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Imaging atomic-scale chemistry from fused multi-modal electron microscopy

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npj Computational Materials 2022年第1期8卷 164-171页

作者： Jonathan Schwartz Zichao Wendy di Yi Jiang Alyssa J.Fielitz don-Hyung Ha Sanjaya d.Perera Ismail el Baggari Richard d.Robinson Jeffrey A.Fessler Colin Ophus Steve Rozeveld Robert Hovden department of Materials Science and engineering University of MichiganAnn ArborMIUSA Mathematics and Computer Science division Argonne National LaboratoryLemontILUSA Advanced Photon Source Facility Argonne National LaboratoryLemontILUSA dow Chemical Co. MidlandMIUSA department of Material Science and engineering Cornell UniversityIthacaNew YorkUSA School of Integrative engineering Chung-Ang UniversitySeoulRepublic of Korea department of Physics Cornell UniversityIthacaNYUSA The Rowland Institute at Harvard CambridgeMAUSA department of electrical engineering and Computer Science University of MichiganAnn ArborMIUSA national Center for electron microscopy Lawrence Berkeley National LaboratoryMolecular FoundryBerkeleyCAUSA Applied Physics Program University of MIchiganAnn ArborMIUnited States

efforts to map atomic-scale chemistry at low doses with minimal noise using electron microscopes are fundamentally limited by inelastic ***,fused multi-modal electron microscopy offers high signal-to-noise ratio(SNR)recovery of material chemistry at nano-and atomic-resolution by coupling correlated information encoded within both elastic scattering(high-angle annular dark-field(HAAdF))and inelastic spectroscopic signals(electron energy loss(eeLS)or energy-dispersive x-ray(edX)).By linking these simultaneously acquired signals,or modalities,the chemical distribution within nanomaterials can be imaged at significantly lower doses with existing detector *** many cases,the dose requirements can be reduced by over one order of *** high SNR recovery of chemistry is tested against simulated and experimental atomic resolution data of heterogeneous nanomaterials.

关键词： materials chemistry fused

儿童青少年回避性/限制性摄食障碍:评估与治疗

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中国全科医学 2024年第9期27卷 1028-1033,1041页

作者：王清玉林征雷阳孙彩云王咪顾珺怡朱展慧唐李晨南京医科大学护理学院江苏省南京市211166 南京医科大学第一附属医院护理部江苏省南京市210029

进食障碍治疗成本高,且发病率逐年增高,与其他精神障碍相比,死亡风险也较高。回避性/限制性摄食障碍作为较新的一类进食障碍,相比其他年龄群体在儿童青少年群体中更易出现,影响儿童青少年正常生长发育和社会心理功能。目前,国外研究较多... 详细信息

进食障碍治疗成本高,且发病率逐年增高,与其他精神障碍相比,死亡风险也较高。回避性/限制性摄食障碍作为较新的一类进食障碍,相比其他年龄群体在儿童青少年群体中更易出现,影响儿童青少年正常生长发育和社会心理功能。目前,国外研究较多,国内研究尚处于起始阶段。因此,本文对儿童青少年回避性/限制性摄食障碍评估工具、影响因素和治疗方式进行综述,以期为国内开展相关研究提供借鉴。

关键词：回避限制性摄食障碍评估工具影响因素治疗措施儿童青少年综述

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炎症性肠病患者恐惧疾病进展潜在类别的影响因素分析及护理启示

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中华护理杂志 2024年第3期59卷 308-316页

作者：王清玉林征雷阳周美景王咪孙彩云顾珺怡朱展慧唐李晨卞秋桂南京医科大学护理学院南京市210000 南京医科大学第一附属医院内分泌科南京医科大学第一附属医院消化科

目的探究炎症性肠病患者恐惧疾病进展的潜在剖面类别,并分析不同类别的影响因素。方法采用便利抽样法,选取2022年7月—2023年7月在南京市某三级甲等医院住院的炎症性肠病患者作为调查对象。使用一般资料调查表、中文版恐惧疾病进展简化... 详细信息

