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The research group of Xinjing Tang developed efficient inhibition of SARS-CoV-2 using chimeric oligonucleotides through RNase L activation

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Journal of Chinese Pharmaceutical Sciences 2021年第7期30卷 621-622页

作者： Su, Xiaoxuan Ma, Wenxiao Feng, Di cheng, boyang Wang, Qian Guo, Zefeng Zhou, Demin Tangfis, Xinjing 北京大学药学院天然药物及仿生药物国家重点实验室

近日,学术期刊《Angewandte Chemie International Edition》在线发表了北京大学药学院天然药物及仿生药物国家重点实验室汤新景研究团队题为"Efficient Inhibition of SARS-CoV-2 Using Chimeric oligonucleotides through RNase L Act... 详细信息

关键词：病毒RNA 反义核酸北京大学药学院学术期刊 RNase 嵌合招募

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity

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Signal Transduction and Targeted Therapy 2023年第2期8卷 795-812页

作者： Bo Zhang Jiaqi Sun Yeshuang Yuan Dezhong Ji Yeting Sun Yudong Liu Shengjie Li Xingxing Zhu Xunyao Wu Jin Hu Qiu Xie Ling Wu Lulu Liu boyang cheng Yuanjie Zhang Lingjuan Jiang Lidan Zhao Fei Yu Wei Song Min Wang Yue Xu Shiliang Ma Yunyun Fei Lihe Zhang Demin Zhou Xuan Zhang State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College HospitalDepartment of RheumatologyBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Rheumatology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineClinical Immunology CenterGraduate School of Peking Union Medical CollegeChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeThe Ministry of Education Key LaboratoryBeijing 100730China

Interleukin-2(IL-2)is a pleiotropic cytokine that orchestrates bidirectional immune responses via regulatory T cells(Tregs)and effector cells,leading to paradoxical ***,we report a strategy that exploited genetic code expansion-guided incorporation of the latent bioreactive artificial amino acid fluorosulfate-L-tyrosine(FSY)into IL-2 for proximity-enabled covalent binding to IL-2Rαto selectively promote Treg *** found that FSY-bearing IL-2 variants,such as L72-FSY,covalently bound to IL-2Rαvia sulfur-fluoride exchange when in proximity,resulting in persistent recycling of IL-2 and selectively promoting the expansion of Tregs but not effector *** assessment of L72-FSY-expanded Tregs demonstrated that L72-FSY maintained Tregs in a central memory phenotype without driving terminal differentiation,as demonstrated by simultaneously attenuated expression of lymphocyte activation gene-3(LAG-3)and enhanced expression of programmed cell death protein-1(PD-1).Subcutaneous administration of L72-FSY in murine models of pristane-induced lupus and graft-versus-host disease(GvHD)resulted in enhanced and sustained therapeutic efficacy compared with wild-type IL-2 *** efficacy of L72-FSY was further improved by N-terminal PEGylation,which increased its circulatory retention for preferential and sustained *** proximity-enabled covalent binding strategy may accelerate the development of pleiotropic cytokines as a new class of immunomodulatory therapies.

关键词： sustained proximity consequences

Explosion damage effects of aviation kerosene storage tank under strong ignition

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Defence Technology（防务技术） 2024年第7期37卷 27-38页

作者： Shixiang Song cheng Wang boyang Qiao Gongtian Gu State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

In order to study the blast damage effects of aviation kerosene storage tanks,the out-field explosion experiments of 8 m3fixed-roof tanks were carried *** fragments,shock wave and fireball thermal radiation of the tank in the presence of bottom oil,half oil and full oil,as well as empty tank,were investigated under internal explosion by various TNT charge contents(1.8 kg,3.5 kg and 6.2 kg).The results showed that the tank roof was the only fragment produced,and the damage forms could be divided into three *** increase of TNT charge content and oil volume enlarged the deformation of the tank,while the hole ratio presented a trend of increase first and then *** H_r,maxand V_(max)values positively increased as increasing the TNT charge content and oil volume(from empty to half oil),but decreased in full *** Pmaxvalues had a progressive increase with the increment of TNT charge content,but not the case with the increase in oil *** development of fireball was divided into three stages:tank roof‘towed'flame,jet flow flame tumbling and rising,and jet flow flame *** Dmaxand Hf,maxvalues both increased as increasing TNT charge content and oil *** oscillation phenomenon of fireball temperature was observed in the cooling *** average temperature of fireball surface was positively correlated with TNT charge content,and negatively correlated with oil volumes.

