,optic neuritis,neuromyelitis optica spectrum disorder,myelin oligodendrocyte glycoprotein antibodyassociated disease,transverse myelitis,and acute disseminated *** these emerging systemic therapies,we also introduce the dimethyl fumarate/silk fibroin nerve conduit and its potential role in the treatment of peripheral nerve *** these aforementioned scientific advancements,this paper maintains the need for ongoing research to deepen our understanding of demyelinating diseases and advance therapeutic strategies that enhance affected patients’quality of life.

关键词： Central nervous system disease Autoimmune Remyelination Demyelination Myelin Oligodendrocyte Emerging therapies Multiple Sclerosis

Updates on management of gliomas in the molecular age

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World Journal of Clinical Oncology 2024年第2期15卷 178-194页

作者： Ali Ahmed Mohamed Rakan Alshaibi Steven Faragalla Youssef Mohamed brandon lucke-wold Charles E.Schmidt College of Medicine Florida Atlantic UniversityBoca RatonFL 33431United States Herbert Wertheim College of Medicine Florida International UniversityMiamiFL 33199United States College of Osteopathic Medicine Kansas City UniversityJoplinMO 64804United States Department of Neurosurgery University of FloridaGainesvilleFL 32611United States

Gliomas are primary brain tumors derived from glial cells of the central nervous system,afflicting both adults and children with distinct characteristics and therapeutic *** developments have ushered in novel clinical and molecular prognostic factors,reshaping treatment paradigms based on classi-fication and grading,determined by histological attributes and cellular *** review article delves into the diverse treatment modalities tailored to the specific grades and molecular classifications of gliomas that are currently being discussed and used clinically in the year *** adults,the therapeutic triad typically consists of surgical resection,chemotherapy,and *** contrast,pediatric gliomas,due to their diversity,require a more tailored *** complete tumor excision can be curative based on the location and grade of the glioma,certain non-resectable cases demand a chemotherapy approach usually involving,vincristine and ***-tionally,if surgery or chemotherapy strategies are unsuccessful,Vinblastine can be *** recent advancements in treatment methodologies,there remains a need of exploration in the literature,particularly concerning the efficacy of treatment regimens for isocitrate dehydrogenase type mutant astrocytomas and fine-tuned therapeutic approaches tailored for pediatric *** review article explores into the therapeutic modalities employed for both adult and pediatric gliomas in the context of their molecular classification.

关键词： Gliomas Chemotherapy Radiotherapy Isocitrate dehydrogenase type mutant Pediatric gliomas Astrocytoma Oligodendroglioma 1p/19q-codeleted

Focus on current and emerging treatment options for glioma:A comprehensive review

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World Journal of Clinical Oncology 2024年第4期15卷 482-495页

作者： brandon lucke-wold Burhanuddin Sohail Rangwala Muhammad Ashir Shafique Mohammad Arham Siddiq Muhammad Saqlain Mustafa Fnu Danish Rana Muhammad Umer Nasrullah Noor Zainab Abdul Haseeb Department of Neurosurgery University of FloridaGainesvilleFL 32608United States Department of Neurosurgery Jinnah Sindh Medical UniversityKarachi 75510Pakistan Department of Neurosurgery Army Medical CollegeRawalpindi 46000Pakistan

This comprehensive review delves into the current updates and challenges associated with the management of low-grade gliomas(LGG),the predominant primary tumors in the central nervous *** a general incidence rate of 5.81 per 100000,gliomas pose a significant global concern,necessitating advancements in treatment techniques to reduce mortality and *** review places a particular focus on immunotherapies,discussing promising agents such as Zotiraciclib and ***,a CDK9 inhibitor,has demonstrated efficacy in glioblastoma treatment in preclinical and clinical studies,showing its potential as a therapeutic ***,a viral immunotherapy,induces inflammation in glioblastoma and displays positive outcomes in both adult and pediatric *** of immunotherapy extends to Pembrolizumab,Nivolumab,and Entrectinib,revealing the challenges and variabilities in patient *** promising preclinical data,the monoclonal antibody Depatuxizumab has proven ineffective in glioblastoma treatment,emphasizing the critical need to understand resistance *** review also covers the success of radiation therapy in pediatric LGG,with evolving techniques,such as proton therapy,showing potential improvements in patient quality of *** treatment is discussed in the context of achieving a balance between preserving the patient’s quality of life and attaining gross total resection,with the extent of surgical resection significantly influencing the survival *** addition to advancements in cancer vaccine development,this review highlights the evolving landscape of LGG treatment,emphasizing a shift toward personalized and targeted *** research is essential for refining strategies and enhancing outcomes in the management of LGG.

