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Testing for hepatitis B virus alone does not increase vaccine coverage in non-immunized persons

World Journal of Gastroenterology 2017年第38期23卷 7037-7046页

作者： Anders boyd Julie Bottero Fabrice Carrat Joel Gozlan Hayette Rougier Pierre-Marie Girard Karine Lacombe Institute Pierre Louis d’épidémiologie et de santéPublique(IPLEsP UMRs 1136) INSERMSorbonne Universités service de maladies infectieuses Hopital Saint-AntoineAP-HP Département de santépublique Hopital Saint-AntoineAP-HP Laboratoire de Virologie Hopital Saint-AntoineAP-HP INsERM UMR_S1135 CIMI

AIM To determine whether hepatitis B virus(HBV)-testing could serve as a gateway to vaccinate non-immunized individuals in a low-prevalent *** Non-immunized subjects participating in a multi-center, HBV-testing campaign in Paris, France were identified and contacted via telephone 3-9 mo after testing in order to determine vaccination status. Vaccination coverage was evaluated in per-protocol(for all respondents) and intent-to-treat analysis(assuming all non-responders did not vaccinate).REsULTs In total, 1215/4924(24.7%) enrolled subjects with complete HBV serology were identified as nonimmunized and eligible for analysis. There were 99/902 successfully contacted subjects who had initiated HBV vaccination after screening: per-protocol, 11.0%(95%CI: 9.0-13.2); intent-to-treat, 8.2%(95%CI: 6.7-9.8). In multivariable analysis, vaccination was more likely to be initiated in individuals originating from moderate or high HBV-endemic countries(P s with limited healthcare coverage(P = 0.01) and men who have sex with men(P = 0.02). When asked about the reasons for not initiating HBV vaccination, the most frequent response was "will be vaccinated later"(33.4%), followed by "did not want to vaccinate"(29.8%), and "vaccination was not proposed by the physician"(21.5%). sub-group analysis indicated a stark contrast in vaccination coverage across centers, ranging from 0%-56%.CONCLUsION HBV-vaccination after HBV screening was very low in this study, which appeared largely attributed to physician-patient motivation towards vaccination. Increased vaccination coverage might be achieved by emphasizing its need at the organizational level.

关键词： Health service organization Hepatitis B virus vaccination Public health Testing intervention Vaccine coverage

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Post-Mortem MRI and Histopathology in Neurologic Disease:A Translational Approach

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Neuroscience Bulletin 2019年第2期35卷 229-243页

作者： Laura E.Jonkman boyd Kenkhuis Jeroen J.G.Geurts Wilma D.J.van de Berg Department of Anatomy and Neurosciences Amsterdam Neuroscience Amsterdam UMC Vrije Universiteit Amsterdam Department of Human Genetics Leiden University Medical Center Department of Radiology Leiden University Medical Center

In this review, combined post-mortem brain magnetic resonance imaging(MRI) and histology studies are highlighted, illustrating the relevance of translational approaches to de?ne novel MRI signatures of neuropathological lesions in neuroin?ammatory and neurodegenerative disorders. Initial studies combining post-mortem MRI and histology have validated various MRI sequences,assessing their sensitivity and speci?city as diagnostic biomarkers in neurologic disease. More recent studies have focused on de?ning new radiological(bio)markers and implementing them in the clinical(research) setting. By combining neurological and neuroanatomical expertise with radiological development and pathological validation,a cycle emerges that allows for the discovery of novel MRI biomarkers to be implemented in vivo. Examples of this cycle are presented for multiple sclerosis, Alzheimer's disease, Parkinson's disease, and traumatic brain *** applications have been shown to be successful, while others require further validation. In conclusion, there is much to explore with post-mortem MRI and histology studies, which can eventually be of high relevance for clinical practice.

关键词： MRI Histology Biomarkers Multiple sclerosis Alzheimer’s disease Parkinson’s disease

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Harnessing the biology of the cell to target "undruggable" targets using PROTAC technology

Harnessing the biology of the cell to target "undruggable" t...

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2018年中国药学大会

作者： Helen boyd AstraZeneca

For many years there have been certain intracellular targets which play a key role in cell signalling,molecular interactions and disease indications which have been termed"undruggable".This terminology has arisen as in many cases traditional approaches to develop small molecules that target these proteins have been *** targeting chimera’s（PROTAC technology） is one new mechanism which facilitates specific degradation of intracellular proteins by harnessing the ubiquitin proteasome system and E3ligase *** drives targeted ubiquitination and degradation of specific proteins in the cell as a new modality for therapeutic *** this presentation I will cover the concept of PROTAC’s and show some of the areas that AstraZeneca is exploring with this exciting technology.

