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非生物型人工肝三种不同治疗模式在肝衰竭治疗中的研究进展

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中国医药科学 2024年第10期14卷 30-33页

作者：罗可刘波颖广东医科大学第一临床学院广东湛江524000 广东医科大学梅州临床医学院广东梅州514031

肝衰竭(LF)是多种病因引起肝脏功能严重障碍的一种临床症候群,其病死率高、预后差。由于内科药物治疗的疗效欠佳、肝移植供体来源紧张且费用昂贵,因此非生物型人工肝支持系统(NBALSS)作为LF最主要的治疗手段目前在临床上广泛应用。NBALS... 详细信息

肝衰竭(LF)是多种病因引起肝脏功能严重障碍的一种临床症候群,其病死率高、预后差。由于内科药物治疗的疗效欠佳、肝移植供体来源紧张且费用昂贵,因此非生物型人工肝支持系统(NBALSS)作为LF最主要的治疗手段目前在临床上广泛应用。NBALSS的治疗模式有血浆置换(PE)、双重血浆分子吸附系统(DPMAS)、PE+DPMAS等,在临床上均能在不同程度改善患者肝功能,但也有不足之处。本文主要针对上述三种不同治疗模式的临床实际应用特点进行阐述总结,以供参考借鉴。

关键词：非生物型人工肝肝衰竭血浆置换双重血浆分子吸附系统

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Health risks and sources of trace elements and black carbon in PM_(2.5)from 2019 to 2021 in Beijing

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Journal of Environmental Sciences 2024年第8期142卷 69-82页

作者： Chenjie Hua Wei Ma Feixue Zheng Yusheng Zhang Jiali Xie Li Ma boying Song Chao Yan Hongyan Li Zhen liu Qian liu Markku Kulmala Yongchun liu Aerosol and Haze Laboratory Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Institute for Atmospheric and Earth System Research Faculty of ScienceUniversity of HelsinkiHelsinki 00014Finland School of Environment and Safety Taiyuan University of Science and TechnologyTaiyuan 030024China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

A comprehensive health risk assessment of PM_(2.5)is meaningful to understand the current status and directions regarding further improving air quality from the perspective of human *** this study,we evaluated the health risks of PM_(2.5)as well as highly toxic inorganic components,including heavy metals(HMs)and black carbon(BC)based on longterm observations in Beijing from 2019 to *** results showed that the relative risks of chronic obstructive pulmonary disease,lung cancer,acute lower respiratory tract infection,ischemic heart disease,and stroke decreased by 4.07%-9.30%in 2020 and 2.12%-6.70%in2021 compared with ***,they were still at high levels ranging from 1.26 to 1.77,in particular,stroke showed the highest value in *** had the highest hazard quotient(HQ,from 2.18 to 2.56)for adults from 2019 to 2021,while Ni,Cr,Pb,As,and BC showed high carcinogenic risks(CR>1.0×10^(-6))for *** HQ values of Mn and As and the CR values of Pb and As showed constant or slight upwards trends during our observations,which is in contrast to the downward trends of other HMs and PM_(2.5).Mn,Cr,and BC are crucial toxicants in PM_(2.5).A significant shrink of southern region sourcesof HMs and BCshrank suggests the increased importance of local ***,dust,and biomass burning are the major contributors to the non-carcinogenic risks,while traffic emissions and industry are the dominant contributors to the carcinogenic risks in Beijing.

关键词： PM_(2.5) Heavy metals Black carbon Health risk Source apportionment

Genetic mutation of Tas2r104/Tas2r105/Tas2r114 cluster leads to a loss of taste perception to denatonium benzoate and cucurbitacin B

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Animal Models and Experimental Medicine 2024年第3期7卷 324-336页

作者： Bowen Niu Lingling liu Qian Gao Meng-Min Zhu Lixiang Chen Xiu-Hua Peng boying Qin Xiaohui Zhou Feng Li Department of Laboratory Animal Science Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Department of Biology College of Life SciencesShanghai Normal UniversityShanghaiPeople's Republic of China