目的探究炎症性肠病患者恐惧疾病进展的潜在剖面类别,并分析不同类别的影响因素。方法采用便利抽样法,选取2022年7月—2023年7月在南京市某三级甲等医院住院的炎症性肠病患者作为调查对象。使用一般资料调查表、中文版恐惧疾病进展简化量表、中文版炎症性肠病自我效能量表和社会支持评定量表进行调查。对炎症性肠病患者恐惧疾病进展进行潜在剖面分析,并通过单因素分析和多元Logistic回归分析探讨其影响因素。结果共回收问卷310份,其中有效问卷303份,有效问卷回收率为97.74%。潜在剖面分析结果显示,炎症性肠病患者恐惧疾病进展分为“低恐惧风险-疾病适应组”(n=127,41.91%)、“中恐惧风险-疾病困扰组”(n=139,45.88%)、“高恐惧风险-功能失调组”(n=37,12.21%)3个潜在剖面类别。其影响因素包括居住地、自评经济压力水平、疾病分期、自我效能(P<0.05)。结论炎症性肠病患者恐惧疾病进展水平具有明显的异质性。护理人员应根据该分类特点制订个性化干预策略,着重提高患者的自我效能,提升其疾病、压力及情绪管理水平。

关键词：炎性肠疾病恐惧疾病进展潜在剖面分析影响因素分析护理

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气候变化情景下中国金荞麦适生区变化分析

中国农业气象 2024年第8期45卷 835-848页

作者：张保得谢准马玉珊赵艳丽韦春冕符莹莹刘米徐福荣云南中医药大学昆明650500

基于Maxent生态位模型和ArcGIS技术,以中国金荞麦为研究对象,结合全国137条金荞麦有效分布点和32项环境因子进行适生区分析,筛选金荞麦适宜生长的关键环境因子,并预测末次盛冰期(The last glacial maximum,LGM)、全新世中期(The mid hol... 详细信息

基于Maxent生态位模型和ArcGIS技术,以中国金荞麦为研究对象,结合全国137条金荞麦有效分布点和32项环境因子进行适生区分析,筛选金荞麦适宜生长的关键环境因子,并预测末次盛冰期(The last glacial maximum,LGM)、全新世中期(The mid holocene,MH)、当前(Current)和未来时期(2041-2060年,2050s;2061-2080年,2070s)3种不同温室气体排放情景金荞麦适宜区域的地理空间格局变化及质心迁移。结果表明:评价Maxent模型的指标训练和测试数据的AUC为0.928±0.005和0.916±0.027,模型模拟精度较高。制约金荞麦生态适宜分布的9个环境因子及阈值为年平均降水量(915~1899mm)、最冷月最低温度(-2.4~6.9℃)、温度季节变化系数(3031~6319)、海拔(61~357.2m,1540~3408m)、昼夜温差月均值(7.5~10.9℃)、7月平均风速(0.6~1.9m·s^(−1))、最暖季度平均降水量(506.8~1060.9mm)、4月平均风速(0.5~2.3m·s^(−1))和降水量季节变化方差(45.4~84.9)。从末次盛冰期到未来时期,金荞麦适生区呈逐渐增加趋势,尤以未来温室气体中高排放情景下扩张幅度较大,最大扩张面积达到45.93×10^(4)km^(2),扩张区域主要集中在横断山脉附近和秦岭-淮河一带。气候变化情景下金荞麦适生区质心呈高纬度、高海拔迁移趋势。

关键词：金荞麦 Maxent模型气候变化适生区变化

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高压电力设备绝缘试验及安全措施分析

电力系统装备 2020年第24期 62-63页

作者：唐咪娜湖南经研电力设计有限公司湖南长沙410000

为保证高压电力设备运行的稳定性,要结合电力设备绝缘试验操作流程,完善相应控制方案的基础上,确保能提升其运行质量,从而维持安全操作管理的实效性。本文从工频交流试验、直流耐压试验、超低频交流耐压试验等方面分析了高压电力设备绝... 详细信息

为保证高压电力设备运行的稳定性,要结合电力设备绝缘试验操作流程,完善相应控制方案的基础上,确保能提升其运行质量,从而维持安全操作管理的实效性。本文从工频交流试验、直流耐压试验、超低频交流耐压试验等方面分析了高压电力设备绝缘试验方案,并对安全设计措施提出了几点建议。