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The 5R’s framework guiding drug discovery and development within AstraZeneca

The 5R’s framework guiding drug discovery and development w...

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2018年中国药学大会

作者： Helen boyd AstraZeneca

Introduction of a’5R framework has been transformational within *** is key for all projects in both discovery and development and provides one framework to guide how we work within AstraZeneca R＆*** first publication in Nature Reviews Drug Discovery in 2014 marked the start of this journey,illustrating the challenges facing the pharmaceutical industry with a comprehensive review of the AZ small molecule portfolio from *** 5R framework we have put in place guides how we discover and develop new drug candidates and importantly focusses on quality not *** addition,we see a sixth element’right culture’which is considered a critical factor in the successful application of the framework by encouraging open,collaborative and effective decision making in *** have recently published a follow up article in Nature Reviews Drug Discovery on the application of the 5R framework and the positive impact this has made within AstraZeneca resulting in a 4-fold increase in success rate of drug molecules progressing from candidate nomination to Phase *** presentation will describe the principles of the 5R’s framework and how it is being used within *** will also describe how we are continuing on this journey by focusing on scientific rigour,precision medicine and focussing on solving future challenges across the 5R *** includes investing in new technologies such as complex phenotypic screens,micro physiological systems and artificial intelligence to ensure we continue to bring new medicines to patients in a time and cost efficient manner.

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Advances in High Density Interconnect substrate and Printed Wiring Board Technology

Advances in High Density Interconnect Substrate and Printed ...

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第六届电子封装技术国际学术会议

作者： Venky sundaram boyd Wiedenman Rao Tummala Packaging Research Center Georgia Institute of technology Packaging Research Center Georgia Institute of technology Packaging Research Center Georgia Institute of technology

The substrate or printed wiring board (PWB), as the largest component in electronic packages and systems, is performing an increasingly critical role in advancedpackages, high performance electronic s

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Nanolaminate-based design for UV laser mirror coatings

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Light(science & Applications) 2020年第1期9卷 1820-1825页

作者： Meiping Zhu Nuo Xu Behshad Roshanzadeh sTPboyd Wolfgang Rudolph Yingjie Chai Jianda shao Laboratory of Thin Film Optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Center of Materials science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Hangzhou Institute for Advanced study University of Chinese Academy of SciencesHangzhou 310024China Key Laboratory of Materials for High Power Laser Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Department of Physics and Astronomy University of New MexicoAlbuquerqueNM 87131USA CREOL The College of Optics and PhotonicsUniversity of Central FloridaOrlandoFL 32816USA

With ever-increasing laser power,the requirements for ultraviolet(UV)coatings increase *** fundamental challenge for UV laser-resistant mirror coatings is to simultaneously exhibit a high reflectivity with a large bandwidth and high laser *** characteristics are traditionally achieved by the deposition of laser-resistant layers on highly reflective *** propose a“reflectivity and laser resistance in one”design by using tunable nanolaminate layers that serve as an effective layer with a high refractive index and a large optical *** Al_(2)O_(3)-HfO_(2) nanolaminate-based mirror coating for UV laser applications is experimentally demonstrated using ebeam *** bandwidth,over which the reflectance is >99.5%,is more than twice that of a traditional mirror with a comparable overall *** laser-induced damage threshold is increased by a factor of ~1.3 for 7.6 ns pulses at a wavelength of 355 *** tunable,nanolaminate-based new design strategy paves the way toward a new generation of UV coatings for high-power laser applications.

关键词： tunable mirror reflectivity

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Mixed Technology Design Demands Parts are Placed Accurately in a 3Dimensional space

Mixed Technology Design Demands Parts are Placed Accurately ...

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2020中国高端sMT学术会议

作者： Jason boyd Kulicke soffa Netherlands B.V.

＜正＞K＆s provides knowledge and support beyond their own equipment set on a daily basis nowadays, working in close partnership with other equipment and service providers beyond pick ＆ place and bonding equipment. Delivering this professional advice objectively together with expert knowledge and experience to both clients and potential clients is a fundamental part of their working relationship by building trust, and is justifiably increasing in its demand. Clients fears of the unknown and making mistakes can be overcome and turned into confidence and sound engineering practices benefiting their organizational profitability and success.