Background:Bitter taste receptors(Tas2rs)are generally considered to sense various bitter compounds to escape the intake of toxic *** taste receptors have been found to widely express in extraoral tissues and have important physiological functions outside the gustatory system in ***:To investigate the physiological functions of the bitter taste receptor cluster Tas2r106/Tas2r104/Tas2r105/Tas2r114 in lingual and extraoral tissues,multiple Tas2rs mutant mice and Gnat3 were produced using CRISPR/Cas9 gene-editing technique.A mixture containing Cas9 and sgRNA mRNAs for Tas2rs and Gnat3 gene was microinjected into the cytoplasm of the ***,T7EN1 assays and sequencing were used to screen genetic mutation at the target sites in founder *** real-time polymerase chain reaction(qRT-PCR)and immunostaining were used to study the expression level of taste signaling cascade and bitter taste receptor in taste *** to taste substance was also studied using twobottle preference ***:We successfully produced several Tas2rs and Gnat3 mutant mice using the CRISPR/Cas9 *** results showed that the expression of GNAT3 and PLCB2 was not altered in Tas2rs mutant *** qRT-PCR results revealed the changed expression profile of m Tas2rs gene in taste buds of these mutant *** two-bottle preference tests,these mutant mice eliminate responses to cycloheximide due to genetic mutation of *** addition,these mutant mice showed a loss of taste perception to quinine dihydrochloride,denatonium benzoate,and cucurbitacin B(CuB).Gnat3-mediated taste receptor and its signal pathway contribute to CuB ***:These findings implied that these mutant mice would be a valuable means to understand the biological functions of TAS2Rs in extraoral tissues and investigate bitter compound-induced responses mediated by these TAS2Rs in many extraoral tissues.

关键词： bitter taste receptor CRISPR/Cas9 genetic mutation two-bottle preference test type 2 taste receptors(Tas2rs)

Study of penetration mechanism of labrasol on rabbit cornea by Ussing chamber, RT-PCR assay, Western blot and immunohistochemistry

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Asian Journal of Pharmaceutical Sciences 2019年第3期14卷 329-339页

作者： Pan Guo Nan Li Lili Fan Jun Lu boying liu Bing Zhang Yumei Wu Zhidong liu Jiawei Li Jiaxin Pi Dongli Qi Tianjin State Key Laboratory of Modern Chinese Medicine The Institute of Traditional Chinese MedicineTianjinUniversity of Traditional Chinese MedicineNo.88Yuquan RoadTianjin300193China Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Tianjin University ofTraditional Chinese MedicineNo.88Yuquan RoadTianjin300193China School of Pharmaceutical Science and Technology Tianjin UniversityTianjin300193China

Labrasol, as a non-ionic surfactant, can enhance the permeation and absorption of drugs, and is extensively used in topical, transdermal, and oral pharmaceutical preparations as an emulsifier and absorption enhancer. Recent studies in our laboratory have indicated that labrasol has a strong absorption enhancing effect on different types of drugs in vitro and in vivo. This study was performed to further elucidate the action mechanism of labrasol on the corneal penetration. In this research, the fluorescein sodium, a marker of passive paracellular transport of tight junction, was selected as the model drug to assess the effect of labrasol on in vitro corneal permeability. To investigate the continuous and real-time influence of labrasol on the membrane permeability and integrity, the Ussing chamber system was applied to monitor the electrophysiological parameters. And, furthermore, we elucidated the effect of labrasol on excised cornea at the molecular level by application of RT-PCR, Western blot, and immunohistochemical staining. The results indicated that labrasol obviously enhance the transcorneal permeability of fluorescein sodium, and the enhancement was realized by interacting with and down-regulating the associated proteins, such as Factin, claudin-1 and β-catenin, which were contributed to cell-cell connections, respectively.

关键词： Enhanced corneal permeation Tight junctions associated proteins Labrasol Ussing chamber Western blot Immunohistochemistry

THE EQUIVALENCE BETWEEN 2Gs AND 2Es AND A NEW PROOF TO PUMPING LEMMA

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Transactions of Tianjin University 1996年第1期2卷 72-77页

作者： ZHOU Yuqing liu boying Dept.of Computer Science and Engineering Management College Tianjin University

In this paper, the concept of type 2 expressions (2Es for short) is briefly introduced, and it is proved strictly that CFL class is precisely the language class expressed by 2Es. A new proof using 2Es to pumping lemma... 详细信息

关键词： language grammar type 2 expression pumping lemma

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工业遗产:为历史文化名城增添新亮点

世界建筑 2022年第12期 83-86页

作者：刘伯英清华大学建筑学院中国建筑学会工业建筑遗产学术委员会

本文阐述了保护工业遗产的意义,工业遗产与历史文化名城保护体系的关系,重点介绍了景德镇、株洲、长春、北京4座不同类型的历史文化名城中,工业遗产保护的做法和与历史文化名城的关系。最终指出工业遗产保护利用将为推动城市的未来发展... 详细信息