关键词： Aviation kerosene Storage tank Internal explosion Shock wave Fireball

Decoupling coefficients of dilatational wave for Biot's dynamic equation and its Green's functions in frequency domain

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Applied Mathematics and Mechanics(English Edition) 2016年第1期37卷 121-136页

作者： boyang DING A.H.D.cheng Zhanglong CHEN City College Zhejiang University Department of Civil Engineering Zhejiang University of Technology College of Civil Engineering and Architecture University of Mississippi

Green＇s functions for Blot＇s dynamic equation in the frequency domain can be a highly useful tool for the investigation of dynamic responses of a saturated porous medium. Its applications are found in soil dynamics, seismology, earthquake engineering, rock mechanics, geophysics, and acoustics. However, the mathematical work for deriving it can be daunting. Green＇s functions have been presented utilizing an analogy between the dynamic thermoelasticity and the dynamic poroelasticity in the frequency domain using the u-p formulation. In this work, a special term ＂decoupling coefficient＂ for the decomposition of the fast and slow dilatational waves is proposed and expressed to present a new methodology for deriving the poroelastodynamic Green＇s functions. The correct- ness of the solution is demonstrated by numerically comparing the current solution with cheng＇s previous solution. The separation of the two waves in the present methodology allows the more accurate evaluation of Green＇s functions, particularly the solution of the slow dilatational wave. This can be advantageous for the numerical implementation of the boundary element method （BEM） and other applications.

关键词： decoupling coefficient dilatational wave Biot's equation poroelastodynamic Green's function frequency domain

Dirac points and the transition towards Weyl points in three-dimensional sonic crystals

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Light(Science & Applications) 2020年第1期9卷 36-44页

作者： boyang Xie Hui Liu Hua cheng Zhengyou Liu Jianguo Tian Shuqi Chen The Key Laboratory of Weak Light Nonlinear Photonics Ministry of EducationSchool of PhysicsTEDA Institute of Applied Physicsand Renewable Energy Conversion and Storage CenterNankai University300071 TianjinChina The Key Laboratory of Artificial Micro-and Nanostructures of the Ministry of Education and School of Physics and Technology Wuhan University430072 WuhanChina The Collaborative Innovation Center of Extreme Optics Shanxi University030006 TaiyuanShanxiChina The Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal University250358 JinanChina

A four-fold-degenerate three-dimensional(3D)Dirac point,represents a degenerate pair of Weyl points carrying opposite ***,3D Dirac crystals have shown many exotic features different from those of Weyl *** these features evolve from 3D Dirac to Weyl crystals is important in research on 3D topological ***,we realized a pair of 3D acoustic Dirac points from band inversion in a hexagonal sonic crystal and observed the surface states and helical interface states connecting the Dirac ***,each Dirac point can transition into a pair of Weyl points with the introduction of chiral *** exotic features of the surface states and interface states are inherited by the resulting Weyl *** work may serve as an ideal platform for exploring exotic physical phenomena in 3D topological semimetals.

关键词： Dirac degenerate topological

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奥沙利铂诱导的结肠癌细胞衰老模型的特性

山西医科大学学报 2021年第12期52卷 1523-1530页

作者：潘鹭翔贺维程柏杨朱茂荣顾锦涛张毅空军军医大学药学系生物制药学教研室西安710032 空军军医大学基础医学院

目的探讨奥沙利铂(OXA)诱导的结肠癌细胞衰老模型的表型及其特性。方法结肠癌细胞HCT-116及HT-29通过不同剂量的奥沙利铂处理(OXA 0,2.5,5,10μmol/L)后,观察细胞形态变化并进行β-半乳糖苷酶染色,筛选β-半乳糖苷酶表达最高的作为后续... 详细信息