关键词：高压电力设备绝缘试验试验方案安全措施

Pd-1 blockade-unresponsive human tumor-infiltrating Cd8^(+)T cells are marked by loss of Cd28 expression and rescued by IL-15

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Cellular & Molecular Immunology 2021年第2期18卷 385-397页

作者： Kyung Hwan Kim Hong Kwan Kim Hyung-don Kim Chang Gon Kim Hoyoung lee Ji Won Han Seong Jin Choi Seongju Jeong minwoo Jeon Hyunglae Kim Jiae Koh Bo mi Ku Su-Hyung Park Myung-Ju Ahn eui-Cheol Shin Graduate School of Medical Science and engineering Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea department of Thoracic and Cardiovascular Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Biomedical Science and engineering Interdisciplinary Program Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Research Institute for Future Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea department of radiation Oncology Yonsei Cancer CenterYonsei University College of MedicineSeoulRepublic of Korea division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea

Blockade of programmed death-1(Pd-1)reinvigorates exhausted Cd8^(+)T cells,resulting in tumor regression in cancer ***,reinvigoration of exhausted Cd8^(+)T cells following Pd-1 blockade was shown to be Cd28-dependent in mouse ***,we examined the role of Cd28 in anti-Pd-1 antibody-induced human T cell reinvigoration using tumor-infiltrating Cd8^(+)T cells(Cd8^(+)TILs)obtained from non-small-cell lung cancer ***-cell analysis demonstrated a distinct expression pattern of Cd28 between mouse and human Cd8^(+)***,we found that human Cd28^(+)Cd8^(+)but not Cd28^(–)Cd8^(+)TILs responded to Pd-1 blockade irrespective of B7/Cd28 blockade,indicating that Cd28 costimulation in human Cd8^(+)TILs is dispensable for Pd-1 blockade-induced reinvigoration and that loss of Cd28 expression serves as a marker of anti-Pd-1 antibody-unresponsive Cd8^(+)*** and phenotypically,Pd-1 blockade-unresponsive human Cd28^(–)Pd-1^(+)Cd8^(+)TILs exhibited characteristics of terminally exhausted Cd8^(+)T cells with low TCF1 ***,Cd28^(–)Pd-1^(+)Cd8^(+)TILs had preserved machinery to respond to IL-15,and IL-15 treatment enhanced the proliferation of Cd28^(–)Pd-1^(+)Cd8^(+)TILs as well as Cd28^(+)Pd-1^(+)Cd8^(+)*** together,these results show that loss of Cd28 expression is a marker of Pd-1 blockade-unresponsive human Cd8^(+)TILs with a TCF1–signature and provide mechanistic insights into combining IL-15 with anti-Pd-1 antibodies.

关键词： anti-Pd-1 T cells TCF1 Cd28 IL-15

Transformation and source of nutrients in the Changjiang estuary

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Science China Chemistry 2014年第5期57卷 779-790页

作者： YAO QingZhen YU ZhiGang LI LingLing CHeN HongTao mi TieZhu key Laboratory of Marine Chemistry Theory and Technology Ministry of Education Ocean University of China

The concentrations of phosphate(PO43-),ammonium,nitrite,nitrate,silicate,dissolved organic nitrogen(don),dissolved organic phosphorus(dOP),particulate phosphorus(PP)and particulate nitrogen(PN)along the salinity gradient were measured in the Changjiang estuary in April *** behavior of nutrient species along the continuum from the freshwater to the coastal zone is *** the mixing zone between the riverine and marine waters,nitrate and phosphate behave non-conservatively,while silicate behaves *** import was quantified from the river *** export to the sea was quantified from river discharge and from the salinity-nutrient gradient in the outer *** these data,a nitrogen and phosphorus budget was *** internal estuarine fluxes played an important role in the nutrient estuarine fluxes,which accounted for approximately 41%of the nitrogen flux and 45%of the phosphorus *** mixing experiments in the laboratory generally reproduced well the inorganic process affecting nutrient dynamics in the Changjiang estuary,indicating that the primary P and N transformation processes were phosphate and nitrate desorption along the salinity gradient.

