检索结果-南通市图书馆

Effect of Indole 3-Butyric Acid and Media Type on Adventitious Root Formation in Sheanut Tree (<i>Vitellaria paradoxa</i>C. F. Gaertn.) Stem Cuttings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2014年第3期5卷 313-318页

作者： Daniel brain akakpo Naalamle Amissah Julius Yeboah Essie Blay Cocoa Research Institute of Ghana (CRIG) Bole Ghana Department of Crop Science College of Agriculture and Consumer Sciences University of Ghana Accra Ghana

Shea nuts play an important role in food security for rural folks within sub-Sahara Africa, serving as the main source of income for many people living in Northern Ghana. Unfortunately, the full economic potential of the Sheanut tree has not been fully realized due to the difficulty involved in its domestication. This difficulty in vegetatively propagating sheanut trees has greatly hindered its cultivation and the realization of its true economic potential. Two experiments were conducted to investigate the effects of rooting media and varying indole 3-butyric acid (IBA) concentrations on adventitious root formation in cuttings taken from coppiced sheanut trees. Results indicated that 3000 ppm produced significantly (p 0.05) better rooting (57.5%) than 5000 ppm (30%), 7000 ppm (45.0%) and the control (7.5%). Although the levels of soluble sugars (SS) and total free phenols (TFP) in the cutting were significantly (p 0.05) higher at the end of the experiment (after IBA treatment) compared to the start (prior to IBA treatment), the SS and TFP trends observed did not clearly explain the rooting differences found between the IBA levels investigated. Callus formation was significantly (p 0.05) higher (35.0%) in the control (no IBA). Generally, callus formation decreased with increasing IBA concentration. In the rooting media experiment, rooting was significantly (p 0.05) higher in the rice husk medium (35.0%) compared to that in the palm fiber (18.3%), saw dust (14.1%) and top soil (16.7%) media.

关键词： Coppiced Indole 3-Butyric Acid Sheanut Tree Cuttings Rooting Medium

Low-intensity extracorporeal shock wave therapy for Peyronie’s disease:a single-center experience

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2022年第1期24卷 45-49页

作者： Maher Abdessater William akakpo Anthony Kanbar Jérome Parra Thomas Seisen Emmanuel Chartier-Kastler Sarah J Drouin Morgan Roupret APHP-Sorbonne University PitiéSalpêtrièreAcademic Urology Unit83 bvd HopitalParis 75013France

The aim of this article is to assess the outcomes of a low-intensity extracorporeal shock wave therapy(LiESWT)protocol for the treatment of Peyronie’s disease(PD).Patients treated for PD were prospectively recorded,and data were retrospectively ***,characteristics of fibrous plaques,concomitant treatments,International Index of Erectile Function(IIEF-5),Lue score,and pain score on Likert scale were *** in acute phase of PD and an angulation of<40°were *** protocol consisted of 6 weekly sessions of 4000 pulses each,applied from different directions,with a maximal power of 20 W and 8 Hz *** included 39 patients(median age:56.8 years,interquartile range[IQR]:35.8–62.2 years).The median number of sessions received per patient was *** treatment,the median Lue score decreased from 6.8 initially to 3.3(P=0.003),the median Likert pain score dropped from 1.8 to 0.7(P=0.004),the median plaque size was reduced from 2 cm to 1.2 cm(P=0.08),and the median penile curvature diminished from 31°to 17°(P=0.07).On univariate and multivariate analysis,the only predictors of success were younger age(odds ratio[OR]=0.95,P=0.03 and OR=0.91,P=0.04,respectively)and concomitant use of phosphodiesterase-5 inhibitors(PDE5i;OR=0.92,P=0.02 and OR=0.93,P=0.01,respectively).LiESWT had a favorable impact on Lue score and notably penile pain,curvature,plaque size,and erectile function in patients treated for PD during the early inflammatory phase,with no side *** age and concomitant use of PDE5i were the only success predictors.

关键词： erectile dysfunction extracorporeal shock wave therapy Peyronie’s disease piezoelectric waves

Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第12期11卷 3740-3755页

作者： Hartmut Jaeschke Olamide B.Adelusi Jephte Y.akakpo Nga T.Nguyen Giselle Sanchez-Guerrero David S.Umbaugh Wen-Xing Ding Anup Ramachandran Department of Pharmacology Toxicology&TherapeuticsUniversity of Kansas Medical CenterKansas CityKS 66160USA

Acetaminophen(APAP)is a widely used analgesic and antipyretic drug,which is safe at therapeutic doses but can cause severe liver injury and even liver failure after *** mouse model of APAP hepatotoxicity recapitulates closely the human *** a result,this clinically relevant model is frequently used to study mechanisms of drug-induced liver injury and even more so to test potential therapeutic ***,the complexity of the model requires a thorough understanding of the pathophysiology to obtain valid results and mechanistic information that is translatable to the ***,many studies using this model are flawed,which jeopardizes the scientific and clinical *** purpose of this review is to provide a framework of the model where mechanistically sound and clinically relevant data can be *** discussion provides insight into the injury mechanisms and how to study it including the critical roles of drug metabolism,mitochondrial dysfunction,necrotic cell death,autophagy and the sterile inflammatory *** addition,the most frequently made mistakes when using this model are ***,considering these recommendations when studying APAP hepatotoxicity will facilitate the discovery of more clinically relevant interventions.

