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三甲医院宣传影像资源库云管理建设模式探究

影像科学与光化学 2024年第2期42卷 155-159页

作者：杨阳潘博宇天津医科大学肿瘤医院天津300060

本文在对国内三甲医院宣传影像资源库建设现状调研的基础上,发现目前影像资源库普遍存在影像资源多且乱,使用效率较低;管理方式和管理手段落后;安全系数不高,存在安全隐患;管理人员素质参差不齐等问题。基于此,本文结合云管理模式在三... 详细信息

本文在对国内三甲医院宣传影像资源库建设现状调研的基础上,发现目前影像资源库普遍存在影像资源多且乱,使用效率较低;管理方式和管理手段落后;安全系数不高,存在安全隐患;管理人员素质参差不齐等问题。基于此,本文结合云管理模式在三甲医院宣传影像信息化建设中的优势,提出宣传影像资源库云管理建设策略:即加强顶层设计,实现标准统一;实现云管理和智能化检索的有机统一;加强安全保障,实现云管理资源共享;优化管理团队,加强人才培养等。

关键词：宣传影像医院医疗机构云管理信息化建设

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室内动态环境语义VSLAM应用研究

计算机应用文摘 2024年第14期40卷 86-88页

作者：潘博宇张剑湖南科技大学信息与电气工程学院湖南湘潭411100

针对VSLAM算法在室内动态场景下精度低、鲁棒性差的问题,结合深度学习和多视图几何的方法,首先利用语义分割网络对RGB-D视频流图像进行处理,建立动态对象的先验语义信息,然后针对无先验信息的移动物体进行多视图几何处理,最后使用静态... 详细信息

针对VSLAM算法在室内动态场景下精度低、鲁棒性差的问题,结合深度学习和多视图几何的方法,首先利用语义分割网络对RGB-D视频流图像进行处理,建立动态对象的先验语义信息,然后针对无先验信息的移动物体进行多视图几何处理,最后使用静态特征点进行特征匹配和位姿估计。在慕尼黑工业大学开源的TUM公开数据下进行实验验证,结果显示,在室内动态环境下,该系统相较于ORB-SLAM2和ORB-SLAM3能够更接近真实轨迹,且轨迹的绝对位姿误差显著降低;在高动态环境下,相较于ORB系列算法,平均提升了79.1625%;在低动态环境下,平均提升了12.4125%。

关键词：深度学习多视图几何 ORB-SLAM3

From complexity to clarity: development of CHM-FIEFP for predicting effective components in Chinese herbal formulas by using big data

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Cancer Biology & Medicine 2024年第11期 1067-1077页

作者： boyu pan Han Zhu Jiaqi Yang Liangjiao Wang Zizhen Chen Jian Ma Bo Zhang Zhanyu pan Guoguang Ying Shao Li Liren Liu Department of Molecular Pharmacology Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin Tianjin's Clinical Research Center for Cancer College of Electronic and Information Engineering Shanghai Research Institute for Intelligent Autonomous Systems Tongji University Department of General Surgery Tianjin Haihe Hospital Beijing Intelligent Medicine and Network Pharmacology Co. Ltd Institute for TCM-X MOE Key Laboratory of Bioinformatics Bioinformatics Division BNRist Department of AutomationTsinghua University Department of Integrative Oncology Tianjin Medical University Cancer Institute and Hospital Laboratory of Cancer Cell Biology Tianjin Medical University Cancer Institute & Hospital

Objective: The presence of complex components in Chinese herbal medicine(CHM) hinders identification of the primary active substances and understanding of pharmacological principles. This study was aimed at developing a big-data-based, knowledgedriven in silico algorithm for predicting central components in complex CHM ***: Network pharmacology(TCMSP) and clinical(GEO) databases were searched to retrieve gene targets corresponding to the formula ingredients, herbal components, and specific disease being treated. Intersections were determined to obtain diseasespecific core targets, which underwent further GO and KEGG enrichment analyses to generate non-redundant biological processes and molecular targets for the formula and each component. The ratios of the numbers of biological and molecular events associated with a component were calculated with a formula, and entropy weighting was performed to obtain a fitting score to facilitate ranking and improve identification of the key components. The established method was tested on the traditional CHM formula Danggui Sini Decoction(DSD) for gastric cancer. Finally, the effects of the predicted critical component were experimentally validated in gastric cancer ***: An algorithm called Chinese Herb Medicine-Formula vs. Ingredients Efficacy Fitting & Prediction(CHM-FIEFP) was developed. Ferulic acid was identified as having the highest fitting score among all tested DSD components. The pharmacological effects of ferulic acid alone were similar to those of ***: CHM-FIEFP is a promising in silico method for identifying pharmacological components of CHM formulas with activity against specific diseases. This approach may also be practical for solving other similarly complex problems. The algorithm is available at http://***/.

