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Mending the broken in amyotrophic lateral sclerosis: DNA damage and repair in motor neuron degeneration

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Neural Regeneration Research 2021年第1期16卷 104-105页

作者： Byung Woo Kim Lee j.Martin Department of Pathology Division of Neuropathologythe Pathobiology Graduate Training ProgramJohns Hopkins University School of MedicineBaltimoreMDUSA Department of Neuroscience Johns Hopkins University School of MedicineBaltimoreMDUSA

Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disease that causes paralysis and respiratory failure(Petrov et al.,2017).The driving mechanisms are unknown,and there are no effective treatments(Petrov et al.,2017).Aging and a few gene mutations,a common one being missense mutations in superoxide dismutase-1(SOD1),are risk factors for ALS(Figure 1).The recent Food and Drug Administration approval of edaravone for the treatment of ALS putatively supports a role for oxidative and nitrative stresses in the disease processes(Figure 1A).DNA damage,abnormalities in DNA repair,and other nuclear abnormalities are implicated also in the pathogenesis of human ALS(bradley and Krasin,1982;Kim et al.,2020).

关键词： al. damage degeneration

维普期刊数据库

1项子宫动脉栓塞与子宫肌瘤切除术的多中心对比性研究

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世界核心医学期刊文摘（妇产科学分册） 2006年第4期2卷 22-23页

作者： Goodwin S.C. bradley L.D. Lipman j.C. 李跃萍 Imaging Services Veterans Administration Greater Los Angeles Health Care System Mail Code 114 11301 Wilshire Boulevard Los Angeles CA 90073 United States Dr.

Objective: To determine whether there is significant quality of life score improvement after uterine artery embolization (UAE)-and to compare UAE and myomectomy outcomes. Design: Prospective cohort controlled study. Setting: Sixteen medical centers in the United States. Patient(s): One hundred forty-nine UAE patients and 60 myomectomy patients. Patients were assigned to myomectomy or UAE on the basis of a best treatment decision made by the patient and her physician. All patients were observed for 6 months. The UAE patients also had follow up examinations at 1 year. Intervention(s): Myomectomy or *** Outcome Measure(s): Quality of life score changes, menstrual bleeding score changes, uterine size differences, time off, and adverse events. Result(s): Both groups experienced statistically significant improvements in the uterine fibroid quality of life score, menstrual bleeding, uterine volume, and overall postoperative quality of life. The mean hospital stay was 1 day for the UAE patients, compared with 2.5 days for the myomectomy patients. The UAE and myomectomy patients returned to their normal activities in 15 days and 44 days, respectively, and returned to work in 10 days and 37 days, respectively. At least one adverse event occurred in 40.1%of the myomectomy patients, compared with 22.1%in the UAE group. Conclusion(s): The uterine fibroid quality of life score was significantly improved in both groups. No significant differences were observed in bleeding improvement, uterine volume reduction, uterine fibroid quality of life score improvement, and overall quality of life score improvement between groups. Patients receiving UAE required fewer days off work, fewer hospital days, and experienced fewer adverse events.

关键词：子宫肌瘤切除术子宫动脉栓塞对比性研究生活质量术后生活患者群观察时间无显著性差异恢复时

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Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-βinduced retinal pigmented epithelium degeneration

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1526-1534页

作者： Siddharth Narendran Felipe Pereira Praveen Yerramothu Ivana Apicella Shao-bin Wang Kameshwari Ambati Shuichiro Hirahara Younghee Kim Meenakshi Ambati Vidya L.Ambati Peirong Huang Akhil Varshney Yosuke Nagasaka Shinichi Fukuda Kirstie L.Baker Kenneth M.Marion jan M.Deussing Srinivas R.Sadda bradley D.Gelfand jayakrishna Ambati Center for Advanced Vision Science University of Virginia School of MedicineCharlottesvilleVAUSA Department of Ophthalmology University of Virginia School of MedicineCharlottesvilleVAUSA Aravind Eye Care System MaduraiIndia Departamento de Oftalmologia e Ciências Visuais Escola Paulista de MedicinaUniversidade Federal de São PauloSão PauloBrazil Center for Digital Image Evaluation CharlottesvilleVAUSA Doheny Eye Institute Los AngelesLos AngelesCAUSA Molecular Neurogenetics Department of Stress Neurobiology and NeurogeneticsMax Planck Institute of PsychiatryMunichGermany Department of Ophthalmology David Geffen School of MedicineUniversity of California–Los AngelesLos AngelesCAUSA Department of Biomedical Engineering University of Virginia School of MedicineCharlottesvilleVAUSA Department of Pathology University of Virginia School of MedicineCharlottesvilleVAUSA Department of Microbiology Immunologyand Cancer BiologyUniversity of Virginia School of MedicineCharlottesvilleVAUSA