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(某些)品德教育对自由主义民主的危害

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开放时代 2006年第5期 54-63页

作者： Dwight boyd 张红娟（译）杨韶刚（译）加拿大多伦多大学安大略教育研究所不详

本文以在加拿大多伦多市一大郊区开发的一个研究项目为案例,批评了北美“品德教育”的某些方面是怎样对维持一个健康的自由主义民主社会造成危害的。作为这种批评之基础的假设认为,把自由主义的动机作为一种政治理论确定下来,并且认为... 详细信息

本文以在加拿大多伦多市一大郊区开发的一个研究项目为案例,批评了北美“品德教育”的某些方面是怎样对维持一个健康的自由主义民主社会造成危害的。作为这种批评之基础的假设认为,把自由主义的动机作为一种政治理论确定下来,并且认为这种动机就表现在民主的原则和实践中,是为了解决生活在同一社会中的人们之间的(几种)冲突,而且要做到这一点,只要把公民的角色分化出来,按照这个目的进行建构即可。以此为抓手,本文把关注的焦点集中在这种观点的危险性上,认为这种观点无法区分好人和好公民这两个概念,尤其是在文化多元主义已经深入人心的背景中。

关键词：自由主义民主品德教育危害文化多元主义民主社会多伦多市政治理论角色分化

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sickle Cell Disease in Children: An Exploration of Family Resilience through the Experiences of Family Caregivers

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Open Journal of Nursing 2019年第4期9卷 347-363页

作者： Dorothy C. Nwanonyiri Catherine Jirak Monetti sharon boyd-Jackson Department of Nursing Kean University Union NJ USA Department of Psychology Kean University Union NJ USA

Background: sickle cell disease (sCD) is a chronic and potentially life-threatening genetic blood disorder with childhood onset. Caring for children with sCD can precipitate greater than average time demands, medical costs, employment constraints, and childcare challenges. Research has shown that family resilience is a key construct capable of enhancing family health and well-being, as well as neutralizing the burden of caring for an ill child. Aim: Applying the Family Resilience Model, this qualitative study involved exploring the phenomenon of family resilience through the perceptions and lived experiences of family caregivers of children with sCD. Methods: 10 self-identified primary sCD caregivers were recruited with the help of the sickle Cell Association of New Jersey (sCANJ). Three researches and five open-ended interview questions elicited participants’ descriptions of their lived experiences. Results: Using an Interpretive Phenomenological Approach and Donabedian’s conceptual model to analyze data, three categories emerged from verbatim transcriptions of interviews: family experiences and caring for a child with sCD (structure);family strengths (Process);and resilience & adaptation (Outcome). The emergent theme was Key Family strengths Fosters Family Resilience and Adaptation. Conclusions: Findings from this study offered insight into the diverse experiences of caring for children with sCD in the framework of family resilience. Results can facilitate the enhancement of family resilience and adaptation for future families and in designing care specifically tailored for these family caregivers. Recognizing resilience processes utilized by family caregivers of children with sCD is important for future research and to render support by healthcare practitioners.

关键词： Chronic Illness Family Adaptation Family Resilience sickle Cell Disease

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硝酸钠改良半咸水凡纳滨对虾(Litopenaeus vannamei)池塘底质和水质的研究

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海洋与湖沼 2009年第5期40卷 557-562页

作者：江兴龙关瑞章 Claude E. boyd 集美大学厦门361021 Auburn University Alabama 36849 U.S.A.

采用在8口土池开展半咸水养殖凡纳滨对虾施用NaNO3对比实验的方法,进行了硝酸钠对半咸水对虾养殖池塘底质和水质的改良效果、机理及应用前景的研究。结果表明,NaNO3处理组显著提高了池塘底泥表层的氧化还原电位,显著降低了底泥的BOD5和... 详细信息

采用在8口土池开展半咸水养殖凡纳滨对虾施用NaNO3对比实验的方法,进行了硝酸钠对半咸水对虾养殖池塘底质和水质的改良效果、机理及应用前景的研究。结果表明,NaNO3处理组显著提高了池塘底泥表层的氧化还原电位,显著降低了底泥的BOD5和可利用磷的浓度;显著降低了池塘水中的蓝藻相对密度;处理组的养殖成活率、产量和饲料系数分别比对照组显著提高8.2%、10.1%和降低9.2%(P<0.05);处理组养殖效益明显高于对照组,每公顷池塘养虾净增加收入人民币9765元;NaNO3的施用起到了有效改良池塘底质和水质的作用。因此,NaNO3的应用可为半咸水对虾养殖池塘底质和水质的改良开辟一个新的途径,具有一定的应用前景。

关键词：硝酸钠半咸水凡纳滨对虾池塘底质改良池塘水质改良

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