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跨境电商背景下我国对外贸易风险防范

安徽电子信息职业技术学院学报 2022年第2期21卷 107-110页

作者：张艺嘉潘博宇江阴职业技术学院江苏江阴214405

跨境电子商务的迅速发展改变了传统的市场概念,也改变了传统的买卖方式,为我国的对外出口找到新的突破点和增长点。我国跨境电商以出口为主,形成初步规模。虽然电商经营形成较好的发展形势,但仍处于发展初级阶段,经营存在着一定的风险,... 详细信息

跨境电子商务的迅速发展改变了传统的市场概念,也改变了传统的买卖方式,为我国的对外出口找到新的突破点和增长点。我国跨境电商以出口为主,形成初步规模。虽然电商经营形成较好的发展形势,但仍处于发展初级阶段,经营存在着一定的风险,仍需进行不断的改革和完善。通过研究跨境电商背景下我国对外贸易风险防范相关内容,有利于跨境电商企业运营时识别不同种类的风险以及掌握相关防范措施。

关键词：跨境电子商务风险识别风险防范

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基于STM32的目标提取处理系统

测试技术学报 2017年第2期31卷 144-147页

作者：刘天霖杨博宇潘广贞中北大学软件学院山西太原030051 中北大学信息与通信工程学院山西太原030051

本文探索了一种监控图像跟踪系统,该系统以STM32微处理器为控制核心,将广角摄像头采集的图像送至LCD显示,并分析获取图像的数据,针对常用的直接帧间差分法存在的误差大,运算量大,导致内存问题,影响运算速度等问题,提出了一种图像目标提... 详细信息

本文探索了一种监控图像跟踪系统,该系统以STM32微处理器为控制核心,将广角摄像头采集的图像送至LCD显示,并分析获取图像的数据,针对常用的直接帧间差分法存在的误差大,运算量大,导致内存问题,影响运算速度等问题,提出了一种图像目标提取处理算法,准确快速计算出目标物体的位置坐标,从而控制云台移动,保证目标处于摄像头视野的中央,解决了在图像处理中误差大、运算速度慢、系统内存不足等问题,以低成本低功耗实现了视频目标的提取跟踪处理.

关键词： STM32 监控系统目标提取互相关性

Rare-earth metal catalysts for alkene hydrosilylation

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Science China Chemistry 2019年第5期62卷 571-582页

作者： Deshuai Liu boyu Liu Zexiong pan Jianfeng Li Chunming Cui State Key Laboratory of Elemento-organic Chemistry and College of Chemistry Nankai University Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

Rare-earth metal catalyzed hydrosilylation of alkenes has emerged as a powerful and selective strategy for the synthesis of organosilanes. This transformation can offer distinctive catalytic sequences and reaction patterns from other catalysts because of the high electropositivity and lack of oxidative-addition process of rare-earth metal. This review summarizes the rare-earth metal catalysts for hydrosilylation of alkene according to the type of ligands. The synthesis and structure of rare-earth metal catalysts,the substrate scope as well as some preliminary structure-activity relationship and mechanism are discussed.

关键词： rare-earth metal hydrosilylation alkene catalysis mechanism

原核表达的人乙醛脱氢酶2(ALDH2)的活性及稳定性研究

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氨基酸和生物资源 2015年第4期37卷 61-66页

作者：王荷花潘博宇黄娟陈孝平吴元欣武汉工程大学化工与制药学院/绿色化工过程教育部重点实验室湖北武汉430073

对由原核载体表达的人乙醛脱氢酶2(Aldehyde dehydrogenase 2,简称ALDH2)纯化工艺、酶活性改善、稳定性以及保存条件分别进行了参数的优化,以期为ALDH2商品化剂型开发提供理论依据。通过NAD(P)+酶活测定法,检测不同纯化工艺、金属离子... 详细信息