关键词：营养来源长江口亚硝酸盐盐度梯度磷酸盐有机氮浓度测定沿海地带

Influence of N, P, Fe Nutrients Availability on Nitrogen Metabolism-Relevant Genes expression in Skeletonema marinoi

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Journal of Ocean University of China 2019年第1期18卷 239-252页

作者： JING Xiaoli mi Tiezhu ZHeN Yu WANG Hualong YU Zhigang College of Marine Life Science Ocean University of China Function Laboratory for Marine ecology and environmental Science Qingdao National Laboratory for Marine Science and Technology key Laboratory of Marine environment and ecology Ministry of Education College of environmental Science and engineering Ocean University of China key Laboratory of Marine Chemical Theory and Technology Ministry of Education

Nitrogen(N), Phosphorus(P), and Iron(Fe) are essential elements for cellular structure and metabolism. In addition to dissolved inorganic nitrogen(dIN), phytoplankton is able to utilize dissolved organic nitrogen(don). There is general consensus that both bacteria and higher plants nitrogen metabolism is affected by phosphate availability; this was also found to be true in coccolithophorid. Iron affects the structure and function of ecosystems through its effects on nitrogen metabolism. However, it is unclear how these nutrients affect Skeletonema marinoi's nitrogen metabolism. Here, using RT-qPCR, we investigate effects of N, P, and Fe on S. marinoi's nitrogen metabolism and nitrate reductase activity. These results illuminate that in S. marinoi, various nutrients have direct regulation on these genes expression at the molecular level. The varying degree of responses for these genes expression with differing N sources may act to increase the efficiency of nutrient capture when nitrate is limited. Suitable gene expression occurs at a N/P ratio of 16, which represents the atomic N/P ratio of phytoplankton cells and N/P concentrations in ocean; thus, nitrogen metabolism gene expression should be regulated by the existing N/P ratios in the phytoplankton's internal and external environment. Fe concentration has a direct and significant effect on nitrogen metabolism by regulating gene expression and nitrate reductase activity. Gene expression profiles identified in S. marinoi provide a foundation for understanding molecular mechanisms behind diatom nitrogen metabolism with changing N, P, and Fe nutrients allowing a basic understanding of how diatom growth is affected by nutrient utilization.

关键词： Skeletonema marinoi nitrogen metabolism relative gene expression RT-qPCR

Optimal precursors of double-gyre regime transitions with an adjoint-free method

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Journal of Oceanology and Limnology 2019年第4期37卷 1137-1153页

作者： YUAN Shijin LI mi WANG Qiang ZHANG Kun ZHANG Huazhen MU Bin School of Software engineering Tongji University Shanghai 201804 China key Laboratory of Ocean Circulation and Waves Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China

In this paper, we find the optimal precursors which can cause double-gyre regime transitions based on conditional nonlinear optimal perturbation (CNOP) method with Regional Ocean Modeling System (ROMS). Firstly, we simulate the multiple-equilibria regimes of double-gyre circulation under different viscosity coefficient and obtain the bifurcation diagram, then choose two equilibrium states (called jet-up state and jet-down state) as reference states respectively, propose Principal Component Analysis-based Simulated Annealing (PCASA) algorithm to solve CNOP-type initial perturbations which can induce double-gyre regime transitions between jet-up state and jet-down state. PCASA algorithm is an adjoint-free method which searches optimal solution randomly in the whole solution space. In addition, we investigate CNOP-type initial perturbations how to evolve with time. The results show:(1) the CNOP-type perturbations present a two-cell structure, and gradually evolves into a three-cell structure at predictive time;(2) by superimposing CNOP-type perturbations on the jet-up state and integrating ROMS, double-gyre circulation transfers from jet-up state to jet-down state, and vice versa, and random initial perturbations don't cause the transitions, which means CNOP-type perturbations are the optimal precursors of double-gyre regime transitions;(3) by analyzing the transition process of double-gyre regime transitions, we find that CNOP-type initial perturbations obtain energy from the background state through both barotropic and baroclinic instabilities, and barotropic instability contributes more significantly to the fast-growth of the perturbations. The optimal precursors and the dynamic mechanism of double-gyre regime transitions revealed in this paper have an important significance to enhance the predictability of double-gyre circulation.

关键词： optimal precursors double-gyre regime transitions conditional nonlinear optimal perturbation (CNOP) Principal Component Analysis-based Simulated Annealing (PCASA) multipleequilibria regimes