本文阐述了保护工业遗产的意义,工业遗产与历史文化名城保护体系的关系,重点介绍了景德镇、株洲、长春、北京4座不同类型的历史文化名城中,工业遗产保护的做法和与历史文化名城的关系。最终指出工业遗产保护利用将为推动城市的未来发展提供新动能,增添新亮点。

关键词：工业遗产历史文化名城保护利用未来发展

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工业遗产视角下公司镇的发展与启示

中国名城 2023年第10期37卷 55-60页

作者：刘伯英孟璠磊刘小慧清华大学建筑学院中国文物学会工业遗产委员会中国建筑学会工业建筑遗产学术委员会中国历史文化名城委员会工业遗产学部中国文物保护技术协会工业遗产保护专业委员会北京建筑大学建筑与城市规划学院北京华清安地建筑设计事务所有限公司

公司镇集工厂、住房、道路、商店、公园等于一体,随工业革命成果的传播从英国蔓延至世界其他国家。罗伯特·欧文在新拉纳克的管理实践开创了兼顾工厂生产和社会治理的新模式;英国的索尔泰尔公司镇留下了大量的物质和非物质遗产;芝加哥... 详细信息

公司镇集工厂、住房、道路、商店、公园等于一体,随工业革命成果的传播从英国蔓延至世界其他国家。罗伯特·欧文在新拉纳克的管理实践开创了兼顾工厂生产和社会治理的新模式;英国的索尔泰尔公司镇留下了大量的物质和非物质遗产;芝加哥近郊的普尔曼镇是美国最具代表性的公司镇。在20世纪的百年里,大量军事工业以隐秘的公司镇的形式为国家承担着特殊的任务。公司镇见证了人类探索工业生产与城市生活的伟大构想和实践,是工业遗产中极具特色的类型,对于理解、治理工业城市和工业区具有重要启发意义。研究从公司镇历史起源入手,通过对3个具有代表意义的早期公司镇的梳理,提出公司镇保护的若干思考,以期进一步丰富中国工业遗产保护与再利用研究。

关键词：公司镇工业遗产历史文化名城名镇名村城市更新

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基于XGBoost的公路隧道驾驶风险识别

自动化与仪器仪表 2023年第11期 67-70,76页

作者：刘伯鹍赵宇璇中国电建集团华东勘测设计研究院有限公司杭州311122

公路隧道因其独特的结构特性,常带来显著的交通安全风险,且其风险因素多种多样。为了识别和分析公路隧道环境下的驾驶风险,本研究招募了13名驾驶员进行实车试验,收集了驾驶员、车辆及道路环境的综合数据。利用滑动时间窗构建了1 023个... 详细信息

公路隧道因其独特的结构特性,常带来显著的交通安全风险,且其风险因素多种多样。为了识别和分析公路隧道环境下的驾驶风险,本研究招募了13名驾驶员进行实车试验,收集了驾驶员、车辆及道路环境的综合数据。利用滑动时间窗构建了1 023个时长为3秒的隧道驾驶样本,基于驾驶员避险行为对风险样本进行标注,得到104个风险样本。通过特征相关性和重要性分析构建合适的输入特征集,并利用RF、GBDT和XGBoost三种机器学习算法建立风险识别模型。结果显示,XGBoost算法表现最佳,特别是在输入特征数量为8时达到最优效果,其F1分数为0.81。进一步的特征重要性分析揭示,车辆的运行状态和驾驶员的生理状态均对驾驶风险产生影响。

关键词：交通安全公路隧道驾驶风险识别机器学习

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水泥混凝土路面板中弯沉的温度梯度影响修正

同济大学学报（自然科学版） 2007年第5期35卷 617-620页

作者：赵军谈至明刘伯莹同济大学道路与交通工程教育部重点实验室上海200092 中国路桥集团北京100011

在详细分析正温度梯度作用下路面板的翘曲变形的基础上,总结归纳了板中局部脱空可予修正的温度梯度范围,给出了可修正范围内的落锤式弯沉仪(FWD)和贝克曼梁(BB)实测弯沉修正方法和相应回归公式,提高了弯沉测试的精度和效率.

关键词：水泥混凝土路面板中脱空温度梯度弯沉测试