关键词： Acetaminophen hepatotoxicity Drug metabolism Mitochondria Apoptosis Ferroptosis Autophagy NRF2 Innate immunity

Seasonal Change of Loline Alkaloids in Endophyte-Infected Meadow Fescue

在线全文

学校读者我要写书评

暂无评论

Agricultural Sciences in China 2006年第10期5卷 793-797页

作者： TONG De-wen WANG Jin-yi brain Patchett Ravi Gooneratne College of Animal Science and Technology Northwest A＆F University Yangling 712100 P. R. China Agriculture and Life Sciences Division Lincoln University P.O. Box 84 Canterbury New Zealand

Lolines are a group of saturated pyrrolizidine alkaloids that possess broad bioactivity against a wide array of herbivorous insects. However, they do not exhibit toxicity to ruminants such as cattle and sheep. In order to study the direct and potential physiological effects on ruminants and the mechanism of insecticide/insectifuge, the distribution of loline alkaloids in endophyte-infected meadow fescue and the seasonal change of the distribution were analyzed. The crowns, roots and leaves of endophyte-infected meadow fescue at its four different growth periods, i.e., spring, summer, early autumn and late autumn, in New Zealand were colleted. After powdering, organic solvent extraction and purification by column chromatography, all loline alkaloid samples were analyzed by capillary gas chromatography with 4-phenylmorpholine （PM） as an internal standard. The analytic results showed that the loline contents in the roots, crowns and leaves of endophyte-infected meadow fescue vary with seasons. Even within the same season, the distribution of lolines in endophyte-infected meadow fescue varies. During summer, lolines mainly existed in the leaves and roots, but in early autumn, they are produced in the crowns. It was concluded that, lolines were mainly produced in the leaves and roots of endophyte-infected meadow fescue. In gas chromatographic analysis, N-formylloline, the major component of loline alkaloid in the plant, was employed to assay the alkaloids.

关键词： Festuca pratensis Huds. loline alkaloids gas chromatography

Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第12期11卷 3791-3805页

作者： Hui Qian Qingyun Bai Xiao Yang Jephte Y.akakpo Lili Ji Li Yang Thomas Rulicke Kurt Zatloukal Hartmut Jaeschke Hong-Min Ni Wen-Xing Ding Department of Pharmacology Toxicology and TherapeuticsUniversity of Kansas Medical CenterKansas CityKS 66160USA The MOE Key Laboratory for Standardization of Chinese Medicines Shanghai Key Laboratory of Compound Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese MedicinesInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China School of Chemistry and Bioengineering Yichun UniversityYichun 336000China Department of Biomedical Sciences University of Veterinary Medicine Vienna Veterina¨rplatzVienna 1210Austria The Institute of Pathology Medical University of GrazGraz A-8036Austria

Acetaminophen(APAP)overdose can induce liver injury and is the most frequent cause of acute liver failure in the United *** investigated the role of p62/SQSTM1(referred to as p62)in APAP-induced liver injury(AILI)in *** found that the hepatic protein levels of p62 dramatically increased at 24 h after APAP treatment,which was inversely correlated with the hepatic levels of *** also activated mTOR at 24 h,which is associated with increased cell *** contrast,p62 knockout(KO)mice showed increased hepatic levels of APAP-adducts detected by a specific antibody using Western blot analysis but decreased mTOR activation and cell proliferation with aggravated liver injury at 24 h after APAP ***,p62 KO mice recovered from AILI whereas the wild-type mice still sustained liver injury at 48 *** found increased number of infiltrated macrophages in p62 KO mice that were accompanied with decreased hepatic von Willebrand factor(VWF)and platelet aggregation,which are associated with increased cell proliferation and improved liver injury at 48 h after APAP *** data indicate that p62 inhibits the late injury phase of AILI by increasing autophagic selective removal of APAP-adducts and mitochondria but impairs the recovery phase of AILI likely by enhancing hepatic blood coagulation.

