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A drug-loaded flexible substrate improves the performance of conformal cortical electrodes

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Bio-Design and Manufacturing 2024年第4期7卷 399-412页

作者： Rongrong Qin Tian Li Yifu Tan Fanqi Sun Yuhao Zhou Ronghao Lv Xiaoli You bowen ji Peng Li Wei Huang Frontiers Science Center for Flexible Electronics(FSCFE) Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&Engineering(IBME)Northwestern Polytechnical UniversityXi’an 710072China Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Flexible Electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingbo 315103China

Cortical electrodes are a powerful tool for the stimulation and/or recording of electrical activity in the nervous ***,the inevitable wound caused by surgical implantation of electrodes presents bacterial infection and inflammatory reaction risks associated with foreign body ***,inflammation of the wound area can dramatically worsen in response to bacterial *** consequences can not only lead to the failure of cortical electrode implantation but also threaten the lives of ***,we prepared a hydrogel made of bacterial cellulose(BC),a flexible substrate for cortical electrodes,and further loaded antibiotic tetracycline(TC)and the anti-inflammatory drug dexamethasone(DEX)onto *** encapsulated drugs can be released from the BC hydrogel and effectively inhibit the growth of Gram-negative and Gram-positive ***,therapeutic cortical electrodes were developed by integrating the drug-loaded BC hydrogel and nine-channel serpentine arrays;these were used to record electrocorticography(ECoG)signals in a rat *** to the controlled release of TC and DEX from the BC hydrogel substrate,therapeutic cortical electrodes can alleviate or prevent symptoms associated with the bacterial infection and inflammation of brain *** approach facilitates the development of drug delivery electrodes for resolving complications caused by implantable electrodes.

关键词： Antibacterial Anti-inflammatory Drug loading Cortical electrodes Bacterial cellulose hydrogel

Smart epidermal electrophysiological electrodes:Materials,structures,and algorithms

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Nanotechnology and Precision Engineering 2023年第4期6卷 75-97页

作者： Yuanming Ye Haochao Wang Yanqiu Tian Kunpeng Gao Minghao Wang Xuanqi Wang Zekai Liang Xiaoli You Shan Gao Dian Shao bowen ji Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China Queen Mary University of London Engineering School Northwestern Polytechnical UniversityXi’an 710072China School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710072China School of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China College of Information Science and Technology Donghua UniversityShanghai 201620China College of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China

Epidermal electrophysiological monitoring has garnered significant attention for its potential in medical diagnosis and healthcare,particularly in continuous signal ***,simultaneously satisfying skin compliance,mechanical properties,environmental adaptation,and biocompatibility to avoid signal attenuation and motion artifacts is challenging,and accurate physiological feature extraction necessitates effective signal-processing *** review presents the latest advancements in smart electrodes for epidermal electrophysiological monitoring,focusing on materials,structures,and ***,smart materials incorporating self-adhesion,self-healing,and self-sensing functions offer promising solutions for long-term ***,smart meso-structures,together with micro/nanostructures endowed the electrodes with self-adaption and ***,intelligent algorithms give smart electrodes a“soul,”facilitating faster and more-accurate identification of required information via automatic processing of collected electrical ***,the existing challenges and future opportunities for developing smart electrodes are *** as a crucial direction for next-generation epidermal electrodes,intelligence holds the potential for extensive,effective,and transformative applications in the future.

关键词： Epidermal electrodes Electrophysiological signal monitoring Smart materials Smart structures Intelligent algorithms

Recent advances in wireless epicortical and intracortical neuronal recording systems

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Science China(Information Sciences) 2022年第4期65卷 5-22页

作者： bowen ji Zekai LIANG Xichen YUAN Honglai XU Minghao WANG Erwei YIN Zhejun GUO Longchun WANG Yuhao ZHOU Huicheng FENG Honglong CHANG jingquan LIU Unmanned System Research Institute Northwestern Polytechnical University Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical University Collaborative Innovation Center of Northwestern Polytechnical University NEURACLE TECH (China) Co. Ltd. College of Electronics and Information Hangzhou Dianzi University Defense Innovation Institute Academy of Military Sciences (AMS) Tianjin Artificial Intelligence Innovation Center (TAIIC) National Key Laboratory of Science and Technology on Micro/Nano Fabrication Department of Micro/Nano ElectronicsShanghai Jiao Tong University

