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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina silvera-simón Manel M.santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia s.Rex David J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National science Foundation(NsF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

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Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： siva s.V.P.sakamuri Anil sakamuri Department of chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

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a-si/c-si heterojunction solar cells on sisiC ceramic substrates

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Rare Metals 2006年第Z1期25卷 186-189页

作者： LI Xudong XU Ying che Xiaoqi Beijing solar Energy Research Institute Beijing 100083 China Beijing Solar Energy Research Institute Beijing 100083 China Beijing Solar Energy Research Institute Beijing 100083 China

silicon thin-film solar cells are considered to be one of the most promising cells in the future for their potential advantages, such as low cost, high efficiency, great stability, simple processing, and none-pollution. In this paper, latest progress on poly-crystalline silicon solar cells on ceramic substrates achieved by our group was reported. Rapid thermal chemical vapor deposition (RTCVD) was used to deposited poly-crystalline silicon thin films, and the grains of as-grown film were enlarged by Zone-melting Recrystallization (ZMR). As a great change in cell′s structure, traditional diffused pn homojunction was replaced by a-si/c-si heterojunction, which lead is to distinct improvement in cell′s efficiency. A conversion efficiency of 3.42% has been achieved on 1 cm2 a-si/c-si heterojunction solar cell (Isc=16.93 mA, Voc=310.9 mV, FF=0.6493, AM=1.5 G, 24 ℃), while the cell with diffused homojunction only got an efficiency of 0.6%. It indicates that a-si emitter formed at low temperature might be more suitable for thin film cell on ceramics.

关键词： a-si/c-si heterojunction thin film solar cell ceramic substrate

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Integrating the ecosystem service in sustainable plateau spatial planning:A case study of the Yarlung Zangbo River Basin

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Journal of Geographical sciences 2021年第2期31卷 281-297页

作者： che Lei ZHOU Liang XU Jiangang school of Architecture and Urban Planning Nanjing UniversityNanjing 210093China Faculty of Geomatics Lanzhou Jiaotong UniversityLanzhou 730070China Institute of Geographic sciences and Natural Resources Research CASBeijing 100101China

The Yarlung Zangbo River Basin(YZRB)is a key ecological protection area on the Qinghai-Tibet Plateau(QTP).Determination of the ecosystem service values(EsVs)can help recognize the benefits of sustainable *** is gradually becoming the main path that constructs plateau spatial planning of integrating ecological protection,and achieves global sustainable development goals(sDGs)in *** this paper,the spatio-temporal dynamic evolutions of the EsVs were estimated on the multiple scales of“basin,subbasin and watershed”from 1980 to *** main factors influencing EsVs were explored in terms of physical geography,human activities,and climate *** had been proposed that sustainable spatial planning including ecological protection,basin management,and regional development was urgent to set *** results show that the increase in wetland and forest and results in an increase of 9.4%in the *** should be paid to the reduction of water and *** conservation(WC),waste treatment(WT),and soil formation and conservation(sFC)are the most important ecosystem services in the *** present,the primary problem is to solve the EsVs decreasing caused by glacier melting,grassland degradation,and desertification in the upper reaches *** middle reaches should raise the level of supply *** services should be increased in the lower reaches region on the premise of protecting *** EsVs in adjacent watersheds are interrelated and the phenomenon of“high agglomeration and low agglomeration”is obvious,existing hot-spots and cold-spots of ***,when the altitude is 4500-5500 m,the temperature is 3-8°C,and the annual precipitation is 350-650 mm,EsVs could reach its maximum.A framework of sustainable plateau spatial planning could provide references to delimit the ecological protection red line,key ecological function zone,and natural resource asset accounting on the QTP.

关键词： ecosystem service values spatial planning ecological protection Yarlung Zangbo River Basin Qinghai-Tibet Plateau

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Review of Middle East Research in China since the 1990s

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World History studies 2018年第1期5卷 88-104页

作者： che Xiaomei school of History and Tourism Culture Shanxi Normal University Taiyuan Shanxi Province P. R. China.

The communication between civilizations of China and the Middle East has long been evidenced by the silk Road that stretches for thousands of miles. While the research of Middle Eastem countries in China emerged in no earlier than the period of the Republic of China, the substantial research of the Middle East only appeared after the founding of the People＇s Republic of China.

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Exploring the efficiency of image metric for assessing the visual quality of 3D mesh model

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International Journal of Modeling, simulation, and scientific Computing 2018年第6期9卷 147-170页

作者： Li che Fengju Kang College of Marine Engineering Northwestern Polytechnical University Xi’an 710072 P.R.China National Key Laboratory of Underwater Information Process and Control Xi’an 710072 P.R.China

Recent developments in 3D graphics technology have led to extensive processes on 3D meshes(e.g.,compression,simplification,transmission and watermarking),these processes unavoidably cause the visual perceptual degradation of the 3D *** existing mesh visual quality evaluation metrics either require topology constrain or fail to reflect the perceived visual ***,for the 3D objects that are observed on 2D screens by the users,it is reasonable to apply image metric to assess the distortion caused by mesh *** attempt to explore the efficiency of image metric for assessing the visual fidelity of the simplified 3D model in this *** this purpose,several latest and most effective image metrics,2D snapshots,number and pooling algorithms are involved in our study,and finally tested on the IEETA simplification *** statistical data allow the researcher to select the optimal parameter for this image-based mesh visual quality assessment and provide a new perspective for the design and performance assessment of mesh simplification algorithms.