关键词： Autophagy Coagulation DILI Liver regeneration Macrophage Hepatotoxicity Platelet

Theoretical analysis of transcranial Hall-effect stimulation based on passive cable model

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2015年第12期24卷 373-378页

作者：袁毅李小俚 Institute of Electrical Engineering Yanshan University State Key Laboratory of Cognitive Neuroscience and Learning & IDG Mc Govern Institute for Brain Research Beijing Normal University Center for Collaboration and Innovation in brain and Learning Sciences Beijing Normal University

Transcranial Hall-effect stimulation（THS） is a new stimulation method in which an ultrasonic wave in a static magnetic field generates an electric field in an area of interest such as in the brain to modulate neuronal activities. However, the biophysical basis of simulating the neurons remains unknown. To address this problem, we perform a theoretical analysis based on a passive cable model to investigate the THS mechanism of neurons. Nerve tissues are conductive; an ultrasonic wave can move ions embedded in the tissue in a static magnetic field to generate an electric field（due to Lorentz force）.In this study, a simulation model for an ultrasonically induced electric field in a static magnetic field is derived. Then,based on the passive cable model, the analytical solution for the voltage distribution in a nerve tissue is determined. The simulation results showthat THS can generate a voltage to stimulate neurons. Because the THS method possesses a higher spatial resolution and a deeper penetration depth, it shows promise as a tool for treating or rehabilitating neuropsychiatric disorders.

关键词： Hall-effect stimulation passive cable model neurons

＂G＂ Mark Influences Consumption

在线全文

学校读者我要写书评

暂无评论

Design（产品设计） 2006年第8期 22-23页

作者： brain 李伟（编译）

日本的“Good Design奖（G标志）”对于做设计的人来说都不陌生，但消费者对于带有优秀设计标志的设计认知程度如何呢？近期的brain杂志发表了针对消费者对于“G”标示认知度的问题进行的相关的大规模调查。

关键词：优秀设计消费观念消费者认知度

The Pushtashan juvenile suprasubduction zone assemblage of Kurdistan (northeastern Iraq): A Cretaceous (Cenomanian) Neo-Tethys missing link

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2017年第5期8卷 1073-1087页

作者： Sabah A.Ismail Sarmad A.Ali Allen P.Nutman Vickie C.Bennett brain G.Jones Department of Applied Geology College of Sciences Kirkuk University Kirkuk 36001 Iraq GeoQuEST Research Centre School of Earth & Environmental Sciences University of Wollongong Wollongong NSW 2522 Australia Research School of Earth Sciences Australian National University ACT 0200 Australia

The Pushtashan suprasubduction zone assemblage of volcanic rocks, gabbros, norites and peridotites occurs in the Zagros suture zone, Kurdistan region, northeastern Iraq. Volcanic rocks are dominant in the assemblage and consist mainly of basalt and basaltic andesite flows with interlayered red shale and limestone horizons. Earlier lavas tend to be MORB-like, whereas later lavas display island arc tholeiite to boninitic geochemical characteristics. Tholeiitic gabbros intrude the norites and display fractionation trends typical of crystallisation under low-pressure conditions, whereas the norites display calc-alkaline traits, suggesting their source included mantle metasomatised by fluids released from subducted oceanic crust. Enrichment of Rb, Ba, Sr, Th and the presence of negative Nb anomalies indicate generation in a suprasubduction zone setting. Trondhjemite and granodiorite intrusions are present in the volcanic rocks, gabbros and norites. SHRIMP U-Pb dating of magmatic zircons from a granodiorite yields a mean^(206)Pb/^(238)U age of 96.0 ±2.0 Ma(Cenomanian). The initial ε_(Hf) value for the zircons show a narrow range from +12.8 to+15.6, with a weighted mean of + 13.90±0.96. This initial value is within error of model depleted mantle at 96 Ma or slightly below that, in the field of arc rocks with minimal contamination by older continental crust. The compositional bimodality of the Pushtashan suprasubduction sequence suggests seafloor spreading during the initiation of subduction, with a lava stratigraphy from earlyerupted MORB transitioning into calc-alkaline lavas and finally by 96 Ma intrusion of granodioritic and trondhjemitic bodies with juvenile crustal isotopic signatures. The results confirm another Cretaceous arc remnant preserved as an allochthon within the Iraqi segment of the Cenozoic Zagros suture zone. Implications for the closure of Neo-Tethys are discussed.

关键词： Pushtashan suprasubduction assemblage Cretaceous Zircon U-Pb dating Hf isotopes Kurdistan region lraq Neo-Terhys

HOW Exoskeletons Work ——Will you be the next Iron Man？

在线全文

学校读者我要写书评

暂无评论

空中英语教室（高级版．彭蒙惠英语） 2012年第5期 35-36,47,48页

作者： Marshall brain