An implantable brain-computer interface(BCI) has proven to be effective in the field of sensory and motor function restoration and in the treatment of neurological disorders. Using a BCI recording system,we can transform current methods of human interaction with machines and the environment, especially to help those with cognitive and mobility disabilities regain mobility and reintegrate into society. However,most reported work has focused on a simple aspect of the whole system, such as electrodes, circuits, or data transmission, and only a very small percentage of systems are wireless. A miniature, lightweight, wireless,implantable microsystem is key to realizing long-term, real-time, and stable monitoring on freely moving animals or humans in their natural conditions. Here, we summarize typical wireless recording systems, from recording electrodes, processing chips and controllers, wireless data transmission, and power supply to the system-level package for either epicortical electrocorticogram(ECo G) or intracortical local field potentials(LFPs)/spike acquisition, developed in recent years. Finally, we conclude with our vision of challenges in next-generation wireless neuronal recording systems for chronic and safe applications.

关键词： wireless implant neuronal recording system recording electrodes processing chips wireless data transmission power supply system-level package

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Stretchable Parylene-C electrodes enabled by serpentine structures on arbitrary elastomers by silicone rubber adhesive

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Journal of Materiomics 2020年第2期6卷 330-338页

作者： bowen ji Zhaoqian Xie Wen Hong Chunpeng jiang Zhejun Guo Longchun Wang Xiaolin Wang Bin Yang jingquan Liu National Key Laboratory of Science and Technology on Micro/Nano Fabrication Department of Micro/Nano ElectronicsShanghai Jiao Tong UniversityShanghai200240China Department of Engineering Mechanics Dalian University of TechnologyDalian116024China

The delicate serpentine structures are widely used in high-performance stretchable electronics over the past *** metal interconnects encapsulated in biocompatible polymer Parylene-C film is a superior choice for long-term implantation in vivo,especially as neural interface to acquire electrophysiological signals or apply electrical *** avoid the physical contact damages from the neural tissues such as the brain or peripheral nerves,serpentine interconnects are utilized as stretchable electrodes and usually bonded to the soft elastomer *** adhesion strength between the serpentine interconnects and the elastomer substrate becomes a considerable issue to ensure reliability and structural *** this paper,the stretchable Parylene-C electrodes can be transfer printed onto arbitrary elastomer substrates by a thin layer of silicone rubber adhesive with low modulus for electrocorticogram(ECoG)*** simulation of serpentine structures consisting of same periodic arcs and different straight segments is investigated by uniaxial ***,the elastic stretchability of serpentine electrodes is further studied by simulation and *** 5000 repetitive stretching cycles,the electrochemical impedance of microelectrodes remains in steady *** results prove that the silicone rubber adhesive facilitates the interfacial bonding in the structure of stretchable electrodes as the compliant and reliable neural interface.

关键词： Stretchable Parylene-C electrodes Serpentine structure Arbitrary elastomers Silicone rubber adhesive

Brainmask:an ultrasoft and moist microelectrocorticography electrode for accurate positioning and long-lasting recordings

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Microsystems & Nanoengineering 2023年第5期9卷 295-307页

作者： bowen ji Fanqi Sun jiecheng Guo Yuhao Zhou Xiaoli You Ye Fan Longchun Wang Mengfei Xu Wen Zeng jingquan Liu Minghao Wang Huijing Hu Honglong Chang Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Collaborative Innovation Center of Northwestern Polytechnical University Shanghai 201108China Institute of Medical Research Northwestern Polytechnical UniversityXi’an 710072China College of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China National Key Laboratory of Science and Technology on Micro/Nano Fabrication Department of Micro/Nano ElectronicsShanghai Jiao Tong UniversityShanghai 200240China