目的探讨奥沙利铂(OXA)诱导的结肠癌细胞衰老模型的表型及其特性。方法结肠癌细胞HCT-116及HT-29通过不同剂量的奥沙利铂处理(OXA 0,2.5,5,10μmol/L)后,观察细胞形态变化并进行β-半乳糖苷酶染色,筛选β-半乳糖苷酶表达最高的作为后续实验衰老模型。将结肠癌细胞HCT-116及HT-29分别分为未处理组(OXA 0μmol/L)和衰老模型组(OXA 2.5μmol/L),通过激光共聚焦检测衰老标志物p21、β-gal的表达水平,通过流式细胞术检测Edu表达情况,通过蛋白免疫印迹检测DNA损伤相关蛋白γ-H2AX、p53及周期相关蛋白p16、CDK2的表达情况,通过qRT-PCR检测衰老相关分泌表型因子IL-6、IL-8、IL-10、CXCL10、MMP-1、MMP-3的表达。分别用0-80μmol/L奥沙利铂处理HCT-116及HT-29,然后CCK-8法检测未处理组和衰老组细胞活力。结果奥沙利铂浓度为2.5μmol/L的处理组β-半乳糖苷酶表达量最高,并出现细胞形态肿胀、直径增大的衰老细胞表征,将2.5μmol/L组作为衰老模型组。与未处理组比较,衰老模型组p21、β-gal双阳性细胞比率显著增高(HCT-116双阳性细胞比率为63.67%±2.028%,HT-29双阳性细胞比率78.33%±1.33%,P<0.001)。与未处理的结肠癌细胞相比,衰老细胞Edu阳性比例显著下降(P<0.001)。与未处理的结肠癌细胞相比,衰老细胞的γ-H2AX、p53、p21及CDK2显著升高(P<0.001)。与未处理的结肠癌细胞相比,衰老细胞衰老相关分泌表型因子IL-6、IL-8、IL-10、CXCL10、MMP-1、MMP-3的mRNA表达水平均显著提高(P<0.001)。与未处理组相比,衰老模型组同一浓度奥沙利铂处理后细胞活力显著升高(P<0.001)。结论低剂量奥沙利铂会造成结肠癌细胞DNA损伤、导致细胞周期阻滞和诱发衰老,而衰老细胞增殖能力下降且具有衰老相关分泌表型及化疗抵抗的特性。

关键词：细胞衰老奥沙利铂结肠癌

Tumor necrosis factor-stimulated gene-6 ameliorates early brain injury after subarachnoid hemorrhage by suppressing NLRC4 inflammasome-mediated astrocyte pyroptosis

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Neural Regeneration Research 2024年第5期19卷 1064-1071页

作者： Mingxiang Ding Lei Jin boyang Wei Wenping cheng Wenchao Liu Xifeng Li Chuanzhi Duan Neurosurgery Center Department of Cerebrovascular SurgeryThe National Key Clinical SpecialtyThe Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular DiseaseGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationThe Neurosurgery Institute of Guangdong ProvinceZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Cerebrovascular Intervention Zhongshan City People’s HospitalZhongshanGuangdong ProvinceChina

Subarachnoid hemorrhage is associated with high morbidity and mortality and lacks effective *** is a crucial mechanism underlying early brain injury after subarachnoid *** studies have confirmed that tumor necrosis factor-stimulated gene-6(TSG-6)can exert a neuroprotective effect by suppressing oxidative stress and ***,no study to date has explored whether TSG-6 can alleviate pyroptosis in early brain injury after subarachnoid *** this study,a C57BL/6J mouse model of subarachnoid hemorrhage was established using the endovascular perforation *** results indicated that TSG-6 expression was predominantly detected in astrocytes,along with NLRC4 and gasdermin-D(GSDMD).The expression of NLRC4,GSDMD and its N-terminal domain(GSDMD-N),and cleaved caspase-1 was significantly enhanced after subarachnoid hemorrhage and accompanied by brain edema and neurological *** explore how TSG-6 affects pyroptosis during early brain injury after subarachnoid hemorrhage,recombinant human TSG-6 or a siRNA targeting TSG-6 was injected into the cerebral *** TSG-6 administration downregulated the expression of NLRC4 and pyroptosis-associated proteins and alleviated brain edema and neurological ***,TSG-6 knockdown further increased the expression of NLRC4,which was accompanied by more severe astrocyte *** summary,our study revealed that TSG-6 provides neuroprotection against early brain injury after subarachnoid hemorrhage by suppressing NLRC4 inflammasome activation-induced astrocyte pyroptosis.