Nonfibrillar amyloid-βoligomers(AβOs)are a major component of drusen,the sub-retinal pigmented epithelium(RPE)extracellular deposits characteristic of age-related macular degeneration(AMD),a common cause of global *** report that AβOs induce RPE degeneration,a clinical hallmark of geographic atrophy(GA),a vision-threatening late stage of AMD that is currently *** demonstrate that AβOs induce activation of the NLRP3 inflammasome in the mouse RPE in vivo and that RPE expression of the purinergic ATP receptor P2RX7,an upstream mediator of NLRP3 inflammasome activation,is required for AβO-induced RPE *** classes of small molecule inflammasome inhibitors—nucleoside reverse transcriptase inhibitors(NRTIs)and their antiretrovirally inert modified analog Kamuvudines—both inhibit AβOs-induced RPE *** findings crystallize the importance of P2RX7 and NLRP3 in a disease-relevant model of AMD and identify inflammasome inhibitors as potential treatments for GA.

关键词： degeneration activation upstream

人体空腹状态下运用PET评估局部游离脂肪酸摄取

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人体空腹状态下运用PET评估局部游离脂肪酸摄取

Effect of Direct-Fed Microbial Supplementation on Pathogenic <i>Escherichia coli</i>Fecal Shedding, Live Performance, and Carcass Characteristics in Feedlot Steers

中华医学会糖尿病学分会第十六次全国学术会议

作者：韩巧君 Nicola Gathaiya Christina Koutsari bradley j.Kemp Michael D.jensen 第二军医大学长海医院内分泌科 Divisions of Endocrinology and metabolism Nuclear MedeineMayo ClinicRochesterMNUSA

目的游离脂肪酸(free fatty acid,FFA)升高导致肥胖并发症如胰岛素抵抗的发生。因此知道不同组织和器官对FFA的摄取,有助于我们理解FFA对代谢的影响。(1)明确用PET、[1-11C]软脂酸评估比较隔夜空腹状态下正常体重与肥胖成人皮下脂肪和...

目的游离脂肪酸(free fatty acid,FFA)升高导致肥胖并发症如胰岛素抵抗的发生。因此知道不同组织和器官对FFA的摄取,有助于我们理解FFA对代谢的影响。(1)明确用PET、[1-11C]软脂酸评估比较隔夜空腹状态下正常体重与肥胖成人皮下脂肪和内脏脂肪、骨骼肌、肝脏摄取FFA是否不同;(2)用PET得到的脂肪组织摄取FFA结果和那些用之前已建立的方法(使用[1-14C]标记的软脂酸)相比较。

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Open journal of Animal Sciences 2020年第4期10卷 683-705页

作者： Alex Thompson M. Alexandra Calle Flavio R. Ribeiro Ansen R. Pond Wanda M. Kreikemeier Allen McDonald Edward G. johnson Matthew D. Edmonds Guy H. Loneragan Mindy M. Brashears bradley j. johnson Department of Animal and Food Sciences Texas Tech University Lubbock TX USA School of Veterinary Medicine Texas Tech University Amarillo TX USA Darling International Inc. Des Moines IA USA Nutrition Physiology Company LLC Overland Park KS USA johnson Research Center Parma Italy

Three experiments were conducted to evaluate direct-fed microbial (DFM) supplementation on live performance, carcass characteristics, and fecal shedding of E. coli in feedlot steers. In Exp. 1, 400 steers (BW = 348 kg) were assigned to treatments: CON = lactose carrier only, BOV = P. freudenreichii (NP24) + L. acidophilus (NP51), BOVD = P. freudenreichii (NP24) + L. acidophilus (NP51), and COMB = BOV fed for the first 101 d on feed, followed by BOVD for the final 28 d prior to harvest. In Exp. 2 (n = 1800;BW = 354 kg) and Exp. 3 (n = 112;BW = 397 kg), steers were utilized in a randomized complete block design and assigned to DFM treatments using low dose and high dose, respectively. Fecal samples were collected prior to harvest and analyzed for E. coli serogroups. In Exp. 1, DFM reduced (P E. coli O157. Prevalence of O157 was reduced by BOVD supplementation in Exp. 2 and 3 (P E. coli O157 in positive samples was reduced in both experiments where enumeration was performed (P ≤ 0.02). Weighted mean differences across the three experiments were equal to a 33% reduction in the prevalence of E. coli O157:H7 in BOVD treated cattle. A significant reduction in prevalence of O26, O45, O103, and O121 was observed in Exp. 2 (P ≤ 0.03). These results indicate that high levels of L. acidophilus (NP51) may represent an effective pre-harvest food safety intervention to reduce fecal shedding of several E. coli serogroups.