关键词： Image metric 3D model visual quality assessment mesh distortion correlation analysis,performance analysis.

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Faster-than-Nyquist signaling based on filter bank multicarrier modulation with joint optimization

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Journal of systems Engineering and Electronics 2022年第6期33卷 1208-1223页

作者： che Hui PENG Dingxiang GUO Fachang BAI Yong school of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China Ruijie Networks Co. LtdFuzhou 350002China school of Information and Communication Engineering Hainan UniversityHaikou 570228China

Multi-carrier faster-than-Nyquist(MFTN)can improve the spectrum efficiency(sE).In this paper,we first analyze the benefit of time frequency packing MFTN(TFP-MFTN).Then,we propose an efficient digital implementation for TFP-MFTN based on filter bank multicarrier *** time frequency packing ratio pair in our proposed implementation scheme is optimized with the sE ***,the joint optimization for the coded modulation MFTN based on extrinsic information transfer(EXIT)chart is *** Monte-Carlo simulations are carried out to verify performance gain of the joint inner and outer code *** results demonstrate that the TFPMFTN has a 0.8 dB and 0.9 dB gain comparing to time packing MFTN(TP-MFTN)and higher order Nyquist at same sE,respectively;the TFP-MFTN with optimized low density parity check(LDPC)code has a 2.9 dB gain comparing to that with digital video broadcasting(DVB)*** with previous work on TFP-MFTN(sE=1.55 bit/s/Hz),the sE of our work is improved by 29%and our work has a 4.1 dB gain at BER=1×10^(-5).

关键词： faster-than-Nyquist filter bank multi-carrier time-frequency packing(TFP) spectrum efficiency(sE) joint optimization

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Construction of one-dimensional hierarchical Mos_(2)/Ni_(3)s_(2) composites with enhanced interfacial polarization and improved wideband microwave absorption

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Journal of Materials science & Technology 2024年第11期178卷 22-28页

作者： Kaicheng Luo Biao Zhao Chunyang Xu Chongyun Liang Chang Zhang Yiqian Du Xiaowei Lv Jincang Zhang Limin Wu Renchao che Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai200438China school of Microelectronics Fudan UniversityShanghai200433China Zhejiang Laboratory Hangzhou311100China Inner Mongolia University Hohhot010021China

The construction of one-dimensional(1D)sulfides has attracted extensive attention for improving mi-crowave absorption(MA)performance owing to the anisotropic conductive ***,the syn-thesis of conductive 1D hierarchical materials with unique interfacial polarization and excellent MA prop-erties remains *** this study,cable-like Mos_(2)/Ni_(3)s_(2) was synthesized by a one-step hydrother-mal *** complex permittivity of the binary composites could be improved by tuning the thick-ness of the Mos_(2) ***,the construction of heterogeneous contacts by Mos_(2) and Ni_(3)s_(2) contributed to enhanced polarization loss,and the charge distribution was validated by electron *** wide efficient absorption bandwidth can reach above 4.8 GHz at a thin *** new discoveries shed light on novel structures for 1D sulfide materials and the design of functional core-shell composites for microwave absorption.

关键词： 1D sulfide materials Microwave absorption Mos_(2)/Ni_(3)s_(2) Interfacial polarization Core-shell composites

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Effects of Biochar Application on soil Organic Carbon in Degraded saline-sodic Wetlands of songnen Plain,Northeast China

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Chinese Geographical science 2021年第5期31卷 877-887页

作者： che Qianjin LI Min ZHANG Zhongsheng 无 Yancheng Tearchers school Yancheng 224002China North Jiangsu Institute of Agricultural and Rural Modernization Yancheng 224002China Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun 130012China Xinfeng Middle school Yancheng 224100China

Biochar amendment is considered as an efficient practice for improving carbon storage in ***,to what extent that biochar application promotes organic carbon in saline-sodic soils remains poorly *** comparing soil organic carbon(sOC)contents change before and after biochar addition,we deciphered the driving factors or processes that control sOC change in response to biochar application.A limited increase in sOC was observed,about by 1.16%-12.80%,even when biochar was applied at the rate of 10%of bulk soil *** application enhanced soil dissolved organic carbon(DOC)significantly by up to 67%.It was estimated that about 50%sOC was allocated to small macroaggregates(250-2000μm,CPOC),and sOC in silt and clay-sized particles(sed obviously after biochar *** biomass increased with biochar amendment,of which actinomycetes(ACT),fungus(FUN),protozoon(PRO),and bacteria with straight-chain saturated fatty acids(OB)increased *** linear regression models implied that DOC was governed by ACT and soil N∶P ratio,while sOC mostly depended on *** principal component analysis and the partial least square path model(PLs-PM)indicated that biochar addition aggravated nitrogen limitation in saline-sodic soils,and effects of microorganisms on regulating sOC greatly depended on nitrogen *** application had vastly changed interactions between environmental factors and sOC in saline-sodic *** of nutrients on sOC shifted to great inhibition from strong stimulation after biochar addition,meanwhile,aggregation was the only factor presenting positive effects on *** to eliminate nutrient limitation and better soil aggregation process should be considered in priority when biochar was used to improve sOC in saline-sodic soils.

关键词： biochar saline-sodic soil soil organic carbon phospholipid fatty acid nutrient songnen Plain China

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