关键词： astrocyte early brain injury inflammasome NLRC4 pyroptosis subarachnoid hemorrhage tumor necrosis factor-stimulated gene-6(TSG-6)

Carbon dots-confined CoP-CoO nanoheterostructure with strong interfacial synergy triggered the robust hydrogen evolution from ammonia borane

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Journal of Energy Chemistry 2021年第6期30卷 198-205,I0006页

作者： Han Wu Yaojia cheng boyang Wang Yao Wang Min Wu Weidong Li Baozhong Liu Siyu Lu College of Chemistry and Institute of Green CatalysisZhengzhou UniversityZhengzhou 450001HenanChina College of Chemistry and Chemical Engineering Henan Polytechnic UniversityJiaozuo 454000HenanChina Guangdong Provincial Key Laboratory of Optical Information Materials and Technology Guangzhou 510631GuangdongChina College of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014ZhejiangChina

Ammonia borane(NH_(3)BH_(3),AB) is promising for chemical hydrogen sto rage;however,current systems for rapid hydrogen production are limited by the expensive noble metal catalysts required for AB *** we report the design and synthesis of a highly efficient and robust non-noble-metal catalyst for the hydrolysis of AB at 298 K(TOF=89.56 molH_(2) min^(-1) molCo^(-1)).Experiments and density functional theory calculations were performed to explore the catalyst’s hybrid nanoparticle heterostructure and its catalytic *** catalyst comprised nitrogen-doped carbon dots confining CoO and CoP,and exhibited strong interface-induced synergistic catalysis for AB hydrolysis that effectively decreased the energy barriers for the dissociation of both AB and water *** co-doping of N and P introduced numerous defects,and further regulated the reactivity of the carbon *** heterogeneous interface design technique presented here provides a new strategy for developing efficient and inexpensive non-noblemetal catalysts that may be applicable in other fields related to energy catalysis.

关键词： Nano-heterostructure Interface engineering Ammonia borane Hydrolysis mechanism Hydrogen

Excretion of manure-borne estrogens and androgens and their potential risk estimation in the Yangtze River Basin

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Journal of Environmental Sciences 2015年第11期27卷 110-117页

作者： Yanxia Li Shiying Gao Shufang Liu Bei Liu Xuelian Zhang Min Gao Linjie cheng boyang Hu State Key Laboratory of Water Environmental Simulation School of Environment Beijing Normal University Yellow River Institute of Hydraulic Research Yellow River Conservancy Commission

The Yangtze River is the longest river in China, and the river basin spans one fifth of the area of the whole country. Based on statistical data, the excretion of manure-borne steroid hormones, including steroid estrogens（SEs） and steroid androgens（SAs）, in 10 provinces of China within the region has been estimated. The potential environmental and ecological risk of manure-borne steroid estrogens to the surface water in this region was also assessed. The manure-borne SE and SA excretions in the 10 provinces and municipalities vary in the order： Sichuan 〉 Hunan 〉 Hubei 〉 Yunnan 〉 Jiangsu 〉 Anhui 〉 Jiangxi 〉Chongqing 〉 Qinghai 〉 Shanghai. The highest increase of manure-borne SEs（1434.3 kg）and SAs（408.5 kg） was found in Hunan and Hubei provinces, respectively, and the total excretion in 2013 was 65% more than 15 years earlier in these two provinces. However, the emissions in Anhui and Shanghai decreased in this 15 year period of time. Swine urine,chicken feces, cattle urine, and laying hen feces were considered the dominant sources of manure-borne E1, βE2, αE2, and SAs, respectively. Although Jiangsu province did not have the largest excretion of manure-borne SEs, it had the highest level of predicted17β-estradiol equivalency（EEQs） value of 16.65 ng/L in surface water because of the limited surface water resources. According to the lowest observable effect level of 10 ng/L for17β-estradiol, the manure-borne SEs in Jiangsu province might potentially pose ecological risk to its wild aquatic organisms.

关键词： Manure-borne steroid hormones Animal manure Pollution risk assessment The Yangtze River basin