对由原核载体表达的人乙醛脱氢酶2(Aldehyde dehydrogenase 2,简称ALDH2)纯化工艺、酶活性改善、稳定性以及保存条件分别进行了参数的优化,以期为ALDH2商品化剂型开发提供理论依据。通过NAD(P)+酶活测定法,检测不同纯化工艺、金属离子以及不同保存条件对ALDH2的酶活性的影响。通过SDS-PAGE检测ALDH2在模拟胃液和胰液中的稳定性。结果显示,低离子磷酸盐缓冲液透析有利于ALDH2酶活性的恢复,且真空冷冻干燥处理可导致ALDH2酶活性下降。K+、Zn2+、Mg2+、Mn2+、Ca2+均能提高ALDH2酶活性。ALDH2在模拟胃液中稳定性良好,但在模拟胰液中迅速被降解。与此同时,ALDH2酶液在-20℃下能良好地保持其稳定性及酶活,但在4℃和30℃下保存一个月酶活急剧下降。以上结果表明,低离子磷酸盐缓冲液透析法、K+均能提高ALDH2的酶活性,同时该酶可耐受模拟胃液的降解作用,且添加山梨酸钾的ALDH2于-20℃可良好地保持其稳定性及酶活。

关键词：乙醛脱氢酶2(ALDH2) 纯化活性稳定性剂型

E674Q(Shanghai APP mutant),a novel amyloid precursor protein mutation,in familial late-onset Alzheimer's disease

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Genes & Diseases 2024年第2期11卷 1022-1034页

作者： Yongfang Zhang Xinyi Xie boyu Chen Lina pan Jianping Li Wanbing Wang Jintao Wang Ran Tang Qiang Huang Xiaofen Chen Rujing Ren Zhentao Zhang Wei Fu Gang Wang Department of Neurology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research Institute of NeuroscienceSchool of MedicineXiamen UniversityXiamenFujian 361102China Shenzhen Research Institute of Xiamen University ShenzhenGuangdong 518063China

Identified as the pathogenic genes of Alzheimer's disease(AD),APP,PSEN1,and PSEN2 mainly lead to early-onset AD,whose course is more aggressive,and atypical symptoms are more common than sporadic ***,a novel missense mutation,APP E674Q(also named“Shanghai APP”),was detected in a Chinese index patient with typical late-onset AD(LOAD)who developed memory decline in his *** results from neuroimaging were consistent with AD,where widespread amyloidβdeposition was demonstrated in 18 F-florbetapir Positron Emission Tomography(PET).APP E674Q is close to theβ-secretase cleavage site and the well-studied Swedish APP mutation(KM670/671NL),which was predicted to be pathogenic in *** dynamics simulation indicated that the E674Q mutation resulted in a rearrangement of the interaction mode between APP and BACE1 and that the E674Q mutation was more prone to cleavage by *** in vitro results suggested that the E674Q mutation was pathogenic by facilitating the BACE1-mediated processing of APP and the production of Aβ.Furthermore,we applied an adeno-associated virus(AAV)-mediated transfer of the human E674Q mutant APP gene to the hippocampi of two-month-old C57Bl/6 J ***-E674Q-injected mice exhibited impaired learning behavior and increased pathological burden in the brain,implying that the E674Q mutation had a pathogenicity that bore a comparison with the classical Swedish ***,we report a strong amyloidogenic effect of the E674Q substitution in *** our knowledge,E674Q is the only pathogenic mutation within the amyloid processing sequence causing LOAD.

关键词： Alzheimer's disease Amyloid beta APP mutation E674Q Late onset

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爆炸冲击载荷下机身壁板的动态响应

航空学报 2022年第6期43卷 194-206页

作者：冯振宇傅博宇解江段竹煊潘汉源中国民航大学安全科学与工程学院天津300300 中国民用航空局民航航空器适航审定技术重点实验室天津300300

为了满足“最小风险炸弹位置(LRBL)”的设计要求,有必要针对爆炸冲击载荷下机身壁板的动态响应开展研究。参考典型客机机身结构建立了铝合金机身壁板有限元模型,分析了增压、爆炸冲击位置与药量对机身壁板变形模式与失效行为的影响。研... 详细信息

为了满足“最小风险炸弹位置(LRBL)”的设计要求,有必要针对爆炸冲击载荷下机身壁板的动态响应开展研究。参考典型客机机身结构建立了铝合金机身壁板有限元模型,分析了增压、爆炸冲击位置与药量对机身壁板变形模式与失效行为的影响。研究结果表明,当机身壁板蒙皮未发生失效时,增压对整体变形模式的影响较小。当机身壁板蒙皮发生失效时,增压对整体失效行为的影响剧烈;爆炸冲击不同位置时,冲击长桁及隔框位置造成的开口损伤较小,但是结构产生了更长的裂纹损伤;随着药量的增加,冲击波更快传递到结构,冲击位置获得了更大的变形速度。

关键词：增压机身壁板铆钉爆炸响应冲击载荷