Bacterial cellulose(BC),a natural biomaterial synthesized by bacteria,has a unique structure of a cellulose nanofiberweaved three-dimensional reticulated *** films can be ultrasoft with sufficient mechanical strength,strong water absorption and moisture retention and have been widely used in facial *** films have the potential to be applied to implantable neural interfaces due to their conformality and moisture,which are two critical issues for traditional polymer or silicone *** this work,we propose a micro-electrocorticography(micro-ECoG)electrode named“Brainmask”,which comprises a BC film as the substrate and separated multichannel parylene-C microelectrodes bonded on the top *** can not only guarantee the precise position of microelectrode sites attached to any nonplanar epidural surface but also improve the long-lasting signal quality during acute implantation with an exposed cranial window for at least one hour,as well as the in vivo recording validated for one *** novel ultrasoft and moist device stands as a next-generation neural interface regardless of complex surface or time of duration.

关键词： recording electrode moisture

Flexible capacitive pressure sensor based on interdigital electrodes with porous microneedle arrays for physiological signal monitoring

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Nanotechnology and Precision Engineering 2024年第1期7卷 18-31页

作者： jiahui Xu Minghao Wang Minyi jin Siyan Shang Chuner Ni Yili Hu Xun Sun Jun Xu bowen ji Le Li Yuhua Cheng Gaofeng Wang School of Electronics&Information MOE Engineering Research Center of Smart Microsensors and MicrosystemsHangzhou Dianzi UniversityHangzhou 310018China Wenzhou Institute of Hangzhou Dianzi University Wenzhou 310018China Key Laboratory of Intelligent Operation and Maintenance Technology&Equipment for Urban Rail Transit of Zhejiang Province College of EngineeringInstitute of Precision Machinery and Smart StructureZhejiang Normal UniversityJinhua 321004China Institute of Guizhou Aerospace Measuring and Testing Technology Guiyang 550009China Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China

Flexible pressure sensors have many potential applications in the monitoring of physiological signals because of their good biocompatibil-ity and ***,their relatively low sensitivity,linearity,and stability have hindered their large-scale commercial ***,aﬂexible capacitive pressure sensor based on an interdigital electrode structure with two porous microneedle arrays(MNAs)is *** porous substrate that constitutes the MNA is a mixed product of polydimethylsiloxane and *** to its porous and interdigital structure,the maximum sensitivity(0.07 kPa-1)of a porous MNA-based pressure sensor was found to be seven times higher than that of an imporous MNA pressure sensor,and it was much greater than that of aﬂat pressure sensor without a porous MNA ***-element analysis showed that the interdigital MNA structure can greatly increase the strain and improve the sensitivity of the *** addition,the porous MNA-based pressure sensor was found to have good stability over 1500 loading cycles as a result of its bilayer parylene-enhanced conductive electrode *** importantly,it was found that the sensor could accurately monitor the motion of aﬁnger,wrist joint,arm,face,abdomen,eye,and Adam’s ***,preliminary semantic recognition was achieved by monitoring the movement of the Adam’s ***,multiple pressure sensors were integrated into a 33 array to detect a spatial pressure distribu-×*** to the sensors reported in previous works,the interdigital electrode structure presented in this work improves sensitivity and stability by modifying the electrode layer rather than the dielectric layer.

关键词： Capacitive pressure sensor Microneedle array Porous PDMS Interdigital electrode

Progress in Mechanical Modeling of Implantable Flexible Neural Probes

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1205-1231页

作者： Xiaoli You Ruiyu Bai Kai Xue Zimo Zhang Minghao Wang Xuanqi Wang jiahao Wang jinku Guo Qiang Shen Honglong Chang Xu Long bowen ji Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an710072China National Key Laboratory of Unmanned Aerial Vehicle Technology Northwestern Polytechnical UniversityXi’an710072China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an710072China School of Automobile Chang’an UniversityXi’an710018China MOE Engineering Research Center of Smart Microsensors and Microsystems College of Electronics and InformationHangzhou Dianzi UniversityHangzhou310018China School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an710129China

