检索结果-南通市图书馆

Analytically depicting the calcium diffusion for Alzheimer's affected cell

International Journal of Biomathematics 2018年第7期11卷 109-121页

作者： Devanshi D.Dave brajesh kumar.jha Department of Mathematics School of Technology Pandit Deendayal Petroleum UniversityRaisan GandhinagarGujarat 382007India

Brain is the most complex structure of the human *** processes going inside the brain and the mechanisms behind it have been unrevealed up to certain extent *** of the various physiological phenomena carried out by the brain,calcium signalling can be considered as one of the most *** being a second messenger plays an important role in transformation of various *** view of above,an attempt has been made here to study calcium signalling in presence of buffers,*** kind of proteins and endoplasmic reticulum (ER),which is also known as store house of the *** the store house of the cell,it has very high amount of calcium,whereas buffers decrease the level of free calcium ions by binding calcium ions to it.A two-dimensional mathematical model has been developed to see the impact of these parameters on cytosolic calcium *** mathematical model is solved analytically using Laplace transforms and similarity *** simulations are carried out using *** is observed that the impact of buffer and ER is significant on calcium *** obtained results are interpreted with the Alzheimeric condition of the nerve cells.

关键词： Calcium buffers endoplasmic reticulum Alzheimer's disease Laplace transforms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Two-dimensional finite element model to study calcium distribution in astrocytes in presence of excess buffer

引用

International Journal of Biomathematics 2014年第3期7卷 137-147页

作者： brajesh kumar.jha Neeru Adlakha M. N. Mehta Department of Mathematics and Computer Science School of Technology Pandit Deendayal Petroleum University Raisen Gandhinagar Gujarat 382007 India Department of MathematicsM. A. National Institute of Technology Bhopal India Department of Applied MathematicsS. V. National Institute of Technology Surat India

In this paper a finite element model is developed to study cytosolic calcium concen- tration distribution in astrocytes for a two-dimensional steady-state case in presence of excess buffer. The mathematical model of calcium diffusion in astrocytes leads to a boundary value problem involving elliptical partial differential equation. The model con- sists of reaction-diffusion phenomena, association and dissociation rates and buffer. A point source of calcium is incorporated in the model. Appropriate boundary conditions have been framed. Finite element method is employed to solve the problem. A MATLAB program has been developed for the entire problem and simulated to compute the numer- ical results. The numerical results have been used to plot calcium concentration profiles in astrocytes. The effect of ECTA, BAPTA and aCa influx on calcium concentration distribution in astrocytes is studied with the help of numerical results.

关键词： Ca2+ profile buffer finite element method.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fractionally delineate the neuroprotective function of calbindin-Z?28fc in Parkinson's disease

引用

International Journal of Biomathematics 2018年第8期11卷 151-169页

作者： Hardik Joshi brajesh kumar.jha Department of Mathematics School of Technology Pandit Deendayal Petroleum University Gandhinagar Gujarat 382007. India

Neuron is a fundamental unit of the brain, which is specialized to transmit information throughout the body through electrical and chemical signals. Calcium (Ca2^+) ions are known as second messengers which play important roles in the movement of the neurotransmitter. Calbindin-D28k is a Ca2^+ binding protein which is involved in regulation of intracellular Ca2^+ ions and main tains homeos tasis level, it also alters the cytosolic calcium concentration ([Ca2^+]) in nerve cells to keep the cell alive. Parkinson's disease (PD) is a chronic progressive neurodegenerative brain disorder of the nervous system. Several regions of the brain indicate the hallmark of the PD. The symptoms of PD are plainly linked with the degeneration and death of dopamine neurons in the substantia nigra pars compacta located in midbrain which is accompanied by depletion in calbindin-Z?28fc - In the present paper, the neuroprotective role of calbindin-￡>28fc in the cytoplasmic [Ca2^+] distribution is studied. The elicitation in [Ca2^+] is due to the presence of low amount of calbindin-D28k which can be portrayed and is a hallmark of PD. A one-dimensional space time fractional reaction diffusion equation is designed by keeping in mind the physiological condition taking place inside Parkinson's brain. Computational results are performed in MATLAB.

关键词： Calbindin-D28k Parkinson's disease calcium concentration fractionalCaputo derivative fractional approach

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：