关键词： Low-grade gliomas Monoclonal antibody Lerapolturev Glioblastoma CDK9 inhibitor

Commentary on a case report and literature review of acute carotid stent thrombosis

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World Journal of Clinical Cases 2023年第7期11卷 1666-1668页

作者： Matthew Willman brandon lucke-wold College of Medicine University of FloridaGainesvilleFL 32610United States Department of Neurosurgery University of FloridaGainesvilleFlorida 32608United States

In this commentary on the article entitled“Acute carotid stent thrombosis:A case report and literature review”,the key points of the article are *** carotid stent thrombosis(ACST)in the setting of carotid artery stenting(CAS)represents a rare but potentially catastrophic *** is a wide range of treatment options available,including carotid endarterectomy,which is generally recommended for cases of refractory *** there is no standard treatment regimen,dual antiplatelet therapy is typically recommended both before and after CAS to reduce risk of ACST.

关键词： Acute carotid stent thrombosis Carotid artery stenting Carotid endarterectomy

Commentary:Evaluating potential glioma serum biomarkers,with future applications

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World Journal of Clinical Oncology 2022年第5期13卷 412-416页

作者： Michael Goutnik brandon lucke-wold Department of Neurosurgery University of FloridaGainesvilleFL 32608United States

Systemic inflammation within malignant glioma is a topic of ongoing *** this commentary,we highlight recent findings from Gandhi et al and discuss alternative *** present a counter argument with findings that IL-6 markers are *** highlight the potential benefit of looking at microRNAs and other ***,we present ideas for future application involving differentiation between radiation necrosis and *** commentary is intended to serve as a catalyst for further scientific discovery.

关键词： Systemic inflammation Malignant glioma Neutrophil-lymphocyte ratio Interleukin-6

“Timing of percutaneous endoscopic gastrostomy tube placement in post-stroke patients does not impact mortality,complications,or outcomes”:Commentary

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2023年第1期14卷 1-3页

作者： Jonathan Willman brandon lucke-wold College of Medicine University of FloridaGainesvilleFL 32610United States Department of Neurosurgery University of FloridaGainesvilleFL 32610United States

In this commentary,we summarize some of the key points of the original paper“Timing of percutaneous endoscopic gastrostomy tube placement in post-stroke patients does not impact mortality,complications,or outcomes”and offer support for the proposed ***,we address how early percutaneous endoscopic gastrostomy(PEG)tube placement may reduce hospital length of stay and *** also discuss topics related to the article including PEG weaning and post-stroke nutritional ***,we note that concerns purported by previous studies that early PEG placement may worsen outcomes are not fully addressed,and further research is needed.

关键词： Percutaneous endoscopic gastrostomy tube Post-stroke Nutritional management Rehabilitation Dysphagia

Neurologic orphan diseases:Emerging innovations and role for genetic treatments

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World Journal of Experimental Medicine 2023年第4期13卷 59-74页

作者： Ivelina P Kioutchoukova Devon T Foster Rajvi N Thakkar Marco A Foreman brandon J Burgess Rebecca M Toms Eduardo E Molina Valero brandon lucke-wold College of Medicine University of FloridaGainesvilleFL 32611United States Florida International University Herbert Wertheim College of Medicine Florida International University Herbert Wertheim College of MedicineMiamiFL 33199United States Department of Neurosurgery University of FloridaGainesvilleFL 32611United States

Orphan diseases are rare diseases that affect less than 200000 individuals within the United *** orphan diseases are of neurologic and genetic *** the current advances in technology,more funding has been devoted to developing therapeutic agents for patients with these *** our review,we highlight emerging options for patients with neurologic orphan diseases,specifically including diseases resulting in muscular deterioration,epilepsy,seizures,neurodegenerative movement disorders,inhibited cognitive development,neuron deterioration,and *** extensive literature review,gene therapy offers a promising route for the treatment of neurologic orphan *** use of clustered regularly interspaced palindromic repeats/Cas9 has demonstrated positive results in experiments investigating its role in several ***,the use of adeno-associated viral vectors has shown improvement in survival,motor function,and developmental milestones,while also demonstrating reversal of sensory ataxia and cardiomyopathy in Friedreich ataxia *** oligonucleotides have also been used in some neurologic orphan diseases with positive *** target of rapamycin inhibitors are currently being investigated and have reduced abnormal cell growth,proliferation,and *** innovations and the role of genetic treatments open a new window of opportunity for the treatment of neurologic orphan diseases.

关键词： Neurologic orphan diseases Gene therapy Clustered regularly interspaced palindromic repeats/Cas9 Antisense oligonucleotides Adeno-associated virus mTOR inhibitors