Implanted neural probes can detect weak discharges of neurons in the brain by piercing soft brain tissue,thus as important tools for brain science research,as well as diagnosis and treatment of brain ***,the rigid neural probes,such as Utah arrays,Michigan probes,and metal microfilament electrodes,are mechanically unmatched with brain tissue and are prone to rejection and glial scarring after implantation,which leads to a significant degradation in the signal quality with the implantation *** recent years,flexible neural electrodes are rapidly developed with less damage to biological tissues,excellent biocompatibility,and mechanical compliance to alleviate *** them,the mechanical modeling is important for the optimization of the structure and the implantation *** this review,the theoretical calculation of the flexible neural probes is firstly summarized with the processes of buckling,insertion,and relative interaction with soft brain tissue for flexible probes from outside to ***,the corresponding mechanical simulation methods are organized considering multiple impact factors to realize minimally invasive ***,the technical difficulties and future trends of mechanical modeling are discussed for the next-generation flexible neural probes,which is critical to realize low-invasiveness and long-term coexistence in vivo.

关键词： Mechanical modeling flexible neural probes invasive theoretical calculation simulation

MODIS时序影像的福建近岸叶绿素a浓度反演

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环境科学学报 2018年第12期38卷 4831-4839页

作者：张明慧苏华季博文福州大学卫星空间信息技术综合应用国家地方联合工程研究中心空间数据挖掘与信息共享教育部重点实验室福州350116

叶绿素a(Chl-a)浓度是可以直接遥感反演的重要水质参数之一,常用来评价近岸水体的富营养化程度.为有效监测福建近岸水域中的叶绿素a浓度变化,本文利用MODIS时间序列影像数据,采用适用于小样本数据的机器学习方法随机森林(Random Forest,... 详细信息

叶绿素a(Chl-a)浓度是可以直接遥感反演的重要水质参数之一,常用来评价近岸水体的富营养化程度.为有效监测福建近岸水域中的叶绿素a浓度变化,本文利用MODIS时间序列影像数据,采用适用于小样本数据的机器学习方法随机森林(Random Forest, RF)和传统的特征波段比值(Band Ratio, BR)方法,结合时序浮标观测数据,在浮标观测站点有限的情况下,采用"以时间连续补空间稀疏"的建模策略,分别对福建近岸不同时相叶绿素a浓度进行遥感反演,并对反演结果进行验证与分析.结果显示RF、BR两种方法反演的均方根误差(RMSE)分别为0.49、0.52μg·L^(-1),平均绝对百分比误差(MAPE)分别为37.50%、50.20%,平均决定系数(R^2)分别为0.87、0.21.可见,基于MODIS时序影像的RF模型可较准确估测福建近岸叶绿素a浓度,且精度优于BR模型.在近岸水环境普遍恶化且浮标观测站点有限的情况下,本研究可提供一种有效监测叶绿素a浓度的方法,有利于福建近岸水环境(如赤潮)的遥感监测.

关键词：福建近岸叶绿素a浓度 MODIS 随机森林特征波段比值

面向变化场景的LiDAR鲁棒定位与地图维护方法

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仪器仪表学报 2022年第4期43卷 291-301页

作者：吕品季博文赖际舟方玮郑国庆南京航空航天大学自动化学院南京211106

无人车在工业场景自主运行时,通常基于先验地图匹配对自身进行定位,然而场景变化会影响其定位精度。针对于此,本文提出了一种面向变化场景的激光雷达鲁棒定位与地图维护架构,其包括地图匹配、定位优化、地图维护模块。在该架构中,提出... 详细信息

无人车在工业场景自主运行时,通常基于先验地图匹配对自身进行定位,然而场景变化会影响其定位精度。针对于此,本文提出了一种面向变化场景的激光雷达鲁棒定位与地图维护架构,其包括地图匹配、定位优化、地图维护模块。在该架构中,提出了一种基于变化检测的匹配算法,降低了变化场景引起的匹配误差;设计了基于激光雷达里程计与先验地图匹配的因子图融合模式,提高了定位解算鲁棒性;提出了一种基于最近点搜索的误检测点滤波方法,提高了变化点检测准确性。最后,通过仿真与试验搭建了变化场景验证环境,对基于Loam的匹配算法与本文算法进行了对比验证。结果表明,本文算法可以有效抑制场景变化引起的匹配误差,在实际场景中定位均方根误差优于3 cm,定位精度相较于传统算法提高67.4%。

关键词：鲁棒定位激光雷达变化检测地图维护

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