关键词： Beef Cattle Direct-Fed Microbial Escherichia coli O157 Lactobacillus acidophilus Pre-Harvest Intervention

Prediction of Impending Drought Scenarios Based on Surface and Subsurface Parameters in a Selected Region of Tropical Queensland, Australia

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Generalized Baumslag-Solitar Graphs with Soluble Fundamental Groups

journal of Water Resource and Protection（水资源与保护） 2021年第8期

作者： Bithin Datta Dilip Kumar Roy jonathan j.Kelley bradley Stevens

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Algebra Colloquium 2014年第1期21卷 53-58页

作者： Alberto L. Delgado Derek j.S. Robinson Mathew Timm vDepartment of Mathematics illinois State University Normal IL 61790 USA Department of Mathematics University of Illinois at Urbana-Champaign Urbana IL 61801 USA Department of Mathematics Bradley University Peoria IL 61625 USA

It is shown that the generalized Baumslag-Solitar graphs which have soluble fundamental groups can be constructed from four simple types of graph by a process of decoration. The method of proof is elementary and emplo... 详细信息

关键词： generalized Baumslag-Solitar graph soluble fundamental group

VERNAUZATION1 Modulates Root System Architecture in Wheat and Barley

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Molecular Plant 2018年第1期11卷 226-229页

作者： Kai P. Voss-Fels Hannah Robinson Stephen R. Mudge Cecile Richard Saul Newman Benjamin Wittkop Andreas Stahl Wolfgang Friedt Matthias Frisch lulian Gabur Anika Miller-Cooper bradley C. Campbell Alison Kelly Glen Fox jack Christopher Mandy Christopher Karine Chenu jerome Franckowiak Emma S. Mace Andrew K. Borrell Howard Eagles David R. jordan jose R. Botella Graeme Hammer lan D. Godwin Ben Trevaskis Rod j. Snowdon Lee T. Hickey Department of Plant Breeding IFZ Research Centre for Biosystems Land Use and Nutrition Justus Uebig University Heinrich-Buff-Ring 26-32 35392 Giessen Germany Queensland Alliance for Agriculture and Food Innovation The University of Queensland St Lucia QLD 4072 Australia School of Agriculture and Food Sciences The University of Queensland Brisbane QLD 4072 Australia CSIRO Agriculture Canberra ACT 2601 Australia Department of Biometry and Population Genetics IFZ Research Centre for Biosystems Land Use and Nutrition Justus Liebig University Heinrich-Buff-Ring 26-32 35392 Giessen Germany Department of Agriculture and Fisheries Leslie Research FacilRy Toowoomba QLD 4350 Australia Queensland Alliance for Agriculture and Food Innovation The University of Queensland roowoomba QLD 4350 Australia Department of Agronomy and Plant Genetics University of Minnesota St Paul MN USA Department of Agriculture and Fisheries Hermitage Research Facility Warwick QLD 4370 Australia Queensland Alliance for Agriculture and Food Innovation Hermitage Research Facility The University of Queensland Warwick QLD 4370 Australia These authors contributed equally to this article.

Dear Editor Roots play a key role in plant growth regulation. It is well described that the below-ground plant architecture has a significant impact on plant performance under abiotic constraints and maintains stabili... 详细信息

关键词： TRAITS RESPONDS

发育基因组解剖工程：寻找人类发育障碍基因的细胞遗传学方法

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中华口腔医学杂志 2009年第Z1期44卷 76-76页

作者： Cynthia C. Morton bradley j. Quade james F. Gusella Richard L .Maas David j. Harris BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA MassachusettsGeneralHospiatalBrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwom BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA MassachusettsGeneralHospiatalBrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwom BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA MassachusettsGeneralHospiatalBrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwom BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA MassachusettsGeneralHospiatalBrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwom BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA MassachusettsGeneralHospiatalBrighamandEwomen'sHospitalHarvardMedicalSchool Boston MA